ライフサイエンスコーパス: calcium-sensing receptor

1 d magnesium and are tightly regulated by the calcium-sensing receptor.

2 cytes, which is identical to the parathyroid calcium-sensing receptor.

3 o utilize a unique signaling mechanism via a calcium-sensing receptor.

4 blast-like cells involves a G-protein-linked calcium-sensing receptor.

5 ce, consistent with the existence of another calcium-sensing receptor.

6 eptor (CASR) is the prototypic extracellular calcium-sensing receptor.

7 is due to loss-of-function mutations of the calcium-sensing receptor, a guanine nucleotide-binding p

8 Calcium-sensing receptor activation was assessed in colo

9 calcimimetic compound NPS R-467, a selective calcium-sensing receptor activator, augmented the calciu

10 of studies have demonstrated a role for the calcium-sensing receptor along the entire gastrointestin

11 An antagonist to the calcium-sensing receptor and an activin receptor fusion

12 Calcimimetics target the calcium-sensing receptor and lower parathyroid hormone l

13 thways for pharmacological intervention, the calcium-sensing receptor and the receptor activator of n

14 ng its pathogenesis focus on the key role of calcium-sensing receptors and TRPV5 channels in the modu

15 Calcium sensing receptors are part of a growing G protei

16 heterocycles and their effects on the human calcium-sensing receptor are discussed.

17 V2 vasopressin receptor, ACTH receptor, and calcium-sensing receptor are responsible for retinitis p

18 Calcium-sensing receptors are present in membranes as di

19 t correlated in vivo with production of anti-calcium-sensing receptor autoantibodies, which are typic

20 This is the exact size of the calcium sensing receptor (Ca-SR).

21 n keratinocytes express both the full-length calcium sensing receptor (CaR) and an alternatively spli

22 ion(s) of the carboxyl terminus of the human calcium sensing receptor (CaR) by assessing extracellula

23 Activation of the calcium sensing receptor (CaR) by small increments in ex

24 e have recently reported the presence of the calcium sensing receptor (CaR) in keratinocytes and sugg

25 The calcium sensing receptor (CaR) is essential for mediatin

26 been previously shown that the extracellular-calcium sensing receptor (CaR) is expressed in intact ra

27 We previously reported that the calcium sensing receptor (CaR) is required for mediating

28 The aminoglycoside antibiotics (AGAs) are calcium-sensing receptor (CaR) agonists that are toxic t

29 ocytes express the full-length extracellular calcium-sensing receptor (CaR) and an alternatively spli

30 rat striatum revealed that the extracellular calcium-sensing receptor (CaR) could be involved in sens

31 The extracellular calcium-sensing receptor (CaR) forms a disulfide-linked

32 ed that the G protein-coupled, extracellular calcium-sensing receptor (CaR) forms disulfide-linked di

33 The calcium-sensing receptor (CaR) has an essential role in

34 r Ca(2+) (Ca(2+)(o)) functioning through the calcium-sensing receptor (CaR) induces E-cadherin-mediat

35 The calcium-sensing receptor (CaR) is a G protein-coupled re

36 The calcium-sensing receptor (CaR) is a G protein-coupled, s

37 The calcium-sensing receptor (CaR) is a G-protein-coupled re

38 The calcium-sensing receptor (CaR) is a G-protein-coupled re

39 The calcium-sensing receptor (CaR) is activated by small cha

40 The calcium-sensing receptor (CaR) is activated by small cha

41 The calcium-sensing receptor (CaR) is an allosteric protein

42 The calcium-sensing receptor (CaR) is the major sensor and r

43 The calcium-sensing receptor (CaR) modulates renal calcium r

44 functional significance of the extracellular calcium-sensing receptor (CaR) on human pancreatic beta-

45 , perhaps acting via the seven-transmembrane calcium-sensing receptor (CaR) on mature monocytes/macro

46 The calcium-sensing receptor (CaR) recently has been shown t

47 The G protein-coupled, extracellular calcium-sensing receptor (CaR) regulates parathyroid hor

48 te in the coding region of the extracellular calcium-sensing receptor (CaR) that are associated with

49 ncreasing the sensitivity of the parathyroid calcium-sensing receptor (CaR) to extracellular calcium.

50 Just a decade after the the calcium-sensing receptor (CaR) was identified, pharmacol

51 The calcium-sensing receptor (CaR), a member of G protein-co

52 ored by the G-protein coupled, extracellular calcium-sensing receptor (CaR), but neither its ontogeny

53 aste receptors (T1Rs), and the extracellular calcium-sensing receptor (CaR), represent a distinct gro

54 express the G protein-coupled, extracellular calcium-sensing receptor (CaR), showed that activation o

55 Recently, a calcium-sensing receptor (CaR), similar to the G protein

56 ons through the seven-transmembrane-spanning calcium-sensing receptor (CaR), which we identified as b

57 by extracellular calcium acting through the calcium-sensing receptor (CaR).

58 The extracellular calcium-sensing receptor (CaR; alternate gene names, CaR

59 g pathways in rat fibroblasts and implicates calcium-sensing receptors (CaR) as mediators of this res

60 Calcium-sensing receptors (CaR) contribute to regulation

61 Calcium-sensing receptors (CaR) regulate cell proliferat

62 ER, and CBS) expressed the human parathyroid calcium sensing receptor (CaSR) and that a function of e

63 SOCE) amplitude, cationic channel TRPC6, and calcium sensing receptor (CaSR) expression.

64 cent studies show that the human parathyroid calcium sensing receptor (CaSR) is expressed in human co

65 d SVR sequences, clustered within a group of calcium sensing receptor (CaSR) sequences.

66 reases in [Ca](o) activate the extracellular calcium sensing receptor (CaSR) which in turn inhibits n

67 ied the glycosylated extracellular domain of calcium-sensing receptor (CaSR) (ECD) (residues 20-612),

68 Here we show that the murine calcium-sensing receptor (CASR) activates the NLRP3 infl

69 Extracellular calcium-sensing receptor (CaSR) and ovarian cancer gene

70 through high-throughput screening as a novel calcium-sensing receptor (CaSR) antagonist.

71 A calcium-sensing receptor (Casr) belonging to the metabot

72 ed normally to activation of the parathyroid calcium-sensing receptor (Casr) by both hypercalcemia an

73 ed in the coding region of the extracellular calcium-sensing receptor (CASR) gene and cause human aut

74 Rare loss-of-function mutations in the calcium-sensing receptor (Casr) gene lead to decreased u

75 diabetes and to evaluate the association of calcium-sensing receptor (CaSR) gene single nucleotide p

76 deduced by the cloning of the extracellular calcium-sensing receptor (CaSR) in 1993 in the laborator

77 To understand the role of the calcium-sensing receptor (CasR) in the skeleton, we used

78 The calcium-sensing receptor (CaSR) is a G-protein-coupled r

79 The extracellular calcium-sensing receptor (CaSR) is the first identified

80 ino acid and extracellular cations, of which calcium-sensing receptor (CASR) is the prototypic extrac

81 The extracellular calcium-sensing receptor (CaSR) monitors the systemic, e

82 not have mutations in the gene encoding the calcium-sensing receptor (CASR) or AP2S1.

83 The calcium-sensing receptor (CASR) plays a pivotal role in

84 The calcium-sensing receptor (CaSR) provides a fundamental m

85 The calcium-sensing receptor (CaSR) regulates PTH secretion

86 amino acid-containing peptide agonist of the calcium-sensing receptor (CaSR) that is being evaluated

87 otein alpha-11 (Galpha11), which couples the calcium-sensing receptor (CaSR) to intracellular calcium

88 Activation of the calcium-sensing receptor (CaSR), a G-protein-coupled rec

89 was associated with higher expression of the calcium-sensing receptor (CaSR), a heterotrimeric G-prot

90 dium phosphate co-transporter (SLC34A1), the calcium-sensing receptor (CASR), and fibroblast growth f

91 oduce parathyroid hormone (PTH), express the calcium-sensing receptor (CASR), and mobilize intracellu

92 ride channel CLCNKB, barttin (BSND), and the calcium-sensing receptor (CASR), each of which is import

93 of plasma membrane constituents such as the calcium-sensing receptor (CaSR).

94 e regulator (CFTR), chymotrypsin (CTR)C, and calcium-sensing receptor (CASR).

95 ulator (CFTR), chymotrypsinogen C (CTRC) and calcium-sensing receptor (CASR).

96 id hormone receptor (PTH1R; type B), and the calcium-sensing receptor (CaSR; type C) using fluorescen

97 GLUT2, could act as a glucose sensor and the calcium-sensing receptor, CasR, could detect amino acids

98 his hypercalcaemia acts on the extracellular calcium-sensing receptor, CaSR, to promote fluid-driven

99 eport a central role in this process for the calcium-sensing receptor, CaSR, which enables cellular r

100 ctivity were attributable to the activity of calcium-sensing receptors (CaSRs), which appear to be fu

101 disulfide bond-mediated dimerization of the calcium-sensing receptor contributes to stabilization of

102 ial role for the G protein-coupled receptor, calcium-sensing receptor (CSR), in the regulation of Ca(

103 t (AP2S1) mutations, which result in altered calcium-sensing receptor endocytosis.

104 sphate response of cloned human keratinocyte calcium-sensing receptor expressed in human embryonic ki

105 hese results support the hypothesis that the calcium-sensing receptor expressed in keratinocytes medi

106 tide receptor, P2Y2 purinergic receptor, and calcium-sensing receptor) expressed in murine dendritic

107 The genetic mutations in the calcium-sensing receptor from patients with autosomal do

108 in of function, like the mutations effecting calcium-sensing receptor gain of function that cause aut

109 10(-22), minor allele frequency 14%) in the calcium-sensing receptor gene (CASR).

110 Identification of mutations of calcium-sensing receptor has improved our understanding

111 A homology model for the human calcium sensing receptor (hCaR) transmembrane domain uti

112 found that cells expressing wild-type human calcium-sensing receptor (hCaSR-wt) and its gain of func

113 In order to define the role of the calcium-sensing receptor in calcium induced epidermal di

114 vious studies demonstrated the presence of a calcium-sensing receptor in human keratinocytes, which i

115 ctly inhibit PTH secretion by activating the calcium-sensing receptor in the parathyroid glands, but

116 pport a role for the luminal and basolateral calcium-sensing receptors in mediating some of the effec

117 asts to extracellular calcium and imply that calcium-sensing receptors may play a role in regulating

118 The benefit of R-568 alone suggests calcium-sensing receptor modulation may have additional

119 um calcium is mediated by G-protein coupled, calcium-sensing receptors on parathyroid cells, whereas

120 stry of calcium equilibrium results from the calcium-sensing receptors on the parathyroid glands, whi

121 Acute activation of the calcium-sensing receptor or feeding a zero phosphate die

122 The recently cloned extracellular calcium-sensing receptor plays a central role in this pr

123 rotein, the phosphate cotransporter Pit-1, a calcium-sensing receptor related factor, osteoprotegerin

124 g gastric acid secretion through the stomach calcium-sensing receptor (SCAR) located on the basolater

125 mutations on Galpha11 protein structure and calcium-sensing receptor signaling in human embryonic ki

126 s of function, since Galpha11 is involved in calcium-sensing receptor signaling, and its gene (GNA11)

127 All studies were carried out on the human calcium-sensing receptor tagged at the carboxyl terminus

128 The calcimimetic cinacalcet HCl acts on the calcium-sensing receptor to increase its sensitivity to

129 ecreased the sensitivity of cells expressing calcium-sensing receptors to changes in extracellular ca

130 n D additionally regulates the expression of calcium-sensing receptors to indirectly alter PTH secret

131 In the future, manipulation of the calcium-sensing receptor using calcimimetic or calcilyti

132 the amount of biotinylated UT-A1 but not the calcium-sensing receptor was increased by forskolin.

133 racellular Ca(2+)-mediated activation of the calcium-sensing receptor was reduced by polyamines.

134 Candidate genes encoding the VDR and the calcium-sensing receptor were localized to regions on ra

135 calcimimetics, allosteric modulators of the calcium-sensing receptor, would reduce cyst growth by in