1 uences of Hst 5 binding iron not only affect
candidacidal ability and proteolyic stability of Hst 5,
2 A significant decrease in the
candidacidal ability of Hst 5 was observed upon iron bin
3 essential component in the Hst mechanism of
candidacidal action.
4 The
candidacidal activities of m1 (Arg-12-->Ile), m2 (Arg-12
5 to examine Hst 5 binding, translocation, and
candidacidal activities.
6 ecombinant histatins were examined for their
candidacidal activity and secondary structure.
7 a within the functional domain contribute to
candidacidal activity and that the His are essential for
8 Enhanced synergistic
candidacidal activity at 144 h was observed over a 10-fo
9 Calcium is a potent inhibitor of Hst 5
candidacidal activity at physiological concentrations an
10 isulfide bond was required to retain optimal
candidacidal activity at physiological NaCl concentratio
11 lationship of histatins with regard to their
candidacidal activity by using recombinant histatin-5 an
12 cifically, C16--C16 and Hsn-5--C16 displayed
candidacidal activity comparable with that of Hsn-5, whi
13 bstitutions demonstrated significantly lower
candidacidal activity in both assays, while the variant
14 Synergistic
candidacidal activity increased from 1 day to 3 days and
15 role of reactive oxygen intermediates in the
candidacidal activity observed.
16 be the biologically active conformation for
candidacidal activity of bactenecin peptides.
17 The
candidacidal activity of histatins appears to be a disti
18 a2Delta mutants were highly resistant to the
candidacidal activity of Hst 5, although the ssa1Delta m
19 The role of macrophage activation in the
candidacidal activity of liposome-incorporated (L) ampho
20 f F- or L-amphotericin B did not augment the
candidacidal activity of macrophages sensitized in vivo;
21 andidacidal in vitro, is responsible for the
candidacidal activity of NO-producing macrophages.
22 oth assays, re-Hst5 displayed dose-dependent
candidacidal activity that was nearly identical to that
23 PMN
candidacidal activity was assessed by transmission elect
24 ked its first four residues showed decreased
candidacidal activity, although their activity against b
25 he well-established role of NO in macrophage
candidacidal activity, NO is not directly candidacidal f
26 n-5--Hsn-5 possessed significantly decreased
candidacidal activity, yet all molecules retained an alp
27 understanding the biochemical basis of Hst 5
candidacidal activity.
28 at none of the multimers possessed increased
candidacidal activity.
29 icromolar concentration of Hsts required for
candidacidal activity.
30 2) of PG-1 or its variants further decreased
candidacidal activity.
31 - or L-amphotericin B, did not enhance their
candidacidal activity.
32 utrophil (polymorphonuclear leukocyte [PMN])
candidacidal activity.
33 ut not Th1-deficient, mice exhibited reduced
candidacidal activity.
34 cans, suggesting that Lys-13 is critical for
candidacidal activity.
35 activity and that the His are essential for
candidacidal activity.
36 cule appears to be the functional domain for
candidacidal activity.
37 nd in human salivary secretions and exhibits
candidacidal activity.
38 tural requirements for eliciting appreciable
candidacidal activity.
39 nce of histatin-5 are, indeed, important for
candidacidal activity.
40 inin, demonstrated a significant increase in
candidacidal activity.
41 same assays either lack or exhibit very low
candidacidal activity.
42 Bactenecin 5 and its fragments are potent
candidacidal agents against C. albicans.
43 lar volume as determined both by a classical
candidacidal assay with exogenous Hst 5 and by using a g
44 Hst 5 killing, compared with intact cells in
candidacidal assays.
45 respectively, which may represent the major
candidacidal capacity of dialyzed parotid secretion.
46 pendent production of TNF-alpha enhances the
candidacidal capacity of neutrophils, limiting fungal di
47 ge candidacidal activity, NO is not directly
candidacidal for Candida albicans.
48 now report that ONOO-, in addition to being
candidacidal in vitro, is responsible for the candidacid
49 ution-limited reaction of NO and O2-, is the
candidacidal molecule of activated macrophages.
50 5), a 24-amino acid polypeptide, is a potent
candidacidal molecule.
51 Possible enhanced
candidacidal synergy of fluconazole and human monocyte-d