ライフサイエンスコーパス: calmodulin

1 in a process depending on Ca binding to CaM (calmodulin).

2 ctivation of Ca2+ -sensitive enzymes such as calmodulin.

3 ssium channels that are activated by calcium-calmodulin.

4 ated Na channels, also potently regulated by calmodulin.

5 interaction of the RS20 peptide and calcium-calmodulin.

6 on and its potential regulators, CAMK IV and calmodulin.

7 mbrane via a peripheral protein complex with calmodulin.

8 e and reveal that the enzyme is regulated by calmodulin.

9 inase A (PKA)-independent CFTR activation by calmodulin.

10 ted at the interface between the channel and calmodulin.

11 teins are instead shielded in the cytosol by calmodulin.

12 Expressions of TRPC3, TRPC4, and calmodulin 1 are increased in the myotubes, and MG53 dir

13 Our results indicate that calmodulin 1a (calm1a), expressed specifically in the MH

14 e target proteins: an alpha-helical protein (calmodulin), a protein with internal cysteines (rubredox

15 nctional roles enhanced by interactions with calmodulin, accessory proteins, or CaMKII that modulate

16 Specifically Ca2+/calmodulin activated kinase II, protein kinase A and exc

17 Calcineurin, the conserved Ca(2+)/calmodulin-activated phosphatase, is required for viabil

18 ABSTRACT: Ca(2+) /calmodulin activation of myosin light chain kinase (MLCK

19 tic spine, we show that SK-channels regulate calmodulin activation specifically during neuron-firing

20 Dynamic release from calmodulin allowed sampling of the endoplasmic reticulum

21 Human calmodulin and bovine ribonuclease S (RNase S) were scre

22 Furthermore, the modulation of UBE3B via calmodulin and calcium implicates a role for calcium sig

23 tegy to characterize the interaction between calmodulin and creatine kinase, which we identify as a n

24 onpalmitoylated state 1, like K-Ras4B, binds calmodulin and is associated with colorectal and other a

25 at disrupts regulation of CaV2.1 channels by calmodulin and related calcium sensor proteins.

26 rmine that the T3SS effector, HopE1, targets calmodulin and the microtubule-associated protein MAP65-

27 A subset of mammalian N-BAR domains bound calmodulin, and co-expression of calmodulin with endophi

28 intracellular calcium, protein kinase C, and calmodulin, and downstream signaling regulated the relea

29 nner dynein arms, the radial spokes, and the calmodulin- and spoke-associated complex.

30 e eagD and cNBHD interact to modulate Ca(2+)-calmodulin as well as voltage-dependent gating.

31 0.1, or Eag1, bound to the channel inhibitor calmodulin, at 3.78 angstrom resolution.

32 Calmodulin-based genetically encoded fluorescent calcium

33 ins and typically comprise two domains, with calmodulin being the archetypal example.

34 ng of ATP (betaK43R and alphaK42M) or Ca(2+)/calmodulin (betaA303R) had no effect on the interaction

35 motif (amino acids 29-58) results in loss of calmodulin binding and a significant increase in the in

36 We describe the competition between calmodulin binding and PKA phosphorylation and the diffe

37 These observations show that calmodulin binding contributes to SPB mechanical integri

38 Calmodulin binding enhanced TRPA1 sensitivity and Ca(2+)

39 , we identified the eNOS peptide as the only calmodulin binding peptide and S peptide as the only rib

40 inding transcription activators (CAMTA)3 and calmodulin binding protein 60g (CBP60g) together amplify

41 rinciple to the long-standing controversy of calmodulin binding to ion channels, we find a surprising

42 domain toward cytochrome c; (v) response to calmodulin binding; and (vi) the rates of interflavin ET

43 lmodulin (CaM) molecules associated with the calmodulin-binding domain (CaM-BD) of these channels.

44 domains, the autoinhibitory domain (AID) and calmodulin-binding domain (CBD), which block the catalyt

45 ion of the carboxy-lobe of calmodulin with a calmodulin-binding domain in the C-terminus of TRPA1.

46 us for a 2 base pair (bp) deletion within IQ calmodulin-binding motif-containing protein-1 (IQCB1), t

47 ctrin-specific domain and Kv7 channel 1-5-10 calmodulin-binding motifs.

48 Calmodulin-binding mutants of Rvs167 exhibited defects i

49 ly adjacent sequence homologous to canonical calmodulin-binding peptides.

50 2 domain containing 3), and Strn3 (Striatin, calmodulin-binding protein 3).

51 We identify a calmodulin-binding protein as a key regulator in the hos

52 ansient membrane-interactions, it contains a calmodulin-binding region, suggesting that in vivo FaEO

53 Furthermore, removal of the calmodulin-binding site from the SPB component Spc110 we

54 RSRE induction via the transcription factor CALMODULIN-BINDING TRANSCRIPTION ACTIVATOR 3 (CAMTA3), i

55 Calcium, calmodulin, calmodulin-binding transcription activators (CAMTA)3 and

56 and constriction by wild-type Rvs167 but not calmodulin-binding-defective mutants.

57 dulin stoichiometry with Ca(2+) channels-one calmodulin binds at basal cytosolic Ca(2+) levels while

58 eceptor and the combined effect of the rapid calmodulin buffer and the frequency-dependent increase i

59 AFM and then measuring the stabilization of calmodulin by myosin light chain kinase at dramatically

60 demonstrate that upon Ca(2+) influx, Ca(2+)/calmodulin (Ca(2+)/CaM) binding to the N-terminus of PSD

61 gered by a conformational change upon Ca(2+)/calmodulin (Ca(2+)/CaM) binding.

62 strictly depends on Ca(2+) and Ca(2+)-bound calmodulin (Ca(2+)/CaM) to relieve autoinhibition of the

63 s revealed that extinction recruited calcium/calmodulin (Ca(2+)/CaMK)-dependent protein kinase II (Ca

64 HR), the SOX11 transcription factor (SOX11), calmodulin (CALM), and estrogen receptor 2 (ESR2A), all

65 Calcium, calmodulin, calmodulin-binding transcription activators

66 represent cellular Ca(2+) sensors, including calmodulin (CaM) 3, CaM7 and several CaM-like proteins,

67 ing of calcium to its intracellular receptor calmodulin (CaM) activates a family of Ca(2+)/CaM-depend

68 results in an order of magnitude decrease in calmodulin (CaM) activation, providing a mechanism for t

69 The calcium-sensor calmodulin (CaM) acts as a common activator of the netwo

70 How calmodulin (CaM) acts in KRAS-driven cancers is a vastly

71 Calcium signalling mediated by Calmodulin (CaM) and calmodulin-like (CML) proteins is c

72 Calmodulin (CaM) and closely related calmodulin-like (CM

73 The proximal Kv7.1 C terminus (CT) binds calmodulin (CaM) and phosphatidylinositol-4,5-bisphospha

74 t requires binding of the incoming Ca(2+) to calmodulin (CaM) and subsequent binding of CaM to the pr

75 in the intracellular Ca(2+)-sensing protein calmodulin (CaM) are arrhythmogenic, yet their underlyin

76 PDEdelta and the Ca(2+)-binding protein calmodulin (CaM) are known to function as potential bind

77 functional calcium-binding messenger protein Calmodulin (CaM) as a function of temperature and Ca(2+)

78 Here, we have studied calmodulin (CaM) as a more universal carrier protein to

79 dothelial NO synthase (eNOS) is triggered by calmodulin (CaM) binding and is often further regulated

80 segment of the channel important for Ca(2+)/calmodulin (CaM) binding as evidenced by bio-layer inter

81 e rates of Ca(2+) binding to the C-domain of calmodulin (CaM) by an unknown mechanism.

82 d in a case study, where we synthesize human calmodulin (CaM) by using a CFPS kit and prove the struc

83 on microscopy (cryo-EM) structure of a KCNQ1/calmodulin (CaM) complex.

84 Furthermore, whether calmodulin (CaM) contributes to CPK regulation, as is th

85 C activates TRPC6 channels is not known, but calmodulin (CaM) contributes to the regulation of TRPC c

86 ypothesis that S100A1 directly competes with calmodulin (CaM) for binding to intact, functional ryano

87 Calmodulin (CaM) has been shown to regulate DR5-mediated

88 Calmodulin (CaM) is a Ca(2+) binding protein modulating

89 Calmodulin (CaM) is a Ca(2+)-sensing protein that is hig

90 Calmodulin (CaM) is a ubiquitous Ca(2+) sensor and a cru

91 Calmodulin (CaM) is encoded by 3 genes, CALM1, CALM2, an

92 (+) channels are gated by calcium binding to calmodulin (CaM) molecules associated with the calmoduli

93 Calmodulin (CaM) mutations are associated with severe fo

94 ng is dependent on Abp1 as well as on Ca(2+)/calmodulin (CaM) signaling and CaM association.

95 It also engages calmodulin (CaM) to reduce subsequent NMDA receptor acti

96 ular rearrangements and its interaction with Calmodulin (CaM) under activation by chemical agonists a

97 activates mTORC1 by inducing association of calmodulin (CaM) with mTOR.

98 Calmodulin (CaM), a Ca(2+)-sensing protein, is constitut

99 ifs in their C termini, which associate with calmodulin (CaM), a universal calcium sensor.

100 with the calcium-binding messenger protein, calmodulin (CaM), and phosphorylation of the CaM-binding

101 be negatively regulated by the Ca(2+) sensor calmodulin (CaM), and previous work has focused on a C-t

102 n, and fragments of the beta-tubulin (BenA), calmodulin (CaM), and RNA polymerase II second largest s

103 HopE1 effector uses the host calcium sensor, calmodulin (CaM), as a co-factor to target the microtubu

104 rectly regulates AKAP79 through its effector calmodulin (CaM), but the molecular basis of this regula

105 ction of Syt-7 on SG recruitment may involve calmodulin (CaM), pretreatment of islets with CaM blocke

106 by desensitizing the CNG channel via Ca(2+)/calmodulin (CaM), to reduce the response.

107 meric and tetradecameric forms, and that the calmodulin (CaM)-binding element of CaMKII can bind to t

108 this form of LQTS is a disruption of Ca(2+)/calmodulin (CaM)-dependent inactivation of L-type Ca(2+)

109 nel P2X4 regulates lysosome fusion through a calmodulin (CaM)-dependent mechanism.

110 longation factor 2 kinase (eEF-2K), the only calmodulin (CaM)-dependent member of the unique alpha-ki

111 citatory synapse strength require the Ca(2+)/calmodulin (CaM)-dependent protein kinase II (CaMKII) an

112 lly composed of one or two subunits, calcium-calmodulin (CaM)-dependent protein kinase II (CaMKII) is

113 We observed that Ca(2+)/calmodulin (CaM)-dependent protein kinase kinase 2 (beta

114 In calmodulin (CaM)-rich environments, oncogenic KRAS plays

115 We investigated the impact of bound calmodulin (CaM)-target compound structure on the affini

116 and phosphorylation in the absence of Ca(2+)/calmodulin (CaM).

117 a ryanodine receptor (RyR) peptide bound to calmodulin (CaM).

118 olled by ER-alpha is modulated by Ca(2+) via calmodulin (CaM).

119 ation in breast cancer cells is modulated by calmodulin (CaM).

120 Although S100B-RSK1 and the calmodulin-CAMKII system are clearly distinct functional

121 The model suggests that calmodulin can act as a protein cross-linker and Spc29 i

122 atase calcineurin (CN) by stabilizing the CN-calmodulin complex, relieving enzymatic autoinhibition a

123 lcium, which results in formation of calcium-calmodulin complexes, followed by recruitment of eNOS fr

124 A protein with similarities to the Ca(2+)/ calmodulin dependent protein kinase II_association domai

125 The Ca(2+)-calmodulin dependent protein kinase kinase-2 (CaMKK2) is

126 Moreover, the NCAM antibody triggers calmodulin-dependent activation of nitric oxide synthase

127 er, they were associated with reduced Ca(2+)/calmodulin-dependent auto-phosphorylation of eEF2 kinase

128 autophosphorylation (activation) of calcium/calmodulin-dependent kinase 2 (CaMKII) and also that inh

129 The Ca(2+) and redox-sensing enzyme Ca(2+) /calmodulin-dependent kinase 2 (CaMKII) is a crucial and

130 We used alpha subunit of the calcium/calmodulin-dependent kinase II (alphaCaMKII) mutant mice

131 dynamin-related protein 1 (Drp1), by Ca(2+)/calmodulin-dependent kinase II (CaMKII) at a serine 616

132 glucagon-induced calcium signaling, calcium/calmodulin-dependent kinase II (CaMKII) phosphorylates O

133 lar LTD depends on the activation of calcium/calmodulin-dependent kinase II (CaMKII).

134 NK1 in vitro Inhibiting PKC, JNK, or calcium/calmodulin-dependent kinase II activity prevented the ef

135 y-dependent phosphorylation event on calcium-calmodulin-dependent kinase II alpha (CaMKIIalpha) at se

136 horylation directly through JNK1 and calcium/calmodulin-dependent kinase II and also by inducing expr

137 FIP2 expression also increases alpha-calcium/calmodulin-dependent kinase II protein expression, and t

138 ude local synthesis of APP and alpha-calcium/calmodulin-dependent kinase II, a kinase that can phosph

139 Ca(2+)/calmodulin-dependent kinase kinase beta (CaMKKbeta) emer

140 utophagy via a pathway that included calcium/calmodulin-dependent kinase kinase beta (CaMKKbeta), AMP

141 n of antiapoptotic protein (c-IAP-2) through calmodulin-dependent kinase-II activation.

142 endent on the relative activities of Ca(2+) /calmodulin-dependent myosin light chain kinase (MLCK) an

143 ght chain (RLC) is phosphorylated by Ca(2+) /calmodulin-dependent myosin light chain kinase and depho

144 ends on the respective activities of Ca(2+) /calmodulin-dependent myosin light chain kinase and myosi

145 Scaffolding the calcium/calmodulin-dependent phosphatase 2B (PP2B, calcineurin)

146 BAA signaling by calcineurin, a calcium- and calmodulin-dependent phosphatase, enables homeostatic ba

147 Psi Here, we characterize a role for calcium/calmodulin-dependent protein kinase (CaMK) I in the regu

148 +)-dependent binding of S100B to the calcium/calmodulin-dependent protein kinase (CaMK)-type domain o

149 ore than 20 years, we have known that Ca(2+)/calmodulin-dependent protein kinase (CaMKII) activation

150 Mice with Ca(2+) -calmodulin-dependent protein kinase (CaMKII) constitutiv

151 prevent the arrhythmias induced by a Ca(2+) -calmodulin-dependent protein kinase (CaMKII)-dependent l

152 cannabinoid type 1 (CB1) receptor and Ca(2+)/calmodulin-dependent protein kinase beta, activates AMP-

153 Here, we show that Ca2+/calmodulin-dependent protein kinase gamma (CaMKIIgamma)

154 Mechanistically, calmodulin-dependent protein kinase I phosphorylates a R

155 oA activity in the cell body through calcium/calmodulin-dependent protein kinase I.

156 Calcium/calmodulin-dependent protein kinase II (CAMK2) is one of

157 tate (NMDA) receptor activation, and Calcium/calmodulin-dependent protein kinase II (CaMKII) activati

158 y (SOCE) and sequential activation of Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) and Ca(2

159 We show that phosphorylation by Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) and Polo

160 phorylated at serine 409 (Ser-409) by Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) and prot

161 The Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) assemble

162 Calcium/calmodulin-dependent protein kinase II (CaMKII) binds to

163 Here we show that the activity of calcium/calmodulin-dependent protein kinase II (CaMKII) is incre

164 Considerable evidence suggests that calcium/calmodulin-dependent protein kinase II (CaMKII) overacti

165 nhanced [(3) H]ryanodine binding and Ca(2+) /calmodulin-dependent protein kinase II (CaMKII) phosphor

166 treated wild-type C57BL/6 mice with calcium/calmodulin-dependent protein kinase II (CaMKII) specific

167 Here, we show that activated Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) strongly

168 Localization of the Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) to dendr

169 which in turn requires binding of the Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) to the N

170 In contrast, when the calcium-calmodulin-dependent protein kinase II (CaMKII) was bloc

171 In contrast, when the calcium/calmodulin-dependent protein kinase II (CaMKII) was bloc

172 CaMK2N2 are endogenous inhibitors of calcium/calmodulin-dependent protein kinase II (CaMKII), a key s

173 triggers the exchange of subunits in Ca(2+)/calmodulin-dependent protein kinase II (CaMKII), an olig

174 tream effector of WNT/Ca(2+) pathway, Ca(2+)/calmodulin-dependent protein kinase II (CaMKII), led to

175 scular smooth muscle (VSM) expresses calcium/calmodulin-dependent protein kinase II (CaMKII)-delta an

176 ators of myocardial excitability, and Ca(2+)/calmodulin-dependent protein kinase II (CaMKII)-dependen

177 he hypotheses that (1) inhibition of Ca(2+) /calmodulin-dependent protein kinase II (CAMKII)-mediated

178 o the model reveal that inclusion of Ca(2+) /calmodulin-dependent protein kinase II (CAMKII)-mediated

179 NMDA receptor-dependent activation of Ca(2+)/calmodulin-dependent protein kinase II (CaMKII).

180 est was mediated by the activation of Ca(2+)/calmodulin-dependent protein kinase II (CaMKII).

181 increase in oxidation-dependent calcium and calmodulin-dependent protein kinase II activity, which c

182 -d-aspartate receptor activation and calcium/calmodulin-dependent protein kinase II activity.

183 Alcohol-sensitive proteins included calcium/calmodulin-dependent protein kinase II alpha (CaMKIIalph

184 rrhythmic manifestations, related to Ca(2+) /calmodulin-dependent protein kinase II and ryanodine rec

185 The calcium/calmodulin-dependent protein kinase II delta (CAMK2D), w

186 The multifunctional Ca(2+)/calmodulin-dependent protein kinase II delta-isoform (Ca

187 Here, we show that calcium/calmodulin-dependent protein kinase II gamma (CAMK2gamma

188 Here, Ca(2+)/calmodulin-dependent protein kinase II gamma (CAMKIIgamm

189 Calcium/calmodulin-dependent protein kinase II gamma knockout mi

190 A null mutation of the Drosophila calcium/calmodulin-dependent protein kinase II gene (CaMKII) was

191 ion and subsequent activation of calcium and calmodulin-dependent protein kinase II has a causal role

192 eam signaling protein, PKC-alpha, and Ca(2+)/calmodulin-dependent protein kinase II in endothelial ce

193 2B, also referred to as Pyk2) and of calcium/calmodulin-dependent protein kinase II in wild-type brai

194 Development of organ-specific calcium and calmodulin-dependent protein kinase II inhibitors may re

195 rom transgenic mice expressing a calcium and calmodulin-dependent protein kinase II inhibitory peptid

196 as phosphorylation of substrates for calcium/calmodulin-dependent protein kinase II was unchanged.

197 Pharmacologic inhibition of calcium and calmodulin-dependent protein kinase II with 2.5 microM o

198 stabilization of postsynaptic CaMKII (Ca(2+)/calmodulin-dependent protein kinase II) at inhibitory sy

199 mitochondrial recruitment of CaMKII (Ca(2+)/calmodulin-dependent protein kinase II), which decreases

200 ng protein, but not the activation of Ca(2+)/calmodulin-dependent protein kinase II, Akt or mitogen-a

201 ellular protein mediators Homer1b/c, calcium/calmodulin-dependent protein kinase II, and the Alzheime

202 a(2+) must first mobilize actin-bound Ca(2+)/calmodulin-dependent protein kinase II, freeing it for s

203 Calcium and calmodulin-dependent protein kinase II, through phosphor

204 turn, led to the phosphorylation of calcium/calmodulin-dependent protein kinase II, which promoted b

205 at have the ryanodine receptor 2 calcium and calmodulin-dependent protein kinase II-dependent phospho

206 used 1 Hz optogenetic stimulation of calcium/calmodulin-dependent protein kinase II-positive principa

207 sarcoplasmic reticulum and activated Ca(2+)/calmodulin-dependent protein kinase II.

208 dent on calcium influx and linked to calcium/calmodulin-dependent protein kinase II.

209 Furthermore, calcium/calmodulin-dependent protein kinase IIalpha (CaMKIIalpha

210 is study, we investigated the role of Ca(2+)/calmodulin-dependent protein kinase IIalpha (CaMKIIalpha

211 d cardiomyocyte apoptosis, fibrosis, calcium/calmodulin-dependent protein kinase IIdelta phosphorylat

212 as a direct inhibitor of CaMKIIdelta (Ca(2+)/calmodulin-dependent protein kinase IIdelta) activity, a

213 ive oxygen species (ROS) production, calcium/calmodulin-dependent protein kinase IV (CaMKIV) activati

214 ally reduced by the application of a calcium/calmodulin-dependent protein kinase kinase 2 inhibitor (

215 istic target of rapamycin complex 1, calcium/calmodulin-dependent protein kinase kinase 2, and protei

216 PK kinases liver kinase B1 (LKB1) and Ca(2+)/calmodulin-dependent protein kinase kinase beta (CaMKKbe

217 AMPK activation by aa is mediated by Ca(2+)/calmodulin-dependent protein kinase kinase beta (CaMKKbe

218 Calcium/calmodulin-dependent protein kinase regulates the PINK1/

219 alcineurin, Akt/protein kinase B, and Ca(2+)/calmodulin-dependent protein kinase signaling pathways i

220 ger, phospholamban, calcineurin, and calcium/calmodulin-dependent protein kinase type II (CaMKII) wer

221 to remodeling pathways (e.g., Akt and Ca(2+)/calmodulin-dependent protein kinase type II) and develop

222 Calcium/calmodulin-dependent protein kinase type IV (CaMKIV) is

223 uptake; one of them encoded CaMK4, a calcium/calmodulin-dependent protein kinase.

224 We identified a role for calcium/calmodulin-dependent protein kinases II gamma isoform (C

225 Calcineurin encodes a calcium- and calmodulin-dependent serine/threonine protein phosphatas

226 or somatostatin-positive interneurons and of calmodulin-dependent, protein kinase-positive, principal

227 Furthermore, our simulations showed that the calmodulin domain binding to the linker region was impor

228 associated Bak interacts with the kinase and calmodulin domains of DAPk1 to increase the contact site

229 Evidence of CFTR binding to isolated calmodulin domains/lobes suggests a mechanism for the ro

230 Using a 3-dimensional model of Ca2+ and calmodulin dynamics within an idealised, but biophysical

231 Activation with Ca2(+)/calmodulin engages additional interactive surfaces and c

232 In vitro, calmodulin enhanced membrane tubulation and constriction

233 This gene family, with a proposed new name, Calmodulin Fused Kinase (CFK), had expanded and diverged

234 d by a de novo fusion of a kinase gene and a calmodulin gene.

235 ty, such as protein inhibitor of NOS1 (PIN), calmodulin, heat shock protein 90, and NOS interacting p

236 pe was rescued by co-expression of TCF4 plus calmodulin in a calcium-dependent manner and by dampenin

237 These studies reveal a conserved role for calmodulin in regulating the intrinsic membrane-sculptin

238 We discovered that calcium binding to calmodulin increases the binding affinity by a factor of

239 This includes the calmodulin inhibitor W-7, the phospholipase-C inhibitor

240 Finally, the calmodulin inhibitors W-7 and W-13 reduced cAMP levels,

241 s at basal cytosolic Ca(2+) levels while two calmodulins interact following Ca(2+) elevation.

242 Unexpectedly, calmodulin is bound tightly to STRA6 in a noncanonical a

243 Calmodulin is thus a critical Ca(2+) sensor enabling TRP

244 tely preventing the pathological increase of calmodulin kinase activity in treated mice.

245 tained reduction of intracellular Ca(2+) and calmodulin kinase activity, ranolazine prevented the dev

246 ted increase in calcium (Ca(2+)) levels, via calmodulin kinase II (CaMKII) phosphorylation, inhibits

247 k-out mice (C3KO), Ca(2+) release and Ca(2+)/calmodulin kinase II (CaMKII) signaling are attenuated.

248 reases depend on protein kinase A (PKA)- and calmodulin kinase II (CaMKII)-mediated enhancement of Ca

249 )-dependent CREB/c-fos activation via Ca(2+)-calmodulin kinase IV (CaMKIV) induces transcriptional re

250 Here we report the identification of 'calmodulin kinase-like vesicle-associated' (CaMKv), a ps

251 aining permutated GFP and the calcium sensor calmodulin (Lck-GCaMP3 and GCaMP3), we demonstrated enri

252 e the differential calcium ion dependence of calmodulin ligand-binding affinities, a system at the fo

253 Calmodulin (CaM) and closely related calmodulin-like (CML) polypeptides are principal sensors

254 Calmodulin-like (CML) proteins are major EF-hand-contain

255 signalling mediated by Calmodulin (CaM) and calmodulin-like (CML) proteins is critical to plant immu

256 asmodesmal-localized Ca(2+) -binding protein Calmodulin-like 41 (CML41).

257 Ser/Thr and Tyr) kinase domain tethered to a calmodulin-like domain (CLD) via an autoinhibitory junct

258 The calmodulin-like domain of alpha-actinin binds to the Z-r

259 l members that contain a kinase domain and a calmodulin-like domain.

260 cting proteins in Arabidopsis, we identified calmodulin-like protein 38 (CML38) as an AtRALF1-interac

261 The calmodulin-like protein CML9, a negative modulator of fl

262 The new component is a calmodulin-like protein that binds AtRALF1, is essential

263 otein related to regulator of gene silencing calmodulin-like proteins (rgsCaMs).

264 for FS, rs1067327 within CAMKMT encoding the calmodulin-lysine N-methyltransferase on chromosomal ban

265 e investigate the direct response of CFTR to calmodulin-mediated calcium signaling.

266 re involved in pathogen recognition, calcium/calmodulin-mediated defense signaling, jasmonic acid (JA

267 ion and carboxy terminus, involved in Ca(2+)-calmodulin-mediated inactivation.

268 We further explore the effect of calmodulin on creatine kinase activity and show that it

269 ion of this region promotes the occupancy of calmodulin on the channel, thus increasing channel open

270 r, we suggest that because only KRas4B binds calmodulin, only KRas can fully activate PI3Kalpha/Akt s

271 Kojak and the popular pLink algorithms on a calmodulin-plectin complex data set, as well as three ad

272 Because calcium/calmodulin protein kinase II (CaMKII) is known to modify

273 arrhythmias produced by exacerbated Ca(2+) /calmodulin-protein kinase (CaMKII) activity, ryanodine r

274 Calcineurin, the conserved Ca(2+)/calmodulin-regulated phosphatase and target of immunosup

275 form in vivo and, as frequently observed for calmodulin-regulated proteins, it may be expressed in di

276 Furthermore, the MAPKKK YDA and two calcium/calmodulin-regulated receptor-like kinases, CRLK1 and CR

277 -D-aspartate (NMDA) receptors activates Ca2+/calmodulin signal transduction networks that either incr

278 e find a surprising Ca(2+)-induced switch in calmodulin stoichiometry with Ca(2+) channels-one calmod

279 the neuronal calcium sensor subclass of the calmodulin superfamily, confers Ca(2+)-sensitive activat

280 e lack of motility at high calcium is due to calmodulin switching to a higher affinity binding site,

281 reatine kinase, which we identify as a novel calmodulin target.

282 on between the regulatory region of CFTR and calmodulin, the major calcium signaling molecule, and re

283 b interface, away from the kinase domain and calmodulin, thus unlocking the ability of activated CaMK

284 cture and position of the S4-S5 linker allow calmodulin to bind to the intracellular domains and to c

285 s reminiscent of the better known binding of calmodulin to CaMKII.

286 ediates calcium influx in LECs and activates calmodulin to facilitate a physical interaction between

287 vealed that FGF13 potentiates the binding of calmodulin to NaV1.5 and that phosphomimetic mutations a

288 The ability of calcium-calmodulin to seek out and bridge between binding site c

289 ich a pathogen effector is activated by host calmodulin to target MAP65 and the microtubule network,

290 calcium (Ca(2+) i) through binding of Ca(2+)-calmodulin to three sites adjacent to the eagD and cNBHD

291 d by the absence from olfactory axons of the calmodulin transcript Calm1, which is highly expressed i

292 anges in calcium levels in vitro disrupt the calmodulin-UBE3B interaction.

293 er's biological utility by first resolving a calmodulin unfolding intermediate previously undetected

294 g activation of CsGAD1 enzymatic activity by calmodulin upon the onset of the stress and accumulation

295 We also discovered that UBE3B interacts with calmodulin via its N-terminal isoleucine-glutamine (IQ)

296 he BRET assay, based on the interaction with Calmodulin, was successfully extended to TRPV3 and TRPV4

297 we show that Ca(2+) regulates TRPA1 through calmodulin, which binds to TRPA1 in a Ca(2+)-dependent m

298 pting the interaction of the carboxy-lobe of calmodulin with a calmodulin-binding domain in the C-ter

299 mains bound calmodulin, and co-expression of calmodulin with endophilin A2 potentiated tubulation in

300 e interaction of FGF13 and, consequently, of calmodulin with NaV1.5.