ライフサイエンスコーパス: calmodulin kinase

1 in MC pretreated with inhibitors of calcium calmodulin kinase.

2 d in part by increases in cell [Ca2+] and Ca-calmodulin kinase.

3 tivation of protein kinase C but not calcium calmodulin kinase.

4 Intracellular Ca2+ ions may activate AMPK by calmodulin kinase 1 kinase-mediated phosphorylation.

5 tinocyte cultures with KN93, an inhibitor of calmodulin kinase 2, known to phosphorylate Ser-325 in C

6 bited more than 100-fold selectivity against calmodulin kinase 2; casein kinase-1 and -2; CDK1 and -4

7 hibiting either [Ca2+]i elevation or calcium calmodulin kinase activation.

8 tely preventing the pathological increase of calmodulin kinase activity in treated mice.

9 tained reduction of intracellular Ca(2+) and calmodulin kinase activity, ranolazine prevented the dev

10 nstrate an important role for the calmodulin/calmodulin kinase and cAMP/protein kinase A pathways in

11 ulin involve downstream signaling via Ca(2+)/calmodulin kinase and gene transcription.

12 avium, activate Ca(2+)-dependent calmodulin/calmodulin kinase and MAPK pathways in murine macrophage

13 anner that is dependent on Ca(2+) and Ca(2+)/calmodulin kinases and independent of ERKs, p38 MAPK, an

14 Both KN-62, an inhibitor of calcium/calmodulin kinase, and calpain inhibitor III, a calpain

15 38 and p42/44 MAP kinases, protein kinase C, calmodulin kinase, and tyrosine kinase, showing that HGF

16 evation of [Ca2+]i and activation of calcium calmodulin kinases are upstream mediators of ET-1-induce

17 Signaling by the Ca(2+)/calmodulin kinase (CaMK) cascade has been implicated in

18 Calmodulin kinase (CaMK) has characteristics suitable fo

19 Calmodulin kinase (CaMK) II is linked to arrhythmia mech

20 MKIV) is the nuclear effector of the Ca(2+) /calmodulin kinase (CaMK) pathway where it coordinates tr

21 2c receptor on VMH neurons, serotonin uses a calmodulin kinase (CaMK)-dependent signaling cascade inv

22 Because H(2)O(2) activates Ca(2+)/calmodulin kinase (CaMK)II, which also impairs I(Na) ina

23 meiotic maturation is dependent upon calcium calmodulin kinase (CamKII) activity.

24 Autonomous activation of calcium-calmodulin kinase (CaMKII) has been proposed as a molecu

25 ermine the role of PPT intracellular calcium/calmodulin kinase (CaMKII) signaling in the regulation o

26 exhibit attenuated calcium release, reduced calmodulin kinase (CaMKII) signaling, and impaired muscl

27 voltage-sensitive Ca2+ channel and the Ca2+/calmodulin kinase cascade.

28 t, trifluoperazine, an antagonist of calcium/calmodulin kinases, completely blocked H(2)O(2)-induced

29 ependence, and is clearly different from the calmodulin kinase-dependent mechanism by which AngII mod

30 omologous to a CNS protein containing a Ca2+/calmodulin kinase domain, suggesting that the DCX protei

31 ved binding site for the peptide on the CASK calmodulin kinase domain.

32 omain protein composed of an N-terminal Ca2+/calmodulin-kinase domain, central PDZ and SH3 domains, a

33 Inhibition of calcineurin or calcium-calmodulin kinase greatly attenuates ionophore-induced a

34 contrast, inhibitors of protein kinase A and calmodulin kinases had no effect on CREB phosphorylation

35 pendent protein kinase, protein kinase C and calmodulin kinases have been implicated in calcium-signa

36 C (PKC) activity and not protein kinase A or calmodulin kinase; however, the identity and role of the

37 We identified a new calmodulin kinase I (CaMKI) substrate, cytidyltransferas

38 ase (CaMKK) and its downstream target Ca(2+)/calmodulin kinase I (CaMKI).

39 binding of the calmodulin-binding domain of calmodulin kinase I on the fast internal dynamics of cal

40 ion (Ca(2+))-dependent activation of Ca(2+)/calmodulin kinase-I (CaMKI), which triggers cAMP respons

41 ozygous for a null mutation of alpha-calcium-calmodulin kinase II (alpha-CaMKII+/-) show normal learn

42 Autophosphorylation of alpha-Ca2+/calmodulin kinase II (alphaCaMKII) at Thr286 is thought

43 The molecule alpha calcium calmodulin kinase II (alphaCaMKII) is known to play a fu

44 ion 286 mutated to alanine (A)] in the alpha calmodulin kinase II (alphaCaMKIIT286A) than in mice def

45 ctivation of the calmodulin-dependent enzyme calmodulin kinase II (CaM kinase II) was studied in PC12

46 ylated by protein kinase C (PKC) and calcium/calmodulin kinase II (CaMK II) after stimulation with ag

47 L-type Ca(2+) channel (LTCC) C terminus and calmodulin kinase II (CaMK) both signal increases in LTC

48 diator of cAMP-protein kinase (PKA) and Ca2+-calmodulin kinase II (CAMK-II) activation, we tested whe

49 otein (alphakap), encoded within the calcium/calmodulin kinase II (camk2) alpha gene, was recently fo

50 -C and TnI phosphorylation using the calcium/calmodulin kinase II (CaMK2) inhibitor autocamtide-2 rel

51 ompanied by changes in protein expression of calmodulin kinase II (CaMKII) (P<0.05) and calmodulin ki

52 tivated protein kinase (MAPK/ERK) and Ca(2+)/calmodulin kinase II (CaMKII) activation.

53 Such changes were related to enhanced Ca(2+)/calmodulin kinase II (CaMKII) activity and increased pho

54 cortex (PFC) via the dual control of calcium/calmodulin kinase II (CaMKII) activity.

55 Excessive activation of calmodulin kinase II (CaMKII) causes arrhythmias and hea

56 In order to study the role of calcium/calmodulin kinase II (CaMKII) in T cells, we generated t

57 GT-1 DNA binding, phosphorylation by calcium/calmodulin kinase II (CaMKII) increased the binding acti

58 [Ca(2+)]i-activated calmodulin kinase II (CaMKII) inhibition with KN-93 (1 m

59 Both the calmodulin kinase II (CaMKII) inhibitor KN-62 and the PK

60 Pretreatment with the Ca-calmodulin kinase II (CaMKII) inhibitor KN-93, but not i

61 The inclusion of Ca2+-calmodulin kinase II (CaMKII) inhibitor peptides in the

62 Calmodulin Kinase II (CamKII) inhibits the transcription

63 Calcium/calmodulin kinase II (CaMKII) is required for LTP and ex

64 ctivation and inhibited by Ca2+ through Ca2+/calmodulin kinase II (CaMKII) phosphorylation at Ser-107

65 51-300) of mouse Emi2 that also contained a calmodulin kinase II (CaMKII) phosphorylation motif and

66 ted increase in calcium (Ca(2+)) levels, via calmodulin kinase II (CaMKII) phosphorylation, inhibits

67 Ca(2+)/calmodulin kinase II (CaMKII) plays an important role in

68 everses LTS, and specific inhibitors of Ca2+/calmodulin kinase II (CaMKII) prevent induction and inhi

69 k-out mice (C3KO), Ca(2+) release and Ca(2+)/calmodulin kinase II (CaMKII) signaling are attenuated.

70 Ca2+-Calmodulin kinase II (CaMKII) was also required since it

71 ac myocyte apoptosis by activation of Ca(2+)/calmodulin kinase II (CaMKII), independently of PKA sign

72 a second Ca2+-activated signaling molecule, calmodulin kinase II (CaMKII), were increased in hearts

73 Calmodulin kinase II (CaMKII), which is not activated di

74 reases depend on protein kinase A (PKA)- and calmodulin kinase II (CaMKII)-mediated enhancement of Ca

75 ses dependent on synaptic activity or Ca(2+)/calmodulin kinase II (CaMKII).

76 We show that the mLin-2/CASK calmodulin kinase II (CKII) domain directly binds to a 6

77 s mediated by direct interaction between the Calmodulin Kinase II (CKII)-like domain of mLin-2 and th

78 ease, which was reduced (50%) by blocking of calmodulin kinase II (KN-62).

79 Here, we show that oxidized calmodulin kinase II (ox-CaMKII) is a biomarker for SND

80 ontrast, currents were not attenuated by the calmodulin kinase II 281-309 peptide (10 micrometer), an

81 out inhibition of calcium elevation, calcium-calmodulin kinase II activation, or cystic fibrosis tran

82 l relationship between a decrease in calcium/calmodulin kinase II activity and the development of sei

83 The data suggest that decreased calmodulin kinase II activity may play a role in epilept

84 of LCC activity (possibly mediated by Ca(2+)-calmodulin kinase II activity).

85 on the bi-directional regulation of calcium/calmodulin kinase II activity.

86 Neither p38 nor Ca2+/calmodulin kinase II agents exert significant influences

87 a(2+) disturbances, this results from Ca(2+)-calmodulin kinase II and reactive oxygen species-mediate

88 dependent Ca(2+) entry, activation of Ca(2+)/calmodulin kinase II and subsequent gating of CLC-3 link

89 tion with the protein effector alpha calcium-calmodulin kinase II and the regulation of the mTOR path

90 mice were bred with mice expressing an alpha-calmodulin kinase II Cre to selectively inactivate Dicer

91 tion of protein kinase C isoforms or calcium calmodulin kinase II did not alter the BzATP-induced inc

92 re observed after a significant reduction in calmodulin kinase II expression.

93 fluorescent images of COS1 cells expressing calmodulin kinase II fused with enhanced yellow fluoresc

94 xpression of a constitutively active form of calmodulin kinase II in neurons.

95 n), completely inhibited by KN-62, a calcium-calmodulin kinase II inhibitor, and only partially repre

96 e I, calphostin C, and Ro31-8220 but not the calmodulin kinase II inhibitor, Kn-93, suggesting a role

97 to play a role in targeting multiple calcium/calmodulin kinase II isoforms to specific subcellular lo

98 Overexpression of activated calmodulin kinase II mimics the effect of Wnt5a, suggest

99 al LTP-mice heterozygous for a alpha-calcium calmodulin kinase II mutation (alpha CaMKII +/-) have lo

100 casein kinase (CK) I or II, but not calcium-calmodulin kinase II or protein kinase A, inhibited DNA

101 tion was dependent on the calcium/calmodulin/calmodulin kinase II pathway in both M. smegmatis- and M

102 sing a decoy peptide representing the Ca(2+)/calmodulin kinase II phosphorylation site on CLC-3, we s

103 on was driven by a forebrain-specific Ca(2+) calmodulin kinase II promoter system resulting in high l

104 (MAPK 1/2) substrate site), and serine 603 (calmodulin kinase II site).

105 eta(IV)-spectrin, to bind and recruit Ca(2+)/calmodulin kinase II to the channel at a cellular locati

106 s inhibited by intracellular calcium through calmodulin kinase II, AC3 may serve as an important inte

107 te, or the calcium-responsive kinase calcium calmodulin kinase II, CpG-induced TNFalpha secretion was

108 ecific phosphorylation events on Erk 1/2 and calmodulin kinase II, two proteins required for CA1 hipp

109 chanistically, this regulation appears to be calmodulin kinase II-dependent and mediated through the

110 ivated by PGE(2) in human arterial SMCs is a calmodulin kinase II-inhibited AC with characteristics s

111 en probability was linked to enhance calcium-calmodulin kinase II-mediated phosphorylation in non-nat

112 Esophageal acid exposure induced calcium calmodulin kinase II-mediated phosphorylation of the sub

113 309 peptide (10 micrometer), an inhibitor of calmodulin kinase II.

114 fluenced when channels are phosphorylated by calmodulin kinase II.

115 m IP3-sensitive internal stores, and calcium/calmodulin kinase II.

116 8 and protein kinase A but not on ERK 1/2 or calmodulin kinase II.

117 otein kinase C, MEK1/2, p38 kinase, and Ca2+/calmodulin kinase II.

118 l inhibitors of calmodulin kinase kinase and calmodulin kinases II and III do not inhibit EGF-induced

119 the hippocampus requires activation of Ca2+/calmodulin-kinase II (CaM-KII), which phosphorylates Ser

120 Similarly, when the Ca(2+)/calmodulin-kinase II (CaMKII) inhibitory peptide was pre

121 tracellular calcium, elevated calmodulin and calmodulin-kinase II expression, whereas calcium chelati

122 eviously to be contingent upon modulation by calmodulin kinase IIalpha (alphaCaMKII).

123 stablished within the context of full-length calmodulin kinase IIalpha (CaM KIIalpha).

124 lar signaling molecules calcineurin, calcium calmodulin kinase IIalpha (CAMKIIalpha) and the receptor

125 signaling molecules calcineurin and calcium calmodulin kinase IIalpha (CAMKIIalpha); and the recepto

126 e myosin light chain kinase but not with the calmodulin kinase IIalpha peptide.

127 construct containing SUR cDNA and a calcium-calmodulin kinase IIalpha promoter.

128 tested this hypothesis in mice with calcium calmodulin kinase IIalpha-Cre-mediated forebrain GR dele

129 ctively, whereas the mutants fully activated calmodulin kinase IIalpha.

130 Calmodulin kinase IID (CaMKIID) was selected as a candid

131 tein expression of Orai1, STIM1, and calcium-calmodulin kinase IIdelta2 (CamKIIdelta2); increased pro

132 cells, but neither protein phosphatase-1 nor calmodulin kinase III (EF-2 kinase) activity was affecte

133 Elongation factor-2 (EF-2) kinase (calmodulin kinase III) is a unique protein kinase that i

134 itor of protein kinase Cdelta (PKCdelta) and calmodulin kinase III, abrogated the up-regulation at bo

135 rt that both calmodulin inhibitor (CaMI) and calmodulin kinase inhibitor could also enhance cleavage

136 ell [Ca2+] low with BAPTA, and by KN62, a Ca-calmodulin kinase inhibitor.

137 f calmodulin kinase II (CaMKII) (P<0.05) and calmodulin kinase IV (CaMKIV) (P<0.05).

138 )-dependent CREB/c-fos activation via Ca(2+)-calmodulin kinase IV (CaMKIV) induces transcriptional re

139 can bind to T cells and activate the Ca(2+)-calmodulin kinase IV (CaMKIV) signaling cascade, resulti

140 iologic synaptic stimulation recruits a fast calmodulin kinase IV (CaMKIV)-dependent pathway that dom

141 y co-transfection with constitutively active calmodulin kinase IV and protein kinase A, and binding o

142 Constitutively active Ca(2+)-dependent calmodulin kinase IV enhanced Glis1-mediated transcripti

143 ampal neurons demonstrates a role for Ca(2+)/calmodulin kinase kinase (CaMKK) and its downstream targ

144 Pharmacological inhibitors of calmodulin kinase kinase and calmodulin kinases II and I

145 LKB1, upstream kinases for AMPK; STO-609, a calmodulin kinase kinase beta inhibitor, had the same ef

146 K phosphorylation was inhibited by siRNA for calmodulin kinase kinase beta, but not LKB1, upstream ki

147 AMPK phosphorylation by stimulating calcium-calmodulin kinase kinase beta.

148 e corresponding to the CaM-binding domain of calmodulin kinase kinase, along with the thermodynamic u

149 Here we report the identification of 'calmodulin kinase-like vesicle-associated' (CaMKv), a ps

150 ular signaling pathways involving Ca2+, Ca2+/calmodulin kinase, mitogen-activated protein kinase, cyc

151 t activation is mediated directly by neither calmodulin kinases nor phosphatidylinositol 3-kinase (PI

152 les, including histone deacetylases, calcium calmodulin kinase, or CK1.

153 We also report that signaling via the Ca(2+)/calmodulin kinase pathway functions upstream of the MAPK

154 duction was also dependent on the calmodulin/calmodulin kinase pathway.

155 Inhibition of Ca(2+)/calmodulin kinase, protein kinases A and C, tyrosine kin

156 Evaluation of these calcium calmodulin kinase superfamily members as candidate Ser(2

157 as used to identify a broad range of calcium calmodulin kinase superfamily members, including CHK2, C

158 f kinases that are components of the calcium calmodulin kinase superfamily, including CHK2, AMP kinas

159 The molecule alpha calcium-calmodulin kinase type II (alphaCaMKII) is known to play

160 el (CaV1.1) facilitates activation of Ca(2+)/calmodulin kinase type II (CaMKII) and Ca(2+) store refi

161 Calcium/calmodulin kinase type II (CaMKII) is a major postsynapt

162 e of Ca2+ and the absence of endogenous Ca2+/calmodulin kinase type II or protein kinase C activity,

163 pecific for the alpha subunit of the calcium/calmodulin kinase were used to decrease the expression o