ライフサイエンスコーパス: calcium flux

1 or functional traits (increased polarity and calcium flux).

2 L-4F, however, fails to induce a calcium flux.

3 nal membrane complexes and regulate neuronal calcium flux.

4 unctions that are dependent on intracellular calcium flux.

5 to protect cardiomyocytes from pathological calcium flux.

6 nking receptor activation with intracellular calcium flux.

7 ns lead to decreased alpha7 nAChR-associated calcium flux.

8 d phospholipase C-gamma1 phosphorylation and calcium flux.

9 in tyrosine phosphorylation but a decreased calcium flux.

10 AT)-dependent signaling without induction of calcium flux.

11 nts, including a defect in anti-IgM-mediated calcium flux.

12 te monophosphate and therefore intracellular calcium flux.

13 ing neuronal damage through NMDA-R-dependent calcium flux.

14 f piconewton integrin tension coincides with calcium flux.

15 ell surface expression, and ligand-dependent calcium flux.

16 sity of LAT phosphorylation and the speed of calcium flux.

17 eutrophil respiratory burst, chemotaxis, and calcium flux.

18 down altered SR phospholipid composition and calcium flux.

19 ntaining a mutation in the pore that reduces calcium flux.

20 of calcium, which prevented an intracellular calcium flux.

21 pled electron transport, ROI generation, and calcium flux.

22 a significant increase in histamine-promoted calcium flux.

23 rve, independent of alterations in cytosolic calcium flux.

24 n inactive state ready for the next cellular calcium flux.

25 T cells respond forcefully to antigen after calcium flux.

26 more promiscuous ligand specificity trigger calcium flux.

27 CD3zeta, SLP76, Erk1/2, AKT, or S6 and lower calcium flux.

28 assessed by inhibition of chemokine-induced calcium flux.

29 d second, it boosts spike-evoked presynaptic calcium flux.

30 l blood mononuclear cells, and CCL2-mediated calcium flux.

31 which signal via protein kinase C (PKC) and calcium flux.

32 affinity and receptor activation measured by calcium flux.

33 when a calcium channel does open and allows calcium flux.

34 response and those that release oscillatory calcium fluxes.

35 als in endothelial cells, including Rac1 and calcium fluxes.

36 s correlated with sIgM-induced intracellular calcium fluxes.

37 737, were necessary for VCAM-1 activation of calcium fluxes.

38 ng in enhanced recruitment of Syk kinase and calcium fluxes.

39 entrate proteins that regulate transmembrane calcium fluxes.

40 transmitter-gated cation channels that show calcium fluxes.

41 urrents or by instabilities in intracellular calcium fluxes.

42 vation may occur in the absence of cytosolic calcium fluxes.

43 phosphorylation of phospholipase Cgamma2 and calcium fluxes.

44 moted activation of kinases Erk and Akt, and calcium fluxes.

45 ng phosphotyrosine signals and intracellular calcium fluxes.

46 5,6-EET potently induced a calcium flux (100 nm) in cultured DRG neurons that was c

47 could be activated by NMDA receptor-mediated calcium flux, activation of calcineurin, and subsequent

48 Vav1 is required for TCR-induced calcium flux, activation of the ERK MAP kinase pathway,

49 respiratory burst, chemotaxis response, and calcium flux activities and exhibit neutropenia.

50 Dimeric CXCL12 activated G-protein-dependent calcium flux, adenylyl cyclase inhibition, and the rapid

51 in GCB-DLBCL lines but did not affect their calcium flux after BCR cross-linking or the proliferatio

52 served transient, oscillatory, and sustained calcium flux after contact with APC, but these behaviors

53 However, the dynamics of calcium flux after stimulation with an APC in vivo remai

54 However, SCH-C inhibited CCL2-induced calcium flux against a CCR5/CCR2b chimera consisting of

55 Galectin-9-induced intracellular calcium flux, aggregation and death of T(H)1 cells were

56 guanosine 5'-3-O-(thio)triphosphate binding, calcium flux, Akt and ERK1/2 phosphorylation, and stimul

57 n functional assays for receptor binding and calcium flux, alanine-scanning variants of nociceptin in

58 ate 13-acetate (PMA), which does not cause a calcium flux, also activated the CaM kinases.

59 Blocking voltage and calcium flux altered mechanically induced changes in pro

60 of CYP4F18 resulted in a marked increase in calcium flux and a 220% increase in the chemotactic resp

61 signal transduction including intracellular calcium flux and a transient increase in F-actin.

62 Bacteria induce calcium flux and action potentials in nociceptor neurons

63 that papain-induced IL-4 production requires calcium flux and activation of PI3K and nuclear factor o

64 els of surface BCR associated with decreased calcium flux and activation-induced markers, compared wi

65 This was accompanied by altered calcium flux and altered expression of genes involved in

66 400 nM for both human and mouse F2L in both calcium flux and cAMP inhibition assays).

67 es, PKC inhibition augmented LTD4-stimulated calcium flux and cell migration assessed in transwell ch

68 imulation and is important for BCR-dependent calcium flux and cell proliferation.

69 itor, C3 toxin, inhibited both BCR-dependent calcium flux and cell proliferation.

70 approximately 2-fold increased signaling in calcium flux and chemotaxis assays relative to wild-type

71 r2, responded to human and mouse F2L in both calcium flux and chemotaxis assays with EC(50) values si

72 pite the two ligands having equal potency in calcium flux and chemotaxis assays, CCL22 showed dominan

73 all but one agonist activated intracellular calcium flux and chemotaxis in human neutrophils, irresp

74 CXCR2-specific calcium flux and chemotaxis were desensitized by injury,

75 38, and ERK activation as well as defects in calcium flux and cytokine production in vitro and expans

76 n and channel activity, leading to increased calcium flux and cytokine production.

77 put, and impaired T-cell survival but normal calcium flux and cytotoxicity, demonstrating the importa

78 sponse by miR-17-92 resulted in the enhanced calcium flux and elevated levels of Myc itself.

79 a1 binding site of LAT (Y136F) have impaired calcium flux and Erk activation.

80 he ability to signal through PTH1R to induce calcium flux and ERK phosphorylation but not cyclic AMP

81 TAT-4BB) affected LPS-induced intracellular calcium flux and excitation in sensory neurons, and beha

82 s erythematosus as demonstrated by increased calcium flux and global B cell hyperactivity.

83 P-YF(292)) experienced greater intracellular calcium flux and had greater increases in the levels of

84 t in live T-B couples correlate with reduced calcium flux and IL-2 secretion.

85 monocytes and iDCs measured by intracellular calcium flux and immediate-early gene expression (FBJ mu

86 ta from the activity assays by intracellular calcium flux and inhibition of CCR5-mediated HIV-1 entry

87 e TCR signal cascade including inhibition of calcium flux and inhibition of multiple MAPK.

88 gh activating NK cell receptors by enhancing calcium flux and LFA-1 integrin activation.

89 ar activation as documented by the inhibited calcium flux and mast cell degranulation.

90 ns, an effect that translates into transient calcium flux and membrane depolarization ( approximately

91 gnate peptide-MHC complexes results in rapid calcium flux and migratory arrest in auto-reactive thymo

92 HuASM increased agonist-evoked intracellular calcium flux and myosin light chain (MLC) phosphorylatio

93 Further, ACK1 promoted calcium flux and NFAT-AP1 promoter activity and decrease

94 d integrin alphaIIbbeta3-dependent cytosolic calcium flux and phosphatidylinositol(3,4)P2 accumulatio

95 esensitization compared to serotonin in both calcium flux and phosphoinositide (PI) hydrolysis assays

96 served in LAT-deficient CTLs due to residual calcium flux and phospholipase C (PLC) activity.

97 pre-TCR) signaling further revealed impaired calcium flux and phospholipase C-gamma1-extracellular si

98 y interacts with sumoylation enzymes, blocks calcium flux and phosphorylation of Btk and TFII-I and i

99 erestingly, proximal TCR signaling including calcium flux and phosphorylation of Vav were not disrupt

100 Stretch of urothelial cells activated calcium flux and PKC translocation to membrane and nucle

101 es, and to a lesser extent, FcgammaR-induced calcium flux and reactive oxygen intermediate production

102 polarization and docking phases and required calcium flux and signaling through both the T cell recep

103 orylation for the induction of intracellular calcium flux and the subsequent activation of master reg

104 ) and CCL23-(26-99) are stronger agonists in calcium flux and Transwell CC receptor transfectant and

105 rticipates in lytic replication by enhancing calcium flux and viral glycoprotein expression, but also

106 f TRPV1, TRPA1 and TRPM8 and the response of calcium flux and whole-cell currents evoked by their res

107 c Golgi protein that regulates intracellular calcium fluxes and apoptosis.

108 nd that during phase I, T cells exhibit weak calcium fluxes and detectable changes in cell motility.

109 ugh the repression of TCR ligation-triggered calcium fluxes and IL-2 production.

110 ge, we found that PACAP evoked intracellular calcium fluxes and increased phospho-PKC levels, as well

111 the functional coupling of TRPV2 protein to calcium fluxes and proinflammatory degranulation events

112 l sites that coordinate VCAM-1 activation of calcium fluxes and Rac1 during leukocyte transendothelia

113 s, with the latter mediating transmission of calcium fluxes and small molecules between cells.

114 uld efficiently inhibit FcepsilonRI-mediated calcium fluxing and serotonin release after co-cross-lin

115 3 receptor phosphorylation and intracellular calcium flux, and activating calcium-dependent calpain p

116 ress CCR9-mediated chemotaxis, intracellular calcium flux, and alpha4beta7-mediated cell adhesion in

117 acid, we measured chemotaxis, intracellular calcium flux, and alpha4beta7-mediated cell adhesion to

118 by causing a reduction in TCR/CD28-mediated calcium flux, and blocked activation of two regulatory e

119 l for VEGFR-2-mediated PLCgamma1 activation, calcium flux, and cell differentiation.

120 t cell protease release, cytokine secretion, calcium flux, and changes in cell number and FcepsilonRI

121 bation decreased the production of H(2)O(2), calcium flux, and ERK1/2 phosphorylation.

122 ated inositol 1,4,5-triphosphate production, calcium flux, and extracellular signal-regulated kinase

123 C-gamma1 and the kinase Erk, more-persistent calcium flux, and increased production of cytokines and

124 cells with PU-H71 attenuated BCR signaling, calcium flux, and NF-kappaB signaling, ultimately leadin

125 It restored MAPK activation, calcium flux, and NFAT activation in LAT-deficient cells

126 cell linker protein (BLNK) phosphorylation, calcium flux, and nuclear factor kappaB (NFkappaB), c-ju

127 ents in their respiratory burst, chemotaxis, calcium flux, and phagocytic activities.

128 th diminished phospholipase Cgamma activity, calcium flux, and protein kinase C-betaII membrane recru

129 roterenol on histamine-induced intracellular calcium flux, and significantly attenuates histamine-sti

130 BCR cross-linking in terms of proliferation, calcium flux, and survival.

131 AM family receptors to phospholipase Cgamma, calcium fluxes, and Erk kinase.

132 sphorylation of ZAP-70, LAT, and PLC-gamma1; calcium flux; and dephosphorylation and nuclear transloc

133 eutrophil respiratory burst, chemotaxis, and calcium flux; and increased susceptibility to bacterial

134 Further testing of these lead compounds in a calcium flux assay in U937 cells yielded similar results

135 ls are selectively responsive to CysLTs in a calcium flux assay when compared with T(H)1 cells with a

136 15a, which displayed an EC50 of 23 nM in the calcium flux assay while showing no beta-arrestin recrui

137 5-HT2A, 5-HT2B, and 5-HT2C receptors in the calcium flux assay with the ultimate goal to generate se

138 -of-concept study) we have used a functional calcium-flux assay in human neuroblastoma SH-SY5Y cells

139 ements in cells expressing transporters, and calcium flux assays in cells coexpressing transporters a

140 -mediated signal transduction as measured by calcium flux assays.

141 We used high-throughput calcium-flux assays and patch clamp recordings of transi

142 All vCXCL-1s were able to induce calcium flux at a concentration of 100 nM and integrin e

143 se T-cell sensitivity for triggering initial calcium flux at fixed total pMHC density.

144 of S100A4 to CD16A, promoted by the initial calcium flux, attenuates the phosphorylation of CY, and,

145 ddition, these B cells were unable to induce calcium flux, become activated, or proliferate in respon

146 orter for intracellular calcium and examined calcium flux both in vitro and in situ.

147 ective T-cell antigen receptor (TCR)-induced calcium flux but enhanced mitogen-activated protein kina

148 lls in these mice show defective TCR-induced calcium flux but enhanced Ras/ERK activation, which is c

149 isease activity, normalizes CD3/CD28-induced calcium fluxing but fails to influence MHP, suggesting t

150 based membrane allows one to establish a net calcium flux by applying a potential step function (i.e.

151 athways that converge to enhance NMDA-evoked calcium flux by clustering NMDA receptors in modified me

152 e calcium channel facilitator that increases calcium flux by generating a larger window current and s

153 D(4) is more potent than LTE(4) for inducing calcium flux by the human MC sarcoma line LAD2, LTE(4) i

154 stimulated by calcium, and ethanol modulates calcium flux by the NMDA receptor, we hypothesized that

155 ntial vanilloid type 1 (TRPV1), and enhanced calcium flux by TRPV1-expressing DRGNs.

156 both the LPA(2) and LPA(3) receptors induce calcium fluxes by hMCs, only the LPA(2) receptor-selecti

157 cid was critical for ERK1/2 phosphorylation, calcium flux, cell growth, and proliferation of naive CD

158 organization, and exhibition of spontaneous calcium flux characteristic of a cardiomyocyte-like phen

159 ceptor 1 protein (CysLT(1)) expression using calcium flux, cyclic AMP, and chemotaxis assays.

160 eutrophil CXCR4 expression and SDF-1-induced calcium flux decreased with maturation and activation of

161 ived mast cells inhibits FcepsilonRI-induced calcium flux, degranulation, and cytokine secretion.

162 (SLP-76) is critical for FcepsilonRI-induced calcium flux, degranulation, and cytokine secretion.

163 ling downstream of Src kinases and increased calcium flux, degranulation, and further enhanced cytoki

164 integrin activation while maintaining normal calcium flux, degranulation, and ROS generation.

165 n generation involves synergistic actions of calcium flux-dependent NFAT transcription factors and ER

166 internalization of CXCR4 yet does not induce calcium flux, ERK (ERK-1/2) phosphorylation, or chemotax

167 or cellular binding and blocks SDF-1-induced calcium flux, ERK-1/2 phosphorylation, and chemotaxis, w

168 njugates demonstrated that a single effector calcium flux event was sufficient for the degranulation

169 ulation: whereas mouse NKs required a single calcium flux event, CD8(+) T cells typically required se

170 t, CD8(+) T cells typically required several calcium flux events before perforin delivery.

171 At GluA2(Q) expressed in HEK293 cells (calcium flux experiment), the most potent compound was 1

172 affinity LFA-1 did not exhibit intracellular calcium flux, F-actin polymerization, cell polarization,

173 Surprisingly, calcium flux following engagement of CD3 was significant

174 c version, which is unable to support normal calcium flux following T cell activation.

175 induced higher ERK activation and increased calcium flux following TCR stimulation compared with tha

176 of c-Jun led to increase in intracytoplasmic calcium flux following TCR stimulation.

177 Inhibiting calcium fluxes from endoplasmic reticulum stores and fro

178 y a major role in mineral weathering driving calcium fluxes from the continents to the oceans that ul

179 Calcium fluxes have been implicated in the specification

180 ing, mature immunological synapse formation, calcium flux, IL-2 production, and proliferation.

181 Simultaneous calcium-flux imaging and single-channel recording in a d

182 Inhibition of intracellular calcium flux impaired CXCL12-mediated migration of IEC-6

183 ast to the TRPA-1 activation and the ensuing calcium flux implicated in cold sensation in C. elegans,

184 CD4(+) T cells increased activation-induced calcium flux, implying that the increased miR-181a level

185 ein by FACS analysis and the LTD(4)-elicited calcium flux in a dose-dependent manner as compared with

186 esented on albumin, were shown to signal for calcium flux in a self- and cross-desensitizing manner,

187 ounds were evaluated for activity to inhibit calcium flux in both human and rat recombinant P2X(7) ce

188 nd increased phosphoinositide hydrolysis and calcium flux in both murine and human airway smooth musc

189 containing immune complexes and induction of calcium flux in CD21-deficient B cells were analyzed by

190 ated Akt phosphorylation, but down-modulated calcium flux in CD34(+) CB cells.

191 agonists ADP and 2-MeS-ADP induced specific calcium flux in cells expressing P2Y12+ Galpha16.

192 enous PtdIns-4,5-P(2) restores BCR-dependent calcium flux in cells lacking functional RhoA.

193 The role of SLC8A1 polymorphisms in altering calcium flux in cells that mediate coronary artery damag

194 ratiometric determination of agonist-induced calcium flux in fluor-loaded human platelets, was optimi

195 cribes the first use of a FLIPR to study the calcium flux in human platelets.

196 tor-induced NFAT activation and TCR-mediated calcium flux in Jurkat T cells.

197 In vitro thymol directly triggered calcium flux in mast cells through transient receptor po

198 CRAMP-induced calcium flux in monocytes was desensitized by MMK-1, an

199 CCR1, CCR2b, and CCR3, and produced a normal calcium flux in mononuclear leukocytes.

200 miR-181a, which enhances activation-induced calcium flux in murine thymocytes, was expressed at sign

201 ceptor/Galphai/phospholipase C signaling for calcium flux in neutrophils.

202 P2Y and cys-LT receptors, failed to mediate calcium flux in response to leukotriene (LT) D(4) with s

203 1 on monocyte-derived DCs and diminish their calcium flux in response to stimulation by a CCR1 ligand

204 main, was necessary to enhance intracellular calcium flux in response to treatment with anti-mu.

205 Calcium flux in resting NK cells was induced with antibo

206 tion and was shown to have stimulated potent calcium flux in the human monocytic cell line.

207 B ligand-induced activation of intracellular calcium flux in vitro.

208 777-treated T. b. gambiense failed to elicit calcium fluxes in BMECs, suggesting that generation of a

209 lls and THP-1 clone 15 cells, but it induced calcium fluxes in DCs.

210 Our results elucidate the role of calcium fluxes in early neural development and uncover a

211 rs, we assessed their contribution to muscle calcium fluxes in mice and tested whether they influence

212 eceptors that generate signals manifested as calcium fluxes in response to binding of the appropriate

213 e calcium reporter cameleon to track in vivo calcium fluxes in the axotomized neuron.

214 ndria accumulate that cannot properly buffer calcium fluxes in the cell.

215 erentiation events and are needed for normal calcium fluxes in the embryo.

216 ant aminophospholipids, we have now examined calcium fluxes in this subpopulation by measuring fluore

217 silonRIgamma and Syk, which mediate enhanced calcium fluxing in lupus T cells, were reversed in patie

218 SWAP-70(-/-) BMMC are impaired in calcium flux, in proper translocation and activity of Ak

219 tributes to anagen re-entry but does so in a calcium flux-independent fashion.

220 ) T cells have enhanced activation-dependent calcium flux, indicative of the retention of a thymocyte

221 evaluated functional activity by monitoring calcium flux inhibition in cell lines expressing recombi

222 limbing fiber stimulus evoking extracellular calcium flux into the cell and parallel fiber stimulus e

223 Calcium flux is essential for entry in apicomplexan para

224 ons, this decrease in alpha7 nAChR-dependent calcium flux is expected due to haploinsufficiency of CH

225 The resulting calcium flux is released into a microliter scale thin la

226 l experiments demonstrate that NMDA-mediated calcium flux is significantly diminished by MMP-7 pretre

227 ls to influence MHP, suggesting that altered calcium fluxing is downstream or independent of mitochon

228 Although NKp46 did not enhance CD16-mediated calcium flux, it synergized with all other receptors.

229 resonance energy transfer (BRET) techniques, calcium flux measurements, and microscopy to study recep

230 screen, PNU-120596 increased agonist-evoked calcium flux mediated by an engineered variant of the hu

231 ) channel polycystin-2 (PC2), resulting in a calcium flux-mediated cell cycle arrest.

232 In addition to calcium fluxes, microinjected dye tracers can be transfe

233 ignaling were abrogated, including increased calcium flux, microtubule organizing center (MTOC) polar

234 the interplay of three important parameters (calcium fluxes, Na pumps, mitochondrial motility) at nod

235 CCL18 induced chemotaxis and calcium flux of human activated highly polarized Th2 cel

236 CCL18 induced chemotaxis and calcium flux of human CCR8-transfected cells.

237 te chemoattractant protein-1 (CCL2)-mediated calcium flux on CCR2b.

238 cell expressed and secreted) (CCL5)-mediated calcium flux on CCR5 with an IC50 of 22.8 nM but was ina

239 and that even if channels open the resulting calcium flux only rarely triggers vesicle fusion.

240 Despite FceRI-internalization, little calcium flux or mast cell degranulation occurred.

241 a consequence of altered signals regulating calcium flux or protein kinase C, but of ineffective cyt

242 dominant negative mutant proteins, blocking calcium flux, or inhibiting electron transport through m

243 We observed that SLPs increased calcium flux, phosphorylation of mitogen-activated prote

244 vitro, KLF2 expression retards VEGF-mediated calcium flux, proliferation and induction of pro-inflamm

245 cells were hyperresponsive and had enhanced calcium flux, protein tyrosine phosphorylation, MAPK and

246 trailing edge of melanoma cells and mediates calcium flux, rear detachment, and motility.

247 f Nrxn-CTF decreases presynaptic release and calcium flux, recapitulating the deficits due to loss of

248 uncation mutation show significantly greater calcium flux relative to control cell lines in response

249 ges in protein concentration, while inducing calcium flux reproduced these changes.

250 ortant role that is likely downstream of the calcium flux required for microneme secretion, parasite

251 oskeletal dynamics impairs TCR/CD28-mediated calcium flux required for NFAT1-mediated c-rel transcrip

252 ay significantly greater PTH suppression and calcium flux response to elevated calcium.

253 han those needed for maximal chemotactic and calcium flux responses.

254 We show that mitochondrial calcium-flux sensing might be important for regulating a

255 Analysis of ligand-induced calcium flux showed that both types of receptors were fu

256 The resulting calcium flux stabilized dense arrays of ILPs (each enric

257 tif) receptor 2 (CCR2), induce intracellular calcium flux, stimulate TNF and CCL2 production, and inh

258 together with PAR4 potentiated PAR4-mediated calcium flux, suggested that PAR4 act as homodimers to s

259 tion occurs in the absence of any detectable calcium flux, suggesting a novel means for the activatio

260 ese receptors and activates a dose-dependent calcium flux that is abrogated by lactose.

261 es SHP-1 or SHP-2 but, unexpectedly, induced calcium flux that led to activation of the kinases MEK-E

262 ion with VacA did not alter the magnitude of calcium flux that occurred upon stimulation of CD4(+) T

263 ADP (0.05-50 muM) induced calcium flux that was completely blocked by a P2Y1 recep

264 a fraction of T cells to release oscillatory calcium fluxes that increase with increasing koff rates.

265 of PLN at Ser-16 and/or Thr-17 reestablishes calcium flux, the regulatory mechanism of SLN remains el

266 ene product targets mitochondria and induces calcium flux, thereby activating Ca(+)-dependent signal

267 7pA signaling and induces chemotaxis but not calcium flux through an unidentified receptor.

268 Purkinje neurons by increasing intracellular calcium flux through calcium permeable AMPA receptors, a

269 DARC-CCR5 interaction impairs chemotaxis and calcium flux through CCR5, whereas internalization of CC

270 due to its inability to induce intracellular calcium flux through L-type calcium channels.

271 Similarly, mutagenic disruption of calcium flux through Orai1 caused PDGF to evoke redistri

272 along a uropod-pseudopod axis that required calcium flux through Orai1.

273 Calcium flux through store-operated calcium entry is a c

274 d PDGF to evoke redistribution, showing that calcium flux through the wild-type channels had been fil

275 s selective coupling is maintained even when calcium flux through voltage-gated channels is increased

276 ed in cells exposed to Abeta is initiated by calcium fluxes through Abeta channels.

277 hemotaxis that links chemoattractant-induced calcium flux to exocytosis and uropod release.

278 d calcium indicator, and used the changes in calcium flux to monitor the activity of many neurons sim

279 This calcium flux triggered the activation of Ca(2+)-calmodul

280 BMMCs has no effect on FcepsilonRI-triggered calcium flux, tyrosine phosphorylation of MAPKs or in ac

281 Phosphorylated CD16A mediates a more robust calcium flux, tyrosine phosphorylation of Syk, and proin

282 ondrial hyperpolarization (MHP) and enhanced calcium fluxing underlie aberrant T cell activation and

283 ts2 in SLE T cells resulted in a decrease in calcium flux upon TCR stimulation.

284 which we were able to detect agonist-induced calcium flux using a microfluidics-based screening platf

285 Enhanced calcium flux was also observed in adult CD4(+) recent th

286 Ang II-induced calcium flux was decreased upon inhibition of TRPC chann

287 ed in 4 s, and diacylglycerol production and calcium flux was observed in 6-7 s.

288 tuning of sarcomeric tension generation and calcium fluxing, we identify a significant relationship

289 Interestingly, physiological nonapoptotic calcium fluxes were capable of activating mu-calpain, im

290 p38MAPK, activation of phospholipase D, and calcium fluxes were equivalent in wild-type and RhoG(-/-

291 dium, which correlated with ability to evoke calcium fluxes, were canceled by K11777, but not by the

292 PAR4SFT failed to induce a calcium flux when expressed independently; however, coex

293 signal-regulated kinase phosphorylation and calcium flux, which are all required for initiation of p

294 GLP-1-induced beta-arrestin recruitment and calcium flux, which suggests a form of allosteric regula

295 ox-mediated H2O2 generation was dependent on calcium flux, which was required for dissociation of the

296 TLR7 in CD4(+) T cells induced intracellular calcium flux with activation of an anergic gene-expressi

297 ha-thrombin induces wild-type PAR4 (PAR4-wt) calcium flux with an EC(50) of 110 nM, whereas mutation

298 Binding analysis and calcium flux with anti-Env-specific B cells confirmed th

299 In assays for metastin receptor binding and calcium flux with receptor-transfected HEK-293 cells, we

300 sphorylated, and responsive to transmembrane calcium fluxes, yet were insensitive to further activati