ライフサイエンスコーパス: calcified

1 lular immune reaction and ova (viable and/or calcified).

2 ion length was 8.3 cm, and 44% were severely calcified.

3 luded; 30 (25.2%) were moderately or heavily calcified.

4 : 0.85, moderately calcified: 0.82, severely calcified: 0.81; P < .05).

5 ed: 0.86, mildly calcified: 0.85, moderately calcified: 0.82, severely calcified: 0.81; P < .05).

6 cteristic curves (noncalcified: 0.86, mildly calcified: 0.85, moderately calcified: 0.82, severely ca

7 ncreased GlaMGP in noncalcified (5-fold) and calcified (20-fold) aortas from rats with renal failure,

8 uted tomography (CT) lesion was described as calcified (24x22x17.5 mm), connected with posterior leaf

9 Mg/Ca ratios of these Arctic-wide occurring calcified algae are sensitive to changes in both tempera

10 structed coral reef communities comprised of calcified algae, corals, and reef pavement that were ass

11 mRNA expression levels were evaluated in 9 calcified and 8 normal aortic valves by RNA sequencing.

12 Additional prespecified endpoints were non-calcified and calcified plaque measures and high risk pl

13 ated different reflectivity patterns in both calcified and decalcified portions of the choroidal oste

14 in renal failure but did not differ between calcified and noncalcified aortas.

15 The 1.4-cm nodule has calcified and remains stable and metabolically inactive.

16 rare cause of coronary thrombosis in highly calcified and tortious arteries in older individuals.

17 s, whereas others allow treatment of heavily calcified and tortuous segments.

18 d plaque (NCP), low-density NCP (NCP<30 HU), calcified and total plaque volumes, and corresponding pl

19 ean percentage of fibrous, fibrofatty, dense calcified, and necrotic core plaques in a mean length of

20 se To assess the relationship between total, calcified, and noncalcified coronary plaque burdens thro

21 areader agreement rates were high for total, calcified, and noncalcified plaques for both CT scanners

22 r stent expansion and the presence of large, calcified, and/or attenuated plaques were independent pr

23 initial loss of calcium was less in heavily calcified aortas and was associated with an increase in

24 To address this, calcified aortas from uremic mice were transplanted orth

25 Calcified aortic valve (AV) cusps have increased express

26 3) whether, in AS with discordant MG, severe calcified aortic valve disease is generally detected.

27 ent with heavy AVC-load reflective of severe calcified aortic valve disease, emphasizing the clinical

28 lf of the patients were identified as severe calcified aortic valve disease, irrespective of flow.

29 with AS severity, allows diagnosis of severe calcified aortic valve disease.

30 odeling the mineralised material produced in calcified aortic valve disease.

31 ts, predominantly during manipulation of the calcified aortic valve while stent valves were being pos

32 Resected normal and calcified aortic valves were analyzed histologically.

33 In both subjects with normal and with calcified aortic valves, minimum diameter increased in s

34 e with multipotent and osteogenic markers in calcified arteries by immunostaining and fluorescence-ac

35 also observed ectopic expression of FGF23 in calcified arteries of alpha-kl(-/-) mice, which might ac

36 mation and resorption have been localized in calcified arteries.

37 ore-reef, turbid water encruster assemblages calcified at a mean rate of 757 (SD +/-317) g m(-2) y(-1

38 These calcified at mean rates of 20.1 (SD +/-27) and 4.0 (SD +

39 dominated by crustose coralline algae which calcified at rates of 105.3 (SD +/-67.7) g m(-2) y(-1) a

40 es, smoking, dyslipidemia, and the extent of calcified atherosclerosis in the nonrenal vasculature, t

41 endent of CVD risk factors and the extent of calcified atherosclerosis in the nonrenal vasculature.

42 disease prevention center for the extent of calcified atherosclerosis in the systemic vasculature.

43 , suggesting partial confounding by systemic calcified atherosclerosis.

44 Although extensively calcified atherosclerotic lesions have been proposed to

45 Coronary artery calcified atherosclerotic plaque (CAC) predicts cardiova

46 Here we revealed that CPB isolated from calcified atherosclerotic plaques and artificially synth

47 with a tailored screening approach; that non-calcified baseline lung nodules greater than 300 mm(3),

48 verse dimension (negative screening result); calcified, benign nodule (negative screening result); or

49 nic precursor- and chondrocyte-like cells in calcified blood vessels of matrix Gla protein deficient

50 mineral nanoparticles have been detected in calcified blood vessels, the nature and role of these pa

51 d bone tissue and the vasculature within the calcified bone matrix.

52 ows for rapid, simultaneous visualisation of calcified bone tissue and the vasculature within the cal

53 rapidly cleared all tested organs, including calcified bone, but the fluorescence of proteins and imm

54 n, there is a lack of information concerning calcified brown algae (Phaeophyta), which are not obliga

55 P2 depletion and increased cytosolic Ca(2+), calcified CaM N lobe interacts with helix B in place of

56 e, we reveal the competition of PIP2 and the calcified CaM N lobe to a previously unidentified site i

57 ntaining channels, with effects disrupted by calcified CaM, but not by PIP(2) depletion.

58 TE and TT were not associated with calcified carotid plaques in either sex.

59 f tissues (uncalcified cartilage [UCC] only, calcified cartilage [CC] and subchondral bone [bone] [CC

60 and spectra were successfully obtained from calcified cartilage and subchondral bone for the first t

61 ng of the subchondral bone plate, comprising calcified cartilage and underlying subchondral bone.

62 Bone and calcified cartilage can be fossilized and preserved for

63 to upward invasion by vascular canals or to calcified cartilage erosion may contribute to biomechani

64 ed to the massive accumulation of unresorbed calcified cartilage in a large area below the growth pla

65 There were large discrete areas of calcified cartilage in the hypertrophic zone, few signs

66 The calcified cartilage layer was thicker (1.5-fold) in part

67 e is aggressive resorption of the underlying calcified cartilage leading to an extraordinary phenotyp

68 Calcified cartilage remodeling due to upward invasion by

69 gnificantly reduced OARSI scores and CC/TAC (calcified cartilage to total articular cartilage), but i

70 were analyzed by 3-dimensional histology for calcified cartilage, subchondral bone, and subchondral b

71 % of these atherosclerotic lesions developed calcified cartilage-like metaplasia.

72 at the boundary of the subchondral bone and calcified cartilage.

73 comes susceptible following focal changes in calcified cartilage.

74 e presence of uncalcified CEP (P = .023) and calcified CEP (P = .007) in the sample were strong predi

75 erent combinations of disk, uncalcified CEP, calcified CEP, and subchondral bone components and were

76 direct visualization of the uncalcified and calcified CEP.

77 rt TE MR images, intact disk/uncalcified CEP/calcified CEP/bone samples exhibited bilaminar intermedi

78 the histologic appearance of uncalcified and calcified CEPs.

79 ions in optical absorption stemming from the calcified clusters and the associated cross-linking mole

80 ition in dominance from more to less heavily calcified coccolithophores".

81 ave suggested a worse prognosis after PCI of calcified compared with noncalcified lesions.

82 h between species even when reduced to their calcified components.

83 Whilst calcified coralline algae (Rhodophyta) appear to be espe

84 nary CT angiography in patients with heavily calcified coronary arteries.

85 compared with SR coronary CT angiography of calcified coronary artery lesions, suggesting a potentia

86 rial measures of CAC quantify progression of calcified coronary artery plaque.

87 and animal calcification models and in human calcified coronary artery.

88 dy investigated the hypothesis that baseline calcified coronary atherosclerosis may determine cardiov

89 th concomitant PAD harbor more extensive and calcified coronary atherosclerosis, constrictive arteria

90 vascular events in those with less extensive calcified coronary atherosclerosis.

91 an important interventional tool for heavily calcified coronary lesions.

92 Pathological studies suggest that calcified coronary nodules are a rare cause of thromboti

93 Although age and sex distributions of calcified coronary plaque have been well described in th

94 We examined the distributions of NCP and calcified coronary plaque in healthy 30- to 74-year-old

95 tent of the blooming artifact in visualizing calcified coronary plaque is reduced by using flat-panel

96 ation between non-subcutaneous fat index and calcified coronary plaque remained after further adjustm

97 Atorvastatin reduced non-calcified coronary plaque volume relative to placebo: me

98 demographics, lifestyle factors, and height, calcified coronary plaque was associated with a 1 SD inc

99 ation between non-subcutaneous adiposity and calcified coronary plaque, a noninvasive measure of coro

100 of 219 participants (55%) were found to have calcified coronary plaque.

101 In human aortic valves, calcified cusps were stiffer and had more collagen depos

102 s, stent frame underexpansion due to heavily calcified cusps, suboptimal placement of the prosthesis,

103 lly silent, a proportion of individuals with calcified cysticerci develop seizures from these lesions

104 issed by CT in patients with apparently only calcified cysticercosis and could be considered for diag

105 cient DNA from five specimens of Neanderthal calcified dental plaque (calculus) and the characterizat

106 Calcified dental plaque (dental calculus) preserves for

107 nt a small group of malformations containing calcified dental tissues of both epithelial and mesenchy

108 give novel insights into the bioactivity of calcified deposits and suggest that small calcium phosph

109 anic nanoparticles are found not only within calcified deposits but also in areas devoid of microscop

110 Alizarin red stained calcified deposits that did not localize with collagen,

111 We show that (18)F-NaF adsorbs to calcified deposits within plaque with high affinity and

112 cified disease in African Americans and more calcified disease in white individuals.

113 V) (OR, 1.34; 95% CI, 1.04-1.73; P = 0.023), calcified drusen (OR, 1.33; 95% CI, 1.04-1.72; P = 0.025

114 4.24; P = 0.023), the complement pathway and calcified drusen (OR, 3.75; 95% CI, 1.79-7.86; P < 0.001

115 additionally associated with the presence of calcified drusen (P = 5.38 x 10(-6)).

116 ile many severe retinal abnormalities (i.e., calcified drusen, drusenoid pigment epithelium detachmen

117 tic acid (EDTA) that were designed to target calcified elastic lamina when administrated by intraveno

118 Because highly calcified enamel enables preservation of detailed dental

119 nation of dental fossils, because the highly calcified enamel that covers teeth causes them to be amo

120 The formation of the calcified endoskeleton of the sea urchin embryo is a val

121 ls can be further modulated with time by the calcified environment, thus contributing to the age-depe

122 ontrolling the amount and the quality of the calcified extracellular matrix.

123 perilesional brain oedema is seen around the calcified foci but its importance, association with seiz

124 esence of some internal echogenic debris and calcified foci in their dependent part.

125 10% (summer) to >90% (winter) of the heavily calcified form.

126 ic calculi (PC), which potentially represent calcified forms of CA, are less common but can cause uro

127 There were 92 cases of calcified granulomas, calcified lymph nodes, or both; 25

128 eNOS expression was reduced in calcified human aortic valves in a side-specific manner.

129 DRP1 protein was observed in calcified human aortic valves, and DRP1 RNA interference

130 scopic analyses of both the hydrogels and of calcified human plaques, we demonstrate that calcific mi

131 ied media of human femoral artery tissue and calcified human valves.

132 Cortical remodeling, limb isometry, and thin calcified hypertrophic metaphyseal cartilages indicate a

133 al environment become relatively more highly calcified, implying a positive climatic feedback.

134 lso suggested that coccolithophores are less calcified in more acidic conditions.

135 plaques were noncalcified, 17 mixed, and 22 calcified; in the non-IRAs, 5 plaques were noncalcified,

136 eral presence was only detectable within the calcified interface and bone regions, and its distributi

137 n mechanical properties were found, with the calcified interface region exhibiting significantly grea

138 7 sections with either small IPHs or heavily calcified IPHs were excluded, sensitivity, specificity,

139 ures and epilepsy even in patients with only calcified larval cysts.

140 Except for the optical system, as in the calcified lenses of trilobite and ostracod arthropods, o

141 atment with Fc-OPG significantly reduced the calcified lesion area without affecting atherosclerotic

142 omoting infiltration of macrophages into the calcified lesion to form osteoclast-like cells.

143 110 patients with only calcified lesions and a history of seizures or severe he

144 -related vascular remodeling and presence of calcified lesions in PAH remain unexplored.

145 ndetected viable cysts in patients with only calcified lesions on brain CT.

146 cantly associated with new ischemic lesions; calcified lesions were negatively associated.

147 4), and 19 additional patients with severely calcified lesions were treated with DA+DCB.

148 Patients with PAH display features of calcified lesions within the distal pulmonary arteries (

149 nd formation of osteoclast-like cells in the calcified lesions.

150 ith a shift toward increasingly fibrotic and calcified lesions.

151 A+DCB, 81.3% for DCB (P=0.78), and 68.8% for calcified lesions.

152 There were 92 cases of calcified granulomas, calcified lymph nodes, or both; 25 cases of apical pleur

153 In contrast to other studies of calcified macroalgae, however, we observed an increase i

154 or part of the mitral annulus, with markedly calcified margins, and no significant impact on the valv

155 r and the preferential extinction of heavily calcified marine animals.

156 that drove the preferential loss of heavily calcified marine biota.

157 Calcified marine organisms typically experience increase

158 trabeculae, loss of osteocytes, presence of calcified marrow, and elevated expression of osteocalcin

159 etrospective computed tomography, mean total calcified mass was 321.3 mg.

160 Amorphous calcified material (size, 0.55-1.8 mm) was identified in

161 The accumulation of calcified material in cardiovascular tissue is thought t

162 thesis that Axl prevents the deposition of a calcified matrix by vascular smooth muscle cells (VSMCs)

163 plasma protein involved in the regulation of calcified matrix metabolism.

164 ted tomography are agglomerations of smaller calcified matrix vesicles.

165 od vessels in bone are deeply encased in the calcified matrix, imaging techniques that are applicable

166 ntiated type of chondrocytes that produces a calcified matrix.

167 expression of androgen receptor (AR) in the calcified media of human femoral artery tissue and calci

168 and Wnt7a mRNAs were not detected in either calcified MGP(-/-) or noncalcified wild-type (MGP(+/+))

169 Our finding that the most heavily calcified morphotype dominates when conditions are most

170 /-) mice, these mice neither accumulate dead calcified myofibers nor lose ambulation.

171 aces helices A and B with the apo C lobe and calcified N lobe, respectively.

172 ed increase in apoptotic chondrocytes in the calcified nasal septum.

173 nd timing of PE episodes in individuals with calcified NCC are variable and commonly chronic, sometim

174 % of the patients with recurrent seizures in calcified neurocysticercosis (NCC).

175 ial prevention and treatments of symptomatic calcified neurocysticercosis (NCC).

176 Serum samples from 39 patients with calcified neurocysticercosis and no viable parasites on

177 h episodic seizure activity in patients with calcified neurocysticercosis.

178 hanges (alkaline phosphatase [ALP] activity, calcified nodule formation) than PVICs.

179 The calcified nodule has been suggested as a rare cause of c

180 nning is extremely sensitive and detects non-calcified nodules (NCNs) in 24-50% of subjects, suggesti

181 n, an independent core laboratory identified calcified nodules as distinct calcification with an irre

182 rrored the origin of most thrombotic events, calcified nodules caused fewer major adverse events duri

183 y, distribution, predictors, and outcomes of calcified nodules have never been described.

184 Calcified nodules in untreated nonculprit coronary segme

185 Thus, the prevalence of calcified nodules was 17% per artery and 30% per patient

186 Overall, 314 calcified nodules were detected in 250 of 1573 analyzabl

187 Two or more calcified nodules were detected in 48 coronary arteries

188 The calcified nodules were located <40 mm from the ostium of

189 Patients with calcified nodules were significantly older and had more

190 and 86% of left circumflex arteries, whereas calcified nodules within the right coronary arteries wer

191 usp retraction, stiffening, and formation of calcified nodules.

192 Our results demonstrate that 'calcified' nodules formed from PAVICs grown in OST+TGF-b

193 esence and extent of atherosclerotic plaque (calcified, noncalcified, or mixed), and obstructive lesi

194 atherosclerotic plaque, plaque composition (calcified, noncalcified, or mixed), and stenosis.

195 of 30) of lesions without this anomaly were calcified (odds ratio, 0.13).

196 composition was classified as noncalcified, calcified, or mixed.

197 es had higher DeltaT compared with mixed and calcified (p < 0.01) plaques.

198 5 plaques were noncalcified, 8 mixed, and 27 calcified (P=0.005).

199 ting to the development of proliferative and calcified PA lesions.

200 American patients had a lower prevalence of calcified plaque (39 [26%] vs 68 [45%] white patients, P

201 The diagnostic accuracy of CT to detect calcified plaque (83% versus 92%), necrotic core (80% ve

202 The presence and severity of coronary artery calcified plaque (CAC) differs markedly between individu

203 l atherosclerosis imaging of coronary artery calcified plaque (CAC) to the primary prevention of coro

204 plaque (HR, 58.06; P = .005) or exclusively calcified plaque (HR, 32.94; P = .02).

205 is, macrophage area, necrotic core area, and calcified plaque area was evaluated by using recursive p

206 ile mixed plaque at coronary CT angiography, calcified plaque at intravascular US, and lipid-rich pla

207 Calcified plaque at the proximal stent edge (relative ri

208 for uptake was significantly associated with calcified plaque burden (P < 0.0001) and cardiovascular

209 Tracer uptake was compared with calcified plaque burden and cardiovascular risk factors.

210 Both spatial distribution and amount of calcified plaque contribute to risk for CHD.

211 supplements and measures of subclinical CVD (calcified plaque in the coronary artery, carotid artery,

212 These data illustrate that calcified plaque limited intravascular drug delivery, an

213 respecified endpoints were non-calcified and calcified plaque measures and high risk plaque features

214 e, a proximal segment with either a mixed or calcified plaque or a stenosis >50% is equivalent to a 5

215 stprocessing techniques enhanced accuracy of calcified plaque quantification by reducing effects of t

216 Comparison of calcified plaque sizes determined with OCT with those de

217 However, statin therapy reduced non-calcified plaque volume and high-risk coronary plaque fe

218 The area of calcified plaque was measured at histopathologic examina

219 therosclerosis was regarded as definite if a calcified plaque was seen in the wall of an artery and p

220 re of noncalcified and calcified plaque, and calcified plaque were significantly higher among men wit

221 nel-volume CT by comparing measured areas of calcified plaque with respect to the reference standard

222 cified plaque, a mixture of noncalcified and calcified plaque, and calcified plaque were significantl

223 t or supplements with any of our measures of calcified plaque, and no greater mortality risk was obse

224 Only 1 ACS occurred in the absence of calcified plaque.

225 o human peripheral arteries with substantial calcified plaque.

226 1, P=0.002; fibrous plaque: r=0.54, P<0.001; calcified plaque: r=0.59, P<0.001; total plaque: r=0.62,

227 f coronary artery calcium, mixed plaque, and calcified plaque; higher CCL2 levels were associated wit

228 ) and of any plaque; noncalcified, mixed, or calcified plaque; or stenosis on coronary CT angiography

229 ; 95% CI, 0.15-0.85) and more often had only calcified plaques (38% versus 16%; ORadjusted=3.57; 95%

230 he number of proximal segments with mixed or calcified plaques (C-index 0.64, p < 0.0001) and the num

231 Attenuated plaques evolved into calcified plaques after stent implantation.

232 raphy showed a better agreement with ICA for calcified plaques compared with SR coronary CT angiograp

233 of HRM (defined as noncalcified or partially calcified plaques) in the LMCA.

234 with fewer mixed plaques and more often only calcified plaques.

235 Total plaque index (calcified plus noncalcified plaque) was defined as plaqu

236 ves (n = 52) dissected into noncalcified and calcified portions were subjected to mRNA extraction, re

237 CT angiography revealed a large partially calcified pseudoaneurysm arising from the right lateral

238 ant of (14)C-labeled, declining 5.5-fold per calcified quadrant (p=0.05, n=7).

239 Compared with noncalcified portions, calcified regions exhibited elevated transcripts for CD8

240 METHODS AND DRP1 was enriched in calcified regions of human carotid arteries, examined by

241 idence that oxidative stress is increased in calcified regions of stenotic aortic valves from humans.

242 sphate oxidase activity was not increased in calcified regions of stenotic valves.

243 roxide levels were also markedly elevated in calcified regions of stenotic valves.

244 Antioxidant mechanisms were reduced in calcified regions of the aortic valve, because total sup

245 roxide levels were increased 2-fold near the calcified regions of the valve (p < 0.05); noncalcified

246 nous interface divided into noncalcified and calcified regions.

247 wever, challenging lesions, such as severely calcified, remain difficult to treat with DCB alone.

248 otein was present principally in bone and in calcified scales, whereas the 22-kDa phosphoprotein was

249 establish, and eventually resolve, leaving a calcified scar.

250 Calcified segments were highly associated (P < .001) wit

251 4% in noncalcified segments, 15.0% in mildly calcified segments, 27.0% in moderately calcified segmen

252 ldly calcified segments, 27.0% in moderately calcified segments, and 43.0% in severely calcified segm

253 ly calcified segments, and 43.0% in severely calcified segments.

254 on between the secreting mantle edge and the calcified shell edge to which the mantle adheres during

255 oach to localize a single component within a calcified skeleton.

256 Calcified skeletons are produced within complex assembla

257 With the realization that many calcified skeletons form by processes involving a precur

258 udies relating the magnesium (Mg) content of calcified skeletons to temperature often report unexplai

259 m should calcifying anthozoans exist as less calcified (soft-bodied) forms in future oceans.

260 Hepatomegaly and small calcified spleen are typical findings in older homozygot

261 rgery group had significantly (P <0.05) less calcified spongiosa bone surface, greater periodontal li

262 y (apposition rate) were three-fold greater, calcified spongiosa decreased by two-fold, and PDL surfa

263 ine whether oxidative stress is increased in calcified, stenotic aortic valves and to examine mechani

264 ing biological uptake and incorporation into calcified structures and, second, that scales may repres

265 Calcified structures such as otoliths and scales grow co

266 4, suggesting that three foraminiferal taxa calcified their shells at similar temperatures in a homo

267 brae was reduced by 35%, the strength of the calcified tissue (sigmamax) was proportionate to a 38% i

268 thickness were reduced, the weakening of the calcified tissue and the geometric component of strength

269 s often placed on acidic protein residues in calcified tissue mineralization; the work presented here

270 xplained by the location of the magnesium in calcified tissue.

271 is an important chemical repository, making calcified tissues important for measuring exposure.

272 Formation of calcified tissues is a well regulated process.

273 factors, and alkaline phosphatase (Alpl) in calcified tissues of kl/kl mice.

274 (+)/osteocalcin(+) cells in the fibrotic and calcified tissues of nephrogenic systemic fibrosis patie

275 acterise structural remodelling in soft (non-calcified) tissues and to conduct in situ studies of nat

276 In vitro, Runx2(f/f) SMCs calcified to a much greater extent than those derived fr

277 tection of treatment response because of the calcified tumor matrix.

278 ave a greater number of OESs, whereas larger calcified tumors have larger OES diameter.

279 FD-OCT imaging of calcified tumors revealed a distinctive latticework patt

280 lectivity similar to spongy bone was seen in calcified tumors.

281 ence was relatively well preserved overlying calcified tumors.

282 of her left eye white, prominent, partially calcified tumour 1 disc diameter in diameter, 1,5 disc d

283 debris from aortic arch atheroma or from the calcified valve itself ranges between 2% and 10%.

284 rim increase was negligible in patients with calcified valves (0.56 +/- 0.85%; p < 0.001) and small e

285 rval [2.1-2.9]; P < 0.0001) in patients with calcified valves (12 +/- 3% at 20 years) relative to the

286 1.50 to 1.85]; p < 0.001), but not severely calcified valves (median 1.51 [IQR: 1.38 to 1.54]; p = 0

287 /4) were obtained in 251 patients (80%) with calcified valves and 661 (93%) with noncalcified valves

288 pression levels of RUNX2 were upregulated in calcified valves and associated with eQTL-SNPs.

289 In the 251 patients with calcified valves who had good immediate results, 15-year

290 eter changes are negligible in patients with calcified valves, because tissue properties allow very l

291 dependent calcium channel was upregulated in calcified valves.

292 n and the appearance of skeletal elements in calcified vascular lesions.

293 The presence of no plaques or purely calcified versus noncalcified plaques, plaque volume acc

294 Macrophages associated with regions of calcified vesicular structures in human carotid plaques

295 vascular smooth muscle cells (VSMCs) and in calcified vessels of patients with atherosclerosis, sugg

296 ification have modestly improved outcomes in calcified vessels, adverse event rates are still high.

297 catheters prevent their use in tortuous and calcified vessels.

298 Of particular interest is the finding of calcified vibrissae in Abcc6(-/-) mice, which facilitate

299 The mechanical properties of this calcified weapon enable extremely powerful punches to be

300 f ccRCCs with the loss of chromosome 3p were calcified, whereas 37% (11 of 30) of lesions without thi