ライフサイエンスコーパス: c-Src kinase

1 ns were mainly mediated by activation of the c-Src kinase.

2 sp90 does not influence the almost identical c-Src kinase.

3 es the tyrosine phosphorylation of villin by c-Src kinase.

4 sine kinase but not of the highly homologous c-Src kinase.

5 ced death by suppressing early activation of c-Src kinase.

6 inic receptor couples to Ca(2+) channels via c-src kinase.

7 st precursors, is tyrosine-phosphorylated by c-Src kinase.

8 essing glutamate-induced early activation of c-Src kinase.

9 pstream elements, such as p38 MAP kinase and c-Src kinase.

10 cted a specific interaction between CD44 and c-Src kinase.

11 c, G6G is a potent inhibitor of both Abl and c-Src kinases.

12 ediated formation of Shc.c-Src complexes and c-Src kinase activation are early events in Ras-dependen

13 Previously, we demonstrated a role for c-Src kinase activation in Ox-PAPC-induced IL-8 transcri

14 sion kinase phosphorylation was dependent on c-Src kinase activation, for which caveolin-1 was requir

15 ts indicate that HA binding to CD44 promotes c-Src kinase activation, which, in turn, increases Twist

16 xpressing clones exhibited increased Akt and c-Src kinase activities, as well as higher levels of mat

17 possessing elevated EGF receptor (EGF-R) and c-Src kinase activities.

18 osphorylation also depended on both EGFR and c-Src kinase activities.

19 tTG function (monodansylcadaverine; MDC) or c-Src kinase activity (PP2) disrupted the formation of t

20 Agonists of the CaR can stimulate increased c-SRC kinase activity and increased extracellular signal

21 c-Src kinase activity and phosphorylations at Src Tyr-41

22 phorylation of FAK in the liver, we measured c-Src kinase activity and the abundance of 3 major prote

23 t osteoclastic bone resorption requires both c-Src kinase activity and the targeting of Src kinase by

24 VEGF stimulation specifically activated c-Src kinase activity but not that of other related Src

25 d levels of Bcl-x(L.) However, inhibition of c-Src kinase activity by PP2 in vector control cells did

26 They also show that c-Src kinase activity can be used differently by individ

27 on, in the presence of EGFR TKIs, inhibiting c-Src kinase activity decreased cell growth in SUM229 ce

28 n Rat-2 cells transiently stimulated Hck and c-Src kinase activity in the absence of extracellular si

29 nism of c-Src regulation have suggested that c-Src kinase activity is downregulated by phosphorylatio

30 nd sufficient to induce IGF-IR upregulation, c-Src kinase activity is necessary, but alone is insuffi

31 c-Src kinase activity is required for the cytoskeletal t

32 Pharmacological blockade of c-Src kinase activity or decreased expression of endogen

33 rast, pharmacologic inhibition of endogenous c-Src kinase activity or small interfering RNA-mediated

34 Further analyses revealed that c-src kinase activity was dramatically elevated in cultu

35 Furthermore, c-Src kinase activity was found to be increased in the h

36 Hepatic c-Src kinase activity was unaltered, but LAR protein was

37 tantly, erbB2:EGFr heterodimer formation and c-src kinase activity were also elevated in TPA-treated

38 In one such cell line, SUM229, inhibiting c-Src kinase activity with either a dominant-negative c-

39 wer c-Src phosphotyrosine 527 level, greater c-Src kinase activity, and increased tyrosine phosphoryl

40 Independent of c-Src kinase activity, c-Src is associated with an N-ter

41 as accompanied by an EGF-induced increase in c-Src kinase activity, relocalisation of c-Src to the ce

42 cortactin was found uncoupled of endogenous c-Src kinase activity, thus further supporting the hypot

43 with its receptor leads to the activation of c-Src kinase activity, which in turn facilitates the bin

44 rc kinase recruitment to CD44 and stimulates c-Src kinase activity, which, in turn, increases tyrosin

45 , myristoylation exerts a positive effect on c-Src kinase activity.

46 TCDD) was accompanied by rapid activation of c-Src kinase activity.

47 tivation of JAK2 by Ox-PAPC was dependent on c-Src kinase activity.

48 cells, while it had no detectable effect on c-Src kinase activity.

49 e swelling, which triggers via integrins and c-Src kinase an activation of the epidermal growth facto

50 ine-rich sequence) as negative regulators of c-Src kinase and demonstrate a new function for these ph

51 High cytoplasmic c-Src kinase and high membrane phosphorylated activated

52 ctivation is required for acid activation of c-Src kinase and NHE3.

53 5-HT stimulated tyrosine phosphorylation of c-Src kinase and PKC delta.

54 D44 (a primary HA receptor) interaction with c-Src kinase and the transcriptional factor, Twist, in b

55 that activate the focal-adhesion kinase and c-Src kinase and their downstream MAP-ERK kinase/extrace

56 ulate osteoclast function by activating pp60(c-Src) kinase and alpha(v)beta3 integrin.

57 Activation of pp60(c-Src) kinase and phosphorylation of ERK were observed i

58 e assessed the involvement of protein kinase C, Src kinases, and proline-rich tyrosine kinase 2 in th

59 n by a mechanism dependent on protein kinase C, Src kinases, and proline-rich tyrosine kinase 2.

60 Epidermal growth factor receptor-kinase, c-src kinase, and focal adhesion kinase were phosphoryla

61 by the expression of a constitutively active c-Src kinase, and repressed by the expression of dominan

62 both CD44 (the hyaluronan (HA) receptor) and c-Src kinase are expressed in human ovarian tumor cells

63 The roles of Akt and c-Src kinases as downstream targets of CEACAM6 signaling

64 In addition, Hsp90 also activated c-Src kinase associated with SREC-I, an activity that we

65 ion site of FAK, which is a reported site of c-Src kinase binding, is required for bacterial internal

66 TCDD appears to be limited to activation of c-Src kinase, but not kinases associated with activation

67 nonphagocytic NAD(P)H oxidases (NOX-1), and c-Src kinases (c-Src) were colocalized in the caveolae o

68 stimulates tyrosine kinases, including pp60(c-src) kinase (c-Src), focal adhesion kinase (FAK), and

69 Met cells treated with inhibitors of MEK1 or c-Src kinases, completely blocked by expression of a cat

70 hat the expression of these genes in src- or c-src kinase-deficient cells did not differ from wild-ty

71 ormed complexes that included an active pp60(c-src) kinase, demonstrating that PP2A activity is not e

72 ulated kinase (Erk) MAPK, an event requiring c-Src kinase-dependent epidermal growth factor receptor

73 Here, we report that the c-Src kinase functions as a key adapter protein for the

74 ylated in TKX1 cells nor was a substrate for c-src kinase in an in vitro kinase assay.

75 lso enhanced the transformation potential of c-Src kinase in focus formation assays, and PELP1 overex

76 They also suggest a central role of c-src kinase in the cross-talk between tyrosine kinase r

77 ontains thermostable components that inhibit c-Src kinase in vitro.

78 c-Src kinase is a rate-limiting activator of osteoclast

79 In the presence of E2, c-Src kinase is activated by membrane ER46 and in turn p

80 rexpression of a dominant-negative mutant of c-Src kinase (K295R) in SK-OV-3.ipl cells impairs the tu

81 olo-like kinase 1 (Plk1) kinase by enhancing c-Src kinase-mediated tyrosine phosphorylation of Plk1.

82 Together, our results establish that c-Src kinase mediates stresses generated by E2 in long-t

83 d that TI-VAMP is phosphorylated in vitro by c-Src kinase on tyrosine 45 of the Longin domain.

84 Here we show that activated c-Src kinase phosphorylates Y281 and Y302 of Mdm2, resul

85 ific effects were prevented by deletion of a c-Src kinase phosphorylation DYD motif, identified in si

86 strongly suggest that CD44 interaction with c-Src kinase plays a pivotal role in initiating cortacti

87 binding of HA to SK-OV-3.ipl cells promotes c-Src kinase recruitment to CD44 and stimulates c-Src ki

88 Further studies using mutants of c-Src kinase revealed that Src mediates mitogen-activate

89 s show for the first time that Rap1 mediates c-Src kinase signaling and reveal mechanistic difference

90 ther, these data demonstrate the role of the c-src kinase/STAT3 pathway in Ox-PAPC-mediated IL-8 expr

91 ol did not influence activity of recombinant c-Src kinase suggesting that its mechanism of action may

92 c-Src kinase was not involved in the IL-8-mediated phosp

93 r402, which mediates the binding of RAFTK to c-Src kinase, was required for the phosphorylation of th

94 Activation of erbB2 and c-src kinase were also observed in the epidermis of TGF

95 tion, pyk2(K457A) blocked acid activation of c-Src kinase, which is also required for acid regulation

96 tive conformation of the catalytic domain of c-Src kinase while the tyrosine 416 in the activation lo

97 antibodies, indicating direct association of c-Src kinase with the Ca2+ channel.