ライフサイエンスコーパス: calcification

1 ompressible vessels because of tibial artery calcification.

2 educed primary human valve interstitial cell calcification.

3 body and may represent precursors of ectopic calcification.

4 ts), positive remodeling (>1.10), and spotty calcification.

5 tein (MGP) is a potent inhibitor of vascular calcification.

6 ralization, significantly attenuated cardiac calcification.

7 emissions can limit future declines in reef calcification.

8 glycan synthesis, collagen accumulation, and calcification.

9 notypically defective being unable to resorb calcification.

10 een the SORT1 gene locus and coronary artery calcification.

11 and bone formation are involved in vascular calcification.

12 ase and functions within and beyond vascular calcification.

13 a reduced cellular bicarbonate allocation to calcification.

14 atients because of the presence of extensive calcification.

15 ion alters the development of cardiovascular calcification.

16 eveloping secondary to severe mitral annular calcification.

17 y little is known about noncoronary vascular calcification.

18 xogenous androgen treatment induces vascular calcification.

19 g atheroma plaque formation and aortic valve calcification.

20 entities and even a cause of cardiovascular calcification.

21 ttenuated mouse and human smooth muscle cell calcification.

22 pyrophosphate, a major inhibitor of ectopic calcification.

23 ion, granuloproliferation, and intracerebral calcification.

24 terial stiffness, as well as coronary artery calcification.

25 , corneal neovascularization, cataracts, and calcification.

26 iates a molecular pathway inhibiting ectopic calcification.

27 fate and contribute directly to heart muscle calcification.

28 s showed a presacral solid mass with nodular calcifications.

29 d a tendency to slightly larger areas of IOL calcifications.

30 mation, endothelial dysfunction and vascular calcifications.

31 lial cells that surrounded ectopic bone-like calcifications.

32 athy is procedure duration in hard and fluid calcifications.

33 important cause of leukoencephalopathy with calcifications.

34 ere documented 78 times, involving 50 of 729 calcifications.

35 esence of intratumoral bleeding, presence of calcifications.

36 nd high Pearson correlation coefficients for calcification (-0.096 mm(2) and 0.973, respectively), LR

37 ol crystals (17.2% versus 27.5%; P=0.01) and calcification (15.4% versus 34.4%; P=0.008), whereas fib

38 Median aortic valve calcification (1973 [1124-3490] Agatston units) and mean

39 by aortic, thoracic, coronary, and valvular calcification); (2) adiposity (defined by pericardial, v

40 (2) thin cerebral cortices with subcortical calcifications; (3) macular scarring and focal pigmentar

41 2%; P=0.13) artery plaques and extraskeletal calcifications (34.4% to 65.6%; P=0.006) increased.

42 s detected in computed tomography scans were calcifications (99%), followed by ventricular enlargemen

43 mutations also had increased coronary-artery calcification, a marker of coronary atherosclerosis burd

44 lating collagen secretion and cardiovascular calcification, a novel area of exploration for the poten

45 zed that DRP1 plays a role in cardiovascular calcification, a process involving cell differentiation

46 e PET-CT allows reproducible localization of calcification activity to different regions of the aorti

47 mography-based measures of valvular/vascular calcification, adiposity, and muscle attenuation.

48 IOL calcifications after (triple-)DMEK occurred in 14 patien

49 IOL calcifications after anterior chamber gas tamponade in D

50 IOL calcifications also occur in hydrophobic acrylic IOLs.

51 greater likelihood of having coronary artery calcification and 9.7% higher (95% CI, 2.2-17.8) burden

52 phosphorus balance and correlate with renal calcification and albuminuria.

53 , increased medial wall thickness, increased calcification and apoptosis relative to TEBVs fabricated

54 statins by ACC/AHA guidelines with vascular calcification and at low to intermediate ASCVD risk.

55 The influences of baseline calcification and drug therapy (dalcetrapib vs. placebo)

56 graphy scans for measures of coronary artery calcification and echocardiographic assessment of left v

57 ion enables accurate differentiation between calcification and hemorrhage in patients presenting for

58 ty of fibroblasts in contributing to ectopic calcification and identify pharmacological targets for t

59 ization completely prevented ectopic cardiac calcification and improved post injury heart function.

60 sing lineage tracing, murine models of heart calcification and in vivo transplantation assays, we sho

61 pen questions in the field of cardiovascular calcification and include a review of the proposed mecha

62 rparathyroidism contributes to extraskeletal calcification and is associated with all-cause and cardi

63 eristics (high-risk plaque, including spotty calcification and low attenuation) of carotid plaque by

64 erosclerotic plaques that regulates vascular calcification and neointimal formation, and inhibits inf

65 racterized by microcephaly, hypomyelination, calcification and neuronal loss.

66 However, as pH declined from 8.0 to 7.5, calcification and oxygen consumption both decreased, sug

67 Multiple metrics of calcification and physiological performance varied with

68 demonstrated innate immune inflammation with calcification and polymicrogyria.

69 7.9 for 3 days, and gene expression levels, calcification and respiration rates were measured relati

70 utic strategies to prevent ectopic cartilage calcification and some forms of congenital craniofacial

71 s may contribute to the severity of vascular calcification and suggests that therapy should be aimed

72 ral microangiopathy leukoencephalopathy with calcifications and cysts (LCC), presenting at any age fr

73 The size, number, and laterality of calcifications and the morphologic characteristics of th

74 nary scale (cavitation, air bronchogram, and calcification) and 6 were rated on a categorical scale (

75 um thinner intima (p<0.001), 45% less plaque calcification, and 2 log orders higher paclitaxel bulk a

76 extreme model for arteriosclerosis, vascular calcification, and bone disorders, all of which are also

77 itis present at day 14, osteophytes, ectopic calcification, and meniscus pathology.

78 adhesions, subependymal cysts, intracerebral calcifications, and microcephaly; however, the Zika viru

79 gnal void on GRE images; one LSIR was due to calcifications, and three LSIRS were due to a recent bio

80 crease in collagen content, without signs of calcification, aneurysm or stenosis.

81 osclerosis is an inflammatory condition with calcification apparent late in the disease process.

82 hondrocyte apoptosis, synovitis, and ectopic calcification appear to be targets for potential therape

83 rocedures, both overall and when considering calcification appearance (P > .089).

84 Silicification and calcification are distinct cellular processes with no kn

85 Acidification-induced reductions in calcification are projected to shift coral reefs from a

86 of microcalcifications and ultimately large calcification areas.

87 Operators subjectively graded calcifications as hard, soft, or fluid according to thei

88 at the development of both acute and chronic calcification associated with ABCC6 deficiency can be pr

89 mporo-parieto-occipital cyst with a marginal calcification, associated with left ventricular uncompen

90 s were classified according to finding type: calcifications, asymmetry or focal asymmetry, mass, and

91 Coronary artery calcification at ages 40 years to 46 years.

92 ation trended to progress more in those with calcification at baseline (p = 0.055).

93 ees C, but both species show a threshold for calcification at cold temperatures: calcification in P.

94 The observed inhibition of calcification at low temperatures indicates that the rol

95 tinct mass margins and fine linear branching calcifications at mammography were significantly associa

96 pen in 13.9% cases (types I), whereas apical calcification bridge formed in 47.2% (type II) and apica

97 ine model, Sort1-deficiency reduced arterial calcification but did not affect bone mineralization.

98 imilar AS severity, women have less valvular calcification but more fibrosis compared with men.

99 of pseudoxanthoma elasticum-like spontaneous calcification, but failed to reverse already established

100 ed tomography scan to assess coronary artery calcification (CAC) and plaque characteristics.

101 ow-turnover bone disease and coronary artery calcification (CAC) in patients on hemodialysis (HD).

102 Coronary artery calcification (CAC) is highly prevalent in dialysis-naiv

103 Coronary artery calcification (CAC) may impair diagnostic assessment of

104 n ancestry participants with coronary artery calcification (CAC) measured by cardiac computed tomogra

105 coronary artery disease and coronary artery calcification (CAC).

106 terial failure of the plaque, but that large calcifications can stabilize it.

107 lcifications, such as primary familial brain calcifications, can be associated with marked leukoencep

108 RUNX2 in cell proliferation, apoptosis, and calcification capacity.

109 the polygenic risk score and coronary artery calcification (CARDIA) and carotid artery plaque burden

110 ase and diffuse neurofibrillary tangles with calcification, characterized by accumulation of all six

111 We measured the elemental composition of calcifications contained within histological sections of

112 d the neointimal presence of macrophages and calcification contributed to the high interobserver vari

113 ed brain abnormalities included intracranial calcifications, corpus callosum abnormalities, abnormal

114 tion with age (continuous increase in global calcification, decrease in muscle attenuation, and U-sha

115 pment of perilesional edema (PE) around >/=1 calcification (defined as 1 episode) occurs in about 50%

116 identified 3 major anatomic axes: (1) global calcification (defined by aortic, thoracic, coronary, an

117 Aortic valve calcification density correlated better with valve weigh

118 tment for age, body mass index, aortic valve calcification density, and aortic annulus diameter, fema

119 ibrium oxygen isotope values implies shallow calcification depths for H. inflatus (75 m).

120 lasma pyrophosphate levels, resulting in the calcification disorder pseudoxanthoma elasticum and some

121 le mutations in ABCC6 underlie the incurable calcification disorder pseudoxanthoma elasticum and some

122 promising strategy to treat ABCC6-dependent calcification disorders.

123 allele-specific therapy of ABCC6-associated calcification disorders.

124 terial calcification of infancy and arterial calcification due to CD73 deficiency.

125 terial calcification of infancy and arterial calcification due to CD73 deficiency.

126 or subclinical CVD measures (coronary artery calcification, early transmitral velocity/late (atrial)

127 sts that stony corals may be able to sustain calcification even under lower pH conditions that do not

128 dard of reference), 27 patients had positive calcification findings, and 27 did not.

129 Mixed-effects models of calcification for each species were then used to project

130 E) computed tomography (CT) to differentiate calcification from acute hemorrhage in the emergency dep

131 tendon; or grade 3, hypoechoic areas and/or calcifications greater than 30% of the tendon.

132 Patients with IOL calcifications had higher rebubbling rates than patients

133 ts to refine statin eligibility via coronary calcification have been studied in white populations but

134 Daytime calcification however, is not detectably affected by Ome

135 Conclusion Adrenal calcifications identified on CT scans are common in pati

136 ing of five fresh human lower limbs revealed calcification in all main arteries.

137 Here, we study growth and calcification in benthic foraminifera that inhabit a the

138 esses osteoclast function and may thus favor calcification in CAVD.

139 We hypothesized that CD8(+) T cells modulate calcification in CAVD.

140 ndicate that under future warming scenarios, calcification in heat-tolerant foraminifera species will

141 This may hamper calcification in marine organisms such as corals and ech

142 ve implications for interpreting patterns of calcification in N. dutertrei and suggest that diurnal M

143 hold for calcification at cold temperatures: calcification in P. calcariformata only occurred above 2

144 major source of osteoblast-like cells during calcification in the media and intima.

145 Calcification in the surface ocean decreases the bufferi

146 ng marine algae, responsible for half of the calcification in the surface ocean, and exert a strong i

147 tion of macroscopic, nodular structures with calcification in the VIC-laden hydrogels.

148 Si is required for calcification in these coccolithophores, indicating that

149 or thalamus were also commonly involved with calcifications in 11 of 17 (65%) and 18 of 28 (64%) infe

150 Despite the importance of calcifications in early detection of breast cancer, and

151 tendon thickening or hypoechoic areas and/or calcifications in less than 30% of the tendon; or grade

152 The prevalence of adrenal calcifications in patients with fCCM was compared with t

153 Adrenal calcifications in patients with fCCM were more frequentl

154 ster antigen was detected in the presence of calcifications in the arteries.

155 rder characterized by symmetrical, bilateral calcifications in the basal ganglia, nucleus gyrus and c

156 ders are frequently associated with spotlike calcifications in the basal ganglia.

157 ia, hydrocephalus, and multifocal dystrophic calcifications in the cortex and subcortical white matte

158 by neural stem cell infection alone, such as calcifications in the cortical plate.

159 ce of a 3.8 mm parietal granuloma with a few calcifications in the left eye.

160 ined cystic-solid components and millimetric calcifications in the liver.

161 SWI enables the reliable detection of calcifications in the rotator cuff in patients with calc

162 imately 1-cm spiculated mass with associated calcifications in the upper outer quadrant of the left b

163 In primary tumors the percentage of calcifications increased, whereas in metastatic tumors c

164 to pre-industrial conditions, net community calcification increases.

165 ed whether 4-PBA treatments could rescue the calcification inhibition potential of selected ABCC6 mut

166 tion of ABCC6 mutants, resulting in enhanced calcification inhibition.

167 converted into pyrophosphate (PPi), a major calcification inhibitor.

168 Vascular calcification is a frequent cause of morbidity and morta

169 Vascular calcification is a major contributor to the progression

170 RATIONALE: Vascular calcification is a process similar to bone formation lea

171 Mitral annular calcification is an increasing problem in elderly people

172 Aortic valve (AV) calcification is an inflammation driven process that occ

173 Soft-tissue calcification is associated with aging, common condition

174 Coronary artery calcification is independently and significantly related

175 The extent to which vascular calcification is reversible and the possible mechanisms

176 ean acidification influences coccolithophore calcification is strongly debated, and the effects of ca

177 hat on hourly timescales nighttime community calcification is strongly influenced by Omega arag, with

178 und, whereas plaque composition (presence of calcification, lipid core, and intraplaque hemorrhage) w

179 acy of the resulting in vivo quantitation of calcification, lipid-rich necrotic core (LRNC), and matr

180 However, women present lower aortic valve calcification loads than men for the same AS hemodynamic

181 th 30 non-NRS plaques with similar degree of calcification, luminal obstruction, localization, and im

182 Reliably predicting how coral calcification may respond to ocean acidification and war

183 This failure to resorb established calcifications may contribute to the severity of vascula

184 arming depends on our understanding of coral calcification mechanisms.

185 s a potential therapeutic target for ectopic calcification/microcalcification and may clarify the mec

186 but not mRNA, is reduced in cell and animal calcification models and in human calcified coronary art

187 , whereas the ODxRS for all other suspicious calcification morphologies was 19.4 (P < .03).

188 Given the association between calcification morphology and cardiovascular outcomes, it

189 We also show that calcification morphology and the plaque's collagen conte

190 ADS features of mammographic breast density, calcification morphology, mass margins at mammography an

191 al cavities (n = 28; 60%), and intralesional calcification (n = 29; 62%).

192 e morphologic features and topography of the calcifications observed in a careful combined analysis o

193 At pH > 8.0, increased calcification occurred without a concomitant rise in res

194 Soft tissue calcification occurs in several common acquired patholog

195 ted end-of-century declines in scleractinian calcification of >50% relative to present-day rates.

196 In the heart, calcification of cardiac muscle leads to conduction syst

197 eutel syndrome patients show diffuse ectopic calcification of cartilaginous tissues and impaired midf

198 Calcification of coronary arteries is a prominent featur

199 lls and molecular events driving deleterious calcification of heart muscle remains elusive.

200 ent in individuals with generalized arterial calcification of infancy (GACI) due to loss-of-function

201 phenotypic overlap with generalized arterial calcification of infancy and arterial calcification due

202 inical features include generalized arterial calcification of infancy and arterial calcification due

203 bone mineralization in generalized arterial calcification of infancy caused by ENPP1 mutations.

204 Generalized arterial calcification of infancy is an intractable ectopic miner

205 ticum and some cases of generalized arterial calcification of infancy.

206 ticum and some cases of generalized arterial calcification of infancy.

207 ed long bones and premature degeneration and calcification of intervertebral discs.

208 t cardiovascular disease involving premature calcification of the aortic valve, a phenotype that clos

209 To address this knowledge gap, calcification of twelve common and understudied Caribbea

210 o identify incidence of and risk factors for calcifications of intraocular lenses (IOLs) after Descem

211 essed growth (linear extension, density, and calcification) of three branching coral species (Acropor

212 ic (CT) images were used to overlay vascular calcification on FE MR angiographic images as composite

213 Flow speed (2-14 cm s(-1) ) enhanced net calcification only at night under elevated pCO2 .

214 and calcium overlay images and classified as calcification or hemorrhage.

215 thout basal ganglia hyperintensity, lacunae, calcification, or heavy metal deposits.

216 sociated with time from treatment, number of calcifications, or sex.

217 P < 0.01), tumor thickness (P < 0.01), tumor calcification (P = 0.01), and logMAR visual acuity (P =

218 ter with the double-needle procedure in hard calcifications (P < .001) and with the single-needle pro

219 nd with the single-needle procedure in fluid calcifications (P = .024).

220 ere was no change in recall examinations for calcifications (P = .977).

221 We demonstrated the calcification pattern of the hydrophilic IOL (Lentis LS-

222 chondral ossification showed morphologic and calcification patterns that were distinct from archetypi

223 However, observed declines in calcification performance and survival probability under

224 The results indicate that vascular calcification persists after reversal of uremia, because

225 We used the dystrophic cardiac calcification phenotype of Abcc6(-/-) mice as an indicat

226 fully inhibited the acute dystrophic cardiac calcification phenotype, whereas alendronate had no sign

227 ed to a major reduction in acute and chronic calcification phenotypes.

228 Vascular calcification powerfully predicts mortality and morbidit

229 odels confirmed that these miRs regulate the calcification process.

230 re acidification (32 degrees C/940 ppm-v) on calcification rate were apparent across both 30-day inte

231 Calcification rates for key species (Acropora formosa, A

232 Laboratory and field studies have shown that calcification rates of many organisms decrease with decl

233 timistic scenarios of reduced CO2 emissions, calcification rates throughout the Florida Keys declined

234 ent and 1200 muatm pCO2 for 7 weeks, and net calcification rates were measured at different flow spee

235 ms contributing to pathological heart muscle calcification remain unknown.

236 oncentration, bone mineral density, vascular calcification, renal function, patient and graft surviva

237 osphorus intake can cause vascular and renal calcification, renal tubular injury, and premature death

238 Furthermore, SMC calcification required Rab11-dependent trafficking and F

239 The ability of MGP to inhibit calcification requires the activity of a vitamin K-depen

240 The dependence of calcification, respiration, and spine repair on seawater

241 Here we quantify the net calcification response of a coral reef flat to alkalinit

242 ernosa, and Porites astreoides, had negative calcification responses to both elevated temperature and

243 ormalities (including microcephaly and brain calcifications), retinal manifestations, and defects on

244 atherosclerosis, assessed by coronary artery calcification score >100 AU; (2) ASCV events, defined as

245 itively associated with high coronary artery calcification score (odds ratio, 2.28; 95% confidence in

246 3; P = .006), and the median coronary artery calcification score changed from 255 to 244 Agatston uni

247 seline, 70 men (50.7%) had a coronary artery calcification score higher than 300 Agatston units, refl

248 Median coronary artery calcification scores were high in both groups (1767 [IQR

249 Purpose To determine if adrenal calcifications seen at computed tomography (CT) are asso

250 re reef growth rely on uniform scleractinian calcification sensitivities to temperature and ocean aci

251 nd abdominal aortic plaques; coronary artery calcification; serum biomarkers; and lifestyle.

252 e challenged the previously held notion that calcification serves to stabilize the atherosclerotic pl

253 Results Small focal calcifications (SFCs) (</=5 mm) were seen in one or both

254 er, is associated with a specific pattern of calcifications: small, symmetric, sparing the basal gang

255 ewly formed bone had already been set before calcification started and that the effects of OP3-4 migh

256 w CO2, suggesting an additional regulator of calcification such as alkalinity.

257 ders primarily associated with basal ganglia calcifications, such as primary familial brain calcifica

258 final chambers were used to calculate their calcification temperatures.

259 h worse aortic valve function, fibrosis, and calcification than those Npr2(+/-) with typical tricuspi

260 hin the epiphyseal cartilage developed a rim calcification that originated from normal subjacent bone

261 puted tomography were used to identify small calcifications that were missed at radiography.

262 idering that it is coronary LRP, rather than calcification, that underlies the majority of acute coro

263 t androgens play a role in inducing vascular calcification through the AR.

264 nhibition reduces PA remodeling and prevents calcification, thus improving pulmonary hemodynamic para

265 Here we show that the calcification to carbon fixation ratio determines whethe

266 ithm should take into account the pattern of calcifications to better target the genetic analyses.

267 Arch calcification trended to progress more in those with cal

268 obtained in two in vitro models of vascular calcification (uremic serum and high-calcium and -phosph

269 sed to project community-level scleractinian calcification using Florida Keys reef composition data a

270 the depth of a buried object, such as breast calcifications, using simple transmission measurement ge

271 ilters in 99% of patients included thrombus, calcification, valve tissue, artery wall, and foreign ma

272 racterized by hyperphosphatemia and vascular calcification (VC).

273 Coronary artery calcification was assessed using electron-beam or multid

274 Coronary artery calcification was defined as an Agatston score above 0.

275 affected by OA, especially at night when net calcification was depressed ~78% compared to ambient pCO

276 Degree of calcification was highest in the low-pH, high-CO2 Miocen

277 Higher prevalence of plaque calcification was noted in RA, despite similar plaque si

278 214, increased thickness of the fibrosa, and calcification was observed when the fibrosa was exposed

279 Finally, baseline calcification was related to changes in vascular inflamm

280 Community net calcification was significantly affected by OA, especial

281 The average ODxRS for fine linear branching calcifications was 29.6, whereas the ODxRS for all other

282 The diameter of calcifications was measured to assess intermodality corr

283 l atherosclerosis (plaque or coronary artery calcification) was present in 49.7% of CVRF-free partici

284 in mortality, respiration, or degree of test calcification were detected between urchins from vent an

285 (dalcetrapib vs. placebo) on progression of calcification were determined.

286 ial tree and confidence in the assessment of calcification were evaluated by using a four-point scale

287 els of uremia, hyperphosphatemia, and aortic calcification were induced by feeding nephrectomized rat

288 the left suprarenal region; cystic areas and calcification were present.

289 mplantation, proteins involved in regulating calcification were upregulated in the neointima of drug-

290 Fifty-six calcifications were detected with radiography in 27 pati

291 CAC score and number of coronary calcifications were directly related to age-adjusted tot

292 Calcifications were most often noted in the tunica media

293 ions increased, whereas in metastatic tumors calcifications were observed only after treatment.

294 adient-echo (GRE) sequence was performed and calcifications were searched for with computed tomograph

295 Cerebral calcifications, when associated with white matter hyperi

296 The risk was higher in women who had calcifications, whether they were (HR, 2.73; 95% CI: 2.2

297 0A2 gene expression, as well as reduce brain calcification which occurs in Fahr's disease and normal

298 but instead the temperature window for their calcification will be expanded throughout much of the ye

299 differences between progression of vascular calcification with dalcetrapib compared to that with pla

300 ated with significantly less coronary-artery calcification within each genetic risk category.