ライフサイエンスコーパス: cGMP-dependent protein kinase

1 hibitor) or Rp-8-pCPT-cGMPS (an inhibitor of cGMP-dependent protein kinase).

2 ntercellular messenger NO, and activation of cGMP-dependent protein kinase.

3 ooth muscle cell relaxation by activation of cGMP-dependent protein kinase.

4 hese genes as egl-4, which we show encodes a cGMP-dependent protein kinase.

5 ggesting block of NO signaling downstream of cGMP-dependent protein kinase.

6 is similar to that for cGMP activation of a cGMP-dependent protein kinase.

7 parate protein kinases, protein kinase C and cGMP-dependent protein kinase.

8 tion of p38 MAPK that requires activation of cGMP-dependent protein kinase.

9 n-1-one (ODQ) and by KT5823, an inhibitor of cGMP-dependent protein kinase.

10 uronal and glial cells by activating type II cGMP-dependent protein kinase.

11 se and by a polymorphism affecting a form of cGMP-dependent protein kinase.

12 Ca2+-sensitive K+ channels are activated by cGMP-dependent protein kinase.

13 ivating cyclic-nucleotide-gated channels and cGMP-dependent protein kinase.

14 ro by both cAMP-dependent protein kinase and cGMP-dependent protein kinase.

15 of the control response) by an inhibitor of cGMP-dependent protein kinase.

16 ation of cGMP and subsequent activation of a cGMP-dependent protein kinase.

17 in contrast, also significantly inhibit the cGMP-dependent protein kinase.

18 protein kinase C, casein kinase II and cAMP-/cGMP-dependent protein kinase.

19 sive and reversed by H8, an inhibitor of the cGMP-dependent protein kinase.

20 PI3K, Akt, nitric-oxide synthase 3, sGC, and cGMP-dependent protein kinase.

21 nylyl cyclase to synthesize cGMP, activating cGMP- dependent protein kinase.

22 tion of cyclic GMP (cGMP), and activation of cGMP-dependent protein kinases.

23 the regulatory subunit of cAMP-dependent or cGMP-dependent protein kinases.

24 hosphorylation of cPLA2 in vivo by cAMP- and cGMP-dependent protein kinases.

25 ion by IL-1 was insensitive to inhibition of cGMP-dependent protein kinases.

26 Exogenous cGMP-dependent protein kinase (0.5 microM) activated by

27 motility through intercellular activation of cGMP-dependent protein kinase 1 (PKG1) signaling in glia

28 cells expressing a dominant-negative form of cGMP-dependent protein kinase 1 (PKG1), and was prevente

29 At the molecular level, the cGMP-dependent protein kinase 1 (PrkG1) mediates this ac

30 ld-type mice induced oxidative activation of cGMP-dependent protein kinase 1 alpha (PKG Ialpha), whic

31 O-induced apoptosis by the inhibition of the cGMP-dependent protein kinase 1 alpha.

32 ed synthesis of cGMP and activation of cGK1 (cGMP-dependent protein kinase 1) in cultured porcine val

33 The cGMP-dependent protein kinase 1-alpha inhibitor 8-(4-chl

34 The cGMP-dependent protein kinase-1alpha (PKG1alpha) transdu

35 Overexpression of cGMP-dependent protein kinase-1alpha caused phosphorylat

36 osphothioate (Sp-isomer) and isoproterenol), cGMP-dependent protein kinase (8-(4-chlorophenylthio)-gu

37 stoylated protein kinase inhibitor () amide; cGMP-dependent protein kinase, (8R,9S, 11S)-(-)-9-methox

38 KT 5823, the inhibitor of cGMP-dependent protein kinase, abolished the permeabilit

39 Inhibition of cGMP-dependent protein kinase activity by the cGMP-depen

40 Moreover, cGK (cGMP-dependent protein kinase) activity was downregulate

41 lular application of selective activators of cGMP-dependent protein kinase also caused increases in L

42 O activate noradrenergic neurons of LC via a cGMP-dependent protein kinase and a nonselective cationi

43 L2) of SERT contains consensus sequences for cGMP-dependent protein kinase and protein kinase C.

44 ison of the patterns of expression of type 1 cGMP-dependent protein kinase and the CNG channels sugge

45 -1 also inhibits cGMP-mediated activation of cGMP-dependent protein kinase and thereby prevents phosp

46 this results in the activation of the type I cGMP-dependent protein kinase and vasorelaxation.

47 cyclic nucleotide-binding sites of cAMP- and cGMP-dependent protein kinases and the bacterial catabol

48 AGC kinases (cAMP dependent Protein Kinase, cGMP dependent Protein Kinase, and Protein Kinase C subf

49 protein phosphatase 2A that is activated by cGMP-dependent protein kinase, and associates with both

50 Nitric oxide (NO), acting via cGMP-dependent protein kinase, and cAMP-dependent pathwa

51 ic subunit of cAMP-dependent protein kinase, cGMP-dependent protein kinase, and p42/44 mitogen-activa

52 es, including cAMP-dependent protein kinase, cGMP-dependent protein kinase, and pp60(c-)(src), have b

53 es, including cAMP-dependent protein kinase, cGMP-dependent protein kinase, and protein-tyrosine kina

54 The present study examined whether cAMP- and cGMP-dependent protein kinases are capable of regulating

55 cGMP-dependent protein kinases are key intracellular tra

56 in kinase II, tyrosine kinase, and cAMP- and cGMP-dependent protein kinases as well as sites for glyc

57 Br-PET-cGMPS is a potent activator of type I cGMP-dependent protein kinase, but a competitive antagon

58 y AMP-PNP reduced NP(o), while activation of cGMP-dependent protein kinase by guanosine 3', 5'-cyclic

59 s the T-loop of several AGC (cAMP-dependent, cGMP-dependent, protein kinase C) family protein kinases

60 Downregulation of the nitric oxide/cGMP/cGMP-dependent protein kinase/c-AMP responsive element-b

61 campal slices in vitro, and that blockade of cGMP-dependent protein kinase, cADPR receptors, or ryano

62 phosphorylated in vitro (4% at best) by PKC, cGMP-dependent protein kinase, casein kinase II, and cas

63 VASP is a prominent substrate for both cGMP-dependent protein kinase (cGK) and cAMP-dependent p

64 This study shows that Ibeta cGMP-dependent protein kinase (cGK) autophosphorylates S

65 We demonstrated that activation of cGMP-dependent protein kinase (cGK) increased the surfac

66 onical cyclic guanosine monophosphate (cGMP)-cGMP-dependent protein kinase (cGK) pathway of NO signal

67 The NO/cGMP/cGMP-dependent protein kinase (cGK) pathway regulates th

68 ide (NO)/soluble guanylyl cyclase (sGC)/cGMP/cGMP-dependent protein kinase (cGK)/cAMP-responsive elem

69 nnel currents was mimicked by stimulation of cGMP-dependent protein kinase (cGK; 8-Br-cGMP) and by in

70 RGS2 can be phosphorylated by type Ialpha cGMP-dependent protein kinase (cGKIalpha), increasing it

71 For the type I cGMP-dependent protein kinases (cGKIalpha and cGKIbeta),

72 Although both the type Ibeta cGMP-dependent protein kinase (cGKIbeta) and the type II

73 kinase activation in the type II isozyme of cGMP-dependent protein kinase (cGKII), alanine was subst

74 Previous research has suggested that cGMP-dependent protein kinases (cGKs) may play a role in

75 tides, the cAMP-dependent protein kinase and cGMP-dependent protein kinases (cGKs) suppress phosphotr

76 The ability of cGMP-dependent protein kinases (cGKs) to activate cAMP r

77 IPG, a specific peptide inhibitor of cGMP-dependent protein kinase (cGMP-PK), blocked the inh

78 d, fluorescent cGMP indicators by bracketing cGMP-dependent protein kinase (cGPK), minus residues 1-7

79 esponse to IBTX and KT 5823, an inhibitor of cGMP-dependent protein kinase, compared with coronary ar

80 We identify a cGMP-dependent protein kinase (CrPKG) within flagella as

81 cGMP-dependent, monomeric deletion mutant of cGMP-dependent protein kinase (Delta(1-52)PKG-I beta).

82 not appear to be dependent on either of the cGMP-dependent protein kinases, dg1 and dg2.

83 Here we show that the cGMP-dependent protein kinase EGL-4 acts partly in paral

84 arning requires nuclear translocation of the cGMP-dependent protein kinase EGL-4 in AWC olfactory neu

85 tors of olfaction uncovered mutations in the cGMP-dependent protein kinase EGL-4 that disrupt olfacto

86 e AWC pair of olfactory neurons requires the cGMP-dependent protein kinase EGL-4.

87 y sensory neurons of C. elegans requires the cGMP-dependent protein kinase EGL-4.

88 of the dimerization domains of RI, RII, and cGMP-dependent protein kinase elucidates fundamental sim

89 ole of cyclic guanosine 3',5'-monophosphate (cGMP)-dependent protein kinase G (PKG) has become of con

90 inase of AGC family (the cAMP-dependent PKA, cGMP- dependent protein kinase G and phospholipid-depend

91 Concordantly, inhibition of the cGMP-dependent protein kinase G (PKG) blocks egress indu

92 unctional conductance by activating the cGMP-cGMP-dependent protein kinase G (PKG) pathway.

93 The activity and expression levels of cGMP-dependent protein kinase G (PKG) were significantly

94 lase (sGC), or Rp-8-Br-cGMP, an inhibitor of cGMP-dependent protein kinase G (PKG).

95 Both PKA and cGMP-dependent protein kinase G phosphorylated AQP2 on t

96 SERT is phosphorylated by cGMP-dependent protein kinase G through interactions wit

97 The cGMP-dependent protein kinase G-1alpha (PKG-1alpha) is a

98 se family (cAMP-dependent protein kinases A, cGMP-dependent protein kinases G, and phospholipid-depen

99 We recently demonstrated that cyclic GMP (cGMP)-dependent protein kinase (G-kinase) activates the

100 ansiently by cyclic guanosine monophosphate (cGMP)-dependent protein kinase (G-kinase).

101 stimulates production of cGMP and activates cGMP-dependent protein kinase (G kinase), which by an un

102 have very low soluble guanylate cyclase and cGMP-dependent protein kinase (G-kinase) activity, and C

103 MP analogs have normal guanylate cyclase and cGMP-dependent protein kinase (G-kinase) activity.

104 not been demonstrated directly for the cGMP/cGMP-dependent protein kinase (G-kinase) signal transduc

105 ide (NO) regulates c-fos gene expression via cGMP-dependent protein kinase (G-kinase), but NO's preci

106 r kidney (BHK) cells, which are deficient in cGMP-dependent protein kinase (G-kinase), we show that 8

107 We found that type II cGMP-dependent protein kinase (G-kinase), which is widel

108 genes in smooth muscle and glial cells in a cGMP-dependent protein kinase (G-kinase)-dependent fashi

109 l and osteogenic cells which express type II cGMP-dependent protein kinase (G-kinase); the effect on

110 is known regarding the mechanisms regulating cGMP-dependent protein kinase gene expression.

111 The protein encoded by the Drosophila cGMP-dependent protein kinase gene, DG1, was expressed i

112 G-substrate, a specific substrate of the cGMP-dependent protein kinase, has previously been local

113 have been reported for the roles of cGMP and cGMP-dependent protein kinase I (cGKI) in various pathol

114 AHR showed normal activation with exogenous cGMP-dependent protein kinase I (cGKI), suggesting no ab

115 8/GC complex formation and activation of the cGMP-dependent protein kinase I (cGKI).

116 We now demonstrate that cGMP-dependent protein kinase I (cGKl) occurs in the DRG

117 d cGMP can occur by nuclear translocation of cGMP-dependent protein kinase I (G-kinase I).

118 lar smooth muscle cell relaxation in part by cGMP-dependent protein kinase I (PKG-Ialpha)-mediated ac

119 h muscle cells (SMCs) in part by stimulating cGMP-dependent protein kinase I (PKGI) and the phosphory

120 ection is dependent on the nitric oxide (NO)/cGMP-dependent protein kinase I (PKGI) pathway.

121 increasing intracellular cGMP and activating cGMP-dependent protein kinase I (PKGI).

122 A 2-kb human cGMP-dependent protein kinase I 5'-noncoding promoter se

123 r proteins and decreased the activity of the cGMP-dependent protein kinase I 591-bp promoter, thus co

124 ase-1 and suggest a novel mechanism by which cGMP-dependent protein kinase I can regulate the activit

125 stream stimulatory factors 1 and 2 increased cGMP-dependent protein kinase I promoter activity.

126 , these data suggest that the human proximal cGMP-dependent protein kinase I promoter is regulated by

127 cGMP-dependent protein kinase I regulates KCC3 mRNA expr

128 ns between its targeting subunit (MYPT1) and cGMP-dependent protein kinase I suggested a pathway for

129 Furthermore, association of cGMP-dependent protein kinase I with MYPT1 is detected b

130 inhibits vascular contraction by activating cGMP-dependent protein kinase I-alpha (PKGI-alpha), whic

131 e or Angeli's salt induced disulfides within cGMP-dependent protein kinase I-alpha (PKGIalpha), an in

132 e K+ channel, Hslo, and the alpha-isoform of cGMP-dependent protein kinase I.

133 Cyclic guanosine monophosphate (cGMP)-dependent protein kinase Ialpha (cGKIalpha) mediat

134 e screened by using (32)P-autophosphorylated cGMP-dependent protein kinase Ialpha (cGPK) to identify

135 yocyte eNOS-dependent cGMP synthesis and the cGMP-dependent protein kinase Ialpha (PKGIalpha).

136 MP (cGMP) levels in VSMC, thereby activating cGMP-dependent protein kinase Ialpha (PKGIalpha).

137 ed these techniques to measure the effect of cGMP-dependent protein kinase Ialpha on the phosphate co

138 rylation of purified bovine Ibeta isozyme of cGMP-dependent protein kinase (Ibeta cGK) in the presenc

139 g2, encoding cyclic guanosine monophosphate (cGMP)-dependent protein kinase II, cGKII, was tagged by

140 We have found that the GluR1 CTD binds to cGMP-dependent protein kinase II (cGKII) adjacent to the

141 gh a sequential two-step mechanism; that is, cGMP-dependent protein kinase II facilitated membrane in

142 ditionally disrupting the Plasmodium berghei cGMP-dependent protein kinase in sporozoites.

143 The importance of cGMP-dependent protein kinase in the activation of p38 M

144 cGMP-dependent protein kinase increased the activity of

145 Both cAMP- and cGMP-dependent protein kinases inhibit agonist-stimulate

146 However, differential effects of cGMP-dependent protein kinase inhibition on neurite grow

147 -bromoguanosine-3,5-cGMP [8-Br-cGMP]), and a cGMP-dependent protein kinase inhibitor (KT5823).

148 e inhibitor (LY-83583) and a highly specific cGMP-dependent protein kinase inhibitor (RKRARKE) blocke

149 GMP-dependent protein kinase activity by the cGMP-dependent protein kinase inhibitor KT5823 or replac

150 The cGMP-dependent protein kinase inhibitor KT5823 reversed

151 10 and 100 microM), which is thought to be a cGMP-dependent protein kinase inhibitor; and the anti-in

152 AP1 is a GKAP, anchoring specifically to the cGMP-dependent protein kinase isoform Ibeta, and provide

153 ults support that PKGIalpha is the principal cGMP-dependent protein kinase isoform mediating inhibiti

154 ow that BMP signaling via Smad1/5/8 requires cGMP-dependent protein kinase isotype I (PKGI) to mainta

155 protein was preferentially phosphorylated by cGMP-dependent protein kinase (Km = 0.2 microM) over cAM

156 on of OPN or BSP, while protein kinase C and cGMP-dependent protein kinase led to minor phosphorylati

157 utyryl cGMP, suggesting that PDE rather than cGMP-dependent protein kinase mediates the cGMP effects.

158 dy, we highlight a role for the nitric oxide-cGMP-dependent protein kinase (NO-G-kinase) signaling pa

159 inine was not influenced by an antagonist of cGMP-dependent protein kinase, nor was the effect mimick

160 Interestingly, inhibition of cGMP-dependent protein kinase only suppresses chemical s

161 nflux was inhibited by agents that activated cGMP-dependent protein kinase only; the inhibition was s

162 te CREB directly, through phosphorylation by cGMP-dependent protein kinase, or indirectly, through ac

163 Here we address this issue for the essential cGMP-dependent protein kinase, PfPKG.

164 glycosylation sites, a single potential cAMP/cGMP-dependent protein kinase phosphorylation site, as w

165 There are two potential cAMP/cGMP-dependent protein kinase phosphorylation sites on p

166 stigate the modulatory role of the cAMP- and cGMP-dependent protein kinase (PKA and PKG, respectively

167 re mediated by cyclic nucleotides, cAMP- and cGMP-dependent protein kinases (PKA, PKG), and largely u

168 yrosine kinases, glycogen synthase kinase 3, cGMP dependent protein kinase (PKG) that are well conser

169 ve found that guanosine 3',5'-monophosphate (cGMP)-dependent protein kinase (PKG) functions directly

170 ich encodes a guanosine 3',5'-monophosphate (cGMP)-dependent protein kinase (PKG).

171 ch encodes a cyclic guanosine monophosphate (cGMP)-dependent protein kinase (PKG).

172 Type I cGMP-dependent protein kinase (PKG I) plays a major role

173 Two splice variants of type I cGMP-dependent protein kinase (PKG Ialpha and Ibeta) dif

174 indazole), guanylyl cyclase (LY 83,583), and cGMP-dependent protein kinase (PKG) (Rp-8-pCPT-cGMPs).

175 clic nucleotide to or autophosphorylation of cGMP-dependent protein kinase (PKG) activates this kinas

176 The postulated pathway of cGMP-dependent protein kinase (PKG) activation of ADP-ri

177 induced reduction of intracellular cGMP- and cGMP-dependent protein kinase (PKG) activity and thereby

178 wth factor (TGF)-beta activation by altering cGMP-dependent protein kinase (PKG) activity as a result

179 cGMP-binding sites of types Ialpha and Ibeta cGMP-dependent protein kinase (PKG) and cGMP-binding cGM

180 an NO/cyclic guanosine monophosphate (cGMP)/cGMP-dependent protein kinase (PKG) and extracellular si

181 We examined the roles of cGMP-dependent protein kinase (PKG) and PI3K in degranul

182 tion by cAMP-dependent protein kinase (PKA), cGMP-dependent protein kinase (PKG) and Raf.

183 el dominant mutation in the C. elegans egl-4 cGMP-dependent protein kinase (PKG) and show that this m

184 lic guanosine 3',5'-monophosphate (cGMP) and cGMP-dependent protein kinase (PKG) and their interactio

185 ression of soluble guanylyl cyclase (sGC) or cGMP-dependent protein kinase (PKG) are altered in cultu

186 chanisms that provide for cGMP activation of cGMP-dependent protein kinase (PKG) are unknown.

187 cAMP-dependent protein kinase (PKA) but not cGMP-dependent protein kinase (PKG) based on the finding

188 KT5283, a cGMP-dependent protein kinase (PKG) blocker, prevented t

189 KC), cAMP-dependent protein kinase (PKA) and cGMP-dependent protein kinase (PKG) can inhibit calmodul

190 s, cGMP binding to type Ialpha or type Ibeta cGMP-dependent protein kinase (PKG) caused (i) a large e

191 cGMP-dependent protein kinase (PKG) expression is highly

192 We identify the cGMP-dependent protein kinase (PKG) gene egl-4 as a regu

193 turally maintained genetic polymorphism at a cGMP-dependent protein kinase (PKG) gene, foraging (for)

194 Activation of cGMP-dependent protein kinase (PKG) has anti-tumor effec

195 eferred to as slow and fast sites) of type I cGMP-dependent protein kinase (PKG) in altering the rate

196 hough expression of guanylate cyclase and/or cGMP-dependent protein kinase (PKG) in Purkinje cells ha

197 scattering data from bovine lung type Ialpha cGMP-dependent protein kinase (PKG) in the absence of cG

198 vitro have underestimated the importance of cGMP-dependent protein kinase (PKG) in the modulation of

199 NO-induced activation of cGMP-dependent protein kinase (PKG) increases the open p

200 In the present work, we show that cGMP/cGMP-dependent protein kinase (PKG) induced dephosphoryl

201 lving sustained increases in cGMP levels and cGMP-dependent protein kinase (PKG) induction not found

202 Unexpectedly, cGMP-dependent protein kinase (PKG) inhibitor, but not g

203 e increase was abated by KT5823 [a selective cGMP-dependent protein kinase (PKG) inhibitor], mercapto

204 ucible expression of the catalytic domain of cGMP-dependent protein kinase (PKG) inhibits glucose-reg

205 It is currently accepted that cGMP-dependent protein kinase (PKG) inhibits platelet ac

206 currents were unaffected by the inhibitor of cGMP-dependent protein kinase (PKG) KT5823 (1 microM).

207 ormed serves to augment the cAMP signal in a cGMP-dependent protein kinase (PKG) manner by direct act

208 fects of cyclic GMP (cGMP) and activation of cGMP-dependent protein kinase (PKG) on the phosphorylati

209 DE5 with a phosphorylation reaction mixture [cGMP-dependent protein kinase (PKG) or catalytic subunit

210 /or activation of the nitric oxide (NO)/cGMP/cGMP-dependent protein kinase (PKG) pathway in platelets

211 reas cAMP-dependent protein kinase (PKA) and cGMP-dependent protein kinase (PKG) phosphorylated the s

212 ncluding soluble guanylate cyclase (sGC) and cGMP-dependent protein kinase (PKG) plays a role in indu

213 We have shown previously that cGMP-dependent protein kinase (PKG) plays a stimulatory

214 de (NO) and cyclic GMP (cGMP) signaling, the cGMP-dependent protein kinase (PKG) promotes modulation

215 cGMP-dependent protein kinase (PKG) relaxation pathways

216 ysfunctions, affected by changes in the cGMP/cGMP-dependent protein kinase (PKG) signaling pathway.

217 Because cGMP-dependent protein kinase (PKG) signaling plays a ke

218 phosphoprotein (VASP), a major substrate of cGMP-dependent protein kinase (PKG) that significantly i

219 cular target of Compound 1 was identified as cGMP-dependent protein kinase (PKG) using a tritiated an

220 ight chain (MLC) phosphatase is activated by cGMP-dependent protein kinase (PKG) via a leucine zipper

221 A cGMP-dependent protein kinase (PKG) was recently identif

222 In this study, we tested the hypothesis that cGMP-dependent protein kinase (PKG), an important mediat

223 messengers - cGMP mediated by the parasite's cGMP-dependent protein kinase (PKG), and Ca(2+) , mediat

224 GMP (cGMP) produced by GUCY2C, activation of cGMP-dependent protein kinase (PKG), and opening of the

225 mooth muscle (SM)-specific genes and loss of cGMP-dependent protein kinase (PKG), but transfection of

226 Since VASP is an in vitro substrate for cGMP-dependent protein kinase (PKG), it has been presume

227 ific inhibitors of guanylyl cyclase (GC) and cGMP-dependent protein kinase (PKG), key elements in the

228 of the regulatory and catalytic subunits of cGMP-dependent protein kinase (PKG), respectively.

229 ed by a pseudosubstrate peptide inhibitor of cGMP-dependent protein kinase (PKG), suggesting both PKG

230 vascular smooth muscle, RGS2 is activated by cGMP-dependent protein kinase (PKG), suppressing Gq-stim

231 compartmentalization of its closest homolog, cGMP-dependent protein kinase (PKG), via its own PKG anc

232 nduces p38 activation, which is inhibited in cGMP-dependent protein kinase (PKG)-knockout mouse plate

233 l effect of N2O is affected by inhibition of cGMP-dependent protein kinase (PKG).

234 nd inhibit cardiac hypertrophy by activating cGMP-dependent protein kinase (PKG).

235 anylate cyclase, which in turn activates the cGMP-dependent protein kinase (PKG).

236 blocked by inhibitors of guanylyl cyclase or cGMP-dependent protein kinase (PKG).

237 nitric oxide synthase, guanylyl cyclase, and cGMP-dependent protein kinase (PKG).

238 Activation of SERT by cGMP requires the cGMP-dependent protein kinase (PKG).

239 olished by inhibitors of NO synthase and the cGMP-dependent protein kinase (PKG).

240 ide (NO) synthesis, leading to activation of cGMP-dependent protein kinase (PKG).

241 hibition increases cGMP levels that activate cGMP-dependent protein kinase (PKG).

242 mulate soluble guanylyl cyclase, or activate cGMP-dependent protein kinase (PKG).

243 ting the production of cGMP, an activator of cGMP-dependent protein kinase (PKG).

244 zation by a fourth AGC kinase family member, cGMP-dependent protein kinase (PKG).

245 We show that cGMP-dependent protein kinase (PKG)/cAMP-dependent prote

246 istance arteries of RGS2-/- mice even though cGMP-dependent protein kinase (PKG)1alpha and PKG1beta a

247 PRKG1 encodes type I cGMP-dependent protein kinase (PKG-1), which is activate

248 The cGMP-dependent protein kinases (PKG) are emerging as imp

249 The cAMP-dependent (PKA) and cGMP-dependent protein kinases (PKG) share a strong prim

250 Although the cAMP-dependent (PKA) and cGMP-dependent protein kinases (PKG) usually participate

251 ted PLC enzymes are the potential targets of cGMP-dependent protein kinases (PKG).

252 how that the cyclic guanosine monophosphate (cGMP)-dependent protein kinase, PKG, maintains the eleva

253 dy, we tested the ability of cGMP and type 2 cGMP-dependent protein kinase (PKG2) to activate forkhea

254 uction of cyclic GMP, which activates type I cGMP-dependent protein kinase (PKGI) in vascular smooth

255 All mammalian cGMP-dependent protein kinases (PKGs) are dimeric.

256 The type I cGMP-dependent protein kinases (PKGs) are key regulators

257 The cGMP-dependent protein kinases (PKGs) are ubiquitous eff

258 f NO synthase, soluble guanylate cyclase, or cGMP-dependent protein kinases (PKGs), supporting a requ

259 ion of cGMP and an increased activity of the cGMP-dependent protein kinase (protein kinase G, PKG) in

260 ronary arteries by "cross-activation" of the cGMP-dependent protein kinase (protein kinase G, PKG).

261 aprinast, which we show acts in part through cGMP-dependent protein kinase (protein kinase G; PKG) to

262 We cloned an Aplysia PKG (cGMP-dependent protein kinase; protein kinase G) that is

263 ge-activated potassium channels by cAMP- and cGMP-dependent protein kinases requires an alternatively

264 did not mimic NO action and an antagonist of cGMP-dependent protein kinase, Rp-8-pCPT-cGMPs, did not

265 Three inhibitors of cGMP-dependent protein kinase, Rp-8Br-PET-cGMPS, KT5823,

266 PDE10 inhibition selectively activates cGMP/cGMP-dependent protein kinase signaling to suppress beta

267 ta bioactivity through down-modulation of NO-cGMP-dependent protein kinase signaling.

268 (P<0.01) and dibutyryl cGMP, an activator of cGMP-dependent protein kinase, significantly attenuated

269 shown that nitric-oxide (NO) synthase 3 and cGMP-dependent protein kinase stimulate platelet secreti

270 These data identify TXA2 receptors as cGMP-dependent protein kinase substrates and support a n

271 phoprotein (VASP), a substrate for cAMP- and cGMP-dependent protein kinases that is associated with a

272 lity of cAMP-dependent protein kinase and/or cGMP-dependent protein kinase to cause relaxation.

273 hodiesterases (PDEs), ion-gated channels, or cGMP-dependent protein kinases to regulate physiological

274 The current model is that PKG, a malarial cGMP-dependent protein kinase, triggers egress, activati

275 lpha1G interacted with NOS3, which augmented cGMP-dependent protein kinase type I activity in alpha1G

276 ast, expression of dominant negative RhoA or cGMP-dependent protein kinase type I alpha inactivates R

277 el of IRS-1 and potential cross-talk between cGMP-dependent protein kinase type I alpha, Rho/Rho kina

278 The nitric oxide-sensitive guanylyl cyclase/cGMP-dependent protein kinase type I signaling pathway c

279 annels of the BK type are stimulated by cGMP/cGMP-dependent protein kinase type I, and recent ex vivo

280 o the autoinhibitory pseudosubstrate site in cGMP-dependent protein kinase type Ialpha and type Ibeta

281 d in PS120 cells, even upon co-expression of cGMP-dependent protein kinase type II (cGKII).

282 Notch was reversed by constitutively active cGMP-dependent protein kinase type II.

283 -dependent protein kinase, protein kinase C, cGMP-dependent protein kinase, tyrosine kinases, or phos

284 ylation by protein kinase C and by cAMP - or cGMP -dependent protein kinase were identified.

285 nd inhibition of cPLA2 activity by cAMP- and cGMP-dependent protein kinases were blocked by the corre

286 to L-LTP by stimulating guanylyl cyclase and cGMP-dependent protein kinase, which acts in parallel wi

287 Tachyphylaxis is mediated by cGMP-dependent protein kinase, which limits the conducta

288 al myocyte caveolae may be the activation of cGMP-dependent protein kinase, which would thereby inhib

289 sure-loaded hearts, leading to activation of cGMP-dependent protein kinase with inhibition of PDE5A.

290 Inhibition of cGMP-dependent protein kinase with KT5823 blocked the in