ライフサイエンスコーパス: c-Maf

1 d cytokine production in mice lacking c-Maf (c-maf(-/-)).

2 clin D3), 4p16 (FGFR3 and MMSET), and 16q23 (c-maf).

3 ic, osteopontin-positive chondrocytes in the c-maf-/-.

4 igher expression of the transcription factor c-Maf.

5 directly and indirectly via up-regulation of c-Maf.

6 X6(5a) variants and other factors, e.g. MafA/c-Maf.

7 egulated by AP-1 and may also be a target of c-Maf.

8 fferent 3'-untranslated region compared with c-Maf.

9 MiR-155 is a microRNA that targets c-Maf.

10 ssion of the Th2-specific factors GATA-3 and c-Maf.

11 interleukin-4-specific transcription factor c-Maf.

12 ted with a decreased induction of GATA-3 and c-maf.

13 anoma cells resulted in the up-regulation of c-maf.

14 other cells is dependent on the presence of c-maf.

15 oncogenes: bcl-9, bcl-10, PAX-5, MMSET, and c-maf.

16 ocation breakpoints in these 6 lines bracket c-maf.

17 R, releasing Twist2, which induces IL-10 via c-Maf.

18 Th2-inducing transcription factors GATA3 or c-Maf.

19 f the anti-inflammatory transcription factor c-Maf.

20 ific molecular target of p53 in microglia is c-Maf.

21 s in vivo required coexpression of Bcl-6 and c-Maf.

22 Here, we report that the proto-oncogene c-maf, a basic region/leucine zipper transcription facto

23 IL-10 and had increased mRNA expression for c-Maf, a transcription factor that upregulates IL-10 gen

24 butes to immune deviation in T1D by reducing c-Maf access to and transactivation of the IL-4 gene.

25 on of both cytokines, other factors, such as c-Maf act specifically on IL-22 and enable the separate

26 Thus, cartilage is a novel system in which c-Maf acts during development, where c-Maf is required f

27 Furthermore, c-Maf acts in synergy with the nuclear factor of activat

28 cation, there is selective expression of one c-maf allele in 2 informative lines with translocations.

29 Co-transfections using Pax6 and c-Maf alone revealed moderate and strong activations of

30 that bind the oncoproteins c-Jun, c-Fos and c-Maf (also called JUN, FOS and MAF, respectively), were

31 Restoring c-Maf and Bmi1 expression in Twist-deficient macrophages

32 vitro translated proteins revealed that both c-Maf and c-Maf bound to NQO1 gene ARE as homodimers and

33 We have shown that the c-Maf and c-Myb transcription factors physically interac

34 a 10 amino acids at the carboxyl terminus of c-Maf and contains a different 3'-untranslated region co

35 d by DNA-binding transcription factors Pax6, c-Maf and CREB bound to its promoter region.

36 data demonstrate a novel mechanism of Pax6, c-Maf and CREB function, through regulation of chromatin

37 pression correlate with increased binding of c-Maf and CREB to the promoter and of CREB to DCR3, a br

38 Both c-Maf and Cryaa regulatory regions contain arrays of AP-

39 s, abolished T-bet expression, and increased c-MAF and GATA-3 protein in vivo.

40 neous induction of the transcription factors c-Maf and Gata-3, mediated by the kinases p38 MAPK and S

41 the expression of the transcription factors c-maf and GATA-3.

42 Both c-Maf and IL-10 induction during Th17 polarization depen

43 imulated PDCD4 degradation and expression of c-Maf and IL-10 production.

44 decreased expression of IL-7Ralpha, BATF and c-Maf and increased expression of Bcl11b and Lef1.

45 These results demonstrate that c-maf and its target binding site are not required for I

46 evels of the requisite transcription factors c-Maf and Jun B.

47 The synergy between c-Maf and JunB can be attributed to cooperative DNA bind

48 c-maf and junB mRNA, protein, and activity were signific

49 lation of the Th2-type transcription factors c-Maf and JunB, which consequently enhances IL-4 and IL-

50 ption factors have been described, including c-Maf and JunB.

51 TBP was also part of c-Maf and MafA (two other large Maf proteins)-containing

52 gism promotes activation of transcription by c-Maf and MafA on the alphaB-crystallin promoter, and is

53 gene signatures were observed in cases with c-MAF and MAFB activation and CCND1 and CCND3 activation

54 embers of the large Maf family, specifically c-Maf and MafB.

55 hey increased nuclear Nrf2 levels, prevented c-Maf and MafG induction, and prevented the fall in Nrf2

56 ell at 20 hours after LCA treatment, whereas c-Maf and MafG remained persistently induced.

57 Nuclear levels of c-Maf and MafG, which can negatively regulate ARE, were

58 We identify transcription factors, c-Maf and NFIL3, and negative co-stimulatory molecules,

59 der Tr1-skewing conditions, the AhR bound to c-Maf and promoted transactivation of the Il10 and Il21

60 periments revealed that CBP and p300 bind to c-Maf and Prox-1 but not to Sox-1.

61 expression of the key transcription factors c-Maf and Prox1.

62 ter binding of the proinflammatory inhibitor c-Maf and the transcriptional repressor Bmi1.

63 multiple myeloma SET domain [MMSET]), 16q23 (c-maf), and 20q11 (mafB).

64 volved in Th2 development (IL-4, GATA-3, and c-maf), and decreased mRNA for genes involved in Th1 dev

65 sion of the transcriptional repressor factor c-Maf, and a decreased binding of GAP-12 to the gene pro

66 ta was also synergistic with IL-27 to induce c-Maf, and it induced Stat1-independent IL-10 expression

67 ociated with sustained expression of GATA-3, c-MAF, and JunB in an IL-4-independent manner.

68 ns of Pax6/Pax6(5a), large Mafs (MafA, MafB, c-Maf, and NRL), Sox1, Sox2, Six3, and RARbeta/RXRbeta.

69 /RXRbeta, and lens fiber-factors Pax6, MafA, c-Maf, and NRL.

70 s of distinct cell types in the gonad: MAFB, C-MAF, and VCAM1.

71 influenced by known genetic lesions, such as c-MAF- and MAFB-, CCND1- and CCND3-, and MMSET-activatin

72 c-Maf appears to function primarily in Treg specializati

73 w that mice lacking the transcription factor c-Maf are microphthalmic secondary to defective lens for

74 and enhanced by IL-21 expression through the c-Maf/aryl hydrocarbon receptor pathway, independent of

75 transcriptional factor Bcl6 as well as IRF4, c-Maf, Batf, and STAT3/5.

76 5 (CXCR5), musculoaponeurotic fibrosarcoma (c-Maf), Bcl6, basic leucine zipper transcription factor

77 The corresponding cellular protein, c-Maf belongs to a family of related bZip proteins toget

78 Furthermore, mutation of a defined c-maf binding site within the proximal IL-4 promoter, wh

79 sion of 22 genes whose promoters contained a c-Maf binding site, including hyaluronan synthase 1 (HAS

80 driven luciferase reporter activity, reduces c-Maf binding to the IL-4p in chromatin immunoprecipitat

81 demonstrate that despite normal expression, c-Maf binds poorly to the IL-4 promoter (IL-4p) in NOD C

82 We demonstrate that c-maf binds this site in vivo and synergistically augmen

83 c-Maf binds to a c-Maf response element (MARE) in the pr

84 ssion of the transcription factors Bcl-6 and c-Maf, both of which are needed for development of folli

85 slated proteins revealed that both c-Maf and c-Maf bound to NQO1 gene ARE as homodimers and heterodim

86 We found that c-Maf bound to the Il22 promoter and was both necessary

87 The co-activation of c-Maf by CBP/p300 requires histone acetyltransferase act

88 As predicted for dysregulation of c-maf by translocation, there is selective expression of

89 examined cytokine production in mice lacking c-Maf (c-maf(-/-)).

90 tion of transcriptional activation domain of c-Maf (c-Maf) led to significant loss of MARE-mediated p

91 Immunoblotting demonstrates that c-Maf can be modified at lysine 33 by SUMO-1 (small ubiq

92 Thus, transgenic c-Maf can strongly influence autoimmune disease developm

93 eloid cell lines, we inducibly expressed the c-Maf cDNA in 2 bipotent human myeloid progenitor cells.

94 e of alternative mediators in the absence of c-Maf, consistent with the observation that a functional

95 It was not known whether c-Maf controlled the transcription of other Th2 cytokine

96 equent stages of lens morphogenesis, whereas c-Maf controls terminal differentiation of lens fibers,

97 h2-specific transcription factors GATA-3 and c-maf correlated with the increased production of Th2 cy

98 ing lens development, link together the Pax6/c-Maf/crystallin regulatory network, and suggest a novel

99 al co-activator p300 and we demonstrate that c-Maf D90V enhances p300 recruitment in a cell-type depe

100 In contrast to wild-type protein, the c-Maf D90V mutant protein is not inhibited by protein ki

101 In c-Maf-deficient murine macrophages, IL-10 production is

102 ules, and general immune homeostasis are not c-Maf dependent.

103 usive evidence that the transcription factor c-Maf directed the tissue-specific expression of IL-4.

104 in Stat6-deficient CD4 and CD8 T cells, and c-Maf directly transactivated IL-10 gene expression thro

105 Although it has been postulated that c-maf directs the Th2-specific expression of the IL-4 ge

106 ow in this article that introduction of Maf (c-Maf) does induce the capacity to express IL-21.

107 errant or reduced expression of Prox1, Pax6, c-Maf, E-cadherin and alpha-, beta- and gamma-crystallin

108 that IL-6 plays a unique role in initiating c-Maf expression after TCR engagement, and may subsequen

109 e defect was associated with a deficiency in c-Maf expression and could be rescued completely by c-Ma

110 It also induced GATA-3 and c-maf expression and downregulated IL-12Rbeta2 chain exp

111 T-cell receptor (TCR)/CD28-induced IL-4 and c-Maf expression and, conversely, enhanced interferon ga

112 Here, we show that Pax6 directly regulates c-Maf expression during lens development.

113 c-Maf expression in effector cells was regulated by IL-4

114 ed by p53 and negatively regulate Twist2 and c-Maf expression in microglia and the RAW macrophage cel

115 IL-6 induces similar c-Maf expression in protein kinase Ctheta-deficient CD4(

116 Northern analysis revealed that c-Maf expression increases 2 h after t-BHQ treatment.

117 lecting, at least in part, the dependence of c-Maf expression on Ca2+/NFAT signaling.

118 enhancer (CR1) recapitulated the endogenous c-Maf expression pattern in lens and retinal pigmented e

119 IL-27-driven c-Maf expression transactivates IL-21 production, which

120 Co-culture led to upregulated c-Maf expression with no decrease in the proportion of T

121 s, Vav1 is selectively required for IL-4 and c-Maf expression, a requirement reflecting, at least in

122 IL-4 can up-regulate c-Maf expression, its binding to IL-10 promoter, and dos

123 cus but also for inducing Il4, Il5, Il13 and c-Maf expression.

124 expression, but only partially by retroviral c-Maf expression.

125 macrophages likely via its ability to induce c-Maf expression.

126 Ca(2+) signal pathways, block IL-6-mediated c-Maf expression.

127 inflammatory and tolerogenic signals promote c-Maf expression.

128 IL-10 expression also correlated with c-maf expression.

129 These data suggest that c-Maf facilitates the initial chondrocyte terminal diffe

130 IL-4-producing mast cells do not express the c-maf factor.

131 the IL-4 gene in vivo, direct evidence that c-maf functions during the differentiation of normal, pr

132 We conclude that c-Maf has a critical and selective function in IL-4 gene

133 Pax6, c-Maf, Hsf4, Prox1, Sox1, and a few additional factors r

134 xhibit T(FH) features (including Batf, Bcl6, c-Maf, ICOS, and IL-21 expression) and are able to migra

135 those elements is essential, because loss of c-Maf, IL-21-signaling, or ICOS decreases the frequency

136 The overexpression of c-Maf in human hepatoblastoma (Hep-G2) cells led to the

137 Expression of c-Maf in human immature myeloblastic cells inhibited CD1

138 in Th2 cells can provide the specificity for c-Maf in IL-4 expression during T cell development and d

139 he role of posttranslational modification of c-Maf in IL-4 production and Th cell-mediated autoimmune

140 y uncovers a novel and important function of c-Maf in macrophages and elucidates its transcriptional

141 Ectopic expression of c-maf in mature Th1 cells did not confer on them the abi

142 ls can be recapitulated by overexpression of c-Maf in myeloid cell lines, we inducibly expressed the

143 -4-independent and CD25-mediated function of c-maf in promoting the production of Th2 cytokines.

144 together, these data reveal a novel role for c-Maf in regulating T effector development, and they sug

145 This was in contrast to the role of c-Maf in the activation of Maf recognition element (MARE

146 nd super shift assays showed the presence of c-Maf in the ARE-nuclear protein complex.

147 and macrophages, we investigate the role of c-Maf in the transcriptional regulation of IL-10 and the

148 We now demonstrate that overexpression of c-maf in vivo skews the Th immune response along a Th2 p

149 To elucidate the role of c-Maf in vivo, we examined cytokine production in mice l

150 Thus, c-maf increases HIV-1 expression in IL-4-producing CD4 T

151 Here, we provide evidence demonstrating that c-maf, independent of IL-4, is essential for normal indu

152 c-Maf induces changes in nuclear DNA-binding activities

153 two genes in the SLI1 region: that encoding c-maf-inducing protein (CMIP, minP = 5.5 x 10(-7) at rs6

154 -stimulated production of IL-4/IL-21 through c-Maf induction is responsible for impaired Th1 differen

155 c-Maf induction requires both IL-6- and TCR-initiated si

156 ze Th17 immunity by IL-10 production through c-Maf induction.

157 [cyclin D1]; 4p16 [FGFR3 and MMSET]; 16q23 [c-maf]) involved in nearly half of MM tumors.

158 In this article, we show that c-Maf is a critical transcription factor regulating this

159 Therefore, c-Maf is a novel regulator of Treg specialization, which

160 c-maf is a T helper (Th)2 cell-specific transcription fa

161 Taken together, these data demonstrate that c-Maf is an indispensable yet constitutive transcription

162 Although c-Maf is crucial for Th2 differentiation and production

163 The transcription factor c-Maf is essential for the induction of IL-10 by Tr1 cel

164 Furthermore, c-Maf is expressed constitutively in resting monocytes/m

165 c-maf is expressed in hypertrophic chondrocytes during f

166 c-Maf is expressed in Th2 but not Th1 clones and is indu

167 Sumoylation of c-Maf is increased in NOD CD4 cells as compared with CD4

168 As in other T cells, c-Maf is induced in Tregs by IL-6 and TGF-beta, suggesti

169 We demonstrate that c-Maf is one of the physiological mediators of IL-10's i

170 udy, we report that the transcription factor c-Maf is required for normal chondrocyte differentiation

171 n which c-Maf acts during development, where c-Maf is required for normal chondrocyte differentiation

172 Thus, c-Maf is required for the differentiation of the vertebr

173 r knowledge, we show for the first time that c-Maf is subjective to tyrosine phosphorylation in Th ce

174 pper transcription factor Maf (also known as c-Maf) is central to osteoblast lineage commitment.

175 more, Twist2, a transcriptional activator of c-Maf, is increased in p53-deficient microglia.

176 his report, we have investigated the role of c-Maf (large Maf) containing the transcriptional activat

177 ore ARE sequence is essential for binding of c-Maf leading to repression of NQO1 gene expression.

178 transcriptional activation domain of c-Maf (c-Maf) led to significant loss of MARE-mediated p53 gene

179 ivity and prevented the increase in MafG and c-Maf levels.

180 iate these phenotypic changes indicated that c-Maf likely plays a key role in myeloid cell developmen

181 tin immunoprecipitation assays, and enhances c-Maf localization into promyelocytic leukemia nuclear b

182 of Pax6 and c-Maf to multiple regions of the c-Maf locus in lens chromatin.

183 elopment and function including Pax-6, Six3, c-Maf, Maf1, Sox-4, Foxc1, Rx, and Ldb2 were present amo

184 multiple myelomas harboring cyclin D1/D3 or c-MAF/MAFB translocations.

185 oxic bile acid induces a switch from Nrf2 to c-Maf/MafG ARE nuclear binding, which leads to decreased

186 ell development; therefore, abnormalities in c-Maf may contribute to reduced IL-4 production by CD4 c

187 Pax6 and c-Maf, Pax6 has a neutral effect on c-Maf-mediated alphaA-crystallin promoter activation.

188 CD4+ T cells and NK T cells from c-maf(-/-) mice were markedly deficient in IL-4 producti

189 While c-Maf mRNA and protein levels remain constant during mye

190 cers and nonproducers have similar Gata3 and c-maf mRNA expression.

191 nding to the c-Maf promoter and induction of c-Maf mRNA.

192 Only these 6 lines overexpress c-maf mRNA.

193 We report a semi-dominant mouse c-Maf mutation recovered after ENU mutatgenesis which re

194 Unlike null and loss-of-function c-Maf mutations, which cause severe runting and renal ab

195 results together led to the conclusion that c-Maf negatively regulates ARE-mediated detoxifying enzy

196 Neither c-Maf nor JunB induced Th2 development in Stat6-deficien

197 c-Maf-null macrophages exhibit strongly impaired IL-10 p

198 d to enhance LPS-induced IL-10 production in c-Maf-null macrophages.

199 In c-maf-null mice, fetal bone length is decreased approxim

200 mature hypertrophic chondrocytes at E15.5 in c-maf-null tibiae, with decreased expression domains of

201 rmal proliferation rate and apoptosis in the c-maf-null.

202 ecrease in MMP-13 expression at E15.5 in the c-maf-null.

203 revious novel finding that the protooncogene c-Maf of the basic leucine zipper family of transcriptio

204 pers with c-Jun, JunB or c-Fos, but not with c-Maf or MafB.

205 Knockdown of c-Maf or MafG individually blunted the LCA-induced decre

206 Knockdown of c-Maf or MafG individually increased the expression of G

207 the expression of Pax-6, alphaA-crystallin, c-maf, or PDGF-R alpha.

208 xpression and could be rescued completely by c-Maf overexpression in T cells.

209 The attenuation of Th1 differentiation by c-maf overexpression occurred by a mechanism that was in

210 the transcription factors NFATc2, NF-kB p65, c-Maf, p300, Brg1, STAT6, and GATA-3 assemble at the Il4

211 activation of alphaB-crystallin by Pax6 and c-Maf, Pax6 has a neutral effect on c-Maf-mediated alpha

212 The transcription factor c-Maf plays a critical and selective role in IL-4 gene t

213 It remains unclear whether c-maf possesses any IL-4-independent function in regulat

214 erized a novel FGF2-responsive region in the c-Maf promoter (-272/-70, FRE).

215 and thereby decreased Twist2 binding to the c-Maf promoter and induction of c-Maf mRNA.

216 We show that Stat3 binds the c-maf promoter in CD4 T cells after IL-6 stimulation, an

217 L-6 stimulation, and also transactivates the c-maf promoter in reporter gene assays.

218 A 1.3-kb c-Maf promoter with a 1.6-kb upstream enhancer (CR1) rec

219 d the complex allowing Twist2 to bind to the c-Maf promoter.

220 These studies demonstrate that c-maf promotes Th2 differentiation by IL-4-dependent mec

221 Elevated levels of c-Maf protein led to marked increases in Myb:Maf complex

222 of MafA and MafB along with two forms of the c-Maf protein.

223 proximately 500-kb region centromeric to the c-maf proto-oncogene at 16q23.

224 site represents the 3' coding region of the c-maf proto-oncogene at 67.0 centimorgans (cM) on chromo

225 The c-maf proto-oncogene encodes a basic leucine zipper prot

226 The c-maf protooncogene is a T helper cell type 2 (Th2)-spec

227 oth CD4 and CD8 T-cells; here too transgenic c-Maf provided significant protection.

228 ding protein (CBP) and/or p300 interact with c-Maf, Prox-1, or Sox-1 to enhance transcription of crys

229 s fiber cell differentiation is regulated by c-Maf, Prox1 and Sox1.

230 y and distinct markers including N-cadherin, c-Maf, Prox1, and alphaA-, alphaB-, and beta-crystallins

231 and differentiation associated with altered c-Maf, Prox1, and p57 expression pattern in the anterior

232 Our results suggest that c-Maf recruits CBP and/or p300 to crystallin promoters l

233 versely, small interfering RNA inhibition of c-maf reduces HIV-1 transcription in IL-4-producing T ce

234 Pax6 and c-Maf regulate multiple stages of mammalian lens develop

235 , we have shown that the bZIP proto-oncogene c-Maf regulates expression of alphaA-crystallin (Cryaa)

236 Thus our data suggest that ICOS-induced c-Maf regulates IL-21 production that in turn regulates

237 tle is known about the mechanism that guides c-Maf regulation during early T cell activation.

238 -Maf, we examined the impact of p53 on known c-Maf regulators.

239 in mice, the transcription factors MafB and c-Maf repress a macrophage-specific enhancer repertoire

240 anscriptional mechanism, we identify a novel c-maf (required for IL-4 expression) transcription facto

241 Inhibition of IL-12 p40 gene expression by c-Maf requires the N-terminal transactivation domain, su

242 c-Maf binds to a c-Maf response element (MARE) in the proximal IL-4 promo

243 in vitro and in vivo experiments identify a c-Maf response element localized to nucleotides -196/-18

244 Nonetheless, the essential c-Maf-responsive element appears to be located elsewhere

245 Genetic loss of c-Maf resulted in a defect in IL-21 production and fewer

246 l lamina-specific transcription factors such c-Maf, Rora, and Satb1 are identified for the first time

247 c-Maf's inhibition of CD13/APN expression correlates wit

248 When overexpressed, c-Maf selectively inhibits transcriptional activation of

249 d activators of transcription 4), T-bet, and c-maf showed reduced expression in UCB compared with AB

250 In addition, Batf-to-c-Maf signalling is an important determinant of IL-4 exp

251 c-Maf siRNA inhibited HAS1 expression in M. tuberculosis

252 tes IL-4 promoter, and ectopic expression of c-Maf skews primary T cell response toward the Th2 pathw

253 c-Maf small interfering RNA (siRNA) inhibited IL-10 prod

254 )(q23;q11), with the breakpoint telomeric to c-maf, so that the translocation breakpoints in these 6

255 Ectopic expression of c-Maf stimulates not only exogenously transfected IL-10

256 stant B10.D2 mice, suggesting that increased c-Maf sumoylation contributes to immune deviation in T1D

257 rentiated in the presence of exogenous IL-4, c-maf(-/-) T cells produced approximately normal levels

258 rmore, we have examined the levels of GATA3, c-Maf, T-bet, and Ets-related molecule during human Th1/

259 Moreover, CS1 increased c-maf-targeted cyclin D2-dependent proliferation, -integ

260 ompletely restored Th2 development, inducing c-Maf, Th2-specific DNase I hypersensitive sites in the

261 the T(H)2-specific factors GATA3, STAT6 and c-Maf, the chromatin-remodeling enzyme Brg1 and RNA poly

262 three key elements: the transcription factor c-Maf, the cytokine IL-21, and the costimulatory recepto

263 directly to the P1 site and synergizes with c-Maf to activate an IL-4 luciferase reporter gene.

264 ells identified the Th2 transcription factor c-Maf to be synergistically up-regulated by IL-6 plus TG

265 l type 2 (Th2)-specific transcription factor c-Maf to cells normally refractory to IL-4 production, s

266 residues is critical for the recruitment of c-Maf to IL-4 promoter and IL-4 production in Th cells.

267 that Stat6 functions upstream of GATA-3 and c-Maf to induce Th2 development.

268 s in myeloid cells, we tested the ability of c-Maf to influence Ets-1- and c-Myb-dependent CD13/APN t

269 ChIP assays revealed binding of Pax6 and c-Maf to multiple regions of the c-Maf locus in lens chr

270 to IL-4 promoter regions and synergizes with c-Maf to positively regulate IL-4 expression.

271 was induced by IL-27, acted in synergy with c-Maf to promote the development of Tr1 cells.

272 served is likely explained by the ability of c-Maf to transactivate the crystallin gene promoter.

273 and the IL-4-inducing transcription factor, c-maf, to augment IL-4 promoter activity as well as to e

274 Expression of c-Maf transactivated each of these promoters.

275 In immune system, c-Maf transactivates IL-4 promoter, and ectopic expressi

276 c-Maf transactivates the IL-4 gene promoting Th2 cell de

277 Ectopic expression of c-Maf transactivates the IL-4 promoter in Th1 cells, B c

278 In transfected cells, sumoylation decreases c-Maf transactivation of IL-4p-driven luciferase reporte

279 A new long form of the c-Maf transcription factor (Lc-Maf) was identified and s

280 We found impaired expression of c-Maf transcription factor functionally associated with

281 The c-maf transcription factor is selectively expressed in I

282 first human tumor in which the basic zipper c-maf transcription factor is shown to function as an on

283 L-4 or other cytokines, rapidly up-regulates c-Maf transcription, as early as 3 h after TCR activatio

284 t beta-cell expression of hemagglutinin, the c-Maf transgene provided significant protection from spo

285 Surprisingly, when the c-Maf transgene was backcrossed with the NOD model of sp

286 L-4 dependent since this was not observed in c-maf transgenic mice bred onto an IL-4-deficient backgr

287 oduction of IgGl and IgE in the CD4 promoter/c-maf transgenic mice was IL-4 dependent since this was

288 rmore, by expressing GATA-3 in wild-type and c-maf transgenic Th1 cells, we demonstrate that the expr

289 llin is regulated by recruitment of Pax6 and c-Maf, two proteins regulating multiple processes of len

290 c-Maf undergoes tyrosine phosphorylation at Tyr(21), Tyr

291 to c-avian musculoaponeurotic fibrosarcoma (c-Maf)/V-maf musculoaponeurotic fibrosarcoma oncogene ho

292 Retroviral transduction of c-Maf was able to induce IL-10 expression in Stat6-defic

293 Up-regulation of c-Maf was dependent on Ca2+/nuclear factor of activated

294 interest, co-expression of CBP or p300 with c-Maf was found to synergistically co-activate each prom

295 To determine how p53 negatively regulates c-Maf, we examined the impact of p53 on known c-Maf regu

296 Because MafA, MafB, and c-Maf were each capable of specifically binding to and a

297 CD14(hi) cells have increased expression of c-Maf, which increases production of two key factors (hy

298 Here we identify the transcription factor c-Maf, which is induced by TGF-beta, as a downstream rep

299 The co-expression of c-Maf with MafG rescued the MafG repression of MARE but

300 established in vivo interactions of Pax6 and c-Maf with the alphaA-crystallin promoter in lens cells.