ライフサイエンスコーパス: cPLA2-alpha

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1 e, thrombin or the calcium ionophore A23187, cPLA2-alpha relocated to intracellular membranes.

2 timulation with calcium-mobilizing agonists, cPLA2-alpha translocates to intracellular phospholipid m

3 Cytosolic phospholipase A2-alpha (cPLA2-alpha) is a calcium-activated enzyme involved in a

4 proteins: cytosolic phospholipase A2-alpha (cPLA2-alpha), protein kinase C-beta (PKC-beta), and syna

5 n of calcium-independent membrane-associated cPLA2-alpha.

6 s the generation of free arachidonic acid by cPLA2-alpha, this enzyme has become an attractive pharma

7 to the catalytic domain of the 85-kDa cPLA2 (cPLA2-alpha).

8 pendent lipid binding (CaLB) domain found in cPLA2-alpha.

9 ntained transcripts and protein for group IV cPLA2-alpha and cPLA2-gamma.

10 expression of cPLA2alpha, but inhibition of cPLA2 alpha, cyclooxygenase-2 (COX-2), or EP1 receptor r

11 ibited tumor cell growth, phosphorylation of cPLA2 alpha promoted growth and counteracted Smad-mediat

12 Calcium-independent membrane association of cPLA2-alpha was not due to hydrophobic or cytoskeletal i

13 is study, the calcium-induced association of cPLA2-alpha with EA.hy.926 endothelial cell membranes wa

14 Finally, the recombinant C2 domain of cPLA2-alpha exhibited calcium-independent membrane bindi

15 A-AM demonstrated that a substantial pool of cPLA2-alpha remained associated with membrane fractions

16 et membrane play a role in the regulation of cPLA2-alpha.

17 rs at micromolar Ca2+ concentrations for the cPLA2-alpha C2 domain, but requires 3- and 10-fold highe

18 ctively, require greater than 400 ms for the cPLA2-alpha domain, compared to 13 ms for the PKC-beta d

19 The greater Ca2+ sensitivity of the cPLA2-alpha domain results from its higher intrinsic Ca2

20 Docking of the cPLA2-alpha domain to zwitterionic lipids is triggered b

21 family of phospholipases A2 with homology to cPLA2-alpha.

22 ective for cleavage at sn-2 as compared with cPLA2-alpha and cPLA2-gamma.

23 LA2-beta, that has significant homology with cPLA2-alpha in both the calcium-dependent lipid binding

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