ライフサイエンスコーパス: calmodulin-dependent protein kinase

1 orphogenic processes is CaMK-II, a conserved calmodulin-dependent protein kinase.

2 uptake; one of them encoded CaMK4, a calcium/calmodulin-dependent protein kinase.

3 crease its activity in BTICs, whereas Ca(2+)-calmodulin-dependent protein kinase 2 (CAMK2) inhibited

4 (Ede1) that can function upstream of Ca(2+)/calmodulin-dependent protein kinase 2 (Cmk2) to suppress

5 hanistically, CaMKK2 signals through Ca(2+) /calmodulin-dependent protein kinase 4 (CaMKIV) to contro

6 Calcium/calmodulin-dependent protein kinase 4 (gene and transcri

7 d dysregulation of Na and Ca handling and Ca/calmodulin-dependent protein kinase and are especially p

8 ined increase in cytosolic Ca(2+), activated calmodulin-dependent protein kinase and the calpain-casp

9 r new protein synthesis and required calcium/calmodulin-dependent protein kinases and the nuclear cal

10 resulting in c-Jun N-terminal kinase, Ca(2+)/calmodulin-dependent protein kinase, and cyclic adenosin

11 by NMDA receptor activation, requires Ca2+ /calmodulin-dependent protein kinase, and is mediated by

12 cannabinoid type 1 (CB1) receptor and Ca(2+)/calmodulin-dependent protein kinase beta, activates AMP-

13 olerance, as did mutants in the gene calcium/calmodulin-dependent protein kinase (caki), encoding the

14 Calcium/calmodulin-dependent protein kinase (CaMK) activation in

15 Psi Here, we characterize a role for calcium/calmodulin-dependent protein kinase (CaMK) I in the regu

16 f D-myo-inositol 1,4,5-trisphosphate/Ca(2+) /calmodulin-dependent protein kinase (CaMK) I. gamma-Amin

17 II could also induce the phosphorylation of calmodulin-dependent protein kinase (CaMK) II and cAMP r

18 ostretrieval bilateral inhibition of calcium/calmodulin-dependent protein kinase (CaMK) II in dorsal

19 +)-dependent binding of S100B to the calcium/calmodulin-dependent protein kinase (CaMK)-type domain o

20 2 model of Huntington disease and the Ca(2+)/calmodulin-dependent protein kinase (CaMK)/p25 double-tr

21 wn that the cytoplasmically oriented calcium/calmodulin-dependent protein kinase (CaMK)Ialpha regulat

22 gnaling in the inner ear is the type II Ca2+/calmodulin-dependent protein kinase (CaMK-II), which is

23 ore than 20 years, we have known that Ca(2+)/calmodulin-dependent protein kinase (CaMKII) activation

24 and the ensuing activation of the Ca(2+) and calmodulin-dependent protein kinase (CaMKII) are require

25 Mice with Ca(2+) -calmodulin-dependent protein kinase (CaMKII) constitutiv

26 Acute activation of calcium/calmodulin-dependent protein kinase (CaMKII) in permeabi

27 lation of RyR2 phosphorylation at the Ca(2+)/calmodulin-dependent protein kinase (CaMKII) site (S2814

28 DLG1 can be phosphorylated by Ca(2+)/calmodulin-dependent protein kinase (CaMKII), resulting

29 prevent the arrhythmias induced by a Ca(2+) -calmodulin-dependent protein kinase (CaMKII)-dependent l

30 Ca(2+)/calmodulin-dependent protein kinases (CaMKs) are major d

31 A calcium/calmodulin-dependent protein kinase (CCaMK) is essential

32 Calcium and Ca(2+)/calmodulin-dependent protein kinase (CCaMK) plays a crit

33 Here, we show that Ca2+/calmodulin-dependent protein kinase gamma (CaMKIIgamma)

34 plex dephosphorylates and inactivates Ca2(+)/calmodulin-dependent protein kinase I (CaMKI), an upstre

35 Mechanistically, calmodulin-dependent protein kinase I phosphorylates a R

36 CaMKKbeta activates Ca(2+)/calmodulin-dependent protein kinase I, Ca(2+)/calmodulin

37 oA activity in the cell body through calcium/calmodulin-dependent protein kinase I.

38 r cAMP-dependent protein kinase and Ca(2)(+)/calmodulin-dependent protein kinases I/II.

39 sphorylation sites in Cx36 and evidence that calmodulin dependent protein kinase II (CaMKII) may pote

40 glycerol lipase-alpha (DGLalpha) and calcium/calmodulin dependent protein kinase II (CaMKII).

41 er brain regions, using Thy1-Cre and calcium/calmodulin dependent protein kinase II alpha-Cre for abl

42 is critically regulated by the alpha-calcium/calmodulin-dependent protein kinase II (alpha-CaMKII), a

43 , a model of memory formation, requires Ca2+.calmodulin-dependent protein kinase II (alphaCaMKII) act

44 The alpha isoform of the calcium/calmodulin-dependent protein kinase II (alphaCaMKII) has

45 The alpha-Ca(2+)/calmodulin-dependent protein kinase II (alphaCaMKII) is

46 Since alpha calmodulin-dependent protein kinase II (alphaCaMKII), a

47 sion of glutamate receptor 2 and beta Ca(2+)/calmodulin-dependent protein kinase II (betaCaMKII).

48 a marker for cholinergic terminals; calcium/calmodulin-dependent protein kinase II (CaMK) was used a

49 Calcium/calmodulin-dependent protein kinase II (CAMK2) is one of

50 e Cl(-) currents can be attributed to Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) activati

51 stically, this effect was mediated by Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) activati

52 calmodulin, but was not dependent on calcium/calmodulin-dependent protein kinase II (CaMKII) activati

53 tate (NMDA) receptor activation, and Calcium/calmodulin-dependent protein kinase II (CaMKII) activati

54 Whereas increased Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) activity

55 ctivity in mutant cultures was lower, Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) activity

56 tamine exposure transiently increases Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) alpha ex

57 y (SOCE) and sequential activation of Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) and Ca(2

58 Dys-/- had reduced expression of Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) and CaMK

59 reduced activation of PLCgamma-alpha-calcium/calmodulin-dependent protein kinase II (CaMKII) and PI3K

60 We show that phosphorylation by Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) and Polo

61 In hypertrophy, Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) and prot

62 kinase signaling pathways, including Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) and prot

63 phorylated at serine 409 (Ser-409) by Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) and prot

64 hibitory peptide (mAIP) selective for Ca2+ / calmodulin-dependent protein kinase II (CaMKII) and U012

65 cription factor DeltaFosB and protein kinase calmodulin-dependent protein kinase II (CaMKII) are co-r

66 Ca(v)1 (L-type) channels and calmodulin-dependent protein kinase II (CaMKII) are key

67 d the contribution of multifunctional Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) as a med

68 The Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) assemble

69 In this study, we show that Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) binds di

70 Calcium/calmodulin-dependent protein kinase II (CaMKII) binds to

71 Ca(2)(+)/calmodulin-dependent protein kinase II (CaMKII) blockers

72 e classic regulators of this current, Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) but not

73 ulation; (5) inhibiting either PKA or Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) during b

74 imulation; (5) inhibiting either PKA or Ca2+/calmodulin-dependent protein kinase II (CaMKII) during b

75 lum (SR) Ca(2+) release that involves Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) effects

76 activation of the multifunctional Ca(2+) and calmodulin-dependent protein kinase II (CaMKII) favors m

77 Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) forms a

78 Calcium-calmodulin-dependent protein kinase II (CaMKII) has been

79 Calcium/calmodulin-dependent protein kinase II (CaMKII) has been

80 The Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) has rece

81 Ca(2+)-calmodulin-dependent protein kinase II (CaMKII) hyperact

82 o signal neuronal cells and activate calcium calmodulin-dependent protein kinase II (CaMKII) in neuro

83 ctly associates with and targets the calcium/calmodulin-dependent protein kinase II (CaMKII) in pancr

84 iew, the functions of multifunctional Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) in VSM p

85 The extent of calcium/calmodulin-dependent protein kinase II (CaMKII) inactiva

86 Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) inhibits

87 Calcium/calmodulin-dependent protein kinase II (CaMKII) interpre

88 Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) is a cen

89 Ca(2+) /calmodulin-dependent protein kinase II (CaMKII) is a maj

90 Calcium/calmodulin-dependent protein kinase II (CaMKII) is a syn

91 The multifunctional Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) is activ

92 e heart; however, the multifunctional Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) is also

93 Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) is an en

94 Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) is an im

95 Calcium/calmodulin-dependent protein kinase II (CaMKII) is essen

96 Here we show that the activity of calcium/calmodulin-dependent protein kinase II (CaMKII) is incre

97 w that Ca(2+)-dependent activation of Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) is requi

98 Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) is up-re

99 Considerable evidence suggests that calcium/calmodulin-dependent protein kinase II (CaMKII) overacti

100 Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) oxidatio

101 nhanced [(3) H]ryanodine binding and Ca(2+) /calmodulin-dependent protein kinase II (CaMKII) phosphor

102 ated Ca(2+) channels (VGCCs) leads to Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) phosphor

103 Calcium/calmodulin-dependent protein kinase II (CaMKII) plays a

104 Calcium/calmodulin-dependent protein kinase II (CaMKII) plays a

105 The multifunctional Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) promotes

106 nel activity reduced EGF receptor (EGFR) and calmodulin-dependent protein kinase II (CAMKII) signalin

107 is downstream of Dalpha7 nAChRs and Calcium/calmodulin-dependent protein kinase II (CaMKII) signalin

108 Ca(2+)/Calmodulin-dependent protein kinase II (CaMKII) signalin

109 treated wild-type C57BL/6 mice with calcium/calmodulin-dependent protein kinase II (CaMKII) specific

110 Here, we show that activated Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) strongly

111 Localization of the Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) to dendr

112 esulted in compromised signaling from Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) to myosi

113 which in turn requires binding of the Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) to the N

114 protein GW182 increases expression of a Ca2+/calmodulin-dependent protein kinase II (CaMKII) translat

115 In contrast, when the calcium/calmodulin-dependent protein kinase II (CaMKII) was bloc

116 In contrast, when the calcium-calmodulin-dependent protein kinase II (CaMKII) was bloc

117 nificantly increased the activity of calcium/calmodulin-dependent protein kinase II (CaMKII) while re

118 ought to determine how activation of calcium/calmodulin-dependent protein kinase II (CaMKII), a centr

119 CaMK2N2 are endogenous inhibitors of calcium/calmodulin-dependent protein kinase II (CaMKII), a key s

120 reduces FRET between the NMDARcd and calcium/calmodulin-dependent protein kinase II (CaMKII), a proce

121 following: 1) that autophosphorylated Ca(2+)/calmodulin-dependent protein kinase II (CaMKII), an impo

122 triggers the exchange of subunits in Ca(2+)/calmodulin-dependent protein kinase II (CaMKII), an olig

123 embranes, synGAP is phosphorylated by Ca(2+)/calmodulin-dependent protein kinase II (CaMKII), another

124 ono pentanoic acid; the inhibitor of calcium/calmodulin-dependent protein kinase II (CaMKII), autocam

125 ed its effects on phosphorylation of calcium/calmodulin-dependent protein kinase II (CaMKII), extrace

126 vented by pharmacological blockade of Ca(2+)/calmodulin-dependent protein kinase II (CaMKII), it was

127 tream effector of WNT/Ca(2+) pathway, Ca(2+)/calmodulin-dependent protein kinase II (CaMKII), led to

128 athway is a kinase cascade involving calcium/calmodulin-dependent protein kinase II (CaMKII), p38alph

129 tors of transient spine expansion, including calmodulin-dependent protein kinase II (CaMKII), RhoA, a

130 d Ang II activate the multifunctional Ca(2+)/calmodulin-dependent protein kinase II (CaMKII), the inh

131 scular smooth muscle (VSM) expresses calcium/calmodulin-dependent protein kinase II (CaMKII)-delta an

132 ators of myocardial excitability, and Ca(2+)/calmodulin-dependent protein kinase II (CaMKII)-dependen

133 lism regulates oocyte cell death via calcium/calmodulin-dependent protein kinase II (CaMKII)-mediated

134 Although many studies have focused on Ca(2+)/calmodulin-dependent protein kinase II (CaMKII)-mediated

135 he hypotheses that (1) inhibition of Ca(2+) /calmodulin-dependent protein kinase II (CAMKII)-mediated

136 o the model reveal that inclusion of Ca(2+) /calmodulin-dependent protein kinase II (CAMKII)-mediated

137 ryanodine receptors or RyR2s) and the Ca(2+)/calmodulin-dependent protein kinase II (CaMKII).

138 lux (nSOC) and continuous activity of Ca(2+)/calmodulin-dependent protein kinase II (CaMKII).

139 the caspase-2 prodomain by activated Ca(2+)/calmodulin-dependent protein kinase II (CaMKII).

140 tion of the calcium-sensitive kinase calcium-calmodulin-dependent protein kinase II (CaMKII).

141 cium flux triggered the activation of Ca(2+)-calmodulin-dependent protein kinase II (CaMKII).

142 y NMDAR downstream signaling protein calcium/calmodulin-dependent protein kinase II (CaMKII).

143 equired cell-autonomous activation of Ca(2+)/calmodulin-dependent protein kinase II (CaMKII).

144 age-gated Na(+) channel (Na(v)1.5) by Ca(2+)/calmodulin-dependent protein kinase II (CaMKII).

145 smic reticulum (ER) and activation of Ca(2+)/calmodulin-dependent protein kinase II (CaMKII).

146 regulated through phosphorylation via Ca(2+)/calmodulin-dependent protein kinase II (CaMKII).

147 NMDA receptor-dependent activation of Ca(2+)/calmodulin-dependent protein kinase II (CaMKII).

148 est was mediated by the activation of Ca(2+)/calmodulin-dependent protein kinase II (CaMKII).

149 tor DeltaFosB and the brain-enriched calcium/calmodulin-dependent protein kinase II (CaMKIIalpha) are

150 Oxidized Ca(2+)/calmodulin-dependent protein kinase II (ox-CaMKII) was s

151 ites by protein kinase A (Ser-7) and calcium-calmodulin-dependent protein kinase II (Ser-13) and at m

152 Moreover, Carabin reduced Ca(2+)/calmodulin-dependent protein kinase II activation and pr

153 id) receptor activation, calcium and calcium/calmodulin-dependent protein kinase II activity, but not

154 increase in oxidation-dependent calcium and calmodulin-dependent protein kinase II activity, which c

155 -d-aspartate receptor activation and calcium/calmodulin-dependent protein kinase II activity.

156 bunit, Rpt6, by the plasticity kinase Ca(2+)/calmodulin-dependent protein kinase II alpha (CaMKIIalph

157 entanyl decreased the activity of the Ca(2+)/calmodulin-dependent protein kinase II alpha (CaMKIIalph

158 Alcohol-sensitive proteins included calcium/calmodulin-dependent protein kinase II alpha (CaMKIIalph

159 Ca(2+)/calmodulin-dependent protein kinase II alpha (CaMKIIalph

160 ling molecules, calcineurin, Ras, and Ca(2+)/calmodulin-dependent protein kinase II and implicates Ca

161 itive deficits via altered levels of calcium/calmodulin-dependent protein kinase II and N-methyl-D-as

162 ociated with reduced levels of total calcium/calmodulin-dependent protein kinase II and N-methyl-D-as

163 lated to higher activation of nuclear Ca(2+)/calmodulin-dependent protein kinase II and nuclear expor

164 o be independent of their effects on calcium/calmodulin-dependent protein kinase II and PKA, respecti

165 rrhythmic manifestations, related to Ca(2+) /calmodulin-dependent protein kinase II and ryanodine rec

166 it that mediates dephosphorylation of Ca(2+)/calmodulin-dependent protein kinase II and tyrosine hydr

167 es and Thr-287 autophosphorylation of Ca(2+)/calmodulin-dependent protein kinase II beta (CaMKIIbeta)

168 However, double knockdown of pygo and Ca2+/calmodulin-dependent protein kinase II caused additional

169 , inhibitors, and a dominant negative Ca(2+)/calmodulin-dependent protein kinase II construct block A

170 The calcium/calmodulin-dependent protein kinase II delta (CAMK2D), w

171 nt and function, including Titin and calcium/calmodulin-dependent protein kinase II delta (Camk2d).

172 Ca(2+)/calmodulin-dependent protein kinase II delta (CaMKIIdelt

173 he mechanical effects of the kinases calcium/calmodulin-dependent protein kinase II delta (CaMKIIdelt

174 myocytes from arrhythmia-susceptible calcium calmodulin-dependent protein kinase II delta C (CaMKIIde

175 The multifunctional Ca(2+)/calmodulin-dependent protein kinase II delta-isoform (Ca

176 the LTP kinase dependency from PKA to Ca2(+)/calmodulin-dependent protein kinase II during synapse ma

177 Here, we show that calcium/calmodulin-dependent protein kinase II gamma (CAMK2gamma

178 Here, Ca(2+)/calmodulin-dependent protein kinase II gamma (CAMKIIgamm

179 Calcium/calmodulin-dependent protein kinase II gamma knockout mi

180 A null mutation of the Drosophila calcium/calmodulin-dependent protein kinase II gene (CaMKII) was

181 hereas inhibiting protein kinase A or Ca(2+)/calmodulin-dependent protein kinase II had no effect.

182 ion and subsequent activation of calcium and calmodulin-dependent protein kinase II has a causal role

183 eam signaling protein, PKC-alpha, and Ca(2+)/calmodulin-dependent protein kinase II in endothelial ce

184 2B, also referred to as Pyk2) and of calcium/calmodulin-dependent protein kinase II in wild-type brai

185 rolled firing rate adaptation whereas Ca(2+)/Calmodulin-dependent protein kinase II induced a delayed

186 ia inhibition of ryanodine receptors, Ca(2+)/calmodulin-dependent protein kinase II inhibition, or by

187 This was abolished by the Ca(2+)/calmodulin-dependent protein kinase II inhibitor KN93, s

188 Development of organ-specific calcium and calmodulin-dependent protein kinase II inhibitors may re

189 ignal-regulated kinase activators and Ca(2+)/calmodulin-dependent protein kinase II inhibitors showed

190 Ca(2+)/calmodulin-dependent protein kinase II inhibitors suppre

191 rom transgenic mice expressing a calcium and calmodulin-dependent protein kinase II inhibitory peptid

192 Calcium/calmodulin-dependent protein kinase II is a prototypical

193 Ca(2+)/calmodulin-dependent protein kinase II is a synapse-enri

194 es including JNK, GSK3alpha/beta, and Ca(2+)/calmodulin-dependent protein kinase II is increased sign

195 p38 and Ca(2+)/calmodulin-dependent protein kinase II pathways were fou

196 our results suggest that Ca(2+)/calmodulin-dependent protein kinase II phosphorylation o

197 on synapsin I, two of which are known Ca(2+)/calmodulin-dependent protein kinase II phosphorylation s

198 mice in which the S2814 Ca(2+)/calmodulin-dependent protein kinase II site on RyR2 is c

199 ignaling kinases protein kinase C and Ca(2+)/Calmodulin-dependent protein kinase II to AngII-mediated

200 In addition, phosphorylation of calcium/calmodulin-dependent protein kinase II was increased in

201 as phosphorylation of substrates for calcium/calmodulin-dependent protein kinase II was unchanged.

202 The inhibition of Ca(2+)/calmodulin-dependent protein kinase II with 1-[N,O-bis(5

203 Pharmacologic inhibition of calcium and calmodulin-dependent protein kinase II with 2.5 microM o

204 nd is accompanied by altered CaMKII (calcium/calmodulin-dependent protein kinase II) and flotillin-1

205 4) is the failure to activate CaMKII (Ca(2+)/calmodulin-dependent protein kinase II) and retinal dege

206 stabilization of postsynaptic CaMKII (Ca(2+)/calmodulin-dependent protein kinase II) at inhibitory sy

207 1 pathway, phospho-alphaCaMKII (alpha Ca2(+)/calmodulin-dependent protein kinase II) level in the hip

208 mitochondrial recruitment of CaMKII (Ca(2+)/calmodulin-dependent protein kinase II), which decreases

209 phosphorylation at Ser16 and CaMKII (Ca(2+)/calmodulin-dependent protein kinase II)-dependent phosph

210 Inhibitors of calcium/calmodulin-dependent protein kinase II, a mitochondrial

211 ng protein, but not the activation of Ca(2+)/calmodulin-dependent protein kinase II, Akt or mitogen-a

212 mitogen-activated protein kinase, and Ca(2+)/calmodulin-dependent protein kinase II, and activators o

213 in cAMP, light-induced activation of Ca(2+) /calmodulin-dependent protein kinase II, and dopamine-ind

214 ellular protein mediators Homer1b/c, calcium/calmodulin-dependent protein kinase II, and the Alzheime

215 c activation of protein kinase A and calcium/calmodulin-dependent protein kinase II, as well as synap

216 a(2+) must first mobilize actin-bound Ca(2+)/calmodulin-dependent protein kinase II, freeing it for s

217 ng postsynaptic density-95 and alpha-calcium/calmodulin-dependent protein kinase II, normally elicite

218 glutamate-mediated Ca(2+) signaling (Ca(2+)/calmodulin-dependent protein kinase II, PPP3CA, and VISL

219 Calcium and calmodulin-dependent protein kinase II, through phosphor

220 th cAMP-dependent protein kinase and calcium/calmodulin-dependent protein kinase II, whereas Ca(V)1.1

221 turn, led to the phosphorylation of calcium/calmodulin-dependent protein kinase II, which promoted b

222 ice using the CaMKIIalpha-Cre (alpha-calcium/calmodulin-dependent protein kinase II-Cre) system to KD

223 2 expression can be upregulated in a calcium/calmodulin-dependent protein kinase II-dependent manner

224 at have the ryanodine receptor 2 calcium and calmodulin-dependent protein kinase II-dependent phospho

225 Genetic inhibition of Ca(2+)/calmodulin-dependent protein kinase II-mediated RyR2-S28

226 used 1 Hz optogenetic stimulation of calcium/calmodulin-dependent protein kinase II-positive principa

227 dent on calcium influx and linked to calcium/calmodulin-dependent protein kinase II.

228 nt downstream enzymes calcineurin and Ca(2+)-calmodulin-dependent protein kinase II.

229 acellular calcium and activation of calcium, calmodulin-dependent protein kinase II.

230 ](i) was insensitive to inhibition of Ca(2+)-calmodulin-dependent protein kinase II.

231 a(2+)-mobilizing phospholipase C, and Ca(2+)/calmodulin-dependent protein kinase II.

232 sarcoplasmic reticulum and activated Ca(2+)/calmodulin-dependent protein kinase II.

233 FTO interacts with three isoforms of calcium/calmodulin-dependent protein kinase II: alpha, beta and

234 icity, but was absent in adult alpha-calcium/calmodulin-dependent protein kinase II;T286A (alphaCaMKI

235 We identified a role for calcium/calmodulin-dependent protein kinases II gamma isoform (C

236 pines, (3) required activation of the Ca(2+)/calmodulin-dependent protein-kinase II, (4) was restrict

237 Calmodulin expression (60%), Ca(2+)/calmodulin-dependent protein kinase-II (CaMKII) autophos

238 Ca(2+)/calmodulin-dependent protein kinase-II (CaMKII) phosphor

239 A protein with similarities to the Ca(2+)/ calmodulin dependent protein kinase II_association domai

240 AT-C24 DAT) and thereby contained the Ca(2+)-calmodulin-dependent protein kinase IIalpha (CaMKIIalpha

241 a synapse-enriched protein kinase, Ca(2)(+)/calmodulin-dependent protein kinase IIalpha (CaMKIIalpha

242 (Arch)-mediated optical silencing of calcium/calmodulin-dependent protein kinase IIalpha (CAMKIIalpha

243 is study, we investigated the role of Ca(2+)/calmodulin-dependent protein kinase IIalpha (CaMKIIalpha

244 e densin C-terminal domain can target Ca(2+)/calmodulin-dependent protein kinase IIalpha (CaMKIIalpha

245 lpha knock-out mice (BalphaKO) using calcium/calmodulin-dependent protein kinase IIalpha (CaMKIIalpha

246 Furthermore, calcium/calmodulin-dependent protein kinase IIalpha (CaMKIIalpha

247 ceptors, p600 associates with the calmodulin.calmodulin-dependent protein kinase IIalpha complex.

248 eract with iPLA(2)beta, including the Ca(2+)/calmodulin-dependent protein kinase IIbeta, and we have

249 d cardiomyocyte apoptosis, fibrosis, calcium/calmodulin-dependent protein kinase IIdelta phosphorylat

250 as a direct inhibitor of CaMKIIdelta (Ca(2+)/calmodulin-dependent protein kinase IIdelta) activity, a

251 se II inhibitor KN93, suggesting that Ca(2+)/calmodulin-dependent protein kinase IIdelta, a target of

252 n vascular smooth muscle (VSM) cells, Ca(2+)/calmodulin-dependent protein kinase IIdelta2 (CaMKIIdelt

253 by inflammatory signals that induce calcium/calmodulin-dependent protein kinase IIgamma (CaMKIIgamma

254 he mechanistic role of the family of calcium/calmodulin-dependent protein kinases in mediating these

255 Multifunctional Ca(2+)/calmodulin-dependent protein kinases, including CaMKII,

256 Here, we present evidence that the calcium/calmodulin-dependent protein kinase IV (CaMK4) is increa

257 The activity of calcium/calmodulin-dependent protein kinase IV (CaMK4) is increa

258 sponse to membrane depolarization and Ca(2+)/calmodulin-dependent protein kinase IV (CaMKIV) activati

259 ive oxygen species (ROS) production, calcium/calmodulin-dependent protein kinase IV (CaMKIV) activati

260 Ca(2)(+)/calmodulin-dependent protein kinase IV (CaMKIV) and cAMP

261 The calcium activated protein, calcium/calmodulin-dependent protein kinase IV (CaMKIV) phosphor

262 describe a novel mechanism in which calcium/calmodulin-dependent protein kinase IV (CaMKIV), through

263 Calcium/calmodulin-dependent protein kinase IV is involved in th

264 almodulin-dependent protein kinase I, Ca(2+)/calmodulin-dependent protein kinase IV, and the AMP-depe

265 KN93, a small-molecule inhibitor of calcium/calmodulin-dependent protein kinase IV, targeted to CD4(

266 is regulated by the classical nuclear Ca(2+)/calmodulin-dependent protein kinase IV-CREB/CREB-binding

267 The Ca(2+)-calmodulin dependent protein kinase kinase-2 (CaMKK2) is

268 he mitotic spindle is dependent upon calcium/calmodulin-dependent protein kinase kinase (CamKK) activ

269 ersely, the DOR effect was reduced by Ca(2+)/calmodulin-dependent protein kinase kinase (CaMKK) inhib

270 alian target of rapamycin (mTOR) via calcium calmodulin-dependent protein kinase kinase (CaMKK).

271 re, we report that the expression of Ca(2+) /calmodulin-dependent protein kinase kinase 2 (CaMKK2) is

272 ally reduced by the application of a calcium/calmodulin-dependent protein kinase kinase 2 inhibitor (

273 istic target of rapamycin complex 1, calcium/calmodulin-dependent protein kinase kinase 2, and protei

274 This highlighted calcium/calmodulin-dependent protein kinase kinase 2, which we s

275 e activation of protein kinase A and calcium/calmodulin-dependent protein kinase kinase 2.

276 e expression of constitutively active Ca(2+)/calmodulin-dependent protein kinase kinase alpha (caCaMK

277 Ca(2+)/calmodulin-dependent protein kinase kinase beta (CaMKKbe

278 PK kinases liver kinase B1 (LKB1) and Ca(2+)/calmodulin-dependent protein kinase kinase beta (CaMKKbe

279 AMPK activation by aa is mediated by Ca(2+)/calmodulin-dependent protein kinase kinase beta (CaMKKbe

280 Activation of calmodulin-dependent protein kinase kinase beta was requ

281 Inhibition of Ca(2+)/calmodulin-dependent protein kinase kinase beta, a known

282 events were blocked by inhibition of Ca(2+)/calmodulin-dependent protein kinase kinase beta, an upst

283 n was significantly impaired by knockdown of calmodulin-dependent protein kinase kinase beta.

284 altered calcium signaling, transduced by the calmodulin-dependent protein kinase kinase cascade, medi

285 and promoted AMPK activation by the calcium/calmodulin-dependent protein kinase kinase-beta.

286 This process involves calcium/calmodulin-dependent protein kinase, matrix metalloprote

287 y AMPA-type glutamate receptors and required calmodulin-dependent protein kinase-mediated phosphoryla

288 ngation factor 2 kinase (eEF2K), an atypical calmodulin-dependent protein kinase, phosphorylates and

289 or somatostatin-positive interneurons and of calmodulin-dependent, protein kinase-positive, principal

290 Calcium/calmodulin-dependent protein kinase regulates the PINK1/

291 alcineurin, Akt/protein kinase B, and Ca(2+)/calmodulin-dependent protein kinase signaling pathways i

292 O)-1, glutathione reductase (GSR)-1, calcium/calmodulin-dependent protein kinase type (CAMK)-IV, cAMP

293 which were abolished by inhibition of Ca(2+)/calmodulin-dependent protein kinase type 2.

294 ger, phospholamban, calcineurin, and calcium/calmodulin-dependent protein kinase type II (CaMKII) wer

295 -bisphosphate binding, protein kinase C- and calmodulin-dependent protein kinase type II phosphorylat

296 to remodeling pathways (e.g., Akt and Ca(2+)/calmodulin-dependent protein kinase type II) and develop

297 Calcium/calmodulin-dependent protein kinase type IV (CaMKIV) is

298 SLE T cells express high levels of calcium/calmodulin-dependent protein kinase type IV (CaMKIV), wh

299 Our studies identified calcium/calmodulin-dependent protein kinase type IV as a valuabl

300 ion approaches, we demonstrated that calcium/calmodulin-dependent protein kinase type IV, which contr