ライフサイエンスコーパス: cGMP phosphodiesterase

1 ty stimulatable by the inhibitory subunit of cGMP phosphodiesterase.

2 sites on G alpha t with the effector enzyme cGMP phosphodiesterase.

3 degeneration caused by a defective opsin or cGMP phosphodiesterase.

4 protein transducin, which in turn stimulates cGMP phosphodiesterase.

5 or the gene encoding the beta-subunit of the cGMP phosphodiesterase.

6 pigment, rhodopsin, and the effector enzyme, cGMP phosphodiesterase.

7 sing it to bind GTP and stimulate the enzyme cGMP phosphodiesterase.

8 ntly after transducin binds to its effector, cGMP phosphodiesterase.

9 es the phosphorylation profile of a putative cGMP-phosphodiesterase.

10 D sulindac that has been reported to inhibit cGMP phosphodiesterases.

11 Rod cGMP phosphodiesterase 6 (PDE6) is a key enzyme of the p

12 P as bait we identified the delta subunit of cGMP phosphodiesterase 6 (PDE6delta) as a novel hIP-inte

13 ed rhodopsin or more efficient activation of cGMP phosphodiesterase 6 by G alpha(t)G2A; alternatively

14 etinitis pigmentosa (RP) is due to defective cGMP phosphodiesterase-6 (PDE6).

15 Our study reveals that rod cGMP phosphodiesterase, a farnesylated protein, is absen

16 Rod cGMP-phosphodiesterase, a key enzyme in visual transduct

17 nd to reduce the Ca2+ concentrations through cGMP phosphodiesterase activation as already known.

18 ation, rhodopsin-transducin (G(t)) coupling, cGMP phosphodiesterase activity, and slower formation of

19 n vitro is less than the light/GTP-activated cGMP phosphodiesterase activity.

20 tly bind the bilin phycocyanobilin via their cGMP phosphodiesterase/adenyl cyclase/FhlA (GAF) domains

21 cysteine-based thioether linkages within the cGMP phosphodiesterase/adenyl cyclase/FhlA domain.

22 r the N terminus to one conserved within the cGMP phosphodiesterase/adenyl cyclase/FhlA domain.

23 , and molecular modeling of the Te-PixJ GAF (cGMP phosphodiesterase/adenyl cyclase/FhlA) domain assem

24 bring together the PAS (Per-ARNT-Sim), GAF (cGMP phosphodiesterase/adenyl cyclase/FhlA), and PHY (ph

25 olution structure of the chromophore-binding cGMP phosphodiesterase/adenylcyclase/FhlA (GAF) domain f

26 ines and a hairpin protrusion connecting the cGMP phosphodiesterase/adenylyl cyclase/FhlA (GAF) and p

27 ture of photoconversion for the photosensing cGMP phosphodiesterase/adenylyl cyclase/FhlA (GAF) domai

28 ytochromobilin chromophore buried within the cGMP phosphodiesterase/adenylyl cyclase/FhlA (GAF) domai

29 states following studies of the 23-kDa GAF (cGMP phosphodiesterase/adenylyl cyclase/FhlA) domain fra

30 -cGMP or by MY-5445 (a specific inhibitor of cGMP phosphodiesterase) alone suggest that NO increases

31 action between the gamma subunit (Pgamma) of cGMP phosphodiesterase and the alpha subunit (Talpha) of

32 ptosyn) and certain derivatives that inhibit cGMP-phosphodiesterases and thereby increase cellular le

33 function, its poor ability to activate PDE6 (cGMP phosphodiesterase) and decreased GTPase activity, a

34 on of G alpha(transducin) with its effector, cGMP phosphodiesterase, and inhibits transducin-mediated

35 ks the lipid modifications found on G(t) and cGMP phosphodiesterase, and the mechanism for membrane a

36 Rhodopsin and cGMP phosphodiesterase are found in raft and nonraft por

37 Mutations in the rod photoreceptor cGMP phosphodiesterase beta subunit (PDEbeta) gene are f

38 ly demonstrated that 350 bp of the human rod cGMP phosphodiesterase beta-subunit (beta-PDE) gene prom

39 utations in the genes encoding rhodopsin and cGMP phosphodiesterase beta-subunit (PDE-beta) respectiv

40 rod-specific genes, including rhodopsin and cGMP phosphodiesterase beta-subunit, in synergy with oth

41 The beta-subunit of cGMP-phosphodiesterase (beta-PDE) is a key protein in ph

42 e OSI-461, both of which inhibit cyclic GMP (cGMP)-phosphodiesterases but lack COX-2 inhibitory activ

43 cin mediates signaling between rhodopsin and cGMP phosphodiesterase by transiently binding its gamma

44 Further evaluation of the cGMP phosphodiesterase demonstrated Michaelis-Menten kin

45 rate photoreceptors leads to activation of a cGMP-phosphodiesterase effector and the generation of a

46 PDE10A is a newly identified cAMP/cGMP phosphodiesterase for which mRNA is highly expresse

47 M in rod photoreceptors, it is possible that cGMP phosphodiesterase functions to increase cytoplasami

48 tion of GAP activity by an effector subunit, cGMP phosphodiesterase gamma and in protein folding and

49 The gamma subunit of the retinal cGMP phosphodiesterase (gammaPDE) acts as an inhibitor o

50 The gamma subunit of the retinal cGMP phosphodiesterase (gammaPDE) acts as an inhibitor o

51 Mutations in the beta subunit of the cGMP phosphodiesterase gene (beta PDE) can cause a reces

52 transducin is crucial for the regulation of cGMP phosphodiesterase in retinal photoreceptors.

53 ansducin is a key step for the regulation of cGMP phosphodiesterase in retinal rod outer segments.

54 ted rhodopsin (R*) with the effector enzyme, cGMP phosphodiesterase in vertebrate photoreceptor cells

55 ucin the G-protein that couples rhodopsin to cGMP-phosphodiesterase in the phototransduction cascade.

56 optosis by a mechanism involving cyclic GMP (cGMP) phosphodiesterase inhibition, sustained elevation

57 Pretreatment with a cGMP phosphodiesterase inhibitor antagonized the anxioge

58 The cGMP phosphodiesterase inhibitor M&B 22948 (30 microM) a

59 ls that is enhanced by pretreatment with the cGMP phosphodiesterase inhibitor sildenafil.

60 with cell permeable cGMP derivatives, or the cGMP phosphodiesterase inhibitor sulindac sulfone (exisu

61 The cGMP phosphodiesterase inhibitor zaprinast enhanced the

62 The specific cGMP phosphodiesterase inhibitor zaprinast reduced the f

63 We have used this natural mutation, and the cGMP phosphodiesterase inhibitor zaprinast, in wild-type

64 gradation with sildenafil, a specific type 5 cGMP phosphodiesterase inhibitor, on flow-mediated dilat

65 tion or environmental acidification, while a cGMP-phosphodiesterase inhibitor circumvents egress repr

66 The cGMP-phosphodiesterase inhibitors and YC-1 increased the

67 transducin (G(t alpha)), interacts with the cGMP phosphodiesterase inhibitory gamma-subunit (Pgamma)

68 The ratio of the cGMP-phosphodiesterase inhibitory subunit gamma to cone

69 otransduction partners transducin (G(t)) and cGMP phosphodiesterase, it is a peripheral protein of th

70 The cGMP phosphodiesterase of rod photoreceptor cells, PDE6,

71 The mammalian multisubunit photoreceptor cGMP phosphodiesterase PDE alpha beta gamma 2 (PDE6 fami

72 of the gamma-subunit of its effector enzyme, cGMP phosphodiesterase (PDE gamma), and another yet unid

73 -displayed arrestin fragments against RP and cGMP phosphodiesterase (PDE) activity inhibition using s

74 PDEdelta was originally copurified with rod cGMP phosphodiesterase (PDE) and shown to interact with

75 it of transducin (Galphat-GTP) activates the cGMP phosphodiesterase (PDE) by binding the inhibitory g

76 The rod cGMP phosphodiesterase (PDE) is the G-protein-activated

77 cGMP phosphodiesterase (PDE) is the key effector enzyme

78 y, there was a reduction in the level of rod cGMP phosphodiesterase (PDE) proportional to the decreas

79 se is generated by spontaneous activation of cGMP phosphodiesterase (PDE) through a process that does

80 alphaT*(S43N) activated the cGMP phosphodiesterase (PDE) with a dose-response simila

81 ontrols inactivation of the effector enzyme, cGMP phosphodiesterase (PDE), during turnoff of the visu

82 hown that P gamma, the regulatory subunit of cGMP phosphodiesterase (PDE), is ADP-ribosylated by endo

83 tolerance would be increased activity of the cGMP phosphodiesterase (PDE), which decreases cGMP level

84 monitored rhodopsin-dependent activation of cGMP phosphodiesterase (PDE), wild type arrestin quenche

85 or interaction with the effector enzyme, rod cGMP phosphodiesterase (PDE).

86 (GalphatGTPgammaS) activation of bovine rod cGMP phosphodiesterase (PDE).

87 red in cones than in rods to activate 50% of cGMP phosphodiesterase (PDE).

88 teins: the G protein, transducin (G(t)), and cGMP phosphodiesterase (PDE).

89 etinal cyclic guanosine 3',5'-monophosphate (cGMP) phosphodiesterase (PDE) is a key regulator of phot

90 cells contain guanosine 3',5'-monophosphate (cGMP) phosphodiesterase (PDE) isoforms of the PDE5 and P

91 Cyclic guanosine 5'-monophosphate (cGMP) phosphodiesterase (PDE) regulates the level of cGM

92 lic 3'-5'-guanosine monophosphate (cGMP) and cGMP-phosphodiesterase (PDE) are uncertain.

93 The catalytic core of photoreceptor-specific cGMP-phosphodiesterase (PDE) consists of two subunits, P

94 cGMP-phosphodiesterase (PDE) is composed of two catalyti

95 cGMP-phosphodiesterase (PDE) is the key effector in rod

96 During photoactivation retinal cGMP-phosphodiesterase (PDE) mediates signal transductio

97 ation channel-3 [CNG3], blue-cone opsin, and cGMP phosphodiesterase [PDE]); were evaluated during dif

98 ccompanied by a rapid phosphorylation of the cGMP phosphodiesterase PDE5, an enzyme whose activity is

99 Retinal rod cGMP phosphodiesterase (PDE6 family) is the effector enz

100 ein transducin (G(t)) on the effector enzyme cGMP phosphodiesterase (PDE6) at the surface of disk mem

101 the inhibitory gamma subunit (Pgamma) of rod cGMP phosphodiesterase (PDE6) has been reported to turn

102 We examined the role of cGMP phosphodiesterase (PDE6) in this difference by expr

103 The cGMP phosphodiesterase (PDE6) involved in visual transdu

104 Retinal cGMP phosphodiesterase (PDE6) is a key enzyme in vertebr

105 Photoreceptor cGMP phosphodiesterase (PDE6) is the central enzyme in t

106 Photoreceptor cGMP phosphodiesterase (PDE6) is the effector enzyme in

107 Photoreceptor cGMP phosphodiesterase (PDE6) is the effector enzyme in

108 The unique feature of rod photoreceptor cGMP phosphodiesterase (PDE6) is the presence of inhibit

109 The photoreceptor cGMP phosphodiesterase (PDE6) plays a key role in verteb

110 was originally identified as a putative rod cGMP phosphodiesterase (PDE6) subunit in the retina, whe

111 ue to the massive reduction in levels of rod cGMP phosphodiesterase (PDE6) subunits (alpha, beta, and

112 transduction in retinal rod photoreceptors, cGMP phosphodiesterase (PDE6), is a catalytic heterodime

113 l enzyme of the visual transduction cascade, cGMP phosphodiesterase (PDE6), is regulated by its gamma

114 mma) of the photoreceptor G-protein effector cGMP phosphodiesterase (PDE6).

115 Retinal rod and cone cGMP phosphodiesterases (PDE6 family) function as the ef

116 Photoreceptor cGMP phosphodiesterases (PDE6) are uniquely qualified to

117 e stable assembly of the retinal cyclic GMP (cGMP) phosphodiesterase (PDE6) holoenzyme.

118 otoreceptor G protein, transducin, activates cGMP-phosphodiesterase (PDE6) by displacing the inhibito

119 o studies, showing that the delta subunit of cGMP phosphodiesterase (PDEdelta), which possesses a hyd

120 ma subunit of the phototransduction effector cGMP phosphodiesterase (PDEgamma).

121 h the gamma subunit of G(talpha)'s effector, cGMP phosphodiesterase (PDEgamma).

122 plex with its effector, the gamma subunit of cGMP phosphodiesterase (PDEgamma).

123 Chimeric cGMP phosphodiesterases (PDEs) have been constructed usi

124 sodilator effect is regulated by a family of cGMP phosphodiesterases (PDEs).

125 GMP but modestly inhibited by rolipram and a cGMP phosphodiesterase peak that was sensitive to inhibi

126 by the gamma-subunit of the effector enzyme, cGMP-phosphodiesterase (Pgamma).

127 cally with transducin bound to its effector, cGMP phosphodiesterase, rather than with transducin alon

128 due to a mutation of the rod-specific enzyme cGMP phosphodiesterase, resulting in permanently opened

129 alysis of the Galpha(t)G38D interaction with cGMP phosphodiesterase revealed marked impairment of the

130 gene PDE6B encoding the beta subunit of rod cGMP-phosphodiesterase shows that the cGMP-binding and c

131 analog) or MY-5445 (a specific inhibitor of cGMP phosphodiesterase) suggests that NO induces GFAP vi

132 er inhibitory activity for trypsin-activated cGMP phosphodiesterase than nonphosphorylated P gamma, i

133 t synergistically with a downstream effector cGMP phosphodiesterase to stimulate the GTPase activity

134 joins rhodopsin and the beta subunit of rod cGMP-phosphodiesterase to become the third component of

135 cGMP phosphodiesterase type 5 protein is upregulated in

136 nd the factors controlling expression of the cGMP phosphodiesterase type 6 (PDE6) genes, we have char

137 to the cytosolic chaperone delta-subunit of cGMP phosphodiesterase type 6 (PDE6delta).

138 d with the alphabeta subunit (Palphabeta) of cGMP phosphodiesterase, was specifically radiolabeled by

139 on of RGS9-1.Gbeta5L by the effector enzyme, cGMP phosphodiesterase, which is based entirely on the e

140 (dB-cGMP), and of the selective inhibitor of cGMP-phosphodiesterase zaprinast (ZAP), caused an inhibi