ライフサイエンスコーパス: calm

1 P180 and the presumed non-neuronal homologue CALM.

2 heavy chain is the major binding partner of CALM.

3 % difference in traffic calming (0.07, 95%CI: -0.07 to 0.20); proportion of scho

4 CALM-1, the calcium and integrin binding protein ortholo

5 r, and centromeric to the calmodulin-2 gene (CALM-2; 2p22-21) and son-of-sevenless gene (SOS; 2p22-21

6 Fusions of the CALM NES (NES(CALM)-AF10) or NES motifs from heterologous proteins (AB

7 ansformation by preventing nuclear export of CALM-AF10 and by upregulating the Hoxa5 gene through H3K

8 S) that mediates cytoplasmic localization of CALM-AF10 and is necessary for CALM-AF10-dependent trans

9 Thus, our study establishes CALM-AF10 fusion as a cause of leukaemia and reveals tha

10 chromosomal translocation gives rise to the CALM-AF10 fusion gene and is found in patients with aggr

11 The t(10;11) translocation results in a CALM-AF10 fusion gene in a subset of leukemia patients.

12 To assess the role of the CALM-AF10 fusion gene in leukemic transformation in vivo

13 e generated transgenic mice that expressed a CALM-AF10 fusion gene.

14 We demonstrate that CALM-AF10 fusion is both necessary and sufficient for le

15 erlying mechanism behind leukaemia caused by CALM-AF10 fusion.

16 nance energy transfer analysis, we show that CALM-AF10 has a propensity to homo-oligomerize, raising

17 b2 activation promotes the transformation of CALM-AF10 hematopoietic precursors toward B-lineage leuk

18 Finally, we observed that CALM-AF10 leukemia cells are selectively sensitive to in

19 tors as therapeutic agents for patients with CALM-AF10 leukemias.

20 ras, Kras, and Ptpn11 point mutations in the CALM-AF10 leukemic mice.

21 In leukemia cells, full-length CALM-AF10 localized to the nucleus with no consistent ef

22 CALM-AF10 mice infected with the MOL4070LTR retrovirus d

23 es from both clinically healthy and leukemic CALM-AF10 mice showed up-regulation of Hoxa cluster gene

24 genetic events are needed to complement the CALM-AF10 transgene and complete the process of leukemic

25 Expression of a CALM-AF10 transgene results in leukemia, with prolonged

26 We developed a mouse model of CALM-AF10(+) leukemia to examine the hypothesis that dis

27 integrations, suggesting cooperativity among CALM-AF10, Zeb2, and Ras pathway mutations.

28 The CALM NES is essential for CALM-AF10-dependent Hoxa gene up-regulation and aberrant

29 calization of CALM-AF10 and is necessary for CALM-AF10-dependent transformation.

30 CALM-AF10-driven leukemias are characterized by HOXA gen

31 hDOT1L contributes to CALM-AF10-mediated leukaemic transformation by preventin

32 een shown to be necessary and sufficient for CALM-AF10-mediated transformation.

33 eage leukemic transformation in concert with CALM-AF10.

34 he molecular mechanism of leukaemogenesis by CALM-AF10.

35 The identification of the CALM/AF10 fusion gene in the widely used U937 cell line

36 Ultrastructural analysis shows that CALM affiliates with a wider range of intracellular traf

37 e mechanism by which psychostimulants act as calming agents in humans with attention-deficit hyperact

38 CALM allowed choice of cognitive behavioral therapy (CBT

39 the two cargo-selecting, clathrin adaptors, CALM and AP2.

40 nerator, which regulates the balance between calm and arousal behaviors.

41 et was "sedated" or "very sedated" for 59%, "calm and cooperative" for 25%, and "unarousable" for 16%

42 n addition, patients were significantly less calm and happy and more anxious.

43 M, we engineered chimeric fusion proteins of CALM and its fragments with the green fluorescent protei

44 They must elicit information, calm and reassure, instruct, check procedures, ask for a

45 ate, temperature and water viscosity, winter calm and summer (iceberg and storm) disturbance and reso

46 ex (SWR) by changing the environment between calm and turbulent.

47 All patients had a clinical diagnosis of CALM and were treated with a Q-switched or picosecond la

48 about the operation of the viscera provide a calming and relaxing influence?

49 h actual suicide attempt, while 'feelings of calm' and 'positive feelings towards self' associated ne

50 itation Sedation Scale score of 0 (alert and calm) and requires failure of intermittent sedative dosi

51 "Cafe-au-lait" macules (CALMs) and overall skin hyperpigmentation are early hall

52 11 transcription factor (SOX11), calmodulin (CALM), and estrogen receptor 2 (ESR2A), all with a signi

53 otein (Bip), calpactin I (CalP), calmodulin (CalM), and Sik similar protein (Sik-SP) genes in ovariec

54 as been used for centuries to promote mental calming, and it is used clinically to suppress excessive

55 rminal halves of their SNARE motifs bind the CALM(ANTH) domain as helices in a manner that mimics SNA

56 Bip, CalP, and CalM are calcium-binding proteins and implicated in calc

57 interference (RNAi) indicate that AP180 and CALM are dispensable for some aspects of embryonic neuro

58 Epsin and AP180/CALM are endocytotic accessory proteins that have been i

59 assembly lymphoid myeloid leukemia protein (CALM) are clathrin accessory proteins that promote the f

60 assembly lymphoid myeloid leukemia protein (CALM), are closely related proteins that play important

61 al and spatial resolution under low wind and calm atmospheric conditions.

62 presenting mainly with cafe au lait macules (CALMs), axillary freckling, and macrocephaly.

63 the substratum even in conditions mimicking calm back-reef flow environments.

64 ult mice left breathing intact but increased calm behaviors and decreased time in aroused states.

65 The C-terminal part of CALM binds clathrin heavy chain, although the full-lengt

66 onsolation of distressed parties by means of calming body contact.

67 the structure of the NH2-terminal domain of CALM bound to phosphatidylinositol-4,5- bisphosphate [Pt

68 Effect sizes favored CALM but were not statistically significant for other co

69 can be rescued by re-expression of wild-type CALM, but not with CALM that lacks a functional N-termin

70 ing Q-switched or picosecond lasers to treat CALMs can use morphologic characteristics to help predic

71 Here we demonstrate that depletion of CALM causes a substantial increase in the ratio of "open

72 AF10 is fused to a novel gene that we named CALM (Clathrin Assembly Lymphoid Myeloid leukemia gene)

73 elated clathrin assembly proteins, AP180 and CALM (clathrin assembly lymphoid myeloid leukemia protei

74 The clathrin assembly proteins AP180 and CALM (clathrin assembly lymphoid myeloid protein) are kn

75 MLL, AF10 has also been reported to fuse to CALM (clathrin-assembly protein-like lymphoid-myeloid) i

76 CALM (cognitive behavior therapy and pharmacotherapy med

77 CALM (cognitive behavior therapy and pharmacotherapy rec

78 y disorders treated in primary care clinics, CALM compared with UC resulted in greater improvement in

79 Coordinated Anxiety Learning and Management (CALM) compared with UC in 17 primary care clinics in 4 U

80 Here, we show that CALM contains a nuclear export signal (NES) that mediate

81 Additionally, CALM-deficient neurons show disrupted secretory transpor

82 tosis is reduced in both AP180-deficient and CALM-deficient neurons.

83 The phenotypic effects of CALM depletion can be rescued by re-expression of wild-t

84 -assembly lymphoid myeloid leukemia protein, CALM, did not influence transferrin endocytosis but cons

85 and the subsequent socializing they seek to calm down.

86 formation flow between circuits, probably by calming down the overactive cells.

87 uenceswhat distressed youngsters learn about calming down.

88 ) in paediatric patients requires them to be calm during the procedure to avoid motion artefacts in t

89 We assessed the calming effect of doppel, a wearable device that deliver

90 This paradoxical calming effect of psychostimulants depended on serotoner

91 r, but not with non-nutritive sweetener, has calming effect on consumers with acute stress, suggestin

92 st holding - by human mothers has a specific calming effect on crying infants, inducing a coordinated

93 delivered through doppel, had a significant calming effect on physiological arousal and subjective e

94 ested whether the use of doppel would have a calming effect on physiological arousal and subjective r

95 ntic Ocean, Franklin observed that oil had a calming effect on waves when poured into rough ocean wat

96 These results may be relevant to GFC's calming effects in attention deficit hyperactivity disor

97 um management should also include ensuring a calming environment and adequate pain control, minimizin

98 CALM expands the applications of SM imaging techniques b

99 dentify the developmental stage of AP180 and CALM expression and suggest that each protein has distin

100 Furthermore, altered CALM expression exacerbates tau-mediated toxicity in zeb

101 d to measure neural responses to fearful and calm faces presented preattentively (for 17 ms followed

102 Amygdala response to fearful and calm faces was predicted to differentiate groups, with t

103 CALM-FIM_EUR was a prospective, first-in-human, open-lab

104 complementation-activated light microscopy (CALM) for subresolution imaging of individual membrane p

105 Exclusion of the C-terminal portion of CALM from the fusion protein, which is required for opti

106 We propose that both AP180 and CALM function as endocytic accessory proteins at synapse

107 clathrin assembly lymphoid myeloid leukemia (CALM) gene encodes a putative homologue of the clathrin

108 The PICALM (CALM) gene, whose product is involved in clathrin-mediat

109 onversely, neurons that overexpress AP180 or CALM generate multiple axons.

110 achieve selective knockdown of any of the 3 CALM genes, making it a generalizable therapeutic strate

111 CALM has a very high homology in its N-terminal third to

112 we found high expression levels of AP180 and CALM in hippocampal tissues as early as embryonic day 18

113 e previously unknown functions for AP180 and CALM in intracellular trafficking that are essential in

114 However, the precise role of CALM in leukemogenesis remains unclear.

115 We found AP180 and CALM in synapses at all developmental stages and in nons

116 y to establish the distribution of AP180 and CALM in the developing hippocampal synapses.

117 most important during the resolution phase, calming inflammation and the activation state of dendrit

118 Long thought to be potassium channels with calming influence quietly working away in the background

119 CALM influences autophagy by regulating the endocytosis

120 Clathrin-CALM interaction seems to be regulated by multiple conta

121 n by restricting their release of gametes to calm intervals.

122 Altogether, the data suggest that CALM is an important component of coated pit internaliza

123 edominantly in presynaptic profiles, whereas CALM is found nonselectively in pre- and postsynaptic pr

124 INTERPRETATION: CALM is the first study to show that timely escalation w

125 Thus, CALM is the second protein besides Grb2 that appears to

126 CALM is thus a major factor in controlling CCV size and

127 to laser treatment for cafe au lait macules (CALMs) is inconsistent and difficult to predict.

128 impairs axonal development, whereas reducing CALM levels results in dendritic dystrophy.

129 Interaction analyses suggest 'calm' moderates the association of 'love' with suicide a

130 Here we show that CALM modulates autophagy and alters clearance of tau, a

131 udy suggests that the AD genetic risk factor CALM modulates autophagy, and this may affect disease in

132 Fusions of the CALM NES (NES(CALM)-AF10) or NES motifs from heterologou

133 The CALM NES is essential for CALM-AF10-dependent Hoxa gene

134 and have risen as much on windy nights as on calm nights, indicating that the observed overall warmin

135 est the hypothesis that irregularly bordered CALMs of the "coast of Maine" subtype respond better to

136 ne, we also report the presence of AP180 and CALM on other types of membrane structures.

137 CALM, on the other hand, is expressed as early as E12, b

138 l effects of psychostimulants, including the calming ones, in attention deficit hyperactivity disorde

139 High levels of expression of GFP-CALM or its fragments with clathrin-binding activity inh

140 rly in the absence of protective feelings of calm or positive self-view associated with current attem

141 In addition, GFP-CALM overexpression caused the loss of clathrin accumula

142 lved in endocytic trafficking such as PICALM/CALM (phosphatidylinositol binding clathrin assembly pro

143 may provide insight into the association of CALM/PICALM mutations with growth retardation, cognitive

144 s4,5P(2)-binding, endocytic clathrin adaptor CALM/PICALM.

145 Here we provide evidence that AP180 and CALM play critical roles in establishing the polarity an

146 calization, and the role in endocytosis of a CALM protein were studied.

147 and Yap1801/2 (homologues of epsin and AP180/CALM proteins), with a plasmid encoding Ent1 or Yap1802

148 Thus, CALM:R-SNARE interactions ensure that R-SNAREs, required

149 s were often interpreted as omens, while the calm regularity of the astronomical cycles must have bee

150 CALM's role in directing the endocytosis of small R-SNAR

151 e anxious or agitated (SAS 5 to 7), 26% were calm (SAS 4), and 29% were sedated (SAS 1 to 3).

152 Mutation of residues in the CALM:SNARE interface inhibits binding in vitro and preve

153 e-expression of wild-type CALM, but not with CALM that lacks a functional N-terminal, membrane-insert

154 tween loss of heterozygosity and the typical CALMs that appear over the general hyperpigmentation.

155 The assembly protein CALM, the ubiquitously expressed homolog of AP180, also

156 23 mothers (92.2%) and 2923 fathers (88.9%), calming their infant, 11396 mothers (94.6%) and 3035 fat

157 96 mothers (94.6%) and 3035 fathers (91.9%), calming themselves; 10060 mothers (85.1%) and 2688 fathe

158 The ability of the GFP-tagged fragments of CALM to affect clathrin-mediated processes correlated wi

159 Our observations link AP180 and CALM to multiple vesicular organelles and raise the poss

160 A significantly greater improvement for CALM vs UC in global anxiety symptoms was found (BSI-12

161 At 12 months, response and remission rates (CALM vs UC) were 63.66% (95% CI, 58.95%-68.37%) vs 44.68

162 CALM was an open-label, randomised, controlled phase 3 s

163 The bulk of cellular CALM was associated with the membrane fractions of the c

164 In the membrane fraction, CALM was present at near stoichiometric amounts relative

165 CALM was superior to UC for comorbid SAD at 6-month (-4.

166 CALM was superior to UC for principal GAD at 6-month (-1

167 GFP-CALM was targeted to the plasma membrane-coated pits and

168 We found the headspace above calm water provides an excellent environment for NP depo

169 To perform structure-function analysis of CALM, we engineered chimeric fusion proteins of CALM and

170 es; P < .001), and were more often awake and calm while intubated (median, 86% [IQR, 67%-100%] of day

171 CALMs with jagged or ill-defined borders of the coast of

172 Of 94 probands with familial CALMs with or without freckling and no other NF1 feature

173 lies with an autosomal dominant phenotype of CALMs with or without freckling and no other NF1 feature

174 riteria based on the presence of more than 5 CALMs with or without freckling or an NF1-compatible fam