ライフサイエンスコーパス: camel

1 umans and in its natural host, the dromedary camel.

2 library constructed from an immunized Arabic camel.

3 RS-CoV was isolated from the patient and the camel.

4 itted through close contact with an infected camel.

5 d bovine MFGMs (100 mug/mL), but not yak and camel.

6 ng force for shaping mitogenome diversity in camels.

7 ocused on two potential reservoirs: bats and camels.

8 oV with a known zoonotic source in dromedary camels.

9 emerged from bats and passed into humans via camels.

10 nfirmed MERS who had no previous exposure to camels.

11 attoir workers with occupational exposure to camels.

12 of individuals who have maximum exposure to camels.

13 ent outbreak affecting both human beings and camels.

14 on for multiple species including horses and camels.

15 d residue at position 94 is not conserved in camels.

16 loned from alpacas, dromedaries and Bactrian camels.

17 is highly stable in vivo in both humans and camels.

18 cats; and 6) four MERS strains isolated from camels.

19 ncluding African buffalo, gazelle, saiga and camels.

20 se vaccine regimens for younger seronegative camels.

21 June 2012 and has since spread in humans and camels.

22 ed protein-coding genes in domestic Bactrian camels.

23 was higher in local camels than in imported camels (224 [47.5%] of 472 vs 157 [13.1%] of 1196; p<0.0

24 CTCF Analyzer (with) Multinomial Estimation (CAMEL), a tool that identifies CTCF footprints at near b

25 onavirus (MERS-CoV) is enzootic in dromedary camels across the Middle East and Africa.

26 weekly) interacting with young (age <1 year) camels (adjusted odds ratio [OR(adj)] 3.85 [95% CI 1.41-

27 rite cigarette advertisement in 1993 and Joe Camel advertisements were the most popular.

28 transmitted back and forth between human and camel after it had acquired the human-camel infection ca

29 rical, p=0.0069), a household owning a young camel (age <18 months; OR(adj) 1.98 [1.02-4.09], p=0.043

30 ating, camel milk at 80 degrees C for 60min, camel alpha-lactalbumin (alpha-la) and peptidoglycan rec

31 In good agreement, the 3D structure of camel alpha-lactalbumin determined by X-ray crystallogra

32 The effect of deamidation on camel alpha-lactalbumin instability was investigated.

33 highest yield of proteins, identifying 1143 camel and 851 cow proteins.

34 e of protein hydrolysis (DH) was observed in camel and bovine colostrum as compared to undigested sam

35 bility pattern and antioxidant properties of camel and bovine colostrum under SIGID conditions, demon

36 hibitory peptide sequences identified within camel and bovine milk protein hydrolysates generated und

37 yme selectivity for peptide bond cleavage of camel and bovine milk proteins as well as dissimilaritie

38 . plantarum DSM2468 were employed to ferment camel and bovine milks separately.

39 rease of the glass transition temperature of camel and bovine whey powder (at 0.13, 0.23, and 0.33 of

40 photoelectron spectroscopy results) in both camel and bovine whey powders regardless the pH (neutral

41 ater activity of lactose crystallization for camel and bovine whey powders.

42 herm and the glass transition temperature of camel and bovine whey protein's powders.

43 Camel and bovine whey proteins were affected by a heat t

44 rovide a comprehensive proteomic resource of camel and cow milk products, mapping potential allergens

45 eatment of 80 degrees C during 60min of both camel and cow milks.

46 L, w/w) extracted by rennet coagulation from camel and cow's milk, respectively.

47 navirus (MERS-CoV) obtained from a dromedary camel and from a patient who died of laboratory-confirme

48 ve tract, these results suggest that GABA in camel and goat milk may participate in GABA-modulated fu

49 We found that camel and goat milks have significantly more bioavailabl

50 2 and 62.9% identity with zeta-crystallin of camel and guinea pig lenses, respectively.

51 ononuclear cells isolated from the immunized camel and purified the antibody from Escherichia coli af

52 probiotic bacterium, on milk extracted from camels and 2) examine the rheological properties of the

53 tudy design was used to test 393 slaughtered camels and 86 abattoir workers for C. burnetii antibodie

54 n of C. burnetti DNA in clotted blood of 366 camels and 86 abattoir workers.

55 was not detected in clotted blood samples of camels and abattoir workers.

56 ic potential and has reservoirs in dromedary camels and bats.

57 in the upper and lower respiratory tracts of camels and humans, respectively.

58 tract, similar to what has been reported for camels and humans.

59 s of single-domain antibodies from camelids (camels and llamas) can circumvent both these obstacles.

60 light (V(L)) chain variable domains, but in camels and llamas, the binding site frequently comprises

61 stic heavy chain-only antibodies produced by camels and llamas.

62 derived from heavy chain antibodies found in camels and llamas.

63 ides virological confirmation of MERS-CoV in camels and suggests a recent outbreak affecting both hum

64 he species barrier to infect dogs, pigs, and camels and therefore may also pose a threat to humans.

65 infect other mammals such as dogs, pigs, and camels and therefore may also pose a threat to humans.

66 idering potentially allergenic proteins, 53 (camel) and 52 (cow) were identified.

67 o periods for both large (cattle, horse, and camel) and small livestock (sheep and goat).

68 ticated livestock (cattle, sheep, goats, and camels) and wildlife collected from a total of 55 of 71

69 an stool samples and local cow, goat, sheep, camel, and chicken meat samples indicated that the major

70 Middle Eastern animals and found that human, camel, and horse receptors sensitized cells to MERS-CoV

71 Human, camel, and horse receptors were potent and nearly equall

72 While bat, camel, and human DPP4 support MERS-CoV infection, severa

73 ed from 228 cattle, 162 goats, 158 sheep, 49 camels, and 257 humans from Narok and Marsabit counties

74 urally in "heavy chain" immunoglobulins from camels, and now produced in fully human form, domain ant

75 We show, in addition, that the binding of a camel antibody fragment, cAb-HuL6, which was raised agai

76 he butchered remains of seven horses and one camel are associated with 29 nondiagnostic lithic artifa

77 Dromedary camels are a likely source of infection and the virus pr

78 Cattle, sheep, goats, and camels are particularly susceptible to RVF and serve as

79 Scientific evidence suggests that dromedary camels are the intermediary host for the Middle East res

80 ivergence between domestic and wild Bactrian camels around 1.1 [0.58-1.8] million years ago (mya).

81 be useful to protect target animals, such as camels, as well as humans from deadly MERS-CoV and RABV

82 nfection, were co-housed with the vaccinated camels at a ratio of 1:2 (infected:vaccinated); nasal di

83 valence, and age-associated prevalence among camels at the largest entry port of camels from Africa i

84 we show that sera obtained from MERS-immune camels augment the kinetics of MERS-CoV clearance and re

85 show that the emulsifying activity (EAI) of camel B-casein is higher than the bovine protein.

86 Conversely, a significant effect of pH on camel B-casein was recorded: at pH 6.0, the lowest value

87 y to pay attention to genetic improvement in camel breeding.

88 in milk from cow (CW) compared to those from camel breeds (CM 1-4).

89 dicated that MERS-CoV was circulating in the camels but not in the patient before the human infection

90 MERS-CoV has been reported in dromedary camels but phenotypic characterisation of such viruses i

91 e detected MERS-CoV in nose swabs from three camels by three independent RT-PCRs and sequencing.

92 k from different species (human HM, cow CoM, camel CaM, and mare MM) using an optimised (31)P NMR spe

93 The dromedary camel (Camelus dromedarius) is a desert mammal whose cyc

94 have cloned and characterized GH genes from camel (Camelus dromedarius), hippopotamus (Hippopotamus

95 Although dromedary camels (Camelus dromedarius) are known to be the host re

96 Dromedary camels (Camelus dromedarius) are natural reservoirs of c

97 ls (Ictidomys tridecemlineatus) and Bactrian camels (Camelus ferus) express TRPV1 orthologs with dram

98 For example, ground squirrels and camels can tolerate temperatures more than 40 degrees C

99 Cow (CwC) and camel casein (CaC) hydrolysates were generated using Alc

100 ange of domestic and wild mammals, including camels, cattle, horses, goats, sheep, cats, rabbits, and

101 as prepared for curdling using a recombinant camel chymosin (50 IMCU/ kg).

102 ltured and non-cultured) using a recombinant camel chymosin, with reference to whey constituents.

103 ing cheese curd from CAM using a recombinant camel chymosin.

104 Our studies suggest that squirrels and camels co-opt a common molecular strategy to adapt to ho

105 SA-positive household member with history of camel contact (OR(adj) 24.74 [2.72-306.14], p=0.0050).

106 Among individuals without history of camel contact, S1 ELISA seropositivity was associated wi

107 dary acquisition; 12 of these 13 also denied camel contact.

108 is a novel zoonotic pathogen associated with camel contact.

109 enced multiple complete genomes of dromedary camel coronavirus HKU23 (DcCoV-HKU23) from Nigeria, Moro

110 nts of recombination of an endemic dromedary camel coronavirus, HKU23, with other clade A betacoronav

111 Our finding links consumption of camel-derived food products to post-transplantation hepa

112 In contrast, MERS is primarily a camel disease on the Arabian Peninsula and in Africa, wi

113 osoma evansi, parasites that cause horse and camel diseases.

114 S-CoV antibodies was significantly higher in camel-exposed individuals than in the general population

115 Dipus sagitta) and horse and the 'even-toed' camel, extensive cell death sculpts the tissue around th

116 larger sample size and collaboration of the camel farmers and more profound understanding will permi

117 We tested serum samples from the camels for IgG immunofluorescence assay, protein microar

118 acid and sweet whey obtained from bovine and camel fresh milk was examined.

119 ed for the presence of MERS-CoV in dromedary camels from a farm in Qatar linked to two human cases of

120 ce among camels at the largest entry port of camels from Africa into the Arabian Peninsula.

121 Despite frequent imports of MERS-CoV with camels from Africa, African lineages of MERS-CoV do not

122 nt study we aimed to produce multiple cloned camels from racing, show and dairy exemplars.

123 Here we report cloned camels from surgical embryo transfer and correlate blast

124 dromedary viruses exists in two versions in camels, full length and deleted, whereas only the delete

125 ody by ChAdOx1-GnGc vaccination in dromedary camels, further illustrating the potency of replication-

126 Camels gained attention since the discovery of MERS-CoV

127 The sequence of camel GH is identical to that reported previously for al

128 the ability of MERS-CoV to bind the DPP4s of camel, goat, cow, and sheep.

129 ommon Middle East livestock species, such as camels, goats, sheep, and cows, these form a potential M

130 The LPO activities ranked as bovine > goat > camel > human in the four types of milk analysed.

131 (with an order of goat > buffalo > bovine > camel > yak) and Bcl-2 expression, but increased the exp

132 haracteristics of fat from the hump of young camels (Hachi) were evaluated.

133 ve camels were enhancedby the vaccine; these camels had a higher average age than seronegative.

134 All camels had MERS-CoV spike-binding antibodies that correl

135 Although bats and dromedary camels have been identified as potential MERS-CoV hosts,

136 For thousands of years, camels have produced meat, milk, and fiber in harsh dese

137 the hydrophobic core of light-chain-lacking camel heavy chains.

138 examine a cohort of 107 milk-drinking Somali camel-herders from Ethiopia.

139 Dromedary camels, hosts for MERS-CoV, are implicated in direct or

140 of approximately 60 m from 540 to 1160 m on Camels Hump in northern Vermont, USA.

141 seholds, particularly individuals engaged in camel husbandry or racing, and household members who are

142 ss routes with monumental rock engravings of camels, ibex, wild equids, gazelles, and aurochs.

143 ngle-chain antibody from an Indian dromedary camel (ICab) immunized against a bacterial 14TM helix tr

144 R(adj) 4.97 [1.80-15.29], p=0.0027) of young camels identified as risk activities.

145 A cDNA-VHH library was constructed from a camel immunized with Bet v 1 and screened for Bet v 1 bi

146 r mutations specific for light-chain-lacking camel immunoglobins.

147 ve genomic study, we took nasal samples from camels imported from Sudan and Djibouti into the Port of

148 Human hunting of horse and camel in Canada, coupled with mammoth, mastodon, sloth,

149 e for prehistoric human hunting of horse and camel in North America occurs at the Wally's Beach site,

150 It was recently discovered that dromedary camels in Saudi Arabia harbor three different HCoV speci

151 The virus is endemic in camels in the Arabian Peninsula and Africa and thus pose

152 MERS-CoV that circulates widely in dromedary camels in the Arabian Peninsula leading to zoonotic tran

153 The vast majority of, if not all, camels in the Middle East have been infected with MERS-C

154 In contrast, nearly all camels in the Middle East have been infected with MERS-C

155 an and camel after it had acquired the human-camel infection capability.

156 Apart from dromedary camels, insectivorous bats are suggested as another natu

157 r we demonstrate that large scale cloning of camels is possible and that further improvements can be

158 fections in people who have had contact with camels is unknown and most index patients cannot recall

159 pid speciation of milk (cow, goat, sheep and camel) is demonstrated with 100% classification accuracy

160 lent; other studies showed that West African camel isolates carry mutations in MERS-CoV accessory pro

161 re can differentiate bovine lactoferrin from camel lactoferrin based on the unique peptides produced

162 driven by recurring zoonotic spillover from camels, leading to demand for camel vaccination.

163 was deleted, leading to the production of a camel-like LAIR1-containing antibody.

164 rom the Camelidae family of mammals, such as camels, llamas, and alpacas) nanobodies specific to huma

165 This patient regularly consumed camel meat and milk, therefore camelid HEV, which is gen

166 tions in the RBD of representative human and camel MERS-CoV strains during the 2012-2015 outbreaks.

167 ssing S proteins of representative human and camel MERS-CoV strains identified during the 2012-2015 o

168 infection by divergent circulating human and camel MERS-CoV strains.

169 MERS vaccines against circulating human and camel MERS-CoV strains.

170 D protein with multiple changes derived from camel MERS-CoV strains.

171 Relying on two analysis tools (camel, metilene) to identify differentially methylated r

172 derived chymosin in rennet cannot coagulate camel milk (CAM).

173 ue to sociocultural and religious influences camel milk (camelus dromedarius) is widely consumed raw,

174 Cheesemaking with camel milk (CM) presents unique challenges and additiona

175 ects are similar to the effects reported for camel milk (CMk); however, it is not known whether compo

176 of protein and lipid fractions from cow and camel milk (four breeds; CM-1 to 4), their functional an

177 s)-casein ratio and protective proteins make camel milk a promising alternative protein base for maki

178 analysis for detection and quantification of camel milk adulteration with goat milk was investigated.

179 d including Australia, studies of Australian camel milk are still lacking.

180 entified to date, which supports the role of camel milk as an antidiabetic agent.

181 obtained results showed that, after heating, camel milk at 80 degrees C for 60min, camel alpha-lactal

182 operties of whole milk proteins from cow and camel milk at different pH revealed that emulsifying act

183 major chemical composition of bulk dromedary camel milk by FT-MIR spectroscopy over a 5-year period.

184 Camel milk caseins are more sensitive to heat, while its

185 Summer camel milk contained higher amounts of functional whey p

186 ns during storage periods, except the WSE of camel milk fermented by Lp.K772.

187 The highest ACE-inhibition of the WSE from camel milk fermented by Lr.K777 was >80%.

188 on, antioxidant and proteolytic activity) of camel milk fermented with indigenous probiotic strains o

189 Camel milk has been gaining immmense importance due to h

190 of MFGMs from bovine, goat, buffalo, yak and camel milk in HT-29 cells.

191 ficant bioactive properties in comparison to camel milk intact proteins.

192 Here we show daily consumption of raw camel milk is associated with Brucella seropositive stat

193 Although camel milk is increasingly becoming a popular alternativ

194 We have evaluated the potential of camel milk lactoferrin for its ability to inhibit the pr

195 d taurine concentrations suggests that whole camel milk may be more efficient to activate GABArho1 re

196 ial enzymes and whey proteomes of Australian camel milk obtained over four seasons was conducted, for

197 Fermented camel milk possesses a weak (liquid-like) gel structure.

198 Although fresh camel milk powder had very poor wettability, it displaye

199 However, at the end of the storage period, camel milk powder still retained very high solubility (>

200 Spray drying offers high-quality camel milk powder with a good nutritional and techno-fun

201 ing to rehydration properties of spray-dried camel milk powders during accelerated storage (11-33% RH

202 in physiochemical properties of spray-dried camel milk powders during storage at 11-32% RH and 37 de

203 The results showed that fresh camel milk powders had amorphous structure, clumsy spher

204 The three camel milk probiotic strains Lb. reuteri-KX881777, Lb. p

205 the rheological properties of the fermented camel milk produced by L. garvieae-C47.

206 The most potent camel milk protein-derived DPP-IV inhibitory peptides, L

207 Camel milk proteins are an important substrate for bioac

208 Cow and camel milk proteins before and after heat treatment at 8

209 Camel milk proteins contain dipeptidyl peptidase IV (DPP

210 Camel milk proteins contain novel DPP-IV inhibitory pept

211 HQGQIV, MPVQA and SPVVPF) were identified in camel milk proteins hydrolysed with trypsin.

212 Camel milk samples were collected from Aldhahira and Sha

213 Milk samples (150 cow and 217 camel milk samples) were analyzed for protein, fat, lact

214 nd PAO activities in human, bovine, goat and camel milk samples, and it can be readily adapted for me

215 Results revealed that proteins from cow and camel milk showed a noticeable separation on sodium dode

216 In this study, protein digestibility of camel milk was compared with that of bovine and human mi

217 otal solids concentrations of bulk dromedary camel milk were 2.87%, 2.94%, 4.15%, 8.00%, and 10.69%,

218 MIR values + NIR values) x 100%) for cow and camel milk were, for protein (+8.2 & +13.4%), fat (-9.3

219 Camel milk, which contains lower saturated and higher un

220 nds of milk, and a single clot was formed in camel milk.

221 ration can jeopardize the health benefits of camel milk.

222 -lactoglobulin (beta-Lg) was not detected in camel milk.

223 gens in cow, had orthologous counterparts in camel milk.

224 y to improve the weak structure of fermented camel milk.

225 bited when treated with the WSE of fermented camel milk.

226 r soluble extracts (WSEs) from all fermented camel milks were higher than those of fermented bovine m

227 We sequenced 24 camel mitogenomes and combined them with three previousl

228 Here, we generate dromedary camel nanobodies targeting B7-H3 and demonstrate that CA

229 Eight additional camel nose swabs were positive on one or more RT-PCRs, b

230 =0.043), and frequently feeding and watering camels of any age (OR(adj) 1.98 [1.09-3.69]; p=0.025).

231 ], p=0.029), frequently feeding and watering camels of any age (OR(adj) 3.18 [1.12-10.84], p=0.040),

232 5, 2018, we collected samples from 472 local camels, of which 189 were from Riyadh and 283 were from

233 018, we collected samples from 1196 imported camels, of which 868 originated from Sudan and 328 from

234 Infection prevalence peaked among camels older than 1 year and aged up to 2 years in both

235 We obtained samples from 14 camels on Oct 17, 2013.

236 bs, rectal swabs, and blood samples from all camels on the Qatari farm.

237 irus RNase P RNA reconstituted in vitro with camel or HeLa cell extracts, which were pre-treated with

238 with exceptions such as H chain-only Abs in camels or natural Ag receptors in sharks.

239 GABAergic activity are present in milk from camels or other species.

240 the people on the farm were infected by the camels or vice versa, or if a third source was responsib

241 er an almost 2-year period and local Arabian camels over 2 months in the year after surveillance of t

242 es, vaccination strategies should prioritise camel-owning households, particularly individuals engage

243 o regional desertion and nomadization (sheep/camel pastoralists) during the preindustrial era in form

244 showed that PGN, GlcNAc, and MurNAc bind to camel PGRP-S (CPGRP-S) with affinities corresponding to

245 infection, as may cross-border movements of camels, poor hand hygiene, and overnight hospital stays

246 rther investigations are needed in human and camel populations to identify DcHEV potential zoonosis t

247 iseases, such as chronic wasting disease and camel prion disease, pose further risks to public health

248 he molecular modelisation performed with the camel protein.

249 irty meat mixtures containing beef, chicken, camel, rabbit, goat and sheep with varying percentage of

250 Attending camel races (OR(adj) 3.73 [1.11-12.47], p=0.029), freque

251 2012-RBD, 2013-RBD, 2014-RBD, 2015-RBD, and Camel-RBD, containing single or multiple mutations in th

252 MERS-CoV seronegative and seropositive camels received a single intramuscular dose of ChAdOx1 M

253 the respiratory tract tissues of humans and camels reflects MERS-CoV tropism.

254 Some camel-related activities may pose a higher risk of MERS-

255 l measures; targeted interventions among the camel reservoir being crucial for effective control.

256 Older seronegative camels responded more strongly to vaccination than young

257 is the first describing Kp and RFRP-3 in the camel's brain with, during the winter period lower RFRP-

258 P-3 in the seasonal control of the dromedary camel's breeding activity.

259 , may be involved in the seasonal control of camel's reproduction.

260 s except kangaroo contained 25(OH)D(3); some camel samples contained relatively high concentrations (

261 ition protein (PGRP) were not detected while camel serum albumin (CSA) was significantly diminished.

262 termination of animal sources of milk; goat, camel, sheep and cow.

263 Finally, we test Y(conc) on clusters from CAMELS simulations and show that Y(conc) is robust again

264 ndrial genome, as the three extant Old World camel species inhabit hot and low-altitude as well as co

265 ERS-CoV, which also cocirculates in the same camel species, may have undergone similar recombination

266 entation of Val37 suggests a function of the camel-specific phenylalanine residue at this position in

267 Species of camel spiders in the family Eremobatidae are an importan

268 nomes from the arachnid order Solifugae (the camel spiders or wind scorpions), representing two famil

269 h is especially promising for organisms like camel spiders that are notoriously difficult to collect.

270 e (MERS), zoonotic transmission pathways and camel subpopulations posing highest transmission risk ar

271 Virus prevalence was higher in local camels than in imported camels (224 [47.5%] of 472 vs 15

272 MERS-CoV infection after close contact with camels that had rhinorrhea.

273 n intact viral gagpol gene in the genomes of camels that is also found in the same genomic location i

274 2, the virus has repeatedly transmitted from camels to humans, with 2,468 confirmed cases causing 851

275 ly does not play a major role in the lack of camel-to-human transmission in Africa.

276 s have played a major role in limiting human/camel-to-human transmission of Middle East respiratory s

277 en shown to infect both humans and dromedary camels using dipeptidyl peptidase-4 (DPP4) as its recept

278 spillover from camels, leading to demand for camel vaccination.

279 , development of effective and safe human or camel vaccines is warranted.

280 Here, we built large dromedary camel VHH phage libraries to isolate nanobodies that bro

281 P gene open reading frames from red deer and camel was carried out to investigate sequence variabilit

282 In this study, a Bactrian camel was immunized with capsid proteins from different

283 re detected only when the usual threshold of camel was lowered.

284 Anxiety Multimodal Extended Long-term Study (CAMELS), was conducted at 6 academic sites in the United

285 Previous studies suggested dromedary camels were a reservoir for this virus.

286 Antibody responses in seropositive camels were enhancedby the vaccine; these camels had a h

287 Llamas and camels were immunized with caffeine covalently linked to

288 Sex, age and body condition of the camels were not associated with the seroprevalence of C.

289 ed from the patient and from one of his nine camels were positive for MERS-CoV RNA.

290 Camelid species (llama and camel) were selected for immunization because of their p

291 Interfacial properties of acid camel whey and acid bovine whey were preserved at air wa

292 A camel whey protein concentrate (WPC, 44.7 +/- 3.4% (w/w)

293 Covalent camel whey protein-quercetin (WQ) conjugates and their n

294 d foaming and interfacial properties of acid camel whey, even if acid and sweet bovine whey exhibited

295 y for both milks, with higher values for the camel whey.

296 ue, while this protein was totally absent in camel whey.

297 from humans, mice, shrews, sheep, bats, and camels, which are mammalian species known to be infected

298 Infectious camels with active naturally acquired MERS-CoV infection

299 Nine camel workers with MERS-CoV antibodies and 43 workers wi

300 n the recent detection of virus in dromedary camels, zoonotic transfer of MERS-CoV to humans is suspe