ライフサイエンスコーパス: calcium-induced

1 n of a dominant-negative CaR that eliminated calcium-induced 5-HT secretion but not secretion in resp

2 Increasing extracellular calcium induced a dose-dependent increase in MMP-9 expre

3 yers of PIP2 mixed with zwitterionic lipids, calcium induced a rapid, PIP2-dependent surface pressure

4 Calcium induced a reversible change in the extracellular

5 Moreover, calcium induced a significant change in the conformation

6 Calcium-induced activation of calpain has been shown to

7 ults in specific cellular changes, including calcium-induced activation of calpain proteases.

8 We propose that calcium-induced activation of cPKC-alpha hypoxia partial

9 data, have been used to develop a model for calcium-induced activation of NDR kinase by S100B.

10 on of PLC-gamma1 by epidermal growth factor, calcium-induced activation of PLC-gamma1 was not a resul

11 Our data suggest that this calcium-induced activation of TGase protein occurs while

12 es in the MyHC IIa promoter are required for calcium-induced activation of the MyHC IIa promoter.

13 This excludes a calcium-induced additive TRPA1 current after TRPV1 stimu

14 Calcium-induced aggregation has been proposed to play a

15 over, this is the first evidence that low pH/calcium-induced aggregation is necessary for sorting of

16 Thus, calcium-induced aggregation is not a passive process; ra

17 eate aggregation chaperones that enhance the calcium-induced aggregation of secretory granule protein

18 cell types, salivary proteins do not exhibit calcium-induced aggregation.

19 ctionality, with increased stability against calcium-induced aggregation.

20 pore antagonist cyclosporin A also inhibited calcium-induced AIF release from mouse liver mitochondri

21 However, the extent to which calcium-induced alternation of electrical activity in th

22 ults suggest that GPAnt-2a peptide augmented calcium-induced amylase release from permeabilized acini

23 antagonist of Go and Gi, showed no effect on calcium-induced amylase release from permeabilized acini

24 ning monolayers; however, in these mixtures, calcium induced an unexpected, PIP2- and multivalency-de

25 The formation of calcium-induced AP-1 binding complexes is regulated by p

26 atinocyte marker genes demonstrated that the calcium-induced AP-1 DNA binding activity does not corre

27 Calcium-induced AP-1 DNA binding complexes consist of Fr

28 results suggested that susceptibility during calcium-induced apoptosis is limited by availability of

29 n the lens, 2) a novel signaling pathway for calcium-induced apoptosis, and 3) a novel antiapoptotic

30 8 kinase and JNK2, which are not involved in calcium-induced apoptosis.

31 disruption of tight junction and accelerates calcium-induced assembly of tight junction in Caco-2 cel

32 In this study, the calcium-induced association of cPLA2-alpha with EA.hy.92

33 in-like protein did not significantly affect calcium-induced biofilm structure.

34 A calcium-induced but Dex-inhibited nuclear complex contai

35 how that the sustained rise in intracellular calcium induced by activation of P2X(7) receptors direct

36 rated calcium entry" - the cellular entry of calcium induced by depletion of intracellular calcium st

37 the GABA-elicited current, but increases in calcium induced by depolarization alone did not.

38 nate between the varying levels of cytosolic calcium induced by different stimuli.

39 d apoE3 affect the increase in intracellular calcium induced by either NMDA or KCl.

40 n without altering the rise in intracellular calcium induced by glucose or K+.

41 RCASBP(A) blocks increases in intracellular calcium induced by nicotine through alpha7-nAChRs and pr

42 xpressed SphK2 also increased cytosolic free calcium induced by serum starvation.

43 o specifically disrupt the transient rise in calcium induced by serum stimulation of starved Swiss 3T

44 d more slowly from an elevation in cytosolic calcium induced by the InsP3 agonist carbachol.

45 In contrast, the increase of intracellular calcium induced by treatment with calcium and ionophore

46 ed [Ca(2+)](i), followed by propagation (via calcium-induced Ca(2+) release, CICR) to the cell centre

47 acaine can be accounted for by depression of calcium-induced Ca2+ release (CICR).

48 from patients with CKD accumulated calcium; calcium induced calcification more potently than phospha

49 ium concentration in stores, and Orai-1, the calcium-induced calcium entry channel, are colocalized w

50 ve Ca2+ waves and oscillations indicative of calcium-induced calcium release (CICR) activity were ind

51 ivity and extracellular calcium, implicating calcium-induced calcium release (CICR) as the novel sour

52 sponsible for the regulation of regenerative calcium-induced calcium release (CICR) during Ca(2+) spa

53 se in the AD strains, suggesting an aberrant calcium-induced calcium release (CICR) effect within spi

54 It has been proposed that calcium-induced calcium release (CICR) from a near-membr

55 MPAR-mediated calcium signal is amplified by calcium-induced calcium release (CICR) from intracellula

56 ent by activation of glutamate receptors and calcium-induced calcium release (CICR) from intracellula

57 ential (V(m)) and calcium current (I(Ca)) of calcium-induced calcium release (CICR) from the junction

58 sion, thereby suggesting that LMO4 regulates calcium-induced calcium release (CICR) in central neuron

59 Calcium-induced calcium release (CICR) is a mechanism by

60 Stable calcium-induced calcium release (CICR) is critical for m

61 l is generated by calcium influx or requires calcium-induced calcium release (CICR) is not yet known.

62 ment of smaller local events, probably via a calcium-induced calcium release (CICR) mechanism.

63 om the stellate ganglia to establish whether calcium-induced calcium release (CICR) modulated action

64 ce suggests that internal calcium stores and calcium-induced calcium release (CICR) provide an import

65 I(Ca) did not evoke significant calcium-induced calcium release (CICR) since (i)[Ca2+]i

66 The gain of calcium-induced calcium release (CICR) was increased at

67 lcium and was diminished by the inhibitor of calcium-induced calcium release (CICR), dantrolene.

68 ats, ryanodine (1-50 microM), a modulator of calcium-induced calcium release (CICR), had no effect on

69 L-type Ca2+ channels, and amplification via calcium-induced calcium release (CICR).

70 of the cochlea with ryanodine, an agonist of calcium-induced calcium release (CICR).

71 Simulations based on a model of calcium-induced calcium release and cell-to-cell diffusi

72 This model uses the calcium-induced calcium release and inositol cross-coupl

73 nts and membrane transporters, mechanisms of calcium-induced calcium release and intracellular calciu

74 Abolishing calcium-induced calcium release by blocking ryanodine re

75 The calcium-induced calcium release channel of the cardiac s

76 ar free calcium concentrations by activating calcium-induced calcium release from intracellular store

77 he amplitude and duration of Ca2+ sparks and calcium-induced calcium release gain.

78 llular stores strongly implicates a role for calcium-induced calcium release in activity-dependent BD

79 6 microm resiniferatoxin caused a pronounced calcium-induced calcium release in either vanilloid rece

80 , they identify a physiological role for the calcium-induced calcium release in hippocampus and provi

81 It is concluded that partial inhibition of calcium-induced calcium release increases SR Ca2+ conten

82 to other stimuli through a ryanodine-based, calcium-induced calcium release mechanism.

83 Waves of calcium-induced calcium release occur in a variety of ce

84 latory release of calcium is inherent in the calcium-induced calcium release process.

85 f rapidly triggering neighboring channels by calcium-induced calcium release to evoke a puff, optimal

86 caffeine, which enhances the contribution of calcium-induced calcium release to the afterhyperpolariz

87 of cardiac excitation-contraction coupling ('calcium-induced calcium release') is now reasonably well

88 ux and hence a decrease in the gain of local calcium-induced calcium release).

89 reticulum and is released by the process of calcium-induced calcium release.

90 rs leads to mobilization of store calcium by calcium-induced calcium release.

91 eart cells are mediated by diffusion-coupled calcium-induced calcium release.

92 onstant amplitude; the spread was mostly via calcium-induced calcium release.

93 antrolene and ruthenium red, two blockers of calcium-induced calcium release.

94 uce the afterhyperpolarization by regulating calcium-induced calcium release.

95 actions of the ryanodine receptor by way of calcium-induced calcium release.

96 These findings indicate that calcium-induced calcium released from intraneuronal stor

97 ent with this possibility, administration of calcium-induced calcium-release blockers, as well as of

98 mic signaling is supported by a ROS-assisted calcium-induced calcium-release mechanism intimately inv

99 e conclude that a Ca(2+) diffusion-dominated calcium-induced calcium-release mechanism is insufficien

100 e release of intracellular calcium through a calcium-induced calcium-release mechanism.

101 During calcium-induced calcium-release, the ryanodine receptor

102 sor") whose intracellular dynamics involve a calcium-induced, calcium release process.

103 se two structures to form dyads within which calcium-induced-calcium-release occurs.

104 Activation is mediated by calcium-induced calmodulin binding to an IQ domain near

105 Calcium-induced calmodulin-mediated inhibition of myocar

106 Q motif binds apo-calmodulin (CaM), and that calcium-induced CaM release triggers a reversible confor

107 e role of tamoxifen in calcium signaling and calcium-induced cell death was studied in both malignant

108 lve the C-terminus and linker regions, these calcium-induced changes have implications for the role o

109 ry protein calmodulin is a major mediator of calcium-induced changes in cellular activity.

110 ion of native disulfide bonds and detectable calcium-induced changes in structure when the two C-term

111 in but depended on propagation of effects of calcium-induced changes in the C-terminal domain.

112 ermeation chromatography was used to resolve calcium-induced changes in the hydrated shape of CaM at

113 The other region that undergoes calcium-induced changes is at the receptor region, where

114 of calcium activation and the basis for the calcium-induced changes remain unclear.

115 vironment, using a biosensor that visualizes calcium-induced chloride ion flux in the cell.

116 t cysteine protease, effectively inhibit the calcium-induced cleavage of p35.

117 ed rate of dissociation is limited by a slow calcium-induced conformational change (3 s-1).

118 Helix 3, which undergoes a large, calcium-induced conformational change necessary for targ

119 t sequence in the hybrid protein undergoes a calcium-induced conformational change to bind to the cal

120 Q), and complete (E151Q,E188Q) disruption of calcium-induced conformational changes determined by NMR

121 Calcium-induced conformational changes expose a hydropho

122 toward describing the molecular dynamics of calcium-induced conformational changes in proteins using

123 ference in the A93G mutant that prevents the calcium-induced conformational changes in the S1 domain

124 148) were interpreted as directly reflecting calcium-induced conformational changes in whole calmodul

125 pray mass spectrometry investigations of the calcium-induced conformational changes of calbindin D(28

126 A plasmonic switch based on the calcium-induced conformational changes of calmodulin is

127 Biophysical studies of the calcium-induced conformational changes of CaM disagree o

128 Possible implications of this calcium-induced conformational switch for the membrane a

129 ccurs because of the antagonistic effects of calcium-induced contractility and stretch-activated calc

130 Similar to binary mixtures, subphase calcium induced contraction of ternary cholesterol-conta

131 t the same level as CaMKII in the pathway of calcium-induced CSF release by cooperating with CaMKII t

132 econd photolytic step originates from a slow calcium-induced dark rearrangement of the first intermed

133 ession of IFN-gamma, and of IL-2, depends on calcium-induced de novo transcription and PKC-dependent

134 V and CREB play a critical role in mediating calcium-induced dendritic growth in cortical neurons.

135 These experiments indicate that calcium-induced dendritic growth is regulated by activat

136 ate, CNS mitochondria maintained a sustained calcium-induced depolarization without appreciable swell

137 This calcium-induced depression of the kainate receptor curre

138 During calcium-induced desmosome assembly, treatment of primary

139 ail to exit S and G2/M phases in response to calcium-induced differentiation and also resist exhausti

140 up-regulated and correlated temporally with calcium-induced differentiation and expression of the la

141 ion of TIP39 in keratinocytes changed during calcium-induced differentiation and shifted to colocaliz

142 mary human keratinocytes that are undergoing calcium-induced differentiation can rapidly activate mat

143 required for mediating calcium signaling and calcium-induced differentiation in keratinocytes.

144 ent in cultured human keratinocytes and that calcium-induced differentiation markedly decreases SR-BI

145 Calcium-induced differentiation of these cells has been

146 keratinocytes and suggested that it signaled calcium-induced differentiation of these cells.

147 n keratinocytes and determined the effect of calcium-induced differentiation on its mRNA levels.

148 In isolated primary mouse keratinocytes, calcium-induced differentiation was accompanied by speci

149 s show alterations in plating efficiency and calcium-induced differentiation, but proliferate normall

150 During calcium-induced differentiation, H3K27me3 was erased at

151 examined its impact on calcium signaling and calcium-induced differentiation.

152 alcium response to extracellular calcium and calcium-induced differentiation.

153 hway integral to or overlapping with that of calcium-induced differentiation.

154 Enzyme activation requires calcium-induced dimerisation plus bilayer perturbation.

155 results suggest that passive clustering, via calcium-induced dimerization or membrane ordering, may c

156 This may arise from calcium-induced disruption of interactions between the a

157 Our results suggest that calcium-induced electrical instability may increase arrh

158 The calcium-induced endocytosis rate increase was a result o

159 the role of the calcium-sensing receptor in calcium induced epidermal differentiation, we investigat

160 In Parkinson's disease oxidative stress and calcium-induced excitotoxicity have been considered impo

161 but not kinase-dead Aurora B INCENP, blocked calcium-induced exit from metaphase arrest in egg extrac

162 sms of platelet secretion, we focused on the calcium-induced exocytosis of dense core granules.

163 Upon calcium-induced exocytosis, XlMyo1c is recruited to exoc

164 es cell proliferation and temporally affects calcium-induced expression of differentiation markers.

165 In this study, we examined the calcium-induced expression of the cytoprotective beta ce

166 The calcium-induced extracellular matrix of mucoid P. aerugi

167 Calcium-induced F-actin depolymerization was attenuated

168 The impact of calcium-induced fat droplet aggregation on the microstru

169 een identified as the PLA(2) responsible for calcium-induced fatty acid release and prostaglandin E(2

170 in fusion at the C-terminus likewise enabled calcium-induced folding but fusions solely at the N-term

171 This demonstrates that calcium-induced folding is an inherent property of the b

172 he involvement of individual residues in the calcium-induced folding reactions.

173 natural C-terminal flank was used to enable calcium-induced folding, pointing to its cooperative par

174 al muscle troponin activator, CK-2066260, on calcium-induced force development was studied in skinned

175 sesses critical determinants necessary for a calcium-induced functionally required conformation.

176 acking SV2 have fewer vesicles competent for calcium-induced fusion.

177 excitability, neurotransmitter release, and calcium-induced gene regulation.

178 ry keratinocytes were partially resistant to calcium-induced growth arrest.

179 We have previously demonstrated that calcium-induced human keratinocyte differentiation requi

180 phospholipase C (PLC)-gamma1 is required for calcium-induced human keratinocyte differentiation.

181 This activation is required for calcium-induced human keratinocyte differentiation.

182 mutation dramatically reduced the extent of calcium-induced hydrophobic exposure by the C-domain.

183 ix of CyaA makes extensive contacts with the calcium-induced, hydrophobic pocket of calmodulin.

184 Calcium-induced in vitro proteolysis was retarded in the

185 he dependence on diastolic calcium is due to calcium-induced inactivation of the L-type calcium curre

186 ke components (pf14 and pf17) do not exhibit calcium-induced increase in dynein activity in pCa4 buff

187 The calcium-induced increase in dynein activity in pf18 axon

188 is, increased p53 levels are necessary for a calcium-induced increase in neurons.

189 However, the calcium-induced increase in tau phosphorylation was inhi

190 of PP2A-Calpha and PP1alpha accelerated the calcium-induced increase in transepithelial electrical r

191 of calcium on energy or fat balance, despite calcium-induced increases (P <0.01) in postprandial seru

192 The calcium-induced increases in tau phosphorylation are not

193 Calcium-induced inhibition of cell proliferation and cal

194 decreased release probability is caused by a calcium-induced inhibition of presynaptic calcium channe

195 s causes calpain-mediated death at levels of calcium-induced injury that are sublethal to cells norma

196 CD26 activity was stimulated by calcium-induced intercellular adhesion in keratinocytes,

197 Yeast CcO also displayed a calcium-induced IR and UV/visible binding spectra, thoug

198 Priming is triggered via calcium-induced JNK signaling, which leads to upregulati

199 Here, we show that upon calcium-induced junction biogenesis in Madin-Darby canin

200 on 5, which were suggested to be involved in calcium induced keratinocyte differentiation.

201 MED21 expression also resulted in defects in calcium-induced keratinocyte differentiation, as indicat

202 ium channel-alpha and -beta increased during calcium-induced keratinocyte differentiation.

203 ation of PI3K and phospholipase C-gamma1 and calcium-induced keratinocyte differentiation.

204 Increased extracellular calcium-induced KLK5 and KLK7 mRNA expression and protei

205 Calcium-induced light-scattering, measured in vitro for

206 signal initiated by RyR1, perhaps through a calcium-induced mechanism.

207 oxygen species, and earlier formation of the calcium-induced membrane permeability transition pore.

208 uced uptake of calcium, but partly inhibited calcium-induced membrane scrambling.

209 ial respiration and increased sensitivity to calcium-induced mitochondrial permeability transition po

210 The threshold for calcium-induced mitochondrial permeability transition wa

211 Both the extent and rate of calcium-induced mitochondrial swelling and depolarizatio

212 am kinase MAPK kinase 3 (MKK3) increased the calcium induced MMP-9 gene expression, demonstrating tha

213 Together these data support a model wherein calcium-induced MMP-9 expression is differentially regul

214 These findings support a model whereby calcium-induced modification of PICK1 structure is criti

215 NFAT confirmed that the BTP compounds block calcium-induced movement of NFAT from the cytosol to the

216 ull mutants, and (3) raise the threshold for calcium-induced mPT in acutely prepared mitochondria fro

217 nd a similar increased susceptibility to the calcium-induced MPT in liver mitochondria isolated from

218 tochondria showed elevated susceptibility to calcium-induced MPTP opening, whereas mitochondrial oxid

219 e to fatty acyl-CoA-mediated augmentation of calcium-induced mPTP opening.

220 the palmitoyl-CoA-mediated amplification of calcium-induced mPTP opening.

221 lus ionomycin, TPA, and raised extracellular calcium, induced nuclear translocation of NFAT1 and calc

222 ion of CCTalpha with 14-3-3 zeta to initiate calcium-induced nuclear entry.

223 However, each isoform undergoes calcium-induced nuclear translocation from the cytoplasm

224 This human lens calcium-induced opacification (HLCO) model enables inves

225 is a critical mechanistic participant in the calcium-induced opening of the mitochondrial permeabilit

226 to longer distances by 8 to 11 A indicate a calcium-induced opening of the N-terminal domain conform

227 se in CaR mRNA in these cells as well as the calcium-induced opening of the nonspecific cation channe

228 ABA-induced, calcium-induced or spontaneous [Ca2+]cyt increases were

229 uard cells, experimentally imposing external calcium-induced oscillations rescued stomatal closure.

230 asome inhibitor, although only CSA inhibited calcium-induced permeability transition in liver-derived

231 sensitivity of mdx diaphragm mitochondria to calcium-induced permeability transition pore opening was

232 tenin at the plasma membrane is required for calcium-induced phospholipase C-gamma1 activation and, u

233 Moreover, we found that protein kinase C and calcium-induced phosphorylation of proteins thought to i

234 Calcium-induced PI3K recruitment to E-cadherin stabilize

235 6Q, E78Q were predicted to cause loss of the calcium-induced positive face in calprotectin, reducing

236 hat is reduced to 54% by calcium, permeating calcium-induced potentiation followed by closure, and re

237 Our work thus reveals a novel calcium-induced PP1 activation pathway critical for home

238 cal domain disulfides, are necessary for the calcium-induced progression from the molten globule towa

239 e formation induced by either alamethicin or calcium-induced PTP opening.

240 h aminophospholipid translocase activity and calcium-induced randomization of membrane phospholipids.

241 calcium transients with photolysis of caged calcium induced rapid outgrowth of axonal processes.

242 into the intercellular junctions during the calcium-induced reassembly of tight junction were much g

243 Calcium-induced reassembly of Y398D/Y402D mutant occludi

244 st that such interactions may be involved in calcium-induced reduction in the open probability of NMD

245 t depolarizes the hair cell and triggers the calcium-induced release of the neurotransmitter glutamat

246 Extracellular calcium induced repetitive [Ca2+]cyt transients with pea

247 ntisense phospholipase C-gamma1 to block the calcium-induced rise in intracellular calcium and found

248 lcium, is, in many cell types, the result of calcium-induced secretion of ATP and activation of purin

249 This calcium-induced secretion relies on the SNARE proteins b

250 The calcium-induced secretion was inhibited by a dominant-ne

251 However, only 1.2 mM calcium induced significant amounts of TGase activity.

252 specifically with nanomolar affinity to the calcium-induced SRCR conformation in an immobilized stat

253 tream of cytosolic calcium and extracellular calcium-induced stomatal closure were unaffected in era1

254 Mutations that interfered with the calcium-induced structural changes in PICK1 precluded LT

255 in is independent of ionic strength, and the calcium-induced structural transition is slightly inhibi

256 he role of gamma-carboxyglutamic acid in the calcium-induced structural transition of conantokin G, w

257 2)gamma(-/-) mice were markedly resistant to calcium-induced swelling in the presence or absence of p

258 Measurements of tissue NAD+ levels and calcium-induced swelling of mitochondria isolated at 3 m

259 ent anion channel and were more resistant to calcium-induced swelling than cardiac mitochondria from

260 ecretion signal, they are believed to act as calcium-induced switches that prevent folding before sec

261 Both constitutive and calcium-induced T-plastin expression was down-regulated

262 levels of alpha(6)p increased 3-fold during calcium-induced terminal differentiation in a normal mou

263 vel of AMPK phosphorylation increases during calcium-induced tight junction assembly and cell polariz

264 We found that AMPK is activated during calcium-induced tight junction assembly.

265 TF family, have been implicated in cAMP- and calcium-induced transcriptional activation.

266 N' region, do not play a direct role in the calcium-induced transition in the cardiac regulatory or

267 2)alpha) is regulated by phosphorylation and calcium-induced translocation to membranes.

268 cells expressing wild type cPLA(2)alpha, but calcium-induced translocation was not impaired.

269 amounts of Yops and display a defect in low-calcium-induced type III secretion of Yop proteins.

270 ion of dominant negative src and fyn blocked calcium-induced tyrosine phosphorylation of the regulato

271 (SLC25A27) and UCP5 (SLC25A14)), compromised calcium-induced uncoupling and increased oxidation of ma

272 Moreover, cGMP, not calcium, induced Unit I/-46GUS activity.

273 This peptide (PP-5) promoted calcium-induced vesicle aggregation of phosphatidylethan

274 pH (pH 4.0) of the BBMV suspension abolished calcium-induced vesicle aggregation, whereas treatment w

275 helium of M. sexta, caused a 50% decrease in calcium-induced vesicle aggregation.

276 rbimycin inhibited the rapid mobilization of calcium induced via CD40, suggesting that calcium mobili