ライフサイエンスコーパス: calcium signaling

1 phagocytic capacity and effects on neuronal calcium signaling.

2 ellum that are accompanied by alterations in calcium signaling.

3 ts of heterogeneous structural remodeling on calcium signaling.

4 ppression of ryanodine receptor (RyR)-evoked calcium signaling.

5 a membrane junctions for STIM-ORAI-dependent calcium signaling.

6 ling of the junctions during store-dependent calcium signaling.

7 rmalities in endoplasmic reticulum-dependent calcium signaling.

8 inflammatory processes, including increased calcium signaling.

9 atically enhanced MAPK, NF-kappaB, PI3K, and calcium signaling.

10 a2B -AR increases the epinephrine-stimulated calcium signaling.

11 ding the importance of synaptic function and calcium signaling.

12 vation of protein kinase C and intracellular calcium signaling.

13 ligand expression through the attenuation of calcium signaling.

14 -causing OCRL allele prevents TRPV4-mediated calcium signaling.

15 ator and attenuates B-cell receptor-mediated calcium signaling.

16 s junctional integrity through modulation of calcium signaling.

17 tric oxide (NO) synthetase, and postsynaptic calcium signaling.

18 It is of course the story of calcium signaling.

19 se loci suggests the involvement of neuronal calcium signaling.

20 induce CaN activation through nonexcitotoxic calcium signaling.

21 rect response of CFTR to calmodulin-mediated calcium signaling.

22 ceptor activator of NF-kappaB-ligand-induced calcium signaling.

23 Further, Kidins220 was required for optimal calcium signaling.

24 cAMP, whereas it increases its intracellular calcium signaling.

25 uced cell surface TF activity independent of calcium signaling.

26 binding to laminin under flow did result in calcium signaling.

27 treatment-induced decreases in intracellular calcium signaling.

28 14-3-3 activates RGS18 to block Gq-dependent calcium signaling.

29 ing, reactive oxygen species production, and calcium signaling.

30 radation of NCS-1, and loss of intracellular calcium signaling.

31 ody wall muscle, through the coordination of calcium signaling.

32 d for understanding the stochastic nature of calcium signaling.

33 inucleotide phosphate in cannabinoid-induced calcium signaling.

34 (NCS-1) and subsequent loss of intracellular calcium signaling.

35 l component in modulating InsP(3)R-dependent calcium signaling.

36 and sympathetic neurites, neurogenesis, and calcium signaling.

37 haft of neurons, triggering an inhibition of calcium signaling.

38 in astrocytes revealed a decrease in resting calcium signaling.

39 ymphatic sprouting, presumably by disturbing calcium signaling.

40 ding partners, suggesting a role of ABCD2 in calcium signaling.

41 es requires highly localized, or nanodomain, calcium signaling.

42 onds of ligand binding and preceding initial calcium signaling.

43 ntry is a central regulator of intracellular calcium signaling.

44 to the vascular architecture via collective calcium signaling.

45 ochondria membrane contacts are hotspots for calcium signaling.

46 fiber mGluR1-dependent synaptic currents and calcium signaling.

47 hanistic basis of the architecture-dependent calcium signaling.

48 in mitochondrial function, ATP release, and calcium signaling.

49 rs, Lrrtm1 and Lrrtm2, as targets of nuclear calcium signaling.

50 mary ischemic injury that triggers a wave of calcium signaling, activating proteolytic mechanisms and

51 , channel, and protein binding that modulate calcium signaling, activity-dependent critical period de

52 ediated barrier changes, which suggests that calcium signaling acts, in part, through calcineurin- an

53 's prooncogenic function, inhibiting PAR2-Gq-calcium signaling alone would not be sufficient to achie

54 anogaster embryos in a process that requires calcium signaling and actomyosin contractility.

55 nding the interplay between Sph homeostasis, calcium signaling and autophagy will be crucial in devel

56 ellular PAR4 C-terminal motif that regulates calcium signaling and beta-arrestin interactions.

57 ession in cholangiocytes, leading to reduced calcium signaling and bile duct secretion.

58 Loss of TrkB.T1 in these cells impairs calcium signaling and causes cardiomyopathy.

59 enomes (KEGG) pathways included networks for calcium signaling and cell adhesion molecules, among oth

60 rangement of endothelial cells in collective calcium signaling and cell contractility.

61 les for PMCA1 and PMCA4 in the regulation of calcium signaling and cell death pathways despite the wi

62 y of genes associated with GTPase signaling, calcium signaling and cell death.

63 that neuronal CALHM1 controls intracellular calcium signaling and cell excitability, two mechanisms

64 ITPR2-knockout cells exhibited less nuclear calcium signaling and cell proliferation than control ce

65 ls to increase, instigating pro-hypertrophic calcium signaling and concomitant pathological remodelin

66 increased, explaining the decoupling between calcium signaling and contractility.

67 that P2X7 plays a critical role in mediating calcium signaling and coordinating cytoskeletal rearrang

68 nted in MDD, providing initial evidence that calcium signaling and dendrite regulation may be involve

69 ling plays an important role in the aberrant calcium signaling and depressed contractile and beta-adr

70 ensitized MSCs to mechanical-loading-induced calcium signaling and differentiated marker expression.

71 Here we have studied glucose-induced calcium signaling and energy metabolism in INS-1E insuli

72 Enhanced calcium signaling and Erk phosphorylation are decoupled

73 anistically novel information on microscopic calcium signaling and excitation-contraction coupling in

74 This effect is mediated by voltage-gated calcium signaling and gap-junctional communication.

75 o rat spinal astrocytes in culture initiates calcium signaling and induces secretion of ATP that with

76 of the probe for these two species triggered calcium signaling and intracellular protein translocatio

77 s has changed our understanding of astrocyte calcium signaling and its consequences for neuronal func

78 y analysis also implicated genes involved in calcium signaling and long-term potentiation.

79 vant targets, including proteins involved in calcium signaling and members of the MEF2 family of tran

80 ducing NAD-derived metabolites that regulate calcium signaling and migration of inflammatory cells.

81 of inter-organelle communication, regulating calcium signaling and mitochondrial activities.

82 was noted in AhR-null mice due to defective calcium signaling and mitochondrial function, concomitan

83 r sarcoplasmic reticulum (SR) for increasing calcium signaling and myocyte contraction.

84 Since calcium signaling and oxidative stress are critical regu

85 cal for temporal regulation of intracellular calcium signaling and prevention of a deleterious rise i

86 -adrenergic receptors couple to Gq proteins, calcium signaling and protein kinase C activation; subse

87 responding cells, the temporal dependence of calcium signaling and provides global and individual cal

88 e expression of cardiac K(ATP) channels with calcium signaling and reveals new targets to improve car

89 racellular calcium abrogates hypoxia-induced calcium signaling and subsequent AMPK phosphorylation du

90 metabolism is essential for glucose-induced calcium signaling and, therefore, insulin granule exocyt

91 defects in activating coreceptor expression, calcium signaling, and BCR aggregation on engagement by

92 c mitochondrial quality control, cell death, calcium signaling, and cardiac development.

93 omeostasis, cell growth and differentiation, calcium signaling, and DMP1 transcription.

94 processes, such as neurotransmitter release, calcium signaling, and gene expression changes.

95 rgy metabolism, oxidative stress, apoptosis, calcium signaling, and growth of the nervous system.

96 tion, nuclear factor (NF)-kappaB activation, calcium signaling, and insulin secretion.

97 Here, we examine phenotypic changes, calcium signaling, and intrathymic migration in a synchr

98 d causative dysfunctions of ion homeostasis, calcium signaling, and neurotransmitter clearance, as we

99 P) is a critical cofactor during metabolism, calcium signaling, and oxidative defense, yet how animal

100 oproxyfan were all markedly biased away from calcium signaling, and principal component analysis of t

101 el role for Akt in viral entry, link Akt and calcium signaling, and suggest a new target for HSV trea

102 s as varied as blood clotting, intracellular calcium signaling, and tissue inflammation are all heavi

103 olume regulation by integrating osmosensing, calcium signaling, and water transport and, when overact

104 apting in response to stress to modulate the calcium signaling apparatus.

105 generation and suggests that redox, SFK, and calcium signaling are immediate "wound signals" that int

106 ensitivity to tubular flow and dysfunctional calcium signaling are important contributors.

107 Aberrant glutamate and calcium signalings are neurotoxic to specific neuronal p

108 function studies, abrogation of the PAR2-Gq-calcium signaling arm failed to suppress TGF-beta1-induc

109 d stretch induced ATP release and purinergic calcium signaling as a central mediator of this chromati

110 pathway analyses identified contraction and calcium signaling as the most affected processes.

111 P+ cells and glucose-responsive synchronized calcium signaling as well as expression of the transcrip

112 ially in children with heritable deficits in calcium signaling associated with autism.

113 lpain and the reductions in NCS-1 levels and calcium signaling associated with these chemotherapeutic

114 importance in light of their involvement in calcium signaling, association of proteins with cellular

115 signal transduction events, or disruption of calcium signaling attenuated the response to acute mecha

116 In response to calcium signaling, autoinhibition is reinforced by calmo

117 tial molecular therapeutics including axonal calcium signaling, axoglial energy metabolism and cell a

118 and gene networks related to cardiomyopathy, calcium signaling, axon guidance, cell adhesion, and ext

119 eleterious to podocytes through pathological calcium signaling, both in genetic and acquired diseases

120 age-gated calcium channels, or intracellular calcium signaling but not by alpha7 nAChR antagonists.

121 1970s were glorious times for mitochondrial calcium signaling, but the golden period was not going t

122 hat Ly6h reduces cell-surface expression and calcium signaling by alpha7 nAChRs.

123 phosphorylation at the C terminus regulates calcium signaling by tuning the content of CaV1.2 at sig

124 Upon glucagon-induced calcium signaling, calcium/calmodulin-dependent kinase I

125 Our findings contribute to understand how calcium signaling can modulate cell cycle length during

126 the cell surface and activation of a complex calcium signaling cascade.

127 Loss of TRPV1 inactivates a calcium-signaling cascade that ends in the nuclear exclu

128 t also demonstrated a cPLA(2)alpha-dependent calcium-signaling cascade that led to cell proliferation

129 ls and examine their potential function as a calcium signaling compartment.

130 ry neurons communicate at synapses through a calcium-signaling complex to regulate stochastic asymmet

131 us, through Ser-513, membrane depolarization/calcium signaling controls a critical spliceosomal assem

132 suggest that one mechanism by which nuclear calcium signaling controls neuronal network function is

133 we show that in hippocampal neurons, nuclear calcium signaling controls synaptic activity-induced pho

134 Calcium signaling controls the function of these cells,

135 As such, selectively regulating calcium signaling could be an alternative approach for a

136 In the absence of nuclear calcium signaling, cytosolic calcium activating nuclear

137 membrane and the size of channel-associated calcium signaling domains, and for understanding the sto

138 r T cell activation is promoted by sustained calcium signaling downstream of the TCR.

139 n calmodulin function will disrupt important calcium signaling events in heart, affecting membrane io

140 (Akt, MAPK, FAK), beta-catenin, GTPases, and calcium signaling events.

141 y significant, parallel changes in astrocyte calcium signaling evoked by corresponding GPCR-specific

142 s, consistent with an abnormality of nuclear calcium signaling feedback control.

143 transfected NSC-34 motor neurons and altered calcium-signaling following glutamate stimulation.

144 ur findings highlight the critical nature of calcium signaling for normal insulin secretion and sugge

145 Calcium signaling has been studied in astrocyte cell bod

146 Calcium signaling has been the primary mechanism in euka

147 Research on calcium signaling has centered on STIM1, ORAI1, and a fe

148 ttention as virulence factors, mycobacterial calcium signaling has not been very well studied.

149 ism; immune response and inflammation; MAPK; calcium signaling) highly associated with longevity (P <

150 sical model of glutamate-based intracellular calcium signaling in astrocytes, we suggest that the ste

151 Abrogation of calcium signaling in B cells by deleting BTK or PLCgamma

152 her organisms, investigations of voltage and calcium signaling in bacteria have lagged due to their s

153 Insufficient nuclear calcium signaling in CA1 hippocampal neurons and, conseq

154 This channel is critical to calcium signaling in cell types as varied as neurons and

155 se our understanding of the critical role of calcium signaling in cells in three-dimensional environm

156 tor targeted to primary cilia, we visualized calcium signaling in cilia of mouse fibroblasts and kidn

157 The immediate SFK and calcium signaling in epithelia was important for late ep

158 find that wounding rapidly activated SFK and calcium signaling in epithelia.

159 Here, we examined calcium signaling in fibroblasts using a minimal-profile

160 reproduces many aspects of voltage dependent calcium signaling in frog skeletal muscle fibers.

161 ts of physiological concentrations of ATP on calcium signaling in isolated CVs.

162 Although the contribution of STIM1 to calcium signaling in lymphocytes has been well studied,

163 pendent Protein Kinases are key effectors of calcium signaling in malaria parasite.

164 um entry, a major mechanism of physiological calcium signaling in mammalian cells.

165 asingly being demonstrated to be involved in calcium signaling in many cell types and species.

166 calmodulin and calcium implicates a role for calcium signaling in mitochondrial protein ubiquitylatio

167 emotaxis of human neutrophils and diminished calcium signaling in monocytic cell line U937 transfecte

168 hydropyridine site, and potent modulation of calcium signaling in muscle cells and vascular tissue.

169 To study mGluR-activated calcium signaling in neurons, we generated mGluR5 transg

170 ted SOCE and define major protein targets of calcium signaling in neutrophil activation during inflam

171 ative stress reduced expression of ITPR3 and calcium signaling in NHC cells; quercetin also reduced s

172 ITPR3 activity was determined by measuring calcium signaling in normal human cholangiocyte cells an

173 ity, neurotransmission, neuroprotection, and calcium signaling in physiological and disease states.

174 To determine the precise role of calcium signaling in polar body formation, we used live-

175 properties of GoC dendrites and the role of calcium signaling in regulating GoC spontaneous activity

176 step toward understanding the involvement of calcium signaling in regulation of ecdysteroidogenesis,

177 st a possible role for the strength of early calcium signaling in selective coordination of subsequen

178 lled delivery with subcellular precision and calcium signaling in targeted cells by selective excitat

179 plicate a novel relationship between FAS and calcium signaling in the heart and suggest that FAS indu

180 A role for astrocytes and glial calcium signaling in the regulation of Drosophila circad

181 Inhibition of calcium signaling in the steroidogenic prothoracic gland

182 ssue ex vivo and blocked capsaicin-triggered calcium signaling in Transient Receptor Potential Vanilo

183 ough phospholipase C (PLC) and intracellular calcium signaling in vivo.

184 Depolarization-induced calcium signaling increased the expression of myocardin,

185 arly in pancreatic injury through pathologic calcium signaling independent of trypsinogen activation.

186 n of MEF2C was associated with intracellular calcium signaling induced by beta-catenin.

187 The ability of NF279 to abrogate cellular calcium signaling induced by the respective chemokines s

188 , that translates neuronal-activity-mediated calcium signaling into gene expression in a light-depend

189 t that the mechanism of D(1)R/D(2)R-mediated calcium signaling involves more than receptor-mediated G

190 To reveal whether Gq-calcium signaling is a prerequisite for PAR2 to enhance

191 Oscillatory calcium signaling is central to the periodicity of defec

192 PC3-dependent mechanisms, by which activated calcium signaling is coupled to lipid metabolism and the

193 Calcium signaling is critical for lymphocyte function, a

194 beled vesicles in the gland is observed when calcium signaling is disrupted, and these vesicles conta

195 tage-gated calcium (Cav1) channels in T-cell calcium signaling is emerging.

196 Understanding mechanically-induced calcium signaling is especially important in fibroblasts

197 eticulum IP3 and ryanodine receptor-mediated calcium signaling is present in the induction of hyperal

198 and salivary gland tissues, indicating that calcium signaling is required for RCH to occur.

199 hree of these four pathways (MAPK; immunity; calcium signaling) is supported by findings in other hum

200 Calcium signaling leads to a promotion of complex format

201 Impaired calcium signaling leads to decreased beta cell mass and

202 led that these shared genes were enriched in calcium signaling, long-term potentiation and neuroactiv

203 Aberrant calcium signaling may contribute to arrhythmias and adve

204 This is a critical issue, because calcium signaling may represent an essential mechanism t

205 iding further evidence for the complexity of calcium signaling mechanisms in CNS astroglia.

206 ese data provide important insights into the calcium signaling mechanisms involved in early developme

207 e data provide evidence that pericanalicular calcium signaling mediated by InsP3R2 plays an important

208 ed in RCH, and here we firmly establish that calcium signaling mediates cold sensing in insect tissue

209 revealing widespread kinetic regulations in calcium signaling, metabolism, proteostasis, and mitocho

210 ifferent cell types and processes, including calcium signaling, migration, adhesion, proliferation, a

211 into key pathogenic cellular events such as calcium signaling, mitochondrial dysfunction, endoplasmi

212 rogeneous pattern reflected in intracellular calcium signaling, mitochondrial energetic, and redox ac

213 ory region of CFTR and calmodulin, the major calcium signaling molecule, and report protein kinase A

214 Four new DRC subunits contain calcium-signaling motifs and/or AAA domains and are near

215 cilia may potentially function as a crucial calcium-signaling nexus in hASCs during EFS.

216 ude of field action potential, and cytosolic calcium signaling of cardiomyocytes.

217 rapid detection of E. coli O157:H7 by using calcium signaling of the B cell upon cellular membrane a

218 nged exendin-4-induced activation (live cell calcium signaling) of NTS astrocytes and neurons; these

219 tigations have described indirect effects of calcium signaling on CFTR or other calcium-activated chl

220 or knockout mice to show distinct effects of calcium signaling on D2S and D2L autoreceptor function.

221 te or mutations disrupting sensory activity, calcium signaling, or genes that restrict outgrowth duri

222 The ER-mitochondrial interface is central to calcium signaling, organellar dynamics, and lipid biosyn

223 ctivated protein kinase (MAPK), insulin, and calcium signaling (P </= 0.007) and of individual genes

224 The calcium signaling pathway (hsa04020) was the only pathwa

225 promising anti-cancer activity by mediating calcium signaling pathway and inducing apoptosis as well

226 We identify the ORAI1/NFAT calcium signaling pathway as an essential regulator of T

227 TRPV3 activation induced a calcium signaling pathway culminating in activation of t

228 The calcium signaling pathway was the top gene set enriched

229 osis of epilepsy, including KEGG categories 'calcium signaling pathway' and 'phosphatidylinositol sig

230 ficant enrichment for genes constituting the calcium signaling pathway, especially those related to t

231 ignaling pathway, cAMP signaling pathway and calcium signaling pathway, were significantly enriched w

232 sceptibility gene, CACNA1C, belonging to the calcium signaling pathway.

233 ons at the cell rear were unaffected by this calcium signaling pathway.

234 al remodeling (LAD, LVA) and AF type via the calcium signaling pathway.

235 thylation of genes in retinol metabolism and calcium signaling pathways (P < 3 x 10(-6)) and with kno

236 ion with members of the phosphoinositide and calcium signaling pathways in the susceptibility for ped

237 Calmodulin (CaM) is the major component of calcium signaling pathways mediating the action of vario

238 Manipulation of calcium-signaling pathways controlling EMT induction in

239 ATPase-dependent calcium uptake, activating calcium-signaling pathways known to improve insulin sens

240 sted an oxidative response and activation of calcium-signaling pathways, as well as the participation

241 The process relies on intracellular calcium signaling, PDZ [postsynaptic density-95 (PSD-95)

242 echanisms of zymogen activation - pathologic calcium signaling, pH changes, colocalization and autoph

243 Calcium signaling played an important role in this proce

244 rly participants, this study identified that calcium signaling plays a central role in hippocampus-de

245 mine sulfate-induced damage, suggesting that calcium signaling plays a critical role in the initial s

246 Although calcium signaling plays an essential role in the enteric

247 ssion and synaptic plasticity in response to calcium signaling produced by neuronal activity.

248 In contrast, mouse CLs demonstrated distinct calcium signaling profiles leading to degranulation: whe

249 populations distinguished by their dendritic calcium signaling, rebound excitation, and physiological

250 l role in setting the repertoire of cellular calcium signaling regimens.

251 es and is believed to be critical in shaping calcium signaling, regulating ATP synthesis and controll

252 Calcium signaling represents the principle pathway by wh

253 roliferation, and preventing the increase of calcium signaling rescues the cell-cell junctional defec

254 y attenuate the alpha7 nAChR-induced Galphaq calcium signaling response as evidenced by a decrease in

255 a7 nAChRs to G proteins enables a downstream calcium signaling response that can persist beyond the e

256 ys, including cell-cell electrical coupling, calcium signaling, small-molecule exchange, and, remarka

257 functions and significantly alter astrocyte calcium signaling stimulated by multiple GPCRs.

258 We further demonstrate that calcium signaling suppresses the transcription of PD-1 l

259 in SH-SY5Y) were significantly enriched for calcium signaling, synaptic transmission, and neuron dif

260 d we show for the ubiquitous and fundamental calcium signaling system that cells monitor cytosolic an

261 al yet are actually operating under aberrant calcium signaling systems.

262 in-dependent protein kinases and the nuclear calcium signaling target CREB-binding protein.

263 in and suggest that it serves as a potential calcium signaling target within stress granules and othe

264 mitochondria resulted in drastically altered calcium signaling that could disrupt neurovascular coupl

265 In both cell types, intracellular calcium signaling that links membrane depolarization to

266 Perturbation of calcium signaling that occurs during cell injury and dis

267 ) are major downstream mediators of neuronal calcium signaling that regulate multiple neuronal functi

268 Two pathways of calcium signaling that regulated D2 autoreceptor-depende

269 results in a disarming of thrombin-activated calcium signaling through PAR1.

270 Here, we demonstrate that intercellular calcium signaling through the NSY-5 gap junction neural

271 Our results imply that insect tissues use calcium signaling to instantly detect decreases in tempe

272 unrecognized function for TRP channels, link calcium signaling to longevity, and, importantly, demons

273 osphorylation pathway that directly connects calcium signaling to the MAPK machinery.

274 This altered calcium signaling, transduced by the calmodulin-dependen

275 mmune evasion, increased stemness, increased calcium signaling, transformation, and novel E-cadherin-

276 n kinase II (CaMKII), a central regulator of calcium signaling, translates into reduced membrane expr

277 In those T cells, calcium signaling triggers the expression of Tle4, a mem

278 We found that inhibition of nuclear calcium signaling using CaMBP4 or increasing the nuclear

279 ion of ER stress occurred through pathologic calcium signaling very early in the course of pancreatic

280 Capa peptide induces calcium signaling via capaR with EC(5)(0) values for cap

281 Its fading happened as the general area of calcium signaling was instead experiencing a phase of ex

282 These discoveries established that calcium signaling was one of the most important areas of

283 Intracellular calcium signaling was unaffected by PKA activation, sugg

284 sed and SiglecG, a molecule shown to inhibit Calcium signaling, was downregulated in the absence of D

285 ctivation inhibits adenylate cyclase but not calcium signaling, was expressed in astrocytes at all de

286 Because LR depends on calcium signaling, we examined the effects of NAFLD on e

287 increased, and some, but not all, changes in calcium signaling were mimicked.

288 (GPCRs) and G-protein effectors involved in calcium signaling were significantly regulated, mostly d

289 elial von Willebrand Factor (vWF)release and calcium signaling were used as PAR activation markers.

290 increased CO2) evokes increases in astrocyte calcium signaling, which in turn stimulates COX-1 activi

291 le-genome expression profiling, and measured calcium signaling, which is implicated in mediating dyna

292 lly, glucose triggers KATP channel-dependent calcium signaling, which promotes HDAC5 phosphorylation

293 ntral position of the regulation of cellular calcium signaling, which they had once rightly occupied.

294 on that is further supported by dysregulated calcium signaling with CaMKII inhibition.

295 Detecting intracellular calcium signaling with fluorescent calcium indicator dye

296 nction, including long-term potentiation and calcium signaling with higher levels of postnatal expres

297 important physiological functions by linking calcium signaling with neuronal excitability.

298 roles in proliferation and differentiation, calcium signaling within the brain, and neurotrophic and

299 hodynamic flow that results in intracellular calcium signaling within the cancer cell.

300 cessive elevation or prolonged activation of calcium signaling would lead to cell death.