ライフサイエンスコーパス: calorie restriction

1 specific rewiring, which can be prevented by calorie restriction.

2 is selectively activated during fasting and calorie restriction.

3 h dietary carbohydrate restriction than with calorie restriction.

4 ngival RAGE expression in rats is reduced by calorie restriction.

5 dent, with a mechanism most likely mimicking calorie restriction.

6 r expression of glucose-repressed genes upon calorie restriction.

7 uction in energy expenditure associated with calorie restriction.

8 ation of IGF-1R prevented hypothermia during calorie restriction.

9 important role in cell survival promoted by calorie restriction.

10 ing behavioral changes induced by short-term calorie restriction.

11 tal immobility in the forced swim test after calorie restriction.

12 reduced depression-like symptoms induced by calorie restriction.

13 side to enhance life span does not depend on calorie restriction.

14 gene silencing, and extends lifespan without calorie restriction.

15 OR signaling mediates life span extension by calorie restriction.

16 extent than does similar weight loss through calorie restriction.

17 by Sir2 activity under conditions that mimic calorie restriction.

18 This process could be prevented by calorie restriction.

19 t deacetylase and may mediate the effects of calorie restriction.

20 gene mediates the life-extending effects of calorie restriction.

21 er certain environmental conditions, such as calorie restriction.

22 portant factor for the beneficial effects of calorie restriction.

23 onstrating replicative lifespan extension by calorie restriction.

24 to study cells as they age in the absence of calorie restriction.

25 nimals is impaired but can be reactivated by calorie restriction.

26 fter ex vivo cytokine withdrawal and in vivo calorie restriction.

27 criptome persist regardless of two months of calorie restriction.

28 ke CREB-deficient mice, poorly responsive to calorie restriction.

29 e, augment stem-cell function in response to calorie restriction.

30 temperature and of energy expenditure during calorie restriction.

31 sed with the introduction of early postnatal calorie restriction.

32 d yet) result in reduced fat storage through calorie restriction.

33 oups was as follows: controls, -1.0% (1.1%); calorie restriction, -10.4% (0.9%); calorie restriction

34 unchanged in controls, but decreased in the calorie restriction (-135 kcal/d [42 kcal/d]), calorie r

35 6 months: control (weight maintenance diet); calorie restriction (25% calorie restriction of baseline

36 When mice are subjected to 7-day calorie restriction (40% of normal food intake), body fa

37 iours (e.g. 88% would routinely advise about calorie restriction; 99.6% about increasing exercise) mo

38 activation of mTORC1 in Paneth cells during calorie restriction abolishes the ISC-augmenting effects

39 Calorie restriction acts by reducing mechanistic target

40 sexual maturation, reproduction, aging, and calorie restriction affect Acrp30.

41 Whether prolonged calorie restriction affects biomarkers of longevity or m

42 and skeletal muscle metabolism; 48 hours of calorie restriction affects the liver (IHTG content, hep

43 Thus, calorie restriction affects the onset but not the progre

44 n-Y gastric bypass (RYGB) surgery than after calorie restriction alone has independent effects on glu

45 ter improvements than those that result from calorie restriction alone.

46 Whether dietary changes without calorie restriction also protect from diabetes has not b

47 Acute injections of GH after 7 d of calorie restriction also restored hepatic autophagy, but

48 doses of exercise or exercise combined with calorie restriction, although further work is required t

49 We previously showed that calorie restriction ameliorated Huntington's disease pat

50 In conclusion, 4-month dietary calorie restriction and aerobic exercise had significant

51 ses that have traditionally been linked with calorie restriction and aging in mammals.

52 The effect of early-onset calorie restriction and aging on the accumulation of ele

53 Interestingly, calorie restriction and avoidance of obesity largely pre

54 through improvements in macroautophagy (eg, calorie restriction and calorie restriction mimetics) ar

55 Core body temperature was reduced in the calorie restriction and calorie restriction with exercis

56 tested the hypothesis that weight loss from calorie restriction and exercise combined (CREX) improve

57 We show that calorie restriction and exercise-mediated weight loss in

58 the physiological changes in mammals during calorie restriction and how they may lead to the observe

59 ary and sufficient for lifespan extension by calorie restriction and low-intensity stress.

60 esponses to a variety of stresses, including calorie restriction and metabolic stress.

61 or cyclic ADP ribose-mediates the effects of calorie restriction and rapamycin on ISC function.

62 cally the Ames dwarf Prop1 (df/df) mutation, calorie restriction and rapamycin.

63 a key transcriptional target and mediator of calorie restriction and stress-induced life span extensi

64 Lack of Sir2 along with calorie restriction and/or mutations in the yeast AKT ho

65 malian sirtuins as regulators of physiology, calorie restriction, and aging.

66 levels were elevated by fasting or prolonged calorie restriction, and declined with feeding.

67 ercise 5 d/wk for 16 wk combined with modest calorie restriction ( approximately 0.84 MJ/d).

68 Moreover, if metabolic syndrome and calorie restriction are opposite extremes of the same me

69 ed to an enhanced starvation response during calorie restriction as evidenced by increased plasma ghr

70 tiveness of 2 wk of dietary carbohydrate and calorie restriction at reducing hepatic triglycerides in

71 with the changes in ARC expression observed, calorie restriction attenuated the increases in cytosoli

72 +124%) in the cortices of the brain and that calorie restriction attenuated this increase significant

73 longer duration are required to determine if calorie restriction attenuates the aging process in huma

74 ine systems and propose that Sirt1 regulates calorie restriction by sensing low calories and triggeri

75 In yeast, resveratrol mimics calorie restriction by stimulating Sir2, increasing DNA

76 are involved in the synchronizing effects of calorie restriction, C57BL/6J mice were injected with go

77 ocus on mitochondrial-targeted antioxidants, calorie restriction, calorie restriction mimetics, and e

78 neth cells, and the ISC-enhancing effects of calorie restriction can be mimicked by rapamycin.

79 Calorie restriction can extend life span in a variety of

80 Calorie restriction can induce phase-advances of daily r

81 Calorie restriction can inhibit or delay carcinogenesis,

82 Excessive calorie restriction causes malnutrition and has adverse

83 Moderate calorie restriction causes temporal changes in liver and

84 Mice were subjected to 1 wk of 60% calorie restriction, causing them to lose nearly all bod

85 Both chronic calorie restriction (CCR) and intermittent calorie restr

86 However, while moderate calorie restriction (CON) resulted in similar decreases

87 Presently, we demonstrate that 10 d of calorie restriction, corresponding to a 20-25% weight lo

88 o of exercise training (EX group; n = 18) or calorie restriction (CR group; n = 18)] or to a healthy

89 Calorie restriction (CR) (consumption of a diet with few

90 Calorie restriction (CR) and alternate-day fasting (ADF)

91 Calorie restriction (CR) and alternate-day fasting (ADF)

92 Calorie restriction (CR) and conserved nutrient-sensing

93 Mammalian life span can be extended by both calorie restriction (CR) and mutations that diminish som

94 Weight loss from calorie restriction (CR) and/or endurance exercise train

95 It is not known if long-term calorie restriction (CR) can ameliorate this relationshi

96 Dietary calorie restriction (CR) delays age-related physiologic

97 We reported previously that calorie restriction (CR) delays spontaneous carcinogenes

98 Dietary methionine restriction (MR) and calorie restriction (CR) each improve metabolic health a

99 Calorie restriction (CR) extends life span and ameliorat

100 Calorie restriction (CR) extends life span in a wide var

101 Calorie restriction (CR) extends life span in a wide var

102 Calorie restriction (CR) extends life span in diverse sp

103 Calorie restriction (CR) extends life span in many diffe

104 Calorie restriction (CR) extends lifespan in a wide spec

105 Calorie restriction (CR) extends the life span of numero

106 It has been reported that 30% calorie restriction (CR) for 3 mo results in large incre

107 Calorie restriction (CR) has been reported to increase S

108 Calorie restriction (CR) improves health and extends lif

109 ulators in the lifespan extending effects of calorie restriction (CR) in a number of species.

110 Calorie restriction (CR) in the absence of malnutrition

111 While moderate calorie restriction (CR) in the absence of malnutrition

112 Calorie restriction (CR) increases life span in yeast in

113 Calorie restriction (CR) increases longevity in many spe

114 Calorie restriction (CR) increases the lifespan of C57Bl

115 Calorie restriction (CR) influences aging processes and

116 Calorie restriction (CR) is a dietary intervention that

117 Calorie restriction (CR) is a feeding paradigm known to

118 ring genetic manipulation, the diet known as calorie restriction (CR) is currently the only way to sl

119 Calorie restriction (CR) is neuroprotective in Parkinson

120 Calorie restriction (CR) is often described as the most

121 Calorie restriction (CR) is the most effective and repro

122 cardiovascular and chronic kidney diseases; calorie restriction (CR) is the most studied means to de

123 idence suggesting weight maintenance through calorie restriction (CR) may limit risk of HER2-positive

124 Because calorie restriction (CR) modulates age-related renal dis

125 Despite initial success, weight loss by calorie restriction (CR) often fails because of rebound

126 Here we examined the effects of aging and calorie restriction (CR) on expression of the oxidative

127 deacetylase mediates many of the effects of calorie restriction (CR) on organismal lifespan and meta

128 In rodents calorie restriction (CR) reduces cancer incidence, impro

129 Clinical trials involving calorie restriction (CR) require an assessment of adhere

130 Calorie restriction (CR) retards aging and increases lon

131 Calorie restriction (CR) slows aging in numerous species

132 er protection observed in NRF2 KO mice under calorie restriction (CR) suggests that most of the benef

133 tion, wild-type NAD+ salvage is required for calorie restriction (CR) to extend replicative lifespan.

134 ion of circadian clock genes are affected by calorie restriction (CR), a dietary paradigm known to in

135 Determining how calorie restriction (CR), a prolongevity metabolic inter

136 Calorie restriction (CR), a reduction of 10-40% in intak

137 Calorie restriction (CR), a robust intervention shown to

138 Calorie restriction (CR), even for brief periods (4-20 d

139 including reduced life span under stress and calorie restriction (CR), G1 arrest defects, dedifferent

140 multiple long-lived mouse models, including calorie restriction (CR), which led us to hypothesize th

141 concomitant decrease in NADH levels mediate calorie restriction (CR)-induced life span extension.

142 ogic features mimicking animals living under calorie restriction (CR).

143 span and the antiaging effects conferred by calorie restriction (CR).

144 icient in SIRT4 or on the dietary regimen of calorie restriction (CR).

145 m cells (ISCs) is instead upregulated during calorie restriction (CR).

146 or, CRTC1 mediates anti-steatotic effects of calorie restriction (CR).

147 Reduced intake of nutrients [calorie restriction (CR)] extends longevity in organisms

148 he hypothesis that the gingiva of rats fed a calorie-restriction (CR) diet expresses lower levels of

149 evaluate the clinical effects of a long-term calorie-restriction (CR) diet on periodontitis in an ani

150 Weight control by exercise and dietary calorie restriction (DCR) has been associated with reduc

151 Calorie restriction delays brain senescence and prevents

152 e a potentially conserved mechanism by which calorie restriction delays the ageing process.

153 iled to further increase life span and, like calorie restriction, deletion of either SCH9 or TOR1 inc

154 s revealed that IGF signaling also modulates calorie restriction-dependent Tb regulation in regions r

155 Calorie restriction did not prevent muscle mass loss wit

156 using terms encompassing various aspects of calorie restriction, dietary restriction, aging, longevi

157 ication of the orexin gene promoter, whereas calorie restriction enhances the activation of orexin ce

158 ead us to propose a genetic pathway by which calorie restriction extends life span and provides a fra

159 Calorie restriction extends life-span in a wide variety

160 Calorie restriction extends lifespan and produces a meta

161 the budding yeast Saccharomyces cerevisiae, calorie restriction extends lifespan by increasing the a

162 Calorie restriction extends lifespan in a broad range of

163 Calorie restriction extends lifespan in organisms rangin

164 It is not known whether calorie restriction extends maximum life span or life ex

165 r PP (mainly legume protein; n = 19) without calorie restriction for 6 weeks.

166 Thus, when body fat is reduced by calorie restriction, ghrelin stimulates growth hormone s

167 However, neither age nor calorie restriction had any effect on caspase-3 and casp

168 Calorie restriction has been reproducibly shown to prolo

169 Calorie restriction has been shown to have neuroprotecti

170 Calorie restriction has been shown to inhibit epithelial

171 However, calorie restriction has not been as successful as expect

172 2 can extend life span, but a direct link to calorie restriction has not been demonstrated.

173 osis in rat brain with age and evidence that calorie restriction has the ability to attenuate this.

174 association with the anti-ageing effects of calorie restriction, has received particular attention,

175 Regular exercise and calorie restriction have long been known to increase ins

176 RT1, is a mediator of life span extension by calorie restriction; however, SIRT1 may paradoxically in

177 c calorie restriction (CCR) and intermittent calorie restriction (ICR) have shown anticancer effects.

178 They also show that calorie restriction, IGF-1R signaling, and body temperat

179 Weight loss induced by exercise training or calorie restriction improves glucose tolerance and insul

180 Calorie restriction improves life span whereas nutrient

181 s were measured before and after 3 months of calorie restriction in 38 healthy, obese women.

182 Calorie restriction in adult men and women causes benefi

183 However, calorie restriction in adult men and women causes many o

184 roved BAT tracer uptake was identified after calorie restriction in diabetic rats (ZDF-CR).

185 body temperature) are decreased by prolonged calorie restriction in humans and support the theory tha

186 hanisms underlying the beneficial effects of calorie restriction in humans and to characterize new ma

187 activator, mimics the anti-ageing effects of calorie restriction in lower organisms and in mice fed a

188 irtuin 1), activates a critical component of calorie restriction in mammals; that is, fat mobilizatio

189 at mediate the life-span-extending effect of calorie restriction in metazoans.

190 During calorie restriction in mice, increased expression of FGF

191 required for the induction of a phenotype by calorie restriction in mice.

192 state of knowledge regarding the effects of calorie restriction in modulating metabolism and aging.

193 response to exercise training combined with calorie restriction in obese and overweight women (n = 7

194 AA diet promotes rapid fat mass loss without calorie restriction in obese mice.

195 Recent studies of calorie restriction in several organisms demonstrate an

196 In this review, we discuss SIR2 genes and calorie restriction in the lower organisms yeast and Dro

197 Thus, like calorie restriction in the mouse, nicotinamide riboside

198 nt deacetylase required for longevity due to calorie restriction in yeast and Drosophila.

199 Here, we mimicked calorie restriction in yeast by physiological or genetic

200 o be involved in life span determination and calorie restriction in yeast mother cells.

201 has been associated with various effects of calorie restriction, including an increase in lifespan.

202 Calorie restriction increases life span in many organism

203 Prolonged calorie restriction increases life span in rodents.

204 Previously, we showed that calorie restriction increases the replicative life span

205 balanced NmR salvage cycle is essential for calorie restriction-induced life span extension and stre

206 Sirtuin 1 is required for calorie restriction-induced lifespan extension in mice,

207 deprivation-induced SIRT1 transcription, and calorie restriction-induced SIRT1 expression.

208 Calorie restriction-induced weight loss is accompanied b

209 sion, and could have a significant impact on calorie restriction-induced, SIRT1-mediated, changes in

210 In mammals, calorie restriction induces a complex pattern of physiol

211 We conclude that yeast lifespan extension by calorie restriction is the consequence of an active cell

212 Calorie restriction lengthens lifespan, in part, due to

213 p53 activity may mediate a component of the calorie-restriction life span-extending pathway in flies

214 report that Sir2 is directly involved in the calorie-restriction life-span-extending pathway in Droso

215 supplementation with resveratrol may produce calorie restriction-like effects on metabolic and longev

216 oration of GH by infusion during the week of calorie restriction maintained autophagy in the Goat(-/-

217 addition, it is possible that even moderate calorie restriction may be harmful in specific patient p

218 ting IGF-I levels which occur as a result of calorie restriction may lead to the inhibition of skin t

219 her important metabolic pathways that affect calorie restriction may serve as entry points for drugs

220 Although it has been suggested that calorie restriction may work by reducing the levels of r

221 Circadian clocks govern calorie restriction-mediated life span extension through

222 ed in various biological processes including calorie restriction-mediated life span extension.

223 biomarkers for brite formation and show that calorie-restriction-mediated weight loss in women dynami

224 lyphenol in red wine, has been reported as a calorie restriction mimetic with potential antiaging and

225 ryotes and has been suggested as a potential calorie restriction mimetic.

226 This has led to the development of calorie restriction mimetics and other pharmacological i

227 ite extremes of the same metabolic spectrum, calorie restriction mimetics might provide another thera

228 macroautophagy (eg, calorie restriction and calorie restriction mimetics) are also presented.

229 -targeted antioxidants, calorie restriction, calorie restriction mimetics, and exercise training.

230 this parameter has only been estimated under calorie restriction, mimicked by starvation.

231 We have previously shown that under calorie restriction, mitochondrial deacetylase Sirt3 dea

232 ollowing carbohydrate restriction (n = 7) or calorie restriction (n = 7).

233 CNTF(Ax15); 0.1 mg x kg(-1) per day; n = 11) calorie-restriction (n = 9), or feeding ad libitum (n =

234 cited other hallmark changes associated with calorie restriction, namely bradycardia and decreased bo

235 bradycardia and hypothermia associated with calorie restriction occur through mechanisms unaffected

236 maintenance diet); calorie restriction (25% calorie restriction of baseline energy requirements); ca

237 for IUGR studies using a moderate 30% global calorie restriction of pregnant mothers and used cardiac

238 Calorie restriction of tor1D or sch9D cells failed to fu

239 has begun to identify important mediators of calorie restriction, offering the hope of new drugs to i

240 ith trial data showing beneficial effects of calorie restriction on aging biomarkers.

241 play a role in the synchronizing effects of calorie restriction on circadian rhythmicity.

242 We report that effects of calorie restriction on neuronal plasticity, memory and s

243 k was to determine the effect of early-onset calorie restriction on sarcopenia in the aging rat.

244 Similar effects occur during long-term calorie restriction or a high protein diet.

245 life span in wild-type yeast require severe calorie restriction or additional mutations to extend li

246 conditions, including Prop1(df/df) dwarfism, calorie restriction or dietary rapamycin.

247 Weight loss, through calorie restriction or increases in energy expenditure v

248 , on the benefits or hazards associated with calorie restriction or overeating, respectively.

249 tors such as high osmolarity and heat shock, calorie restriction, or inhibitors of TOR and phosphatid

250 Additionally, calorie restriction partially restored the impaired BAT

251 n addition, several longevity factors in the calorie restriction pathway, including the NADH shuttle

252 Calorie restriction phase-advanced by 80 min the locomot

253 s); calorie restriction with exercise (12.5% calorie restriction plus 12.5% increase in energy expend

254 Calorie restriction prevented fiber loss with age, and t

255 lomerulosclerosis did not develop if dietary calorie restriction prevented weight gain and glomerular

256 Calorie restriction prevents both oxidant injury and glo

257 n levels, through subcutaneous injections or calorie restriction, produced anxiolytic- and antidepres

258 We also found that calorie restriction promotes lifespan extension at least

259 iator of the beneficial metabolic effects of calorie restriction, protects neurons against mutant HTT

260 Furthermore, our data suggest that calorie restriction provides neuroprotection through ARC

261 Although calorie restriction reduced the number of ETS abnormalit

262 There is some evidence that calorie restriction reduces or delays many of the age-re

263 gest that the increased longevity induced by calorie restriction requires the activation of Sir2p by

264 charomyces cerevisiae, lifespan extension by calorie restriction requires the NAD+-dependent histone

265 n the social defeat model of chronic stress, calorie restriction reverses the behavioral deficits see

266 hormonal adaptations related to longevity in calorie restriction rodents.

267 In diverse organisms, calorie restriction slows the pace of ageing and increas

268 ent sensitivity of the promoter and impaired calorie restriction-stimulated tissue expression of SIRT

269 By using data from a 24-wk calorie-restriction study, we tested the validity of the

270 ith metformin mimics some of the benefits of calorie restriction, such as improved physical performan

271 a key mediator of the pathways downstream of calorie restriction that have been shown to delay the on

272 rincipal modulator of pathways downstream of calorie restriction that produce beneficial effects on g

273 idol; juvenile enrichment; sucrose drinking; calorie restriction; the serotonin selective reuptake in

274 mice is elevation of GH levels during severe calorie restriction, thereby preserving blood glucose an

275 These results imply that the ability of calorie restriction to inhibit or delay cancer incidence

276 vide a possible molecular pathway connecting calorie restriction to life extension in mammals.

277 onsidered to be required in combination with calories restriction to allow an effective decrease of i

278 stration of exogenous betaOHB, or fasting or calorie restriction, two conditions associated with incr

279 rading off against longevity, with trials of calorie restriction underway.

280 tion-induced lifespan extension in mice, and calorie restriction upregulates sirtuin 1 in humans.

281 Life span extension induced by calorie restriction was not affected by the loss of CL.

282 n protein, vinegar, fish oil, tea, cinnamon, calorie restriction, weight loss, exercise, and low-dose

283 is syndrome are often oppositely affected by calorie restriction, which extends lifespan and prevents

284 Calorie restriction, which increases life span and insul

285 In rodent models, calorie restriction with adequate nutrient intake decrea

286 e physiological and clinical implications of calorie restriction with adequate nutrient intake.

287 axa in individuals either practicing chronic calorie restriction with adequate nutrition (CRON) or wi

288 hough it is currently not known if long-term calorie restriction with adequate nutrition extends maxi

289 Moreover, calorie restriction with adequate nutrition protects aga

290 determined the effects of acute and chronic calorie restriction with either a low-fat, high-carbohyd

291 lorie restriction (-135 kcal/d [42 kcal/d]), calorie restriction with exercise (-117 kcal/d [52 kcal/

292 estriction of baseline energy requirements); calorie restriction with exercise (12.5% calorie restric

293 e was reduced in the calorie restriction and calorie restriction with exercise groups (both P<.05).

294 (1.1%); calorie restriction, -10.4% (0.9%); calorie restriction with exercise, -10.0% (0.8%); and ve

295 Long-term calorie restriction without malnutrition and reduced fun

296 ifespan in humans, we do know that long-term calorie restriction without malnutrition results in some

297 When subjected to 60% calorie restriction, WT and Goat(-/-) mice both lost 30%

298 ed into a no-restriction (ZDF-ND) and a mild calorie restriction (ZDF-CR) group.