ライフサイエンスコーパス: cactus

1 transcription factor inhibitor (Ikappabeta) cactus.

2 o degradation of the IkappaB-like inhibitor, Cactus.

3 lated inhibition of Dorsal nuclear uptake by Cactus.

4 d in the spatially controlled degradation of Cactus.

5 the cytoplasm by the IkappaB-family protein Cactus.

6 al phosphorylation, but still interacts with Cactus.

7 ned in the cytoplasm by the IkappaB protein, Cactus.

8 om activated Toll to a complex of Dorsal and Cactus.

9 sal and Dif is accompanied by degradation of Cactus.

10 induces the spatially graded degradation of Cactus.

11 ytoplasmic Dorsal from the I kappa B homolog Cactus.

12 kinase, Pelle, placed upstream of Dorsal and Cactus.

13 roperties distinct from those of full-length Cactus.

14 d outside the nucleus by the IkappaB homolog Cactus.

15 ) were previously unknown for any species of cactus.

16 stribution of different LAA morphologies was Cactus (278 [30%]), Chicken Wing (451 [48%]), Windsock (

17 Finally, we provide evidence that Dorsal and Cactus act posttranscriptionally, outside the nucleus, t

18 lated in vivo and are required for wild-type Cactus activity.

19 These results indicate that Cactus acts to bolster Dorsal activation, in addition to

20 ave implemented these algorithms in the new "Cactus" alignment program.

21 lieve inhibition of Dorsal nuclear uptake by Cactus, allowing Dorsal to enter the nucleus and activat

22 rotein Dorsal from its cytoplasmic inhibitor Cactus, allowing Dorsal to translocate into ventral and

23 n lateral and dorsal embryo domains, loss of Cactus allows more Dorsal to translocate to the nucleus.

24 The silencing of Cactus also led to developmental arrest and death of the

25 rlapping with I kappa B-alpha, as well as to cactus, an I kappa B homolog of Drosophila.

26 Toll mutant and a loss-of-function mutant of Cactus, an I kappa B-like factor that inhibits the Toll

27 ved in the mosquitoes with RNAi knockdown of Cactus, an IkappaB inhibitor in the Toll/REL1 pathway.

28 knockdown of an Aedes homolog to Drosophila cactus, an IkappaB inhibitor of Drosophila Toll pathway.

29 First, we assume that Cactus, an inhibitor that binds to Dorsal and prevents i

30 Simultaneous knockdown of cactus and AGAP001476 failed to reverse the near refract

31 g-down their respective negative modulators (Cactus and Caspar) increases LDs numbers in the midgut.

32 entral signal-dependent modification of both Cactus and Dorsal is required for the graded nuclear imp

33 As maternally encoded proteins, Toll, Cactus and Dorsal, along with Tube and Pelle, participat

34 radient requires the phosphorylation of both Cactus and Dorsal.

35 l dissociates from its cytoplasmic inhibitor Cactus and enters the nucleus.

36 e ventralized phenotype of embryos that lack Cactus and faithfully reconstitutes dorsal group-regulat

37 ts degradation of the IkappaB-like inhibitor Cactus and nuclear translocation of the Rel protein Dors

38 ases levels of the I(kappa)B-related protein Cactus and reduces the magnitude of the nuclear concentr

39 interactor of the Drosophila IkappaB factor Cactus and shown to play a role in controlling embryonic

40 tion of Cactus results in the degradation of Cactus and the nuclear targeting of Dorsal.

41 The number of mitotic cells in the cactus and TollD hemolymph is higher than that in the wi

42 Through genetic studies, Tube, Pelle, Cactus, and Dif have been identified as downstream compo

43 We propose a model in which Tube, Pelle, Cactus, and Dorsal form a multimeric complex that repres

44 We then show that mutations in dorsal, cactus, and IRAK/pelle kinase specifically impair GluR l

45 is encoded by Toll, tube, pelle, dorsal, and cactus, and it functions to form the dorsal-ventral axis

46 ased upon our data we speculate that Dorsal, Cactus, and Pelle could function together, locally at th

47 by the ventral signal while associated with Cactus, and that Dorsal phosphorylation is essential for

48 Dorsal binds specifically to Tube, Pelle and Cactus, and that the protein kinase activity of Pelle di

49 Lethality of mutant cactus animals could be rescued either by the selective

50 on of fusion proteins comprising segments of Cactus attached to Escherichia coli beta-galactosidase (

51 orsal Rel homology region rather than at the Cactus binding site.

52 lear localization signal is not required for Cactus binding.

53 ments of Dorsal reflect both free Dorsal and Cactus-bound Dorsal.

54 adjacent areas, including the iconic saguaro cactus (Carnegiea gigantea) of the Sonoran Desert.

55 he prevalence of pre-procedure stroke/TIA in Cactus, Chicken Wing, Windsock, and Cauliflower morpholo

56 nt morphologies were used to categorize LAA: Cactus, Chicken Wing, Windsock, and Cauliflower.

57 ant capacity and (poly)phenolic compounds of cactus cladodes (Opuntia ficus-indica) was evaluated.

58 Component Analysis distributed heat treated cactus cladodes according to their distinctive polypheno

59 Cactus cladodes fried in olive oil showed a healthier fa

60 naling on the ventral side breaks the Dorsal/Cactus complex, allowing Dorsal to enter the nucleus to

61 tated diffusion, or shuttling, of the Dorsal/Cactus complex.

62 to relay the signal from Toll to the Dorsal-Cactus complex.

63 ude that dorsoventral signaling results in a Cactus concentration gradient and propose that signal-de

64 The antioxidant properties of red cactus cultivar were higher than the yellow cactus culti

65 cactus cultivar were higher than the yellow cactus cultivar.

66 onal and pharmaceutical potential of the two cactus cultivars that must be widespread cultivated in a

67 Signal-induced Cactus degradation frees Dorsal for nuclear translocatio

68 e system which reconstitutes Pelle-dependent Cactus degradation, we show that a motif in Cactus resem

69 y reducing a signal-independent component of Cactus degradation.

70 IkappaB-beta is essential for Pelle-induced Cactus degradation.

71 P001476-mediated anti-Plasmodium response is Cactus-dependent.

72 Cactus depletion resulted in transcriptional activation

73 The immune effects caused by Cactus depletion were eliminated by double knockdown of

74 must discriminate between Cactus-Dorsal and Cactus-Dif complexes.

75 us for degradation must discriminate between Cactus-Dorsal and Cactus-Dif complexes.

76 uring early Drosophila development, the Toll-Cactus-Dorsal pathway regulates the establishment of the

77 milarities exist between the Drosophila Toll/Cactus/Dorsal signaling pathway and the mammalian cytoki

78 ructs that lack the first 125 amino acids of Cactus escape dorsal group-dependent degradation.

79 with establishment of industries beside the cactus farms that used all parts of plants.

80 A new paper shows that a cactus-feeding fly became restricted to its host by chan

81 eterospecific juveniles, no juveniles) for a cactus-feeding insect, Narniafemorata (Hemiptera: Coreid

82 (medium ground finch) and Geospiza scandens (cactus finch) changed several times in body size and two

83 us, ground finches have deep and wide beaks, cactus finches have long and pointed beaks (low depth an

84 gher levels in the long and pointed beaks of cactus finches than in more robust beak types of other s

85 k, recapitulating the beak morphology of the cactus finches.

86 dient can behave differently with respect to Cactus fluctuations.

87 fore the two signalling pathways that target Cactus for degradation must discriminate between Cactus-

88 that proteolytic cleavage by CalpA generates Cactus fragments lacking an N-terminal region required f

89 rotein Dorsal from its cytoplasmic inhibitor Cactus; free Dorsal translocates into nuclei and directs

90 The microencapsulation of betalains from cactus fruit by spray drying was evaluated as a stabiliz

91 e found that females laid 56% more eggs when cactus fruit was present versus when it was absent.

92 d both resource quality (presence/absence of cactus fruit) and social cues (conspecific juveniles, he

93 Betalains were extracted from purple cactus fruits and encapsulated in calcium-alginate and i

94 ctly from the mash of whole Opuntia dillenii cactus fruits have been investigated.

95 etic experiments support the conclusion that cactus functions in concert with, rather than in opposit

96 rs of an unusual dorsalizing mutation in the cactus gene, cact(E10).

97 Using Cactus graphs, recently introduced for representing sequ

98 (medium ground finch) and Geospiza scandens (cactus ground finch) from 1978 to 2010 on Daphne Major I

99 jection of RNA encoding this altered form of Cactus has a dominant negative effect on establishment o

100 s species includes four genetically isolated cactus host races each individually specializing on the

101 vensis lineage at Adh-1, suggesting that the cactus host shift that occurred in the divergence of D.

102 rosophila mojavensis and D. arizonae utilize cactus hosts, and each host contains a characteristic mi

103 ificity and in the adaptation to alternative cactus hosts.

104 ural and functional similarities (Toll/IL-1, Cactus/I-kappaB, and dorsal/NF-kappaB).

105 rentially affects the levels and activity of Cactus in embryos, but does not inhibit the binding of C

106 le for dorsal group-dependent degradation of Cactus in the absence of this motif.

107 he Drosophila melanogaster IkappaB homologue Cactus in vivo.

108 scription of the Drosophila IkappaB homolog, Cactus, in Toll receptor-mediated antimicrobial response

109 ownstream of Toll to release Dorsal from the Cactus inhibitor.

110 Phosphorylation of both Dorsal and Cactus is regulated by a Toll-receptor-dependent ventral

111 Compared to other plant taxa, this cactus is rich in polymorphic loci (Ps=89.5%), with high

112 Results showed that the cactus juice exhibited desirable technological character

113 fied Drosophila casein kinase II (CKII) as a Cactus kinase and shown that CKII specifically phosphory

114 Furthermore, Cactus-lacZ constructs that lack only the putative Ikapp

115 Full-length Cactus-lacZ expressed in vivo normalizes the ventralized

116 pha can also direct polarized degradation of Cactus-lacZ fusion protein.

117 In addition, the lymph glands of cactus larvae are considerably enlarged.

118 Phosphorylation of Cactus leads to its degradation and to the release of Do

119 ence suggesting that Dpp signaling increases Cactus levels by reducing a signal-independent component

120 phylogenomic approach, we estimated that the cactus lineage diverged from its closest relatives appro

121 Diversification rates of several cactus lineages rival other estimates of extremely rapid

122 loned by chromosomal walking from the nearby cactus locus.

123 Unexpectedly, cactus loss-of-function alleles decrease Dorsal nuclear

124 tivity at least in part by counteracting the Cactus-mediated inhibition of Dorsal nuclear localizatio

125 c diversity was measured in the mixed-mating cactus, Melocactus curvispinus, in Venezuela.

126 Here, we investigate how cactus modulates Toll signals through its effects on the

127 e Drosophila immune organ, leads to elevated cactus mRNA levels, decreased expression of antimicrobia

128 A combination of cactus mucilage and ferric (Fe(III)) salt was investigat

129 We explore the application of cactus mucilage, pectic polysaccharide extracts from Opu

130 it completely destabilizes the protein in a cactus mutant background.

131 Analysis of cactus mutants that lack Cactus protein revealed that al

132 In cactus mutants we found an additional kind of melanized

133 Therefore, Cactus not only has the primary role of regulating Dorsa

134 onals were characterized in two prickly pear cactus (Opuntia ficus indica Mill.) cultivars; red and y

135 Mutations in cactus or Toll, or constitutive expression of dorsal can

136 tion about their age, but progress in dating cactus origins has been hindered by the lack of fossil d

137 ing factor and/or discriminant analysis, the cactus pad samples were clearly differentiated according

138 Consumption of cactus pads contributes to the intake of dietary fiber,

139 g, Fe, Cu, Zn, Mn and Cr) were determined in cactus pads from Opuntia dillenii and Opuntia ficus indi

140 and green fruit pulp of O. ficus indica; the cactus pads of O. dillenii could be differentiated accor

141 hat the intracellular portion of the Toll to Cactus pathway also controls the innate immune response

142 hemical and physiological ripening events in cactus pear (Opuntia ficus-indica) fruit of cultivars 'N

143 Pulp (CP) and ultrafiltered (UF) cactus pear extracts were encapsulated with Capsul (C) b

144 rvest handling protocols for premium quality cactus pear fruit.

145 compounds and betalains are characterized in cactus pear juice using a single LC-DAD-ESI-MS/MS method

146 and Stenocereus) and a more distant outgroup cactus, Pereskia We used these to construct 4,436 orthol

147 orylates a set of serine residues within the Cactus PEST domain.

148 quires CKII-catalyzed phosphorylation of the Cactus PEST domain.

149 e Toll stems from the mobilization of a free Cactus pool induced by the Calpain A protease.

150 eracts physically with Cactus, recognizing a Cactus pool that is not bound to Dorsal, a fly NFkappaB/

151 her by the selective expression of wild-type Cactus protein in the larval lymph gland or by the intro

152 Analysis of cactus mutants that lack Cactus protein revealed that almost all of these animals

153 inhibitor, IkappaBalpha, and the Drosophila Cactus protein.

154 rects the spatially regulated proteolysis of Cactus protein.

155 CalpA alters the absolute amounts of Cactus protein.

156 retention of both Dorsal and Dif depends on Cactus protein; nuclear import of Dorsal and Dif is acco

157 Major cactus radiations were contemporaneous with those of Sou

158 vidence that CalpA interacts physically with Cactus, recognizing a Cactus pool that is not bound to D

159 , covering 2.9 million base pairs of the Adh-cactus region of chromosome 2 and 85,000 base pairs of t

160 Cactus degradation, we show that a motif in Cactus resembling the sites of signal-dependent phosphor

161 induces degradation of the IkappaB inhibitor Cactus, resulting in a ventral-to-dorsal nuclear gradien

162 Signal-dependent phosphorylation of Cactus results in the degradation of Cactus and the nucl

163 etion were eliminated by double knockdown of Cactus/RUNX4.

164 Finally, we make an empirical assessment of Cactus's ability to properly align genes and find intere

165 d interface will soon be available at http://cactus.salk.edu/RankProd

166 analyzing A in urine and mescaline (MSC) in cactus samples.

167 The data indicate that the defatted cactus seed wastes still contain various components that

168 Our results suggest that the Toll/Cactus signal transduction pathway plays a significant r

169 ow using these and existing simulations that Cactus significantly outperforms all of its peers.

170 We selected 55 cactus species from the Americas, all geo-referenced see

171 root biomass gathered for the large columnar cactus species Pachycereus pringlei.

172 The necrosis of each cactus species provides the resident D. mojavensis popul

173 vative scenario (+3.7 degrees C) that 25% of cactus species will have reduced germination performance

174 Pilosocereus machrisii and P. aurisetus are cactus species within the P. aurisetus complex, a group

175 ions in Baja as well as from closely related cactus species.

176 nin types in the seed coats of 130 different cactus species.

177 izing on the necrotic tissues of a different cactus species.

178 geometry with a widening slope, analogous to cactus spines, directly couples facilitated droplet grow

179 ing on conical wire-like structures, such as cactus spines, spider silk, and water striders' legs.

180 with the support of experimental results on cactus spines.

181 Cactus stability is regulated by amino-terminal serine r

182 r refractoriness induced by the knockdown of cactus, suggesting that the AGAP001476-mediated anti-Pla

183 he NF-kappaB and IkappaB homologs Dorsal and Cactus surround postsynaptic glutamate receptor (GluR) c

184 tly acting determinants in the N terminus of Cactus that direct dorsal group-dependent degradation.

185 ylatable alanine residues generated a mutant Cactus that still functions as a Dorsal inhibitor but is

186 Regulated proteolysis of Cactus, the cytoplasmic inhibitor of the Rel-related tra

187 in the presence of a non-signaling allele of Cactus, the IkappaB protein in Drosophila.

188 known Dorsal-interacting proteins (Twist and Cactus), three that encode novel proteins, and one that

189 embryos, but does not inhibit the binding of Cactus to Dorsal.

190 ssion analysis suggests that this ability of Cactus to enhance Toll stems from the mobilization of a

191 Cactus, Toll, Tube and Pelle proteins are expressed in t

192 ghlight the importance of regulating IkappaB/Cactus transcription in innate immunity, and identify Gr

193 Both vitellogenin and TEP1 are regulated by Cactus under the Toll pathway.

194 We test Cactus using the Evolver genome evolution simulator, a c

195 Compared with chicken wing, cactus was 4.08 times (p = 0.046), Windsock was 4.5 time

196 pulation genetic structure observed for this cactus was attributed to, at least, three factors: short

197 Dorsal protein that failed to interact with Cactus was still regulated by the ventral signal.

198 ion, nuclear targeting, and interaction with Cactus, we have performed an in vivo structure-function

199 n with its cognate IkappaB inhibitor protein Cactus, which is degraded on the ventral side of the emb

200 We propose that CalpA targets free Cactus, which is incorporated into and modulates Toll-re

201 Cactus with fruit is a high-quality environment for juve