ライフサイエンスコーパス: calmodulin kinase II

1 m IP3-sensitive internal stores, and calcium/calmodulin kinase II.

2 8 and protein kinase A but not on ERK 1/2 or calmodulin kinase II.

3 otein kinase C, MEK1/2, p38 kinase, and Ca2+/calmodulin kinase II.

4 309 peptide (10 micrometer), an inhibitor of calmodulin kinase II.

5 fluenced when channels are phosphorylated by calmodulin kinase II.

6 ontrast, currents were not attenuated by the calmodulin kinase II 281-309 peptide (10 micrometer), an

7 s inhibited by intracellular calcium through calmodulin kinase II, AC3 may serve as an important inte

8 out inhibition of calcium elevation, calcium-calmodulin kinase II activation, or cystic fibrosis tran

9 l relationship between a decrease in calcium/calmodulin kinase II activity and the development of sei

10 The data suggest that decreased calmodulin kinase II activity may play a role in epilept

11 of LCC activity (possibly mediated by Ca(2+)-calmodulin kinase II activity).

12 on the bi-directional regulation of calcium/calmodulin kinase II activity.

13 Neither p38 nor Ca2+/calmodulin kinase II agents exert significant influences

14 ozygous for a null mutation of alpha-calcium-calmodulin kinase II (alpha-CaMKII+/-) show normal learn

15 Autophosphorylation of alpha-Ca2+/calmodulin kinase II (alphaCaMKII) at Thr286 is thought

16 The molecule alpha calcium calmodulin kinase II (alphaCaMKII) is known to play a fu

17 ion 286 mutated to alanine (A)] in the alpha calmodulin kinase II (alphaCaMKIIT286A) than in mice def

18 a(2+) disturbances, this results from Ca(2+)-calmodulin kinase II and reactive oxygen species-mediate

19 dependent Ca(2+) entry, activation of Ca(2+)/calmodulin kinase II and subsequent gating of CLC-3 link

20 tion with the protein effector alpha calcium-calmodulin kinase II and the regulation of the mTOR path

21 l inhibitors of calmodulin kinase kinase and calmodulin kinases II and III do not inhibit EGF-induced

22 ctivation of the calmodulin-dependent enzyme calmodulin kinase II (CaM kinase II) was studied in PC12

23 the hippocampus requires activation of Ca2+/calmodulin-kinase II (CaM-KII), which phosphorylates Ser

24 ylated by protein kinase C (PKC) and calcium/calmodulin kinase II (CaMK II) after stimulation with ag

25 L-type Ca(2+) channel (LTCC) C terminus and calmodulin kinase II (CaMK) both signal increases in LTC

26 diator of cAMP-protein kinase (PKA) and Ca2+-calmodulin kinase II (CAMK-II) activation, we tested whe

27 otein (alphakap), encoded within the calcium/calmodulin kinase II (camk2) alpha gene, was recently fo

28 -C and TnI phosphorylation using the calcium/calmodulin kinase II (CaMK2) inhibitor autocamtide-2 rel

29 ompanied by changes in protein expression of calmodulin kinase II (CaMKII) (P<0.05) and calmodulin ki

30 tivated protein kinase (MAPK/ERK) and Ca(2+)/calmodulin kinase II (CaMKII) activation.

31 Such changes were related to enhanced Ca(2+)/calmodulin kinase II (CaMKII) activity and increased pho

32 cortex (PFC) via the dual control of calcium/calmodulin kinase II (CaMKII) activity.

33 Excessive activation of calmodulin kinase II (CaMKII) causes arrhythmias and hea

34 In order to study the role of calcium/calmodulin kinase II (CaMKII) in T cells, we generated t

35 GT-1 DNA binding, phosphorylation by calcium/calmodulin kinase II (CaMKII) increased the binding acti

36 [Ca(2+)]i-activated calmodulin kinase II (CaMKII) inhibition with KN-93 (1 m

37 Both the calmodulin kinase II (CaMKII) inhibitor KN-62 and the PK

38 Pretreatment with the Ca-calmodulin kinase II (CaMKII) inhibitor KN-93, but not i

39 The inclusion of Ca2+-calmodulin kinase II (CaMKII) inhibitor peptides in the

40 Calmodulin Kinase II (CamKII) inhibits the transcription

41 Calcium/calmodulin kinase II (CaMKII) is required for LTP and ex

42 ctivation and inhibited by Ca2+ through Ca2+/calmodulin kinase II (CaMKII) phosphorylation at Ser-107

43 51-300) of mouse Emi2 that also contained a calmodulin kinase II (CaMKII) phosphorylation motif and

44 ted increase in calcium (Ca(2+)) levels, via calmodulin kinase II (CaMKII) phosphorylation, inhibits

45 Ca(2+)/calmodulin kinase II (CaMKII) plays an important role in

46 everses LTS, and specific inhibitors of Ca2+/calmodulin kinase II (CaMKII) prevent induction and inhi

47 k-out mice (C3KO), Ca(2+) release and Ca(2+)/calmodulin kinase II (CaMKII) signaling are attenuated.

48 Ca2+-Calmodulin kinase II (CaMKII) was also required since it

49 ac myocyte apoptosis by activation of Ca(2+)/calmodulin kinase II (CaMKII), independently of PKA sign

50 a second Ca2+-activated signaling molecule, calmodulin kinase II (CaMKII), were increased in hearts

51 Calmodulin kinase II (CaMKII), which is not activated di

52 reases depend on protein kinase A (PKA)- and calmodulin kinase II (CaMKII)-mediated enhancement of Ca

53 ses dependent on synaptic activity or Ca(2+)/calmodulin kinase II (CaMKII).

54 Similarly, when the Ca(2+)/calmodulin-kinase II (CaMKII) inhibitory peptide was pre

55 Calmodulin kinase IID (CaMKIID) was selected as a candid

56 We show that the mLin-2/CASK calmodulin kinase II (CKII) domain directly binds to a 6

57 s mediated by direct interaction between the Calmodulin Kinase II (CKII)-like domain of mLin-2 and th

58 te, or the calcium-responsive kinase calcium calmodulin kinase II, CpG-induced TNFalpha secretion was

59 mice were bred with mice expressing an alpha-calmodulin kinase II Cre to selectively inactivate Dicer

60 chanistically, this regulation appears to be calmodulin kinase II-dependent and mediated through the

61 tion of protein kinase C isoforms or calcium calmodulin kinase II did not alter the BzATP-induced inc

62 re observed after a significant reduction in calmodulin kinase II expression.

63 tracellular calcium, elevated calmodulin and calmodulin-kinase II expression, whereas calcium chelati

64 fluorescent images of COS1 cells expressing calmodulin kinase II fused with enhanced yellow fluoresc

65 xpression of a constitutively active form of calmodulin kinase II in neurons.

66 ivated by PGE(2) in human arterial SMCs is a calmodulin kinase II-inhibited AC with characteristics s

67 n), completely inhibited by KN-62, a calcium-calmodulin kinase II inhibitor, and only partially repre

68 e I, calphostin C, and Ro31-8220 but not the calmodulin kinase II inhibitor, Kn-93, suggesting a role

69 to play a role in targeting multiple calcium/calmodulin kinase II isoforms to specific subcellular lo

70 ease, which was reduced (50%) by blocking of calmodulin kinase II (KN-62).

71 en probability was linked to enhance calcium-calmodulin kinase II-mediated phosphorylation in non-nat

72 Esophageal acid exposure induced calcium calmodulin kinase II-mediated phosphorylation of the sub

73 Overexpression of activated calmodulin kinase II mimics the effect of Wnt5a, suggest

74 al LTP-mice heterozygous for a alpha-calcium calmodulin kinase II mutation (alpha CaMKII +/-) have lo

75 casein kinase (CK) I or II, but not calcium-calmodulin kinase II or protein kinase A, inhibited DNA

76 Here, we show that oxidized calmodulin kinase II (ox-CaMKII) is a biomarker for SND

77 tion was dependent on the calcium/calmodulin/calmodulin kinase II pathway in both M. smegmatis- and M

78 sing a decoy peptide representing the Ca(2+)/calmodulin kinase II phosphorylation site on CLC-3, we s

79 on was driven by a forebrain-specific Ca(2+) calmodulin kinase II promoter system resulting in high l

80 (MAPK 1/2) substrate site), and serine 603 (calmodulin kinase II site).

81 eta(IV)-spectrin, to bind and recruit Ca(2+)/calmodulin kinase II to the channel at a cellular locati

82 ecific phosphorylation events on Erk 1/2 and calmodulin kinase II, two proteins required for CA1 hipp