ライフサイエンスコーパス: calcium uptake

1 creased depolarization-induced mitochondrial calcium uptake.

2 verse diffusion barriers and sites of active calcium uptake.

3 f environmental signals as well as nutritive calcium uptake.

4 d ADP plus oligomycin restored potential and calcium uptake.

5 ted ATPase activity and completely inhibited calcium uptake.

6 to 60 min significantly inhibited microsomal calcium uptake.

7 lls was highly correlated with mitochondrial calcium uptake.

8 antagonist properties on human P2X4-mediated calcium uptake.

9 inhibitor KT195, by preventing mitochondrial calcium uptake.

10 sis balances passive calcium leak and active calcium uptake.

11 rial membrane potential, ATP production, and calcium uptake.

12 tors was silenced demonstrated a decrease in calcium uptake.

13 red function of aged hearts through improved calcium uptake.

14 onth-old mice did not change LV function and calcium uptake.

15 terocytes were tested for steroid-stimulated calcium uptake.

16 ins required for high-capacity mitochondrial calcium uptake.

17 , but did respond to forskolin with enhanced calcium uptake.

18 we have found that the PKA pathway mediates calcium uptake.

19 receptor failed to block 1,25D(3)-stimulated calcium uptake.

20 r CaMKII, namely, promotion of mitochondrial calcium uptake.

21 s in kidney cells show channel-mediated cell calcium uptake.

22 -ATPase (SERCA), thus modulating the rate of calcium uptake.

23 explained by reduced sarcoplasmic reticulum calcium uptake.

24 ining calcium-binding proteins mitochondrial calcium uptake 1 (MICU1) and MICU2 and the pore-forming

25 s controlled by its gatekeeper Mitochondrial Calcium Uptake 1 (MICU1).

26 CBARA1, that we call hereafter mitochondrial calcium uptake 1 (MICU1).

27 f mitochondrial Ca(2+) uptake, Mitochondrial Calcium Uptake 1 (MICU1/CBARA1) drives aerobic glycolysi

28 alcium uniporter (MCU) and the mitochondrial calcium uptake 1 protein (MICU1) with no change in level

29 ndoplasmic reticulum Ca(2+) ATPase-dependent calcium uptake, activating calcium-signaling pathways kn

30 ociated with impaired sarcoplasmic reticulum calcium uptake activity.

31 d in a significant decrease in mitochondrial calcium uptake, an increase in reactive oxygen species p

32 stitution with phospholamban suppressed both calcium uptake and ATPase activities by approximately 50

33 cium waves are associated with mitochondrial calcium uptake and consequent depolarization.

34 Ai knockdown of MCU attenuated mitochondrial calcium uptake and dendritic/neuritic shortening elicite

35 cur over a broad region of relatively slower calcium uptake and elevated diastolic calcium levels.

36 rease in SERCA2 protein leads to accelerated calcium uptake and enhanced Ca2+ loading.

37 use enterocytes paralleled that for enhanced calcium uptake and for LM females reached 250% of contro

38 rylated state, PLN binds SERCA, reducing the calcium uptake and generating muscle contraction.

39 f mammalian TRPV6, an important regulator of calcium uptake and homeostasis, is essential for channel

40 At the cellular level, AbetaP1-42 allows calcium uptake and induces neuritic abnormality in a dos

41 Here, capsaicin increases calcium uptake and induces vasoconstriction, an effect t

42 In 3T3-Trk cells, NGF increased both calcium uptake and intracellular calcium mobilization.

43 stimulated calcium uptake, the regulation of calcium uptake and intracellular mobilization by nerve g

44 AC6) expression in cardiac myocytes improves calcium uptake and left ventricular (LV) function in agi

45 myocyte shortening rate through increases in calcium uptake and more rapid lengthening.

46 suggest that HBx can increase mitochondrial calcium uptake and promote increased SOCE to sustain hig

47 insight into the mechanisms of mitochondrial calcium uptake and release that are important in healthy

48 as increased in the absence of mitochondrial calcium uptake and slowed when MCU was overexpressed.

49 u can be inhibited by blocking mitochondrial calcium uptake and store-operated calcium entry (SOCE).

50 rexpression of CaBP stimulates both cellular calcium uptake and vectorial calcium transport activitie

51 n the presence of a blocker of mitochondrial calcium uptake and was mimicked by injection of ATP into

52 between prognosis, changes in mitochondrial calcium uptake, and bioenergetic status in the heart dur

53 calcium transients showed a reduced rate of calcium uptake, and expression analysis showed reduced l

54 roblasts, along with increased mitochondrial calcium uptake, and in postmortem brains of sporadic PD/

55 Channel conductance, calcium uptake, and neurite degeneration are selectively

56 Respiration, oxidative phosphorylation, calcium uptake, and the mitochondrial membrane potential

57 Neurotrophin-stimulated presynaptic calcium uptake appears to play a key role in this proces

58 calculation, mutagenesis, and mitochondrial calcium uptake assays to determine the functional role o

59 was not a result of inhibited mitochondrial calcium uptake because robust calcium waves were still o

60 tion was increased independent of changes in calcium uptake because sarco(endo)plasmic reticulum Ca(2

61 acid release not by preventing mitochondrial calcium uptake but by inhibiting MPTP formation.

62 ablation of activity-dependent mitochondrial calcium uptake but had no effect on the rate or extent o

63 In 3T3-p75 cells, NGF increased calcium uptake but not intracellular calcium mobilizatio

64 ecrotic cell death by blocking mitochondrial calcium uptake but not the enzyme releasing fatty acids

65 kinase II on gene expression did not require calcium uptake but was synergistically enhanced by calci

66 xicity of glutamate depends on mitochondrial calcium uptake, but the toxicity to mitochondria also re

67 25-Hydroxycholesterol stimulated calcium uptake by CHO-K1 cells within 2 min after additi

68 t C. communis leaves is increased apoplastic calcium uptake by guard cells.

69 0 microM); and (d) blockade of mitochondrial calcium uptake by microinjection of diaminopentane penta

70 lting in increased ER-mitochondria contacts, calcium uptake by mitochondria, and mitochondrial divisi

71 [(3)H]Resiniferatoxin (RTX) binding and calcium uptake by rat dorsal root ganglion (DRG) neurons

72 ECaC, have been postulated to mediate apical calcium uptake by rat intestine and rabbit kidney, respe

73 responses to JYL1421 and KJM429 differed for calcium uptake by rVR1 induced by heat or pH.

74 sted as a link for the mechanisms leading to calcium uptake by the colon and may thus reduce the risk

75 Nifedipine blocked the increase in calcium uptake by these agents as well as their attenuat

76 Calcium uptake by TRPV5 was directly inhibited by magnes

77 of CaBP expression had a negative effect on calcium uptake, calcium transport, and trophoblast diffe

78 ubes with knocked-down ANT1 exhibited higher calcium uptake capacity and voltage-thresholds of mPT op

79 we measured a slightly reduced mitochondrial calcium uptake capacity in the knockout mutant.

80 A possible function for the calcium uptake caused by albumin is to potentiate the pr

81 initiated to determine whether the decreased calcium uptake caused by ischemia was the result of inhi

82 hondria exhibit membrane potential-dependent calcium uptake compatible with uniporter activity, and a

83 s demonstrated slower sarcoplasmic reticulum calcium uptake, decreased Ca(2+) release, and increased

84 ssion of DdMCU complements the mitochondrial calcium uptake defect in human cells lacking MCU or EMRE

85 lations, only reduced sarcoplasmic reticulum calcium uptake explained our results, causing calcium os

86 )/Ca(2+) ATPase activity or an uncoupling of calcium uptake from ATP hydrolysis.

87 Mitochondrial calcium uptake has a central role in cell physiology by

88 The biophysical properties of mitochondrial calcium uptake have been studied in detail, but the unde

89 trast to its antagonism of vanilloid-induced calcium uptake, IBTU (30 microM) inhibited [3H]resinifer

90 upon their suppression of capsaicin-induced calcium uptake in a mouse dorsal root ganglion primary c

91 These channels allow calcium uptake in amyloid precursor protein-deficient ce

92 JM429 had little or no effect on ATP-induced calcium uptake in CHO cells lacking rVR1, unlike capsaze

93 ations increased dendritic and mitochondrial calcium uptake in cortical neurons and familial PD patie

94 r 6 (TRPV6) channels play a critical role in calcium uptake in epithelial tissues.

95 male LM mice with 1,25D(3) elicited enhanced calcium uptake in females and males within 5 min.

96 strate that there is increased mitochondrial calcium uptake in HBx-expressing cells.

97 ven, supported both alpha-latrotoxin-induced calcium uptake in HEK293 cells and alpha-latrotoxin-stim

98 ral importance to steroid hormone-stimulated calcium uptake in mammalian intestinal cells.

99 how that these mutants reduced mitochondrial calcium uptake in MEF cells.

100 The role of mitochondrial calcium uptake in modulating SV recycling has been debat

101 brain-derived neurotrophic factor stimulates calcium uptake in p75(NGFR) cells but not in p140(trk) c

102 rophenone blocked MCU-mediated mitochondrial calcium uptake in permeabilized fibroblasts but not in i

103 Pyrophosphate was able to drive calcium uptake in permeabilized T. cruzi.

104 OX(R) showed no enhanced calcium uptake in response to 25-hydroxycholesterol.

105 s did not increase during culture in A23187, calcium uptake in the lens may be responsible for CPE ac

106 pholamban, a key player in the regulation of calcium uptake in the sarcoplasmic reticulum, and by pro

107 a high-throughput screening assay, measuring calcium uptake in TRPV1-expressing cells, we identified

108 sed of genes previously linked to intestinal calcium uptake, including S100g, Trpv6, Atp2b1, and Cldn

109 the other hand, did not affect the level of calcium uptake induced by glutamate but rather the durat

110 The channel mediated calcium uptake induces neurite degeneration in human cor

111 Nerve growth factor stimulates calcium uptake into both transfectants but not into untr

112 t the later stages of the secretory pathway, calcium uptake into CTL SGF1 and CHX SGF1 was examined.

113 All calcium uptake into CTL SGF1 was dependent on a thapsiga

114 atio of rate of calcium extrusion to rate of calcium uptake into internal stores increased, indicatin

115 eased by approximately 100 microM s-1 due to calcium uptake into internal stores.

116 Inhibition of calcium uptake into mitochondria by ruthenium red induce

117 Calcium uptake into mitochondria occurs via a recently i

118 Calcium uptake into mitochondria was sometimes evident w

119 Finally, manipulating calcium uptake into or release from intracellular stores

120 lum calcium ATPase, being the main agent for calcium uptake into the ER, plays a central role in this

121 actions of cAMP are distinct from increasing calcium uptake into the sarcoplasmic reticulum.

122 itochondrial pathology, especially when that calcium uptake is accompanied by another stressor, in pa

123 SR calcium uptake is mediated by a Ca(2+)-ATPase (SERCA2),

124 Mitochondrial calcium uptake is present in nearly all vertebrate tissu

125 f 875 miRNAs tested, miR-25 potently delayed calcium uptake kinetics in cardiomyocytes in vitro and w

126 pus oocytes, microinjected Calx cRNA induces calcium uptake like that of its homolog, the 3Na+-1Ca2+

127 her energetic demand decreased mitochondrial calcium uptake may constitute an adaptive cellular respo

128 Calcium-dependent calcium uptake measurements showed that the maximal velo

129 ischemia significantly inhibited microsomal calcium uptake mediated by Mg(2+)/Ca(2+) ATPase, the maj

130 l stimulation to the optic nerve can enhance calcium uptake more than a double pulse stimulation of t

131 can account for both the ligand binding and calcium uptake observed in rat DRG neurons.

132 Calcium uptake occurs through a channel called the unipo

133 = 0.01), velocity of sarcoplasmic reticulum calcium uptake (p < 0.0001), and sarcoplasmic reticulum

134 calcium, and the high opacity mitochondrial calcium uptake pathway provides a mechanism that couples

135 molecular characterization of mitochondrial calcium uptake pathways, and offers genetic strategies f

136 The calcium uptake potentiates the efficacy of low concentra

137 tion of an inhibitory subunit, mitochondrial calcium uptake protein 1, is central to PAH's pathogenes

138 nger RNA encoding the sarcoplasmic reticulum calcium uptake pump SERCA2a (also known as ATP2A2).

139 nd that both proteins associated with the ER calcium uptake pump SERCA2B, and TMTC2 also bound to the

140 sed SERCA2a protein expression and decreased calcium uptake rate by muscle homogenates.

141 , could account for most of the increases in calcium uptake rate observed in homogenates of muscles f

142 rowth of the target fungal cells by blocking calcium uptake rather than forming channels, as had been

143 resolve the submitochondrial localization of calcium uptake regulatory protein MICU1.

144 Mitochondrial calcium uptake stimulates bioenergetics and drives energ

145 Calcium uptake studies revealed that, in the atria, abla

146 hough concurrent inhibition of mitochondrial calcium uptake substantially enhanced this cytoplasmic c

147 ns sufficient to promote local mitochondrial calcium uptake, suggesting a tight coupling of calcium s

148 ivities are low concomitant with a defective calcium uptake, suggesting an extracellular accumulation

149 ll morphology with a concomitant increase in calcium uptake that is dependent on the MID1 and CCH1 ge

150 and the mechanism of neurotrophin-stimulated calcium uptake, the regulation of calcium uptake and int

151 Nifedipine, an inhibitor of calcium uptake through L-type calcium channels, inhibite

152 This calcium uptake, through a mitochondrial calcium uniporte

153 Comparing calcium uptake to ATP hydrolysis as ischemia increased f

154 antigen-induced degranulation, extracellular calcium uptake, tyrosine phosphorylation of several key

155 from heterozygous mice showed an attenuated calcium uptake upon agonist stimulation.

156 PEF parameters necessary to cause observable calcium uptake, using cells preloaded with calcium green

157 tions of enhanced calcium entry, the rate of calcium uptake was faster compared with control conditio

158 ed that the effect of ischemia on microsomal calcium uptake was mediated by an uncoupling of calcium

159 ater, LV function and sarcoplasmic reticulum calcium uptake were assessed.

160 ifferences in H(2)O(2) production or maximal calcium uptake were detected in the Ts16 mitochondria, t

161 CaT2 mediated saturable calcium uptake with a Michaelis constant (K(m)) of 0.66

162 +/- 6.5 nM and antagonized capsaicin-induced calcium uptake with an EC(50) of 9.2 +/- 1.6 nM, reflect

163 fibroblasts were depolarized and had reduced calcium uptake with impaired ATP production by oxidative

164 F reduced the magnitude of glutamate-induced calcium uptake with no apparent regulation thereafter.

165 Monitoring calcium uptake with the fluorescent dye calcein shows th