ライフサイエンスコーパス: caloric restriction

1 nduced by dietary restriction (also known as caloric restriction).

2 ons, but also lowered BW and adiposity under caloric restriction.

3 ptive decreases of metabolic rate induced by caloric restriction.

4 remodeling, to cardioprotection arising from caloric restriction.

5 accumulation through a mechanism resembling caloric restriction.

6 tween IDH2 and SIRT3 under acute and chronic caloric restriction.

7 betes and regulated by feeding, fasting, and caloric restriction.

8 volved in life-span extension in response to caloric restriction.

9 own and delays age-related kidney disease is caloric restriction.

10 bserved in controls matched for adiposity by caloric restriction.

11 neither has the correction that occurs upon caloric restriction.

12 ats were subjected to 0, 2, 4, or 6 weeks of caloric restriction.

13 tensity aerobic exercise is performed during caloric restriction.

14 ed to the beneficial effects of exercise and caloric restriction.

15 gevity through pathways common to effects of caloric restriction.

16 e in the antiaging cardiovascular effects of caloric restriction.

17 se and the changes in their capacities after caloric restriction.

18 ling pathway, mitochondrial dysfunction, and caloric restriction.

19 yeast and promotes lifespan extension during caloric restriction.

20 oposed to underlie the beneficial effects of caloric restriction.

21 plicated in the lifespan-enhancing effect of caloric restriction.

22 stimuli as pharmacological interventions or caloric restriction.

23 cted by MsrA or MsrB, and further reduced by caloric restriction.

24 pendent of the lifespan extension offered by caloric restriction.

25 be predicted to increase weight loss during caloric restriction.

26 ageing by mechanisms that may be related to caloric restriction.

27 -old ob/ob mice either by leptin infusion or caloric restriction.

28 tabolic potential and a mechanism resembling caloric restriction.

29 eral adipose tissue in response to prolonged caloric restriction.

30 glycemia and prevalent mortality upon severe caloric restriction.

31 nisms promotes longevity in a manner akin to caloric restriction.

32 groups followed a Mediterranean diet without caloric restriction.

33 Volunteers then underwent 6 weeks of 50% caloric restriction.

34 uenced by the energy expenditure response to caloric restriction.

35 armacologic agents that mimic the effects of caloric restriction.

36 n in different species by mechanisms akin to caloric restriction.

37 isms and may underlie the health benefits of caloric restriction, a diet that delays aging and neurod

38 Caloric restriction, a near-universal lifespan extending

39 Caloric restriction activates SIRT3 expression in both w

40 It is possible that caloric restriction acts by improving insulin sensitivit

41 of Molecular Cell, Molin et al. reveal that caloric restriction alleviates PKA-dependent inhibition

42 Caloric restriction alone also led to significant decrea

43 ve caloric restriction and aerobic exercise, caloric restriction alone, aerobic exercise alone, or us

44 tion to one of the following 2 diets without caloric restriction: an HP diet (>40% of energy from pro

45 for potential factors that are regulated by caloric restriction and act as caloric restriction mimet

46 tested the hypothesis that implementation of caloric restriction and aerobic exercise is feasible and

47 ts consented, 111 were randomized to receive caloric restriction and aerobic exercise, caloric restri

48 , and finally we discuss the role of Sir2 in caloric restriction and aging.

49 models of longevity are related primarily to caloric restriction and alterations in metabolism.

50 fy the molecular pathways responsive to both caloric restriction and dietary composition within adipo

51 to the idea that prevention of obesity, and caloric restriction and exercise could reduce the predis

52 the beneficial effects on neural function of caloric restriction and exercise, which are among the mo

53 has also been proposed to mimic benefits of caloric restriction and exercise.

54 Both caloric restriction and fasting significantly reduced PP

55 by two manipulations that extend life span, caloric restriction and genetic attenuation of the norma

56 issue mass in obese humans in the absence of caloric restriction and markedly accelerate weight and b

57 provided by the in vivo efficacy of dietary caloric restriction and natural product-based energy res

58 Caloric restriction and periodic fasting can extend adul

59 ed in the beneficial effects of exercise and caloric restriction and putative anti-inflammatory effec

60 g histone deacetylase, which is increased by caloric restriction and reduced by overfeeding.

61 trations and reduced HDL is improved by both caloric restriction and reduced carbohydrate consumption

62 eeminence for their roles in the response to caloric restriction and the regulation of aging and life

63 lycemia and promoting survival during severe caloric restriction and the requirement for ghrelin cell

64 In rodents, caloric restriction and young blood-induced revitalizati

65 the weight-loss program included nutrition (caloric restriction) and psychological therapies.

66 eating a biological state similar to that of caloric restriction, and consequently leading to life sp

67 potential regulation of pathways mediated by caloric restriction, and growing links to human disease

68 en shown to decrease with age, increase with caloric restriction, and influence stress resistance.

69 lated by leptin deficiency, not modulated by caloric restriction, and markedly suppressed by short-te

70 t stimulate AMPK and PGC1alpha via exercise, caloric restriction, and medications result in stimulati

71 ttenuated in the kidney, ovary, and heart by caloric restriction, and this decrease correlates with d

72 ently in young and old rats after 6 weeks of caloric restriction ( approximately decrease 53%; P = 0.

73 Disturbed eating and severe caloric restriction are characteristic features of patie

74 ) localized to ghrelin cells is required for caloric restriction-associated ghrelin release and the e

75 Previous reports indicate that caloric restriction attenuates anxiety and other behavio

76 We propose that caloric restriction attenuates behavioral and physiologi

77 Glycemic control improves in part because of caloric restriction but also because gut peptide secreti

78 n (TFCA) was measured at baseline and during caloric restriction by using a dual-stable calcium isoto

79 Caloric restriction (by 33% of energy intake) for 4 wk d

80 Lipoapoptosis can be prevented by caloric restriction, by thiazolidinedione treatment, and

81 Thus, a reduction of fat mass without caloric restriction can be associated with increased lon

82 by environmental modification; for example, caloric restriction can increase life span.

83 Even moderate exercise or caloric restriction can lead to lower progesterone level

84 Six weeks of caloric restriction caused a similar reduction in body w

85 Caloric restriction causes many changes in glucose metab

86 ew study in the mouse intestine reveals that caloric restriction causes Paneth cells to repress mTORC

87 lerate weight and body fat loss secondary to caloric restriction compared with diets low in dairy pro

88 In mammals, caloric restriction consistently results in extended lif

89 sir2.1 deletion, we show that heat shock and caloric restriction cooperate to promote increased survi

90 CONCLUSIONS Improved S(I) during caloric restriction correlated with a preferential abdom

91 Whether caloric restriction (CR) acts synergistically with RT to

92 ric restriction, we show that the effects of caloric restriction (CR) and the GHRH mutation are addit

93 Caloric restriction (CR) can increase longevity in roden

94 is unclear, but prior evidence suggests that caloric restriction (CR) can slow thymic aging by mainta

95 It has been shown that caloric restriction (CR) delays aging and possibly delay

96 In yeast, caloric restriction (CR) delays aging by activating the

97 Because caloric restriction (CR) delays aging, at least in part,

98 that adult female mice maintained under 40% caloric restriction (CR) did not exhibit aging-related i

99 Caloric restriction (CR) enhances the sensitivity of ske

100 Importantly, caloric restriction (CR) extends lifespan in several org

101 Caloric restriction (CR) extends the life span and healt

102 Caloric restriction (CR) extends the lifespan of flies,

103 h to ad libitum low-fat diet (DIO-switch) or caloric restriction (CR) for 4 weeks before being killed

104 Caloric restriction (CR) has been found to extend the li

105 Long-term caloric restriction (CR) has been repeatedly shown to in

106 Caloric restriction (CR) has been shown to retard aging

107 We determined whether caloric restriction (CR) has cardiac-specific effects th

108 Caloric restriction (CR) has long been known to increase

109 Caloric restriction (CR) has SSRI-like effects on neural

110 Caloric restriction (CR) improves insulin sensitivity an

111 ectra of blood serum in a long-term study of caloric restriction (CR) in the dog (n = 24 control fed

112 Mice under caloric restriction (CR) increased Sirt3 protein levels,

113 Caloric restriction (CR) is a dietary intervention known

114 Caloric restriction (CR) is a dietary regimen known to p

115 Caloric restriction (CR) is commonly recommended for imp

116 Caloric restriction (CR) is proposed to decrease tumorig

117 Caloric restriction (CR) is the most potent intervention

118 Caloric restriction (CR) markedly extends life span and

119 was designed to explore the possibility that caloric restriction (CR) may benefit Alzheimer's disease

120 e effects of life- and health-span-extending caloric restriction (CR) on gene expression among young

121 is known regarding the long-term effects of caloric restriction (CR) on the risk for atherosclerosis

122 e examined whether these features are due to caloric restriction (CR) or altered nutrient handling.

123 tion was modulated in a group of old rats by caloric restriction (CR) or by surgical removal of visce

124 Adult-onset, long-term caloric restriction (CR) prolongs maximum life span in l

125 Caloric restriction (CR) protects against aging and dise

126 Caloric restriction (CR) reduces the incidence and progr

127 Caloric restriction (CR) reduces the pathological effect

128 Caloric restriction (CR) reduces the pathological effect

129 In laboratory rodents, caloric restriction (CR) retards several age-dependent p

130 In laboratory rodents, caloric restriction (CR) retards several age-dependent p

131 Caloric restriction (CR) started at 14 months of age res

132 In animal models, caloric restriction (CR) suppresses these diseases as we

133 e to adjust their activities when faced with caloric restriction (CR) to deal with reduced energy int

134 Caloric restriction (CR) without malnutrition extends li

135 Caloric restriction (CR) without malnutrition increases

136 Caloric restriction (CR), a manipulation that protects t

137 (iePPARgammaKO) to a two-week period of 25% caloric restriction (CR), following which iePPARgammaKO

138 activities similar to those associated with caloric restriction (CR), such as increased life span an

139 Caloric restriction (CR), the consumption of fewer calor

140 Caloric restriction (CR), the consumption of fewer calor

141 ntly mediate the health-promoting effects of caloric restriction (CR), which includes the retardation

142 Caloric restriction (CR), without malnutrition, delays a

143 xtension of chronological life span (CLS) by caloric restriction (CR).

144 ction of resting energy expenditure (REE) to caloric restriction (CR).

145 for 6 months on a reduced-calorie diet [30% caloric restriction (CR)] or an ad libitum control diet

146 Caloric restriction decreases oxidative damage and exten

147 In rodents, caloric restriction decreases the levels of plasma gluco

148 +-dependent protein deacetylases involved in caloric restriction-dependent life span extension.

149 tmenopausal women were randomized to 1-year: caloric restriction diet (goal of 10% weight loss, N = 1

150 nth randomized controlled trial, comparing a caloric restriction diet arm (goal: 10% weight loss, N =

151 , when Car(-/-) animals were placed on a 40% caloric restriction diet for 12 weeks, Car(-/-) animals

152 In this study we find that caloric restriction dramatically rescues the motor incoo

153 The caloric restriction effect did not require the induction

154 the effects of 12 mo of weight loss through caloric restriction, exercise intervention, or both on s

155 sponsivity and orexigenic drives by moderate caloric restriction experience.

156 Gene expression and caloric restriction experiments in model organisms confi

157 Caloric restriction extends life span by slowing down th

158 Caloric restriction extends life span in a variety of sp

159 Caloric restriction extends lifespan in numerous species

160 mates, and exposure of Ghsr-null mice to 60% caloric restriction fails to elicit antidepressant-like

161 ditis elegans BAF-1 mobility is regulated by caloric restriction, food deprivation, and heat shock.

162 h before death (F), subjected to short-term caloric restriction for 23 days (SCR), or LCR for 9 mont

163 treatment with 2.24 mg/kg.d rapamycin or 40% caloric restriction for 9 weeks partially rescued cardio

164 Biase et al. independently demonstrate that caloric restriction from fasting and pharmacologic inhib

165 nsumption and did not include weight loss or caloric restriction goals.

166 eeding analysis revealed that mutant mice on caloric restriction had a growth rate and body compositi

167 , a downstream mediator in this pathway, and caloric restriction had an additive effect, resulting in

168 ension of life span in response to long-term caloric restriction, had lower GSH/GSSG ratios and highe

169 rift is a determinant of lifespan in mammals.Caloric restriction has been shown to increase lifespan

170 Caloric restriction has been shown to increase longevity

171 Caloric restriction has cardiac-specific effects that am

172 BHB levels are elevated by starvation, caloric restriction, high-intensity exercise, or the low

173 eral drugs to the gene expression profile of caloric restriction identified metformin as a drug whose

174 sely, lifespan-extending maneuvers including caloric restriction impose beneficial pleiotropic effect

175 , it is significantly prevented by long-term caloric restriction in aged mice.

176 eplacement of ghrelin blocked the effects of caloric restriction in beta1AR-deficient mice.

177 F-1 immobilization as a specific response to caloric restriction in C. elegans intestinal cells.

178 hypothesis, we have determined the effect of caloric restriction in Caenorhabditis elegans on activat

179 Severe caloric restriction in humans may confer protection from

180 ediate the blood pressure lowering effect of caloric restriction in hypertensive rats.

181 triking similarity to the effect on aging of caloric restriction in mammals.

182 tion drift correlates with lifespan and that caloric restriction in mice and rhesus monkeys results i

183 sized by the hypoglycemia that is induced by caloric restriction in mouse models of deficient ghrelin

184 Caloric restriction in obese diabetic patients quickly i

185 n inhibitor of fat absorption, combined with caloric restriction in overweight subjects with nonalcoh

186 In contrast to wild type animals, caloric restriction in these mice had little effect on A

187 a drug whose action could potentially mimic caloric restriction in vivo.

188 In a mouse model of moderate caloric restriction in which a 10-15% weight loss simila

189 ovement in glucose metabolism, after 1 wk of caloric restriction, in severely obese diabetic patients

190 ficial effects that met or exceeded those of caloric restriction including reduced serum glucose and

191 energy deficit (kilocalories per day) during caloric restriction, incorporating energy intake and was

192 Both obesity and caloric restriction increase fracture risk and are regul

193 Also, caloric restriction increased apoptosis of DG subgranula

194 ers of enhanced neuroendocrine adaptation to caloric restriction, increased hunger, and a shift in re

195 We propose that caloric restriction increases bioavailability of NO, dec

196 Finally, we show that caloric restriction increases the ability of heat shock

197 We have previously reported that caloric restriction increases the expression of one of t

198 many forms of reward-seeking behavior, with caloric restriction increasing the drive for drugs of ab

199 role of the plasma membrane redox system in caloric restriction-induced pathways responsible for sen

200 ht thereby adjunctively aid consolidation of caloric restriction-induced weight loss and might also b

201 Caloric restriction inhibits hepatosteatosis, reduces Wn

202 Leanness secondary to caloric restriction is known to be associated with impro

203 Caloric restriction is known to up-regulate expression o

204 ller reductions in energy expenditure during caloric restriction is not known.

205 ed with an increased risk for cancers, while caloric restriction is protective, perhaps through clear

206 Longevity-promoting caloric restriction is thought to trigger downregulation

207 Starvation, or caloric restriction, is known to activate the transcript

208 Metabolic factors such as caloric restriction, ketogenic diet, and hyperglycemia i

209 short-term and lifespan-prolonging long-term caloric restriction (LCR) on gene expression in white ad

210 Our studies show that caloric restriction leads to an altered anticipatory fee

211 th the FXR-TGR5 dual agonist INT-767 induced caloric restriction-like effects and reversed age-relate

212 LG isoflavone supplementation resulted in a caloric restriction-like gene expression profile for bot

213 Inasmuch as caloric restriction lowers blood glucose levels, this st

214 of chronic viral infection, suggesting that caloric restriction may modulate viremia to some extent

215 nd nutritional factors, such as exercise and caloric restriction, may exert their known health benefi

216 Caloric restriction mimetic drugs have geroprotective ef

217 y systems, or longevity pathways targeted by caloric restriction mimetic drugs.

218 Caloric restriction mimetics (CRMs) mimic the biochemica

219 anism, effects, and organ specificity of the caloric restriction mimetics RSV and SRT.

220 regulated by caloric restriction and act as caloric restriction mimetics.

221 "habit," supporting the view that persistent caloric restriction mimics some aspects of addiction to

222 Unlike caloric restriction, MSI-1436 decreased mRNA levels of a

223 immune response to weight loss was dynamic; caloric restriction of high-fat diet-fed mice led to an

224 been inferred from genetic manipulations and caloric restriction of model organisms.

225 These results suggest that although caloric restriction on a HFD provides metabolic benefits

226 (AE) versus resistance exercise (RE) without caloric restriction on abdominal adiposity, ectopic fat,

227 uin SIRT3 mediates the protective effects of caloric restriction on age-related hearing loss by promo

228 The effects of caloric restriction on DNA methylation were detectable a

229 east Sir2 gene, which mediates the effect of caloric restriction on life span extension in yeast and

230 herefore determined the effects of aging and caloric restriction on the expression of FXR and TGR5 in

231 and induced in a VHR1 dependent manner upon caloric restriction, on non-fermentable carbon sources,

232 Thus, retrograde response and caloric restriction operate along distinct pathways in d

233 older patients with clinically stable HFPEF, caloric restriction or aerobic exercise training increas

234 te of oxygen consumption was not affected by caloric restriction or by the exclusion of proteins and

235 Yet, since environmental stressors, such as caloric restriction or exposure to mild stress, can incr

236 normalization of weight was mediated not by caloric restriction or increased activity, but by increa

237 magnitude of this change is primarily due to caloric restriction or is unique to the surgical procedu

238 uggest that the anti-inflammatory effects of caloric restriction or ketogenic diets may be linked to

239 Dietary habits such as caloric restriction or nutrients that mimic these effect

240 e on control diet or one of 2 diet regimens (caloric restriction or rapamycin) that altered protein t

241 signed to address features of aging, such as caloric restriction or visceral fat depletion, have succ

242 6 y] men were recruited to either WL through caloric restriction or weight maintenance (WM) for 6 mo.

243 xtend life span in response to sensory cues, caloric restriction, or stress.

244 idative stress, exercise-induced adaptation, caloric restriction, osmotic stress, mechanical stress,

245 ce to weight loss during extended periods of caloric restriction, our findings have important implica

246 Caloric restriction partially or completely restored the

247 us can also increase longevity in a separate caloric-restriction pathway.

248 eater decreases in energy expenditure during caloric restriction predict less weight loss, indicating

249 s are decreased in the aging kidney and that caloric restriction prevents these age-related decreases

250 Animal studies reveal that fasting and caloric restriction produce increased activity of specif

251 Kume et al. demonstrated that caloric restriction protected the aging kidney by preser

252 Evidence suggests that caloric restriction protects against age-associated loss

253 he current study demonstrate that short-term caloric restriction readily normalizes hypothalamic resp

254 Leptin-induced lipopenia prevented and caloric restriction reduced steatosis, hyperglycemia, an

255 Although obesity rates are rapidly rising, caloric restriction remains one of the few safe therapie

256 We further show that caloric restriction rescues SIRT1 levels in transgenic M

257 Moreover, short-term caloric restriction restores hepatic expression of this

258 Caloric restriction resulted in the downregulation of ge

259 hotgun lipidomics to demonstrate that modest caloric restriction results in phospholipid depletion, m

260 red with depletions by exercise alone, acute caloric restriction results in rapid changes in appetite

261 Caloric restriction retards the aging process in small m

262 ell-like features, whereas CtBP depletion or caloric restriction reverses gene repression and increas

263 Reducing lipogenesis by leptin or caloric restriction should prevent or reduce the destruc

264 how that both short-term fasting and chronic caloric restriction significantly reduce the percentage

265 to 30-year-old rhesus monkeys exposed to 30% caloric restriction since 7-14 years of age showed atten

266 mpromises the longevity-promoting effects of caloric restriction, Sirtuin 1 activation, inhibition of

267 (ii) Why does caloric restriction slow aging?

268 ined on a low-calorie medium to determine if caloric restriction slows the aging process.

269 seen in 2.7-3.2-year-old mice exposed to 40% caloric restriction starting at 0.3 years of age.

270 cations such as reduced carbohydrate intake, caloric restriction, structured exercise, and/or pharmac

271 ect to 140 (1)H NMR rat urine spectra from a caloric restriction study and is compared with several o

272 as rapidly growing and was down-regulated by caloric restriction, suggesting a role of Akt in nutrien

273 by specific interventions: metabolic risk by caloric restriction, systemic inflammation by statins, p

274 es with overfeeding, lose less weight during caloric restriction than those with a "spendthrift" phen

275 d accumulation of triglycerides during brief caloric restriction that represented 50% of total myocar

276 either completely or partially prevented by caloric restriction, the only intervention known to reta

277 nstituents, particularly under conditions of caloric restriction, thereby normalizing cellular metabo

278 F levels increase with physical activity and caloric restriction, thus BDNF may mediate some of the o

279 persons who may need additional exercise or caloric restriction to minimize the likelihood of furthe

280 Caloric restriction was accompanied by a slowing of the

281 tuin linked to lifespan-enhancing effects of caloric restriction, was measured by immunoblot.

282 While these effects overlap with those of caloric restriction, we show that the effects of caloric

283 to increased energy expenditure rather than caloric restriction, we were interested in determining w

284 We examined the effects of a caloric restriction weight loss diet and exercise on inf

285 Our findings indicate that a caloric restriction weight loss diet with or without exe

286 Specific biological functions impacted by caloric restriction were identified using the Gene Ontol

287 The effects of age and caloric restriction were qualitatively similar in C57BL/

288 e after bariatric surgery independently from caloric restriction, whereas the level of WAT TGR5 prote

289 ergic nature of AgRP neurons is increased by caloric restriction, whether the GABAergic phenotype of

290 ons may create a metabolic state that mimics caloric restriction, which has been shown to extend life

291 Second, caloric restriction, which increases rodent life span an

292 be more effective for reducing body fat than caloric restriction, which is currently the treatment of

293 Caloric restriction, which retards the ageing process in

294 lipolysis and preserve thermogenesis during caloric restriction, which thereby markedly accelerates

295 in Ghsr-null mice exposed to either CSDS or caloric restriction, while the more highly active analog

296 14 days of moderate caloric restriction with 8.5 or 5.5 hours of nighttime s

297 oluntary wheel running (HFD+Ex) and then 25% caloric restriction with exercise (Ex/CR), each for an a

298 nimal model of binge eating where history of caloric restriction with footshock stress (R + S) causes

299 ls of cAMP, thereby mimicking the effects of caloric restriction with respect to metabolic reprogramm

300 We hypothesized that caloric restriction would have beneficial effects on the