ライフサイエンスコーパス: calprotectin

1 e inflamed gut was rescued in the absence of calprotectin.

2 e antibiotic sensitivities of spirochetes in calprotectin.

3 kers of inflammation in stool, such as fecal calprotectin.

4 ch comes from the abundant cytosolic protein calprotectin.

5 own to inhibit the antimicrobial activity of calprotectin.

6 th excessively high plasma concentrations of calprotectin.

7 lmonella organisms bound to cells expressing calprotectin.

8 s were delayed, however, in cells expressing calprotectin.

9 ction was abrogated by zinc and depletion of calprotectin.

10 microbial activity similar to that of native calprotectin.

11 against Candida albicans similar to that of calprotectin.

12 s placed on top of an agarose gel containing calprotectin.

13 ier defense via mucosal release of IL-22 and calprotectin.

14 oides was increased in infants with abnormal calprotectin.

15 nd manganese chelation by neutrophil-derived calprotectin.

16 robial peptides RegIIIbeta, RegIIIgamma, and calprotectin.

17 in S100A9(-/-) mice by injecting recombinant calprotectin.

18 binding of Mn(II) to the His6 site of human calprotectin.

19 Exposure to calprotectin (a host protein known to sequester metal io

20 on provided a stool sample to be assayed for calprotectin (a neutrophil-specific marker), and patient

21 To isolate the effects of calprotectin, a calprotectin-negative oral epithelial ce

22 Calprotectin, a heterodimer of MRP8 and MRP14 with antim

23 Epithelial cells expressing calprotectin, a heterodimer of S100A8 and S100A9 protein

24 Calprotectin, a heterodimer of S100A8 and S100A9, is an

25 A major player in this process is calprotectin, a host protein that exerts antimicrobial a

26 mmation and down-regulates the expression of calprotectin, a molecule which influences neutrophil fun

27 We conclude that calprotectin, a potent bacteriostatic agent from a cell

28 icant carbonylation of the S100A9 subunit of calprotectin, a truncated form of Hsp70, actin, and hemo

29 icroscopic and regrowth assays revealed that calprotectin acted in a bacteriostatic fashion against B

30 In a hospital setting, fecal calprotectin added the most diagnostic value to symptoms

31 In this study, we aimed to evaluate fecal calprotectin, alpha-1-antitrypsin (alpha(1)-AT), and ela

32 A review of published calprotectin amino acid sequences revealed the HEXXH mot

33 e also found that TdfH confers resistance to calprotectin, an immune effector protein highly produced

34 Calprotectin, an S100 calcium-binding protein with broad

35 Multiple regression modeling identified calprotectin and alpha(1)-AT concentration as independen

36 Calprotectin and alpha(1)-AT concentrations increased wi

37 Our results showed that fecal calprotectin and alpha(1)-AT levels at the time of diagn

38 In contrast, calprotectin and alpha(1)-AT were predictors for SR-GVHD

39 r fecal levels of two GVHD severity markers, calprotectin and alpha1-antitrypsin.

40 completely reversed by specific antibody to calprotectin and by Zn(2+), a cation essential for the g

41 with melioidosis resulted in lower levels of calprotectin and C-reactive protein (P < 0.0001), coinci

42 The median percent reduction of calprotectin and C-reactive protein was 71% for both bio

43 Serum levels of calprotectin and C-reactive protein were significantly h

44 s of intestinal inflammation, such as faecal calprotectin and C-reactive protein, have been recommend

45 ), video capsule endoscopy (VCE), CRP, fecal calprotectin and CDAI.

46 biopsies were collected and used to quantify calprotectin and expression of 12 Wnt-related genes, res

47 gut by overcoming the zinc sequestration of calprotectin and highlight the importance of zinc acquis

48 Fecal markers such as calprotectin and lactoferrin have been studied for their

49 Calprotectin and lactoferrin levels were quantified by s

50 The levels of calprotectin and lactoferrin varied directly with one an

51 of this study was to determine the levels of calprotectin and lactoferrin, 2 microbiostatic proteins,

52 Serum levels of calprotectin and MMP-8 are elevated in patients with AgP

53 eria to evade neutrophil killing mediated by calprotectin and reactive oxygen species.

54 Plasma calprotectin and serum 25 (OH) vitamin D levels were mea

55 bind and invade transfected cells expressing calprotectin and sham transfectants.

56 nscription, and reversed the upregulation of calprotectin and Toll-like receptor (TLR) 4 in inflamed

57 CDAI, CRP, fecal calprotectin and VCE Lewis inflammatory score did not ch

58 coefficient = 0.49), whereas diarrhea, high calprotectin, and low SCFA production related to death i

59 athogens (n = 15), cytokines (n = 29), fecal calprotectin, and the short-chain fatty acids (SCFAs) bu

60 In conclusion, expression of calprotectin appears to protect epithelial cells in cult

61 In periodontitis, calprotectin appears upregulated and is detected at high

62 ral mucosa, the expression of immunoreactive calprotectin appears upregulated.

63 Serum C-reactive protein and fecal calprotectin are among the best-studied noninvasive biom

64 erfacial His(3)Asp and His(4) sites of human calprotectin are identified by using Co(II) as a spectro

65 In addition, cells expressing calprotectin are more resistant to detachment mediated b

66 Blood markers and fecal calprotectin are used in the diagnostic workup for infla

67 c curve analysis revealed a high accuracy of calprotectin (area under the curve, 0.94) in the differe

68 These studies highlight Zn sequestration by calprotectin as a key functional arm of NET-mediated kil

69 We identified calprotectin as a lead biomarker of B. pseudomallei infe

70 We identify the host protein calprotectin as a neutrophil-dependent factor expressed

71 jacks and directly utilizes the host protein calprotectin as a zinc source and thereby evades nutriti

72 ammation, specifically stool lactoferrin and calprotectin as well as small intestine contrast ultraso

73 idermis and found S100A8-S100A9, also called calprotectin, as the most upregulated proteins, followed

74 tion of the IL-6-Janus kinase 2 (JAK2)-STAT3-calprotectin axis with FDA-approved drugs, alone and in

75 In physiologic calprotectin, B. burgdorferi is not eliminated by therap

76 s and markers of inflammation, such as fecal calprotectin, C-reactive protein, and Crohn's disease ac

77 for zinc; however, experiments to show that calprotectin can inhibit growth of microorganisms across

78 a conventional ELISA setup measuring canine calprotectin (cCP).

79 lular pathogens; in the extracellular space, calprotectin chelates Mn and Zn.

80 evels of the innate immunity-related markers calprotectin, colony-stimulating factor (CSF)-1, macroph

81 subunit mRNA by RNase protection assays and calprotectin complex by enzyme-linked immunosorbent assa

82 l line was stably transfected to express the calprotectin complex.

83 Calprotectin (complex of S100A8 and S100A9) is the major

84 stigation for intestinal inflammation (fecal calprotectin concentration), HLA-B27 genotyping, and com

85 NDC supplementation did not affect fecal calprotectin concentration.

86 ce range 11-18 micromol/L) and raised plasma calprotectin concentrations (1.4-6.5 g/L, reference rang

87 30 subjects (75%) had increased repeat fecal calprotectin concentrations above the upper limit of nor

88 stant starch (RS) and polydextrose] on fecal calprotectin concentrations and Wnt pathway-related gene

89 necrotising enterocolitis had raised faecal calprotectin concentrations at the time of diagnosis com

90 Calprotectin concentrations of patients with stable graf

91 extrose supplementation did not affect fecal calprotectin concentrations.

92 Recombinant calprotectin, consisting of 2 individual peptide chains

93 These results suggest that intact calprotectin, consisting of a heterodimer of MRP8 and MR

94 How calprotectin contributes to the pathogenesis of periodon

95 The S100A8/S100A9 heterodimer calprotectin (CP) functions in the host response to path

96 Calprotectin (CP) is a transition metal-chelating antimi

97 Calprotectin (CP) is an antimicrobial protein produced a

98 Human calprotectin (CP) is an antimicrobial protein that coord

99 The antimicrobial protein calprotectin (CP), a hetero-oligomer of the S100 family

100 Human calprotectin (CP, S100A8/S100A9 oligomer) is a metal-seq

101 The human innate immune protein calprotectin (CP, S100A8/S100A9 oligomer, calgranulin A/

102 Human calprotectin (CP, S100A8/S100A9 oligomer, MRP-8/MRP-14 o

103 Levels of calprotectin, CSF-1, MIF, MIG, and MMP-8 were measured u

104 atus, intestinal mucosal inflammation (fecal calprotectin), daily morbidity, and cognitive developmen

105 l burdens in the livers of wild-type but not calprotectin-deficient mice, suggesting that these syste

106 rrent study, we showed that neutrophils from calprotectin-deficient S100A9(-/-) mice have an impaired

107 The abundant PMN cytoplasmic protein calprotectin, elevated 10- to 100-fold in inflammation,

108 crobial communities are found to co-exist in calprotectin-enriched airspaces of a cystic fibrosis lun

109 Similarly, binding to calprotectin expressing cells was reduced approximately

110 Calprotectin-expressing and sham-transfected cells showe

111 Calprotectin-expressing cells appeared to have internali

112 Listeria organisms bound to the surfaces of calprotectin-expressing cells, and 10-fold fewer were lo

113 supplemented direct antimicrobial effects in calprotectin-expressing cells.

114 acterial pathogens showed reduced binding to calprotectin-expressing epithelial cells.

115 Calprotectin-expressing transfectants expressed calprote

116 In this study, we assessed whether calprotectin expression affects bacterial binding and up

117 Calprotectin expression was accompanied by altered actin

118 Calprotectin expression was constitutive in the primary

119 To test whether calprotectin expression was inducible, immortalized ging

120 estigated whether monitoring levels of fecal calprotectin (FC) can substitute for endoscopic analysis

121 Serum and mucosal ST2, and fecal calprotectin (FC) content were determined by ELISA and c

122 Faecal calprotectin (FC) is one of the most widely used non-inv

123 Faecal calprotectin (FC), Gastrointestinal Symptoms Rating Scal

124 ationship between the concentration of fecal calprotectin (FCP) and clinical and endoscopic outcomes

125 ccuracy of more than 1 blood marker or fecal calprotectin for IBD, confirmed by endoscopy and histopa

126 MntABC and MntH compete with calprotectin for manganese, which enables S. aureus grow

127 50 mg/L, the sensitivity and specificity of calprotectin for predicting relapse in all patients with

128 al epithelial cell line was transfected with calprotectin genes to enable expression.

129 p before and after random assignment: faecal calprotectin >/=250 mug/g, C-reactive protein >/=5mg/L,

130 L, C-reactive protein >/=5.0 mg/L, and fecal calprotectin >/=300 mug/g.

131 on, we show that the Zn-binding S100 protein calprotectin has antimicrobial effects against C. diffic

132 Calprotectin has been proposed as a useful marker of inf

133 Urinary calprotectin has recently been identified as a promising

134 The best marker-fecal calprotectin-improved the area under the curve of sympto

135 The use of faecal calprotectin in addition to EPAGE criteria improved diag

136 The use of faecal calprotectin in addition to EPAGE criteria improved the

137 We evaluated the diagnostic value of fecal calprotectin in patients with abdominal discomfort.

138 We measured calprotectin in plasma and protein fractions by ELISA as

139 Immunohistochemical stainings for calprotectin in renal allograft biopsy specimens confirm

140 ught to learn if epithelial cells upregulate calprotectin in response to proinflammmatory agents.

141 osal epithelial cells constitutively express calprotectin in the cytoplasm.

142 me in the azurophil granule compartment; and calprotectin in the cytosolic compartment.

143 In these studies, calprotectin in the gels underneath did suppress growth

144 t to hyphae, we found no role for neutrophil calprotectin in uptake or killing of intracellular A. fu

145 and following incubation with neutrophils or calprotectin in vitro as compared with wild-type.

146 00A8/A9 [myeloid-related protein (MRP) 8/14, calprotectin] in promoting glomerulonephritis.

147 All blood markers and fecal calprotectin individually significantly improved the dis

148 studies of bone marrow-derived MPhis showed calprotectin-induced CCL11 production via a p65-dependen

149 Neutrophil-derived calprotectin inhibited S. aureus growth through chelatio

150 These results indicate that calprotectin inhibits C. albicans growth in the absence

151 Calprotectin is a calcium- and zinc-binding protein that

152 These results demonstrate that calprotectin is a critical factor in the innate immune r

153 ity." The manganese and zinc binding protein calprotectin is a key component of the nutrient-withhold

154 Urinary calprotectin is a promising biomarker for the differenti

155 Calprotectin is a protein in neutrophil cytoplasm and ab

156 In patients with abdominal discomfort, fecal calprotectin is a useful non-invasive marker to identify

157 The present study investigates whether calprotectin is able to differentiate between these 2 en

158 We find that while calprotectin is induced by neutrophils during infection

159 in surrounds staphylococcal heart abscesses, calprotectin is not released into the abscess nidus and

160 ctivity of polyhistidine, as well as that of calprotectin itself, was reversed by addition of zinc or

161 We investigated fecal calprotectin level (FCL) as a candidate noninvasive mark

162 Calprotectin levels (n = 68) were measured in this pilot

163 Increased calprotectin levels activate signaling pathways involved

164 Low stool calprotectin levels correlate well with a low risk for i

165 Median stool calprotectin levels from patients with rejection were si

166 We measured calprotectin levels in 732 stool samples collected, anal

167 Median calprotectin levels in the relapse groups (122 mg/L for

168 tients with serial levels, elevations in the calprotectin levels preceded histologic changes by 6 to

169 ection episodes have greater fluctuations in calprotectin levels than those without, suggesting incre

170 Median calprotectin levels were higher (81.5 mug/g, interquarti

171 Median calprotectin levels were higher in patients with melioid

172 Median calprotectin levels were higher in patients with signifi

173 Thus, reductions in serum calprotectin levels were linked to therapeutic responses

174 gged with six C-terminal histidines did have calprotectin-like zinc-reversible antimicrobial activity

175 In periodontal disease, calprotectin may augment both the barrier protection and

176 Our results suggest that calprotectin may be a sensitive indicator of melioidosis

177 Calprotectin may modify the clearance of spirochetes at

178 ity to CDI and severity of disease, and that calprotectin-mediated metal limitation is an important f

179 ith the gut pathogen Salmonella Typhimurium, calprotectin-mediated metal sequestration does not inhib

180 Calprotectin-mediated Mn sequestration is a newly apprec

181 Remarkably, S. Typhimurium overcomes calprotectin-mediated zinc chelation by expressing a hig

182 Calprotectin mediates the cytoplasmic activity, whereas

183 Faecal calprotectin might be a useful marker of gastrointestina

184 ejection, based on these data, routine stool calprotectin monitoring is not strongly supported.

185 These data show that calprotectin mRNA is expressed constitutively in culture

186 cal biomarkers of environmental enteropathy (calprotectin, myeloperoxidase, alpha1-antitrypsin) and t

187 Other proteins identified, including calprotectin, myeloperoxidase, and alpha-defensins, are

188 00A9 encoding plasmids were transfected into calprotectin-negative KB carcinoma cells.

189 To isolate the effects of calprotectin, a calprotectin-negative oral epithelial cell line was tran

190 protectin-expressing transfectants expressed calprotectin on the cell surface as well as in the cytos

191 We did not find increased fecal calprotectin or IgA as marker of inflammation in childre

192 k showed that the S100A8/S100A9 heterodimer (calprotectin, or calgranulin A/B) binds zinc and repress

193 markers such as leukocytes, lactoferrin, or calprotectin, or positive stool culture for an invasive

194 Wolbachia DNA and the antibacterial peptides calprotectin (P =.021) and calgranulin B (P <.0001).

195 tive components such as soluble defensin and calprotectin peptides.

196 Calprotectin-positive neutrophils were abundant in regio

197 Fecal calprotectin predicts clinical relapse of disease activi

198 crine stimulus to increase S100A8/9 complex (calprotectin) production and secretion.

199 nsistent with these results, the presence of calprotectin promotes co-colonization of the murine lung

200 loss of the calcium-induced positive face in calprotectin, reducing interactions with microtubules an

201 Cells expressing calprotectin resist invasion by Listeria monocytogenes a

202 ) mutants or the S100A9(1-114) (full-length) calprotectin resisted bacterial invasion better than KB-

203 , these data provide a working model whereby calprotectin responds to physiological Ca(II) gradients

204 zinc and manganese binding are necessary for calprotectin's antihyphal activity.

205 These results suggest that calprotectin's antimicrobial activity may be related to

206 two effector antimicrobial peptides (AMPs): calprotectin (S100A8-S100A9 heterodimer [S100A8/A9]) in

207 alyses revealed a link between expression of calprotectin (S100a8/S100a9), Ccl11 expression, and eosi

208 Calprotectin sequesters essential micronutrient metals s

209 uses specialized metal transporters to evade calprotectin sequestration of manganese, allowing the ba

210 lood cell count, C-reactive protein or fecal calprotectin, serologic testing for celiac disease, and

211 Transfected cells expressing calprotectin showed 40 to 50% fewer internalized P. ging

212 en of the disease (C-reactive protein, fecal calprotectin) since symptoms-based scores are subjective

213 e in the primary gingival keratinocytes, but calprotectin-specific mRNA and protein tended to increas

214 flamed prostate epithelium; however, IHC for calprotectin suggested prostate-infiltrating neutrophils

215 canonical mammalian Mn-sequestering protein calprotectin surrounds staphylococcal heart abscesses, c

216 ent a baseline capsule enteroscopy and fecal calprotectin test.

217 h rejection have higher mean levels of stool calprotectin than those without, but because of signific

218 00A9) form MRP-8/14 heterodimers (S100A8/A9, calprotectin) that regulate myeloid cell function and in

219 Faecal calprotectin, thyroid tests, celiac serology, breath tes

220 d the incremental diagnostic value of faecal calprotectin to EPAGE criteria.

221 ng release of antimicrobial proteins such as calprotectin to inhibit bacterial growth.

222 Adding fecal calprotectin to the diagnostic workup of pediatric patie

223 ed expression of both systems in response to calprotectin treatment.

224 Final diagnoses were adjudicated blinded to calprotectin values.

225 Final endoscopic diagnoses were blinded to calprotectin values.

226 ved that metal content and the importance of calprotectin varies between murine organs, and infection

227 l ion starvation mediated by lipocalin-2 and calprotectin via alternative pathways, IL-22 boosted its

228 Median urinary calprotectin was 36 times higher in intrinsic AKI (1955

229 When fecal calprotectin was added to the model, the proportion of p

230 Urinary calprotectin was assessed by enzyme-linked immunosorbent

231 Calprotectin was measured in stool samples collected wit

232 Faecal calprotectin was measured in stool samples collected wit

233 ia activity of U-Cyt lysates and recombinant calprotectin was partially or completely reversed by spe

234 Calprotectin was significantly higher in children who di

235 Fecal calprotectin was useful as a diagnostic parameter both f

236 In serum, mean levels of calprotectin were 2.06-fold higher in patients with AgP

237 xclusion chromatography showed that zinc and calprotectin were associated in a broad fraction with mo

238 The abscesses of mice lacking calprotectin were enriched in metal, and staphylococcal

239 Fecal samples were collected, levels of calprotectin were measured, and microbiota were analyzed

240 We found that TdfH directly binds calprotectin, which enables gonococcal Zn accumulation i

241 icrobial proteins, including lipocalin-2 and calprotectin, which sequester essential metal ions from

242 radshaw index, C-reactive protein and faecal calprotectin will be collected at recruitment and 3 mont

243 Furthermore, using recombinant calprotectin with mutations in either the Zn and Mn bind

244 of the IL-22 inducible antimicrobial protein calprotectin without modulating IL-17 expression.