ライフサイエンスコーパス: canalicular

1 ared membrane targeting of newly synthesized canalicular ABC (ATP-binding cassette) transporters MDR1

2 ecretion, eyelid malposition, and punctal or canalicular abnormalities.

3 more, SLC30A10 and SLC39A14 localized to the canalicular and basolateral domains of polarized hepatic

4 ce suggests that AQPs are likely involved in canalicular and ductal bile secretion, gluconeogenesis a

5 The pathway between canalicular and intracellular membranes that BSEP consti

6 These differences in both canalicular and lamellar structure are probably linked t

7 station, period of maximal fetal growth, and canalicular and saccular stages of fetal lung developmen

8 canaliculi in KO livers along with decreased canalicular and sinusoidal microvilli.

9 tion and for normal development of secretory canalicular and tubulovesicular membranes in mouse parie

10 ifferentiation, and development of secretory canalicular and tubulovesicular membranes.

11 ges, including prebud, bud, pseudoglandular, canalicular, and terminal.

12 onally distinct sinusoidal (basolateral) and canalicular (apical) plasma membrane domains.

13 traffics from the trans-Golgi network to the canalicular area of hepatocytes, where it facilitates ex

14 copper into the bile, ATP7B traffics toward canalicular area of hepatocytes.

15 As a canalicular bile acid effluxer, the bile salt export pum

16 ial function of the liver, and impairment of canalicular bile acid secretion leads to cholestatic liv

17 to decreased expression of the major hepatic canalicular bile acid transport protein.

18 secreted into bile in unconjugated form by a canalicular bile acid transporter and is absorbed by cho

19 ies could demonstrate that deficiency of the canalicular bile acid transporter bile salt export pump

20 rget gene that functions as an ATP-dependent canalicular bile acid transporter.

21 Insulin stimulates canalicular bile flow by interaction with hepatocytes.

22 Canalicular bile flow, as measured by [14C]erythritol cl

23 sport provides the osmotic driving force for canalicular bile formation.

24 nate-rich hypercholeresis when secreted into canalicular bile in unconjugated form; the mechanism is

25 Canalicular bile is formed by the osmotic filtration of

26 nstrated to encode for the rat ATP-dependent canalicular bile salt export protein, and mutations of h

27 1 encoding bile salt export pump (BSEP), the canalicular bile salt export pump of hepatocyte.

28 olism enzymes CYP27A1 and CYP3A11 as well as canalicular bile salt pump ABCB11.

29 nd Fyn-dependent retrieval of sinusoidal and canalicular bile salt transport systems from the corresp

30 flux rates, sulindac competitively inhibits canalicular bile salt transport; such inhibition may con

31 "flux proteins", including AQPs, involved in canalicular bile secretion.

32 quaporins are involved in agonist-stimulated canalicular bile secretion.

33 bile salt homeostasis without impairment of canalicular bile secretion; in humans this process is li

34 senger RNA (mRNA) expression of the two main canalicular bile transporters, bile salt export pump (BS

35 y also because of the absence of micelles in canalicular bile.

36 pose that polarization of hepatocytes (i.e., canalicular biogenesis) requires recruitment of rab11a a

37 ts (BS) and the functional expression of the canalicular BS export pump (BSEP; ABCB11).

38 Canalicular BSEP, mostly present in raft (high cholester

39 of membrane fractions localized Fic1 to the canalicular, but not basolateral, plasma membrane domain

40 tructural findings included coarse, granular canalicular Byler bile, effaced canalicular microvilli,

41 selectively transported to the apical (i.e., canalicular) cell membrane, revealed two polarization ph

42 most common complications of stents included canalicular cheese-wiring and tube prolapse in approxima

43 ytes and eosinophils, rosette formation, and canalicular cholestasis yielded an area under the receiv

44 Liver histology showed canalicular cholestasis, mild-to-moderate fibrosis, and

45 type1 in humans, which is characterized by a canalicular cholestasis.

46 f the nuclear bile salt receptor FXR and the canalicular cholesterol transporter ABCG5/ABCG8 in the g

47 th the genes Abcg5 and Abcg8 that encode the canalicular cholesterol transporter.

48 intubation for PANDO, there were no cases of canalicular closure or stenosis at 12 months.

49 ation of highly purified Golgi membranes and canalicular (CMVs) and sinusoidal/basolateral (SMVs) mem

50 Canalicular DHE could completely redistribute to the bas

51 p = 0.022), perimeter (+14%, p = 0.008), and canalicular diameter (+6%, p = 0.037).

52 efined donor hepatocyte colonies with strong canalicular dipeptidyl peptidase IV activity.

53 Cases of canalicular disease were excluded.

54 f the bile salt export pump persisted at the canalicular domain in all 3 models.

55 ocalized by immunohistochemistry to the bile canalicular domain of hepatocytes and to the luminal sid

56 membrane from where they transcytose to the canalicular domain.

57 om where they transcytose to the apical bile canalicular domain.

58 t liver revealed P2X4 in the basolateral and canalicular domains.

59 Newly synthesized canalicular ectoenzymes and a cell adhesion molecule (cC

60 ssociated with doxorubicin and doxorubicinol canalicular egress were decreased, and other doxorubicin

61 An improved awareness of the normal canalicular epithelial structure and its immunohistochem

62 ns in normal conjunctival epithelium, normal canalicular epithelium, and canaliculops epithelium.

63 Basolateral and canalicular excretion of APAP was also assessed in the i

64 role in lipid homeostasis by regulating the canalicular excretion of bile acids.

65 can restore the polarity of hepatocytes and canalicular export of bile acids or act as bile alkalini

66 De novo or retargeted canalicular expression of BSEP occurred in four of these

67 De novo or retargeted canalicular expression of BSEP occurs in treatment respo

68 The canalicular expression of CD10 was identified in 9 of 15

69 Hepatocyte canalicular expression of hAQP1 through adenoviral gene

70 ds to Mrp2, and plays a critical role in the canalicular expression of Mrp2 and its function as a det

71 sion of the rab11a-GDP locked form prevented canalicular formation as did overexpression of the myosi

72 es a unique function of taurocholate in bile canalicular formation involving signaling through a cAMP

73 ine, we observed that rab11a is required for canalicular formation.

74 ed apical ABCB11 (Bsep) trafficking and bile canalicular formation.

75 ats improves bile flow, in part by enhancing canalicular hAQP1-mediated osmotic water secretion.

76 e role of InsP(3)R2 and of Ca(2+) signals in canalicular insertion and function of Mrp2 is not known.

77 with radiologically confirmed PANDO without canalicular involvement underwent endonasal DCR without

78 etermine whether delayed repair of traumatic canalicular laceration affects the final outcome.

79 hod in 33 cases of acute and late presenting canalicular laceration for canalicular reconstruction wi

80 334 patients who underwent primary traumatic canalicular laceration repair were retrospectively revie

81 r, especially in patients with complex acute canalicular lacerations and late presenting canalicular

82 ent an improvement in the surgical repair of canalicular lacerations.

83 canalicular lacerations and late presenting canalicular lacerations.

84 f drugs with MDR3 and the effect of drugs on canalicular lipid secretion in a newly established polar

85 d cell line system that serves as a model of canalicular lipid secretion.

86 atocyte couplets confirmed the intracellular/canalicular localization of aquaporins 0 and 8 and the b

87 ion of fluorescent cholephiles into the bile canalicular lumina.

88 e cells show polarization defects as well as canalicular malformations.

89 othelial cell marker, RECA-1, but lacked the canalicular marker leucine aminopeptidase.

90 ntrast to organic anions, substrates for the canalicular mdr1a and b are usually organic cations and

91 Transport of DHE to the canalicular membrane after photobleaching was very rapid

92 tate distribution after 20 h of SPGP between canalicular membrane and a combined endosomal fraction.

93 nt of ATP-dependent transporters to the bile canalicular membrane and are accompanied by increased ca

94 ransport of bile acids across the hepatocyte canalicular membrane and for generation of bile acid-dep

95 revealed that BSEP-YFP was localized at the canalicular membrane and in tubulo-vesicular structures

96 suggests cycling of ABC transporters between canalicular membrane and intrahepatic sites before degra

97 ATP)-dependent transport of E217G in the rat canalicular membrane and protect against E217G-mediated

98 ated the exocytic insertion of Mrp2 into the canalicular membrane and the recovery of bile flow and b

99 Transporters at the hepatic canalicular membrane are essential for the formation of

100 ved, and BSEP, which was not detected at the canalicular membrane before treatment, appeared at the c

101 by favoring bile acid-induced injury in the canalicular membrane but does not directly affect FXR ex

102 amounts of SPGP, MDR1, and MDR2 in the bile canalicular membrane by 3-fold; these effects abated aft

103 ut during stimulation, it is shuttled to the canalicular membrane by a poorly understood mechanism th

104 rter pools, one of which is mobilized to the canalicular membrane by cAMP and the other, by taurochol

105 ering that BSEP activity directly depends on canalicular membrane cholesterol content, decreased BSEP

106 ic bile acid CDCA resulted in focal areas of canalicular membrane disruption by electron microscopy a

107 phosphatidylcholines and cholesterol to the canalicular membrane for ongoing biliary lipid secretion

108 With both basolateral and canalicular membrane fractions, sulindac inhibited choly

109 ne proteins to their site of function at the canalicular membrane front.

110 nslocator specifically expressed at the bile canalicular membrane in hepatocytes, highly homologous t

111 strated endocytic retrieval of Mrp2 from the canalicular membrane into pericanalicular and intracellu

112 ny cell systems, and Ca(2+) release near the canalicular membrane is mediated by the type II inositol

113 Its localization in the apical canalicular membrane is physiologically regulated by the

114 istance-associated protein 2 (Mrp2) from the canalicular membrane leading to cholestasis.

115 es phosphatidylcholine (PC) secretion at the canalicular membrane of hepatocytes and its genetic defe

116 The secretion of phospholipids across the canalicular membrane of hepatocytes occurs via the multi

117 inding cassette transporter localized at the canalicular membrane of hepatocytes that plays an import

118 wo sites (apical membrane of enterocytes and canalicular membrane of hepatocytes) to mediate choleste

119 cassette (ABC) transporter expressed at the canalicular membrane of hepatocytes, where it mediates p

120 t the apical membrane of enterocytes and the canalicular membrane of hepatocytes.

121 the major bile salt transport system at the canalicular membrane of hepatocytes.

122 In the liver, P-gp is localized on the canalicular membrane of hepatocytes.

123 tte (ABC) transporters and is located in the canalicular membrane of hepatocytes.

124 pump, which is exclusively expressed at the canalicular membrane of hepatocytes.

125 Mrp2 remained localized at the apical/canalicular membrane of NHERF-1(-/-) mouse hepatocytes,

126 ntly discovered that NPC1L1 localizes to the canalicular membrane of primate hepatocytes and that NPC

127 alt export pump (Bsep), a transporter on the canalicular membrane of the hepatocyte.

128 ctivity and abundance of transporters in the canalicular membrane regulate bile flow; however, little

129 as associated with a marked reduction in the canalicular membrane structure as observed by differenti

130 the polarized targeting and/or retaining of canalicular membrane transporters and is a critical dete

131 e and dinitrophenyl-glutathione transport in canalicular membrane vesicles above maximal ATP-dependen

132 HAX-1 was bound to BSEP, MDR1, and MDR2 in canalicular membrane vesicles and co-localized with BSEP

133 macrophages doubled PI 3-kinase activity in canalicular membrane vesicles and enhanced taurocholate

134 ate and PI 3-kinase activity were reduced in canalicular membrane vesicles isolated from rat liver th

135 ncrease in the amount of ABC transporters in canalicular membrane vesicles was observed, whereas the

136 a rat liver subcellular fraction enriched in canalicular membrane vesicles, and MLC2 colocalized with

137 rat liver subcellular fractions enriched for canalicular membrane vesicles, microsomes, and clathrin-

138 In canalicular membrane vesicles, translocase activity had

139 hosphate-dependent taurocholate transport in canalicular membrane vesicles, was induced by 90% (P < 0

140 Release of DHE from the canalicular membrane was also ATP-independent but slower

141 ocytes, (2) altered targeting of BSEP to the canalicular membrane, and (3) increased ileal BA absorpt

142 8 expression was localized to the hepatocyte canalicular membrane, and bile Mn levels were increased

143 omol/L E(2)17G, respectively, whereas in rat canalicular membrane, both E(2)17G and the choleretic es

144 bstrates by inducing Mrp2 retrieval from the canalicular membrane, whereas cyclic adenosine monophosp

145 molecules and the ectoplasmic leaflet of the canalicular membrane, which result in biliary secretion

146 secretion into bile by targeting Mrp2 to the canalicular membrane.

147 es, and maintained an abnormal intracellular canalicular membrane.

148 ated Ca(2+) signals in targeting Mrp2 to the canalicular membrane.

149 tes, although Bsep remained localized to the canalicular membrane.

150 r (FXR) or by impairing the structure of the canalicular membrane.

151 esistance-associated protein 2 to the apical canalicular membrane.

152 traffic directly from Golgi membranes to the canalicular membrane.

153 solateral membranes, but only fused with the canalicular membrane.

154 compared with the amount present in the bile canalicular membrane.

155 d and nonbile acid organic anions across the canalicular membrane.

156 nce analysis, was due to interactions at the canalicular membrane.

157 is constitutively expressed in normal liver canalicular membrane.

158 ective bile acid transport at the hepatocyte canalicular membrane.

159 r membrane before treatment, appeared at the canalicular membrane.

160 retrieval of bile salt export pump from the canalicular membrane.

161 the endoplasmic reticulum instead of at the canalicular membrane.

162 ABC transporters are targeted to the apical (canalicular) membrane of hepatocytes where they execute

163 tte transporters are targeted to the apical (canalicular) membrane of hepatocytes, where they mediate

164 , recombinant ABCG5 localized to the apical (canalicular) membrane when coexpressed with ABCG8, but n

165 of DHE but not its enrichment in the apical (canalicular) membrane.

166 ietal cells exhibited limited development of canalicular membranes and a virtual absence of tubuloves

167 Electron microscopy revealed abnormal apical canalicular membranes and loss of tubulovesicles in muta

168 Rat canalicular membranes contain microdomains enriched in c

169 tical trans-locator for phospholipids across canalicular membranes of hepatocytes, evidenced by the f

170 ed that single BSEP-YFP molecules resided in canalicular membranes only transiently before exchanging

171 cid transporters on both the basolateral and canalicular membranes, resulting in intrahepatic cholest

172 2 and 4, which localize to granules and open canalicular membranes, together with the general target

173 ll, predominantly localizing with F-actin to canalicular membranes.

174 ile acid transporters on both sinusoidal and canalicular membranes.

175 a protein, which is highly enriched in mouse canalicular membranes.

176 te and dinitrophenyl-glutathione directly in canalicular membranes.

177 d along basolateral (sinusoidal) and apical (canalicular) membranes of hepatocytes, are integral dete

178 1-transduced cholestatic rats, BSEP showed a canalicular microdomain distribution similar to that of

179 ls had dilated canaliculi and lacked typical canalicular microvilli and tubulovesicles, and subsets o

180 se, granular canalicular Byler bile, effaced canalicular microvilli, and proliferative pericanalicula

181 The codistribution of parallel cisternae, canalicular-mitochondrial complexes, and synaptic-like v

182 KO mice had bile canalicular morphologic abnormalities as evidenced by st

183 loss of beta-catenin leads to defective bile canalicular morphology, bile secretory defect, and intra

184 Canalicular multidrug resistance-associated protein 2 (M

185 the endocytic retrieval and function of the canalicular multidrug resistance-associated protein 2 (M

186 sistance-associated protein 1 (MRP1) and the canalicular multispecific organic anion transporter (cMO

187 rug resistance-associated protein (MRP)1 and canalicular multispecific organic anion transporter (cMO

188 drug resistance-associated protein (MRP) and canalicular multispecific organic anion transporter (cMO

189 ic expression of Mrp2 (Abcc2), the principal canalicular multispecific organic anion transporter.

190 on probing and irrigation suggested further canalicular narrowing, silicone intubation was offered.

191 s between the bile duct and the lobular bile canalicular network by the canals of Hering decreases pr

192 In control cultures, an extensive bile canalicular network developed with properly localized ap

193 Taurocholate accelerated canalicular network formation and concomitantly increase

194 another cAMP downstream kinase, accelerated canalicular network formation similar to the effect of t

195 that activated-LKB1 and AMPK participate in canalicular network formation.

196 ciliary region and outflow through a ventral canalicular network that connects with an aqueous plexus

197 These concentrations are present in the canalicular network, bile ducts, and gallbladder.

198 osed of plates, ducts, and a well-delineated canalicular network.

199 The vital canalicular networks required for osteocyte nourishment

200 adiologically confirmed nasolacrimal duct or canalicular obstruction.

201 ceived chemotherapy or radiation, and common canalicular obstructions.

202 displayed oscillatory movement toward either canalicular or basolateral membranes, but only fused wit

203 ate pseudoglandular stage but not during the canalicular or saccular stage surprisingly delayed dista

204 ve measured the effects of substrates of the canalicular organic ion transporter multidrug resistance

205 njugated form and induced hypercholeresis of canalicular origin.

206 patic shunting, a pathway that amplifies the canalicular osmotic effects of bile acids.

207 These studies indicate that FIC1 is a canalicular P-type ATPase that participates in maintaini

208 ne intubation for the purpose of maintaining canalicular patency is not necessary when performing end

209 nd endoscopic evidence of ostium patency and canalicular patency.

210 d consent and who had no lid malpositions or canalicular pathology.

211 p cells during either the pseudoglandular or canalicular phases of development.

212 resistance 3 gene (MDR3), which encodes the canalicular phospholipid flippase, cause a wide spectrum

213 ficiency of multidrug resistance 2 (mdr2), a canalicular phospholipid floppase, leads to excretion of

214 ult transgenic livers lack expression of the canalicular phospholipid transporter, mdr2, which is con

215 ar membrane and are accompanied by increased canalicular PI 3-kinase activity.

216 rectional (i.e., from the outer to the inner canalicular plasma membrane leaflet).

217 phosphatidylcholines across the hepatocyte's canalicular plasma membrane provides the driving force f

218 yryl cAMP), aquaporin 8 redistributed to the canalicular plasma membrane; the subcellular distributio

219 ment of aquaporins 0 and 8 in microsomes and canalicular plasma membranes; aquaporin 9 was enriched o

220 hat allows lysosome translocation toward the canalicular pole of hepatocytes.

221 rough the pericellular matrix in the lacunar-canalicular porosity due to mechanical loading can induc

222 apex of infrequent, previously unrecognized canalicular projections.

223 It has been proposed that all canalicular proteins are targeted via this indirect rout

224 We studied the membrane targeting of rat canalicular proteins by in vivo [(35)S]methionine metabo

225 al vein radicles that failed to exhibit bile canalicular reconstitution.

226 d late presenting canalicular laceration for canalicular reconstruction without any complications.

227 (InsP(3)R2) regulates Ca(2+) release in the canalicular region of hepatocytes.

228 InsP(3)R2 was concentrated in the canalicular region of WT mice but absent in InsP(3)R2 KO

229 docytic recycling compartment and the apical canalicular region paralleling the movement of SR-BI.

230 sP3R2 and Bsep are in close proximity in the canalicular region, both in rat liver and in hepatocytes

231 Delayed canalicular repair in unstable patients did not lead to

232 llowing trauma is the most difficult part of canalicular repair, especially in patients with complex

233 s Golgi bodies intermingled with this apical canalicular reticulum (CR).

234 was equal in WT versus Hrn, indicating that canalicular secretion capacity was normal.

235 pendent bile acid transporter and diminished canalicular secretion of bile salts secondary to down-re

236 Canalicular secretion of the organic anion 5-chloromethy

237 mice, 6-CF remained largely in hepatocytes, canalicular secretion was delayed, and 6-CF appeared in

238 ermore, when sodium dehydrocholate augmented canalicular secretion, biliary glucose excretion increas

239 of hepatocellular secretion of bile salts is canalicular secretion.

240 ype and distribution of terminals across the canalicular sensory neuroepithelium with morphophysiolog

241 tocytes actively secrete bile acids into the canalicular space and cholangiocytes then transport bile

242 At the canalicular stage of E16.5, the lungs of TACE mutant mic

243 ansgenic lungs retained many features of the canalicular stage of lung development, including undilat

244 By contrast, during the later canalicular stage, the distal epithelial tip cells only

245 n a cluster expressed in pseudoglandular and canalicular stages whereas adenocarcinoma homologues wer

246 A characteristic canalicular-staining pattern was observed in normal hepa

247 Moderate or severe canalicular stenosis was seen in about one-third of pati

248 During each visit, epiphora and canalicular stenosis were graded.

249 Nine patients had worsened canalicular stenosis; six underwent surgery.

250 The definitive treatment of severe canalicular stricture remains conjunctivodacryocystorhin

251 In canalicular structure, and to some extent in fibre bundl

252 ed that loss of LKB1 led to longer and wider canalicular structures correlating with mislocalization

253 By electron microscopy, the cells formed canalicular structures that are typical of hepatocytes a

254 lular polarity by delimiting functional bile-canalicular structures, forming the blood-biliary barrie

255 urred in cells that resemble PHH, exhibiting canalicular structures.

256 e architectural complexity of the hepatocyte canalicular surface has prevented examination of apical

257 located in very narrow portions of the open canalicular system (OCS) to antibodies, the same methods

258 that both cells share an identical dendritic canalicular system and express extensive processes formi

259 d the fusion of alpha-granules with the open canalicular system and plasma membrane.

260 hese studies provide a link between the open canalicular system and platelet adhesive function that h

261 All cases had a patent canalicular system as demonstrated by syringing and prob

262 Rewarming eliminated open canalicular system dilation and restored lentiform appea

263 Solute transport through the bone lacunar-canalicular system is believed to be essential for osteo

264 The osteocyte and cementocyte lacuno-canalicular system of both alveolar bone and cementum is

265 at cardiac ventricular myocytes and the open canalicular system of human platelets.

266 Osteocytes in the lacunar-canalicular system of the bone are thought to be the cel

267 Interstitial fluid flow in the lacunar canalicular system produces focal strains at localized a

268 on external (surface) versus internal (open canalicular system) membranes in resting discoid platele

269 rcation membrane system) and platelets (open canalicular system) that results in dysregulated platele

270 among membranes of alpha-granules, the open canalicular system, and plasma membrane.

271 abnormal lipid inclusions, abnormal platelet canalicular system, and reduced number of microtubules)

272 gins, differentiation, morphology and lacuno-canalicular system, selective markers, and potential fun

273 failed to empty their contents into the open canalicular system.

274 cteristic anatomical features of the lacunar-canalicular system.

275 h one another and with membranes of the open canalicular system.

276 s been measured directly in the bone lacunar-canalicular system.

277 ed shape change but not dilation of the open canalicular system.

278 embrane network resembling the platelet open canalicular system.

279 to ABCB11 missense mutations affecting BSEP canalicular targeting.

280 estation is required for transition from the canalicular to the saccular stage of lung development.

281 normally in Tr(-) rats, indicating that its canalicular transport did not require mrp2.

282 f proteins for storage, glucuronidation, and canalicular transport of bilirubin.

283 ntification of the mechanisms directing bile canalicular transport of these agents will provide insig

284 ABCB11 is a canalicular transport protein that controls the rate-lim

285 er PEBD, perhaps by induction of alternative canalicular transport proteins.

286 expression profiles, phase I/II metabolism, canalicular transport, secretion of liver-specific produ

287 rized using Tr(-) rats (deficient in mrp2, a canalicular transporter for organic anions), the isolate

288 -AC-PKA is a key factor in the alteration of canalicular transporter function and localization induce

289 trongly prevented E17G-induced impairment of canalicular transporter function and localization.

290 tranferases, and TR- rats, deficient in the canalicular transporter Mrp2 (Abcc2).

291 resistance associated protein 2 (Mrp2) is a canalicular transporter responsible for organic anion se

292 rapid decline in the expression of the bile canalicular transporters Abcb4, Abcb11, and Abcc2.

293 Changes in the expression of bile canalicular transporters were analyzed by real-time poly

294 olestasis in rat liver with retrieval of the canalicular transporters, bile salt export pump (Abcb11)

295 cumulation of (fluorescent) bile acid in the canalicular vacuoles (cVA) of this polarized cell prepar

296 te and dinitrophenyl-glutathione in isolated canalicular vesicles from rat liver was reduced 50-70% b

297 ring elements that attach the process to the canalicular wall and their finite flexural rigidity EI.

298 between the osteocyte cell membrane and its canalicular wall are sites where pN-level fluid-flow ind

299 hed directly at discrete locations along the canalicular wall by beta(3) integrins at the apex of inf

300 lets to dibutyryl cAMP caused an increase in canalicular water transport in the presence and absence