ライフサイエンスコーパス: calcitonin receptor

1 in receptor), 87.5% of which coexpressed the calcitonin receptor.

2 ielded cDNAs that encode two isoforms of the calcitonin receptor.

3 siological function of amylin binding to the calcitonin receptor.

4 s occurred at the concentration of the Kd of calcitonin receptor.

5 .9 nm) and was able to efficiently label the calcitonin receptor.

6 vasoactive intestinal polypeptide type 1 and calcitonin receptors.

7 um stability and specific affinity for human calcitonin receptors.

8 ant peptide sequence homology with the human calcitonin receptor, a member of the G-protein-coupled r

9 gest that the deltae13 variant of the rabbit calcitonin receptor acts to regulate the surface express

10 Small molecule calcitonin receptor agonists are of potential utility in

11 Only chimeric constructs including the calcitonin receptor amino terminus exhibited responses t

12 ssed mRNA for the noninserted isoform of the calcitonin receptor and excavated characteristic resorpt

13 The OCL that form express calcitonin receptors and contract in response to calcito

14 ated from the gene for the G protein-coupled calcitonin receptor, and some of the splice variants sho

15 ressions of vitronectin receptors, c-src and calcitonin receptors, and bone resorption.

16 cells that stably express the cloned rabbit calcitonin receptor, as in many other cells that express

17 Activation of calcitonin-calcitonin receptor autocrine loop in prostate cancer ce

18 In addition, the activation of calcitonin-calcitonin receptor axis induced epithelial-mesenchymal

19 he first time identify actions of calcitonin-calcitonin receptor axis on prostate cancer cells that l

20 re potent stimulants of cAMP accumulation in calcitonin receptor-bearing human embryonic kidney 293 c

21 /or alanine replacement of the region of the calcitonin receptor between residues 150 and 153 resulte

22 lated all phases of angiogenesis through the calcitonin receptor, but its effect on tube morphogenesi

23 fail to multinucleate and do not up-regulate calcitonin receptor, but they express tartrate-resistant

24 inizing hormone receptor by 97% and from the calcitonin receptor by 100%.

25 3 cell line that stably expresses the rabbit calcitonin receptor C1a isoform.

26 ne that overexpresses the C1a isoform of the calcitonin receptor (C1a-HEK), calcitonin induces the ty

27 The presence of calcitonin receptor, calcitonin receptor-like receptor,

28 ession and that amylin functions through the calcitonin receptor (CalcR) and receptor activity modify

29 his latter function after its binding to the calcitonin receptor (CALCR).

30 Since the calcitonin receptor can couple to all three of these G p

31 Thus, the calcitonin receptor can couple to Gi, but the inhibition

32 The CAL-RAMP1 selectively activates the calcitonin receptor (CR), whereas, the CGRP-RAMP1 activa

33 selectivity of the class B G protein-coupled calcitonin receptor (CTR) and the CTR-like receptor (CLR

34 The calcitonin-like receptor (CLR) and the calcitonin receptor (CTR) interact with receptor activit

35 We found that the G protein-coupled calcitonin receptor (CTR) undergoes tonic internalizatio

36 mRNA for the calcitonin receptor (CTR) was localized to these MNCs in

37 how that the core component of the AmyR, the calcitonin receptor (CTR), is expressed on VTA dopamine

38 The crystal structure of the human calcitonin receptor ectodomain (CTR ECD) in complex with

39 Silencing of calcitonin receptor expression in HMEC-1 cells abolished

40 region of the amino terminus of the Family B calcitonin receptor for agonist drug action.

41 Although calcitonin was able to activate the calcitonin receptor fully with the first 58 residues abs

42 or activity-modifying protein-1 (RAMP-1) and calcitonin receptor gene (CT-R) expression in striatum [

43 Human calcitonin receptor (hCTR) subtypes contain three or fou

44 affinities of these analogues for the human calcitonin receptor, hCTR(I1)(-), and for rat-brain memb

45 identical to two previously described human calcitonin receptors (hCTR1 and hCTR2).

46 d sequencing of labeled wild type and mutant calcitonin receptors identified the sites of labeling fo

47 oclast marker genes NFATc1, cathepsin K, and calcitonin receptor in a RANKL-dependent manner, and con

48 They covalently labeled the calcitonin receptor in a saturable and specific manner.

49 tor assays showed the presence of functional calcitonin receptor in HMEC-1 cells.

50 cture of a full-length class B receptor, the calcitonin receptor, in complex with peptide ligand and

51 lls, that stably express a myc-tagged rabbit calcitonin receptor, induced the formation of complexes

52 dependent protein kinase plays a key role in calcitonin receptor-induced destabilization of cell-cell

53 Our results suggest that the calcitonin receptor induces Shc phosphorylation and Erk1

54 or and Galphai subunits, confirming that the calcitonin receptor interacts with Gi.

55 consisting of 32 amino acid residues and the calcitonin receptor is a Class B G protein-coupled recep

56 The calcitonin receptor is a member of the class B family of

57 The calcitonin receptor is a member of the class B family of

58 The Family B G protein-coupled calcitonin receptor is an important drug target.

59 Thus, in C1a-HEK cells, the calcitonin receptor is coupled to the tyrosine phosphory

60 at the deltae13 splice variant of the rabbit calcitonin receptor is expressed together with the more

61 The calcitonin receptor is known to couple to Gs and Gq, act

62 Calcitonin receptor like-receptor is a family B G-protei

63 enomedullin (AM) and its receptor complexes, calcitonin receptor-like receptor (Calcrl) and receptor

64 get CGRP receptor, produced in part from the calcitonin receptor-like receptor (Calcrl) gene, has bee

65 ator that transduces its effects through the calcitonin receptor-like receptor (calcrl) when the rece

66 , whereas, the CGRP-RAMP1 activates both the calcitonin receptor-like receptor (CLR) and CR.

67 It forms a complex with the calcitonin receptor-like receptor (CLR) and is required

68 Rs) is formed through the association of the calcitonin receptor-like receptor (CLR) and one of three

69 resence of CGRP and its receptor components, calcitonin receptor-like receptor (CLR) and receptor act

70 r is a heterodimer of two membrane proteins: calcitonin receptor-like receptor (CLR) and receptor act

71 pression and define cellular localization of calcitonin receptor-like receptor (CLR) and receptor act

72 Calcitonin receptor-like receptor (CLR) and receptor act

73 Calcitonin receptor-like receptor (CLR) and the receptor

74 Calcitonin receptor-like receptor (CLR) and the receptor

75 AM and its putative receptor calcitonin receptor-like receptor (CLR) are implicated i

76 ) with the G protein-coupled receptor (GPCR) calcitonin receptor-like receptor (CLR) enables selectiv

77 e contribution of endosomal signaling of the calcitonin receptor-like receptor (CLR) to pain transmis

78 ization of a G protein-coupled receptor, the calcitonin receptor-like receptor (CLR), and receptor ac

79 -related peptide (CGRP) co-internalizes with calcitonin receptor-like receptor (CLR), receptor activi

80 t identified through an interaction with the calcitonin receptor-like receptor (CLR), these single tr

81 ide mediates neurogenic inflammation via the calcitonin receptor-like receptor (CLR).

82 G-protein-coupled receptor (GPCR) called the calcitonin receptor-like receptor (CLR).

83 eric CGRP receptor requires co-expression of calcitonin receptor-like receptor (CRLR) and an accessor

84 eatment of 293T cells expressing recombinant calcitonin receptor-like receptor (CRLR) and one of the

85 A candidate CGRP receptor named calcitonin receptor-like receptor (CRLR) has been identi

86 Calcitonin receptor-like receptor (CRLR) is a seven-tran

87 eteromer formation is the interaction of the calcitonin receptor-like receptor (CRLR) with different

88 ide (CGRP) receptor requires dimerization of calcitonin receptor-like receptor (CRLR) with receptor a

89 cently the G-protein coupled receptor (GPCR) calcitonin receptor-like receptor (CRLR), and receptor a

90 2 or RAMP3 (AM1R and AM2R, respectively) and calcitonin receptor-like receptor (CRLR), while a CRLR h

91 o act through the G protein-coupled receptor calcitonin receptor-like receptor (CRLR), with specifici

92 eceptors, adrenomedullin receptor (ADMR) and calcitonin receptor-like receptor (CRLR).

93 lin (AM), is comprised of RAMP2 or RAMP3 and calcitonin receptor-like receptor (CRLR).

94 tonin gene-related peptide receptor subunits calcitonin receptor-like receptor and receptor activity

95 alcitonin gene-related peptide receptor, the calcitonin receptor-like receptor and the receptor activ

96 the CGRP-binding protein referred to as the calcitonin receptor-like receptor is highly concentrated

97 ion competing for RAMP3 association with the calcitonin receptor-like receptor to yield a functional

98 tance of the most likely candidate receptor, calcitonin receptor-like receptor, a gene-targeted knock

99 ented lysosomal trafficking and recycling of calcitonin receptor-like receptor, a non-ubiquitinated r

100 The presence of calcitonin receptor, calcitonin receptor-like receptor, and receptor activity

101 duce arterial differentiation in ECs via the calcitonin receptor-like receptor, thus revealing a surp

102 s and endothelial cells are known to express calcitonin receptor-like receptor, we examined the poten

103 ceptor with seven transmembrane domains, the calcitonin-receptor-like receptor (CRLR), can function a

104 Expression of RANK, TRAP, cathepsin K, calcitonin receptor, matrix metalloproteinase 9, NFATc1,

105 The gene encoding the murine calcitonin receptor (mCTR) was isolated, and the exon/in

106 The abundance of calcitonin and calcitonin receptor mRNA displays positive correlation w

107 13 accounting for less than 15% of the total calcitonin receptor mRNA in osteoclasts, kidney, and bra

108 action to estimate the relative abundance of calcitonin receptor mRNA, a 25-fold accumulation of the

109 mediate in the synthesis of pyrazolopyridine calcitonin receptor partial agonists 2a-f.

110 The activated calcitonin receptor phosphorylated glycogen synthase kin

111 n-polymerase chain reaction amplification of calcitonin receptor sequences from rabbit osteoclast RNA

112 eceptor, as in many other cells that express calcitonin receptors, shows little pertussis toxin sensi

113 e examined whether heterodimerization of the calcitonin receptor splice variants occurs and, if so, w

114 ated following stimulation of the rabbit C1a calcitonin receptor stably expressed in HEK-293 cells.

115 ta are two proximal signal effectors for the calcitonin receptor, the more distal signaling pathways

116 d sequencing of labeled wild-type and mutant calcitonin receptors, the site of attachment was identif

117 lpha(s) mutant blocks all signaling from the calcitonin receptor to G(q).

118 entrations of the G(s) protein-coupled human calcitonin receptor type 2 (hCTR2) cDNA produced suffici

119 The cDNA that encodes the rabbit calcitonin receptor was cloned by screening a rabbit ost

120 Expression of mRNA for calcitonin receptor was confirmed in all cases by revers

121 In addition, Calcr (calcitonin receptor), which regulates osteoclast surviva

122 Both probes specifically bound to the human calcitonin receptor with high affinity and were potent s

123 All compounds were full agonists at the calcitonin receptor with no activity at the secretin rec

124 thin the extracellular amino terminus of the calcitonin receptor, with the former adjacent to the fir