ライフサイエンスコーパス: calcium ion

1 zyme increased in the presence of starch and calcium ion.

2 irmed that modified hPC2 binds an additional calcium ion.

3 ia a transition state capable of binding one calcium ion.

4 production, respectively, in the presence of calcium ion.

5 N-terminal IgV domain in coordination with a calcium ion.

6 rane-targeting C2 domains, including a bound calcium ion.

7 onnected by a loop capable of coordinating a calcium ion.

8 h is composed of four manganese ions and one calcium ion.

9 subtle porin-LPS interactions and a bridging calcium ion.

10 vicinal diol coordinates to a protein-bound calcium ion.

11 s solid hydrogel matrices by adding divalent calcium ions.

12 transmit important information by conducting calcium ions.

13 ication, HG can form complexes with divalent calcium ions.

14 abilized by disulfide bonds and chelation of calcium ions.

15 lays a jellyroll beta-sandwich including two calcium ions.

16 anoparticles with variable concentrations of calcium ions.

17 ch sodium is the most likely substituent for calcium ions.

18 and the oxidation of thiol groups induced by calcium ions.

19 as defined by CD is the same with or without calcium ions.

20 n the same time scale as the dissociation of calcium ions.

21 ing to Galpha subunits and its regulation by calcium ions.

22 itivity of dopamine release to extracellular calcium ions.

23 nding to Sonic hedgehog (Shh) is enhanced by calcium ions.

24 nted by high concentrations of extracellular calcium ions.

25 ntly reduced the affinity of the domains for calcium ions.

26 ce of activated platelets in the presence of calcium ions.

27 sed to intermittently buried upon removal of calcium ions.

28 mediately dissociated after the depletion of calcium ions.

29 calcium ions, providing a linear response to calcium ions.

30 anoparticles with pectic polysaccharides and calcium ions.

31 rs of LPS molecules, which are stabilized by calcium ions.

32 ociation and dissociation in the presence of calcium ions.

33 S100 domain of human profilaggrin with bound calcium ions.

34 tidylcholine (DMPC) bilayer coincubated with calcium ions.

35 affinity for zinc, (3) a binding site for a calcium ion, (4) the ability to form stable heterocomple

36 ] and consequent ability to chelate divalent calcium ions [8].

37 oyment of genetically encoded indicators for calcium ions (a proxy for action potentials), membrane p

38 r other electrolytes (potassium, sodium, and calcium ions), a PVC-based ion-selective membrane is add

39 x with hydroxycarboylate groups affected the calcium ion activity, which may influence the gelation p

40 rations in the dispersed phase increased and calcium-ion activity (ACa(++)) decreased during manufact

41 ed the effects of calcium chelating salts on calcium-ion activity (ACa(++)), calcium distribution, an

42 The calcium ion acts as a second messenger in response to me

43 ch studied in an underivatized form as their calcium ion adducts, barium ion adducts, and gas-phase e

44 in hemolymph sodium ions and an increase in calcium ions after 24 h post-exposure.

45 nct structural rearrangements in response to calcium ion and small molecule inhibitors such as triflu

46 DAR), which leads to influx of extracellular calcium ions and activation of calcium-dependent phospha

47 repeats, and a lectin-like module) binds 30 calcium ions and forms extensive interactions among its

48 ccharide contents, our results indicate that calcium ions and HG gelation increase the amount of boun

49 A strict dependence for calcium ions and inhibition at high NaCl concentration w

50 Assembly requires low pH and calcium ions and is reversed at neutral pH.

51 lf-association was measured as a function of calcium ions and loading rate.

52 any organism; this activity was inhibited by calcium ions and stimulated by bicarbonate.

53 Compared to a control, presence of calcium ions and tannic acid decreased FL formation sign

54 Removal of calcium ions and the consequent extraction of homogalact

55 ase of phosphate depends on concentration of calcium ions and this influences soluble oxalate concent

56 Calbindin-D28k is known to bind four calcium ions and upon calcium binding undergoes a confor

57 permeate divalent cations, are inhibited by calcium ions, and demonstrate weak rectification in asym

58 aI: unbound enzyme, a DNA-bound complex with calcium ions; and a DNA-bound, fully cleaved complex wit

59 Addition of calcium ions appeared to result in release of the second

60 ), negatively charged membrane vesicles, and calcium ions approached the same diffusion-limited rate

61 brane shows no response in the ON state when calcium ions are absent.

62 e shows thiamine pyrophosphate (TPP) and two calcium ions are bound to Cypl and give the first insigh

63 nt with experimental data and confirmed that calcium ions are bridged between polymer chains, resulti

64 Calcium ions are crucial for the antibacterial activity

65 Because calcium ions are important biological cofactors that pla

66 Calcium ions are involved in a plethora of cellular func

67 ce of 1.5 mM Ca(2+) is not cyclized, and two calcium ions are observed in the 2.9 A resolution struct

68 s among charged residues, lipid bilayer, and calcium ions are optimized to provide additional attract

69 rmation (elongated and slightly curved) when calcium ions are present.

70 Calcium ions are well-known intracellular signalling mol

71 Finally, we demonstrate the influx of calcium ions as a response of our mechanically activated

72 ium showed that repeat 1C contains two bound calcium ions as in the crystal of the Asn(702) protein,

73 d on lipid monolayers in the absence of free calcium ions as revealed by electron microscopy.

74 This mechanical response is modulated by calcium ions at both low and high force, switching from

75 he continuous matrix was firstly attacked by calcium ions at low lime levels (<0.20% w/w), disrupting

76 e, and anti-glycation agents (tannic acid or calcium ion) at different molar ratios were heated at 90

77 Calcium ions bind specifically in the Tse3 active site a

78 aptic transmission (P = 2.70 x 10(-)(1)(4)), calcium ion binding (P = 3.55 x 10(-)(1)(5)), and cation

79 m ligands fully supports the suggestion that calcium ion binding by the major pseudopilin is essentia

80 perties have been studied in detail, but its calcium ion binding properties and subsequent conformati

81 F3 constitute a rigid rod via an interdomain calcium ion binding site, the long linker between EGF1 a

82 f three to six corresponding to the multiple calcium ion binding sites on the calcium sensor responsi

83 Calcium ion binding to CaM induced an increase in thickn

84 Human calmodulin mutations disrupt calcium ion binding to the protein and are associated wi

85 transmembrane transporter activity, iron and calcium ion binding, (inorganic) anion transmembrane tra

86 Many have proposed that calcium ions binding to daptomycin is a precondition for

87 e CUB module from human TSG-6, identifying a calcium ion-binding site and chelating glutamic acid res

88 tion may also provide an explanation for how calcium-ion-binding affinity is increased upon binding a

89 100B would also have to cause an increase in calcium-ion-binding affinity to be effective therapeutic

90 (EHEC) GspG were elucidated, and all show a calcium ion bound at the same site.

91 For example, singly charged magnesium and calcium ion bound complexes of [Lys8]-vasopressin exhibi

92 Interestingly, this enzyme contains a calcium ion bound nearby to the glycone-binding region,

93 Calcium ions bound both strongly and weakly to fibrin(og

94 imilar to that in human pentraxins, with two calcium ions bound in each subunit.

95 s, suggests distinct roles of three putative calcium ions bound to ADAM22, with one in the metallopro

96 is crucial because of high energy needs and calcium ion buffering along axons to synapses during neu

97 e phi6, the assembly reaction is promoted by calcium ions but its biomechanics remain poorly understo

98 Chelation of calcium ions by 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-

99 Chelation of calcium ions by EDTA or warfarin treatment of cells led

100 ey events underlying the active transport of calcium ions by SERCA.

101 etry was used to characterize the binding of calcium ion (Ca(2)(+)) and phospholipid to the periphera

102 ound to form networks exhibiting synchronous calcium ion (Ca(2+)) activity that stimulated cell proli

103 nce the activity of ryanodine receptor (RyR) calcium ion (Ca(2+)) channels, which play a central role

104 sed to the extracellular space due to a high calcium ion (Ca(2+)) concentration and finally reached t

105 brane fusion to an increase of intracellular calcium ion (Ca(2+)) concentration.

106 Intracellular calcium ion (Ca(2+)) elevation on the left side of the m

107 monary vasculature leads to perturbations in calcium ion (Ca(2+)) homeostasis and transition of pulmo

108 The introduction of calcium ion (Ca(2+)) indicators based on red fluorescent

109 om one color to another by illumination, and calcium ion (Ca(2+)) indicators.

110 ing materials are clinically being used, and calcium ion (Ca(2+)) released from these materials is kn

111 oped FP-calmodulin biosensor, GEM-GECO1, for calcium ion (Ca(2+)) sensing.

112 In neurons, PDZD8 was required for calcium ion (Ca(2+)) uptake by mitochondria after synapt

113 ther these channels signal via the influx of calcium ion (Ca(2+)), voltage-dependent conformational c

114 The C2A domain is one of two calcium ion (Ca(2+))- and membrane-binding domains withi

115 vity in the developing brain, is mediated by calcium ion (Ca(2+))-dependent activation of Ca(2+)/calm

116 lling are nuclear-associated oscillations in calcium ions (Ca(2+) ), occurring in the root hairs of s

117 ive oxygen species (ROS) that, together with calcium ions (Ca(2+)) and pH, sustain polar growth over

118 Calcium ions (Ca(2+)) are critical second messengers in

119 Calcium ions (Ca(2+)) function as universal second messe

120 5 (mGluR5)-dependent increases in cytosolic calcium ions (Ca(2+)) in response to glutamatergic trans

121 Intracellular calcium ions (Ca(2+)) modulate sodium channel inactivati

122 Calcium ions (Ca(2+)) modulate the phototransduction cas

123 selectivity filter is partially selective to calcium ions (Ca(2+)) moving into the cell, but blocked

124 lly coupled ferric iron ions (Fe(3+)), three calcium ions (Ca(2+)), and an oxo group bridging three o

125 o membranes containing PS in the presence of calcium ions (Ca(2+)), but whose function is unknown.

126 ations of the intracellular concentration of calcium ion ([Ca(2+)](i)) are at the heart of intracellu

127 second site binds through a Gla domain-bound calcium ion Ca1, Gla30, and Lys11.

128 -methyl-d-aspartate (NMDA) receptor-mediated calcium ion (Ca2+) accumulations from the dendrite and o

129 In hippocampal neurons, calcium ion (Ca2+) flux through N-methyl-D-aspartate (NM

130 Removal of free calcium ions (Ca2+) dissociates VP7 trimers into monomer

131 Signal transduction via calcium ions (Ca2+) represents a fundamental signaling p

132 ease cheese yield but high concentrations of calcium ions can have adverse effects.

133 Voltage-gated calcium ion (CaV) channels convert neuronal activity int

134 First, calcium ions change the tertiary structure of the bound

135 ies of steps that involve a sudden influx of calcium ions, changes in mitochondria, and modification

136 ed in in vitro and in vivo assays for T-type calcium ion channel activity.

137 enriched gene sets include the voltage-gated calcium ion channel and the signalling complex formed by

138 th Ca(2+), further indicating that CD20 is a calcium ion channel that can transport these metal ions

139 Membrane current through voltage-sensitive calcium ion channels at the postsynaptic density of a de

140 e hypothesize that activation of light-gated calcium ion channels by blue and green light could expla

141 Calcium ion channels that determine many of the properti

142 Polycystins function as calcium ion channels, but their impact on cell physiolog

143 his F-actin peripheralization was blocked by calcium ion chelation.

144 sient increase in endothelial cytosolic free calcium ion concentration ( upward arrow[Ca(2+)]i) is re

145 gen substrate topography, free intracellular calcium ion concentration ([Ca(2+)]i, and the associatio

146 H pylori infection increases intracellular calcium ion concentration [Ca2+]i of GECs, which induces

147 Bitter compounds increased the intracellular calcium ion concentration and stimulated ciliary beat fr

148 A surge in cytosolic calcium ion concentration by entry of extracellular Ca2+

149 s between the increase in intracellular free calcium ion concentration evoked by histamine and the fi

150 ions (pH 4.5), BAG was found to increase the calcium ion concentration from 0.7 mM ([Ca(2+)] in artif

151 e dependence of important cellular events on calcium ion concentration propelled us to investigate th

152 R stress in SMCs was increased intracellular calcium ion concentration, resulting in increased contra

153 e Ras-ERK pathway and increase intracellular calcium ion concentrations, whereas PLC-gamma1 is dispen

154 physiological temperatures and low divalent calcium ion concentrations.

155 lesions opens to allow influx of sodium and calcium ions, contributes to axonal injury in experiment

156 it binds a third calcium ion, with all three calcium ions contributing to the binding and orientation

157 w, using molecular dynamics simulations, how calcium ions control the structural integrity of cadheri

158 Functional studies of GspG with mutated calcium ion-coordinating ligands were performed to inves

159 )-TRTK-12 and S100B-Ca(2+) were compared and calcium ion coordination by the protein was found to be

160 Third, because calcium ions demonstrate strong affinity to negatively c

161 Moreover, we explore the differential calcium ion dependence of calmodulin ligand-binding affi

162 The antibiotic activity is calcium-ion dependent and correlates with the target mem

163 Three-dimensional pH and calcium ion distribution mapping were also obtained by u

164 ton, suggesting that influx of extracellular calcium ions drives spine shrinkage.

165 The calcium ions electrostatically stabilize the lone pair o

166 gamma1 activation and subsequent cytoplasmic calcium ion elevation.

167 ressed spontaneous fusion and activated fast calcium ion-evoked fusion.

168 k blood flow due to a deficiency in a sodium calcium ion exchanger expressed specifically in the hear

169 with the fluorescent dye calcein shows that calcium ions first penetrate the embryo and later are de

170 e channel (RyR1) in skeletal muscle disrupts calcium ion flux.

171 t of the central pseudopilus is dependent on calcium ions for activity.

172 Highly reactive calcium ions form a direct interaction with starch to al

173 that take place subsequent to removal of the calcium ion from the regulatory sites I and II.

174 new study reveals a role for the release of calcium ions from intracellular stores in mediating spat

175 ed inhibition of thrombin-induced release of calcium ions from intracellular stores.

176 ykinin triggers the release of intracellular calcium ions from nociceptive sensory neurons of rat dor

177 SERCA promotes muscle relaxation by pumping calcium ions from the cytoplasm into the sarcoplasmic re

178 y, we observed force-induced dissociation of calcium ions from the duplicated loop-helix F-hand motif

179 echanics of the capsid: the sequestration of calcium ions from the intracapsid binding sites reduces

180 e major cellular mediators of the release of calcium ions from the sarcoplasmic reticulum, an essenti

181 the notion that CP responds to physiological calcium ion gradients to become a high-affinity transiti

182 The role of the cofactor, calcium ions, has been confusing.

183 sing for marrow and a site for regulation of calcium ion homeostasis.

184 m, phospholipid biosynthesis/metabolism, and calcium ion homeostasis.

185 In the absence of calcium ions, however, it assumes a disordered conformat

186 tends out into the solvent and away from the calcium ion; however, in the complexes, the Glu-202 side

187 mbbell EF-hand protein that accommodates one calcium ion in its fourth EF-hand.

188 To remove noise, we prepare a pair of calcium ions in a superposition of two decoherence-free

189 iveness of BAG in neutralizing and releasing calcium ions in acidic conditions.

190 , permease activity required the presence of calcium ions in both the association and activation step

191 or the transient elevation of cytosolic-free calcium ions in endothelium that is required for TEM and

192 hows an absolute requirement of magnesium or calcium ions in enzyme activity.

193 l gel electrophoresis, the identification of calcium ions in protein spots by X-ray fluorescence (SR-

194 formation pathway of calcium carbonate from calcium ions in sea water to mineral deposition and inte

195 ations of negatively charged amino acids and calcium ions in the Abeta binding footprint overlap.

196 Here we investigated the role of calcium ions in the sensitization of TRPV3 to repetitive

197 ce, which is responsible for coordination of calcium ions in type II binding sites, is only partially

198 This work shows the mechanical role of calcium ions in viral shell stability and identifies TBS

199 f excess intracellular cations, particularly calcium ions, in neuronal and glial cell injury in multi

200 Calcium ion influx through NMDARs recruits Ca(2+)-depend

201 tential target for Parkinson's disease since calcium ion influx through the channel was implicated in

202 split an electron wave packet bound inside a calcium ion into two parts with different orientations a

203 The enzyme was activated by introducing calcium ions into cells, and its activity was assayed by

204 o form the channel that controls the flow of calcium ions into mitochondria.

205 self-healing protein gel is made by inducing calcium ions into the mixture of heat-induced BSA nano-a

206 cle is regulated by the influx and efflux of calcium ions into the muscle cytoplasm.

207 they regulate the conductance of sodium and calcium ions, intravesicular pH, trafficking and excitab

208 Calcium ion is a versatile second messenger for diverse

209 Calcium ion is an intracellular messenger that plays a c

210 al structure showed that binding of a fourth calcium ion is structurally possible in the DE loop of t

211 TnC domain in which the presence of only one calcium ion is sufficient to induce a closed-to-open tra

212 ly, the simultaneous detection of sodium and calcium ions is enabled voltammetrically in contrast to

213 NK cells, the intracellular concentration of calcium ions is increased through the sequential operati

214 Once fully loaded with four calcium ions, it again takes on an ordered state.

215 cium ions, with a population of inner-sphere calcium ions larger than on unconfined calcite surfaces.

216 The visinin-like domain binds three calcium ions, leading to a conformational change involvi

217 embranes of mitochondria can be triggered by calcium ions, leading to swelling of the organelle, disr

218 Opening can be triggered by calcium ions, leading to swelling of the organelle, disr

219 y be disrupted in diseases where cytoplasmic calcium ion levels are chronically high and where target

220 (K(d) </= 20 nM) implied occupancy at basal calcium ion levels.

221 a(2+)-bound structure contains only a single calcium ion, located in the DE loop of repeat I and coor

222 This mechanism involves two factors: 1) calcium ions make the DMPC bilayer partially cationic an

223 rants in heterologous cells as determined by calcium ion mobilization.

224 y growth factor stimulation of intracellular calcium-ion mobilization.

225 Our experiments show that calcium ions modulate the mechanics of the capsid: the s

226 ly of factor Xa, factor Va, prothrombin, and calcium ions, myosin greatly enhanced prothrombinase act

227 ation is stable, reduces the interference of calcium ions nearly 5-fold, and mitigates phosphate inte

228 By contrast, the voltammetric exchange of calcium ion (nI = 3) with lithium ion (nJ = 1) by a Ca(2

229 ese simulations, we have determined that the calcium ions not only stabilize the cis peptide bond the

230 rmed by Asp116 and Arg92 in the place of the calcium ion of the dormant (high-calcium) state might tr

231 The affinity for calcium ions of visinin-like domain EF-hands 1 and 2 (K(

232 e deleterious effects of abrupt increases in calcium ion on membrane potential during reperfusion.

233 n this contribution, the effects of divalent calcium ions on domain formation in monolayers containin

234 a(2+)-bound structure we detected five bound calcium ions, one of which is a novel, highly coordinate

235 der coordination shell, the newly identified calcium ion organizes the active site residues to mediat

236 tability are dependent on the binding of one calcium ion per protein molecule.

237 of the P-type ATPases family, transports two calcium ions per hydrolyzed ATP molecule via an "alterna

238 icles, we determined a stoichiometry of four calcium ions per protein molecule using isothermal titra

239 vitro, ZPI not only inhibits factor Xa in a calcium ion-, phospholipid-, and PZ-dependent fashion, b

240 Herein, we have revealed that magnesium and calcium ions play a major role in modulating the ability

241 Regardless of calcium ion presence, the fluorescence intensity results

242 Mitochondrial calcium ions promote a number of events that sustain ATP

243 r knowledge, physiological mechanism whereby calcium ions promote sodium current facilitation due to

244 ce and cell-based assays and determined that calcium ions promote the formation of a stable ternary c

245 +)-binding moiety, has two binding sites for calcium ions, providing a linear response to calcium ion

246 Calcium ions react with silicic acid released from disso

247 ABSTRACT: Calcium ions regulate mitochondrial ATP production and c

248 KEY POINTS: Calcium ions regulate mitochondrial ATP production and c

249 lex diterpenoids that modulate intracellular calcium-ion release at ryanodine receptors, ion channels

250 The calcium ion remains bound to wild-type OLF at neutral an

251 ng the Ser allele binds a full complement of calcium ions, repeat 1C is altered, leading to destabili

252 ial protocol is established on potassium and calcium ion-selective membranes.

253 tate, low-poly(vinyl chloride), carbon-based calcium ion-selective microelectrode (Ca(2+)-ISME), 25 m

254 ynaptic exocytosis, where synaptotagmin (the calcium-ion sensor for fusion) cooperates with complexin

255 BtuB, and earlier simulations suggested that calcium ions serve to stabilize key substrate-binding ex

256 These results indicate that the calcium ion serves as a trigger at the pentamer interfac

257 Calcium ion signaling regulates central aspects of the b

258 tein (WASP) deficiency results in defects in calcium ion signaling, cytoskeletal regulation, gene tra

259 erstanding of the events connecting WASP and calcium ion signaling.

260 A calcium ion, sodium ion and glycerol molecule were ident

261 pectroscopy is used to characterize divalent calcium ions solvated by up to 69 water molecules.

262 At higher concentrations, calcium ions stabilize monomeric RsaA, which can then tr

263 Calcium ion stimulated the production of 2-arachidonoyl-

264 on our data, we propose a mechanism by which calcium ions strengthen Abeta-bilayer interactions.

265 ocation is also regulated by nucleotides and calcium ions, suggesting a potential role of the transpo

266 cin M reveals the presence of an active site calcium ion that is coordinated by a conserved aspartic

267 r release is triggered by the binding of few calcium ions that can originate either from the synaptic

268 s peak absorbance at 765 nm upon addition of calcium ions that was translated into robust signal chan

269 Moreover, with the presence of calcium ions, the self-healing behavior can be significa

270 potentials and are modulated by cytoplasmic calcium ions through a poorly understood mechanism.

271 MGP binds calcium ions through gamma-carboxylated glutamates (Gla

272 mouth of the pore, thus blocking the flow of calcium ions through the channel, with consequent blocki

273 Abeta monomer does not promote permeation of calcium ions through the zwitterionic bilayer.

274 creases from 21.4 kcal/mol in the absence of calcium ions to 10.3 kcal/mol in their presence.

275 O biofouling was enhanced by complexation of calcium ions to bacterial EPS.

276 a cascade of pathological events by allowing calcium ions to enter the cell.

277 n methylesterase enzymes and cross-linked by calcium ions to form a gel.

278 ulphonate (PSS), we show that the binding of calcium ions to form Ca-PSS globules is a key step in th

279 o perceive threshold levels of environmental calcium ions to trigger secretion.

280 artilage via the generation of intracellular calcium ion transients.

281 ators emerge from i) mechanical stretch with calcium ion transport and ii) fluid shear stress induced

282 L to play a regulatory role in mitochondrial calcium ion transport.

283 ium histolyticum collagenase, the binding of calcium ions triggers the formation of a cis peptide bon

284 ss were obtained, which when challenged with calcium ions underwent a contraction of approximately 0.

285 revealed how some GH43 ABNs are activated by calcium ions via hyperpolarization of the catalytically

286 ging, where bacterial EPS in the presence of calcium ions was globular, while that with magnesium ion

287 olayer of cultured cells, which fluoresces a calcium ion wave at a controlled ionic current.

288 e is shown to actively exchange protons with calcium ions when switched ON after illumination at 470

289 eat is triggered by a pulse of intracellular calcium ions which bind to troponin on the actin-contain

290 idue is predicted to coordinate binding of a calcium ion, which influences the conformational binding

291 In addition, the experiments confirmed that calcium ions, which are required to maintain proper conf

292 Moreover, we demonstrate that calcium ions, which bind within the confines of the TolB

293 oacid polymer in an ion-sensing membrane for calcium ions, which highly discriminates potassium, sodi

294 tions controlling the release and effects of calcium ions, which may regulate migration in a spaciote

295 activity, whereas removal of the more buried calcium ion with EDTA resulted in a 60-90% reduction in

296 also abolished by chelation of intracellular calcium ions with 1,2-bis(2-aminophenoxy)ethane-N,N,N',N

297 ons that utilize an accurate force field for calcium ions with scaled charges effectively accounting

298 H probe was used to correlate the release of calcium ions with the change in local pH.

299 ding PE, however, each subunit binds a third calcium ion, with all three calcium ions contributing to

300 se counterions to be inner- and outer-sphere calcium ions, with a population of inner-sphere calcium