ライフサイエンスコーパス: candidate gene

1 turned out to be a functional and positional candidate gene.

2 n chromosome 9 as a beta-costic acid pathway candidate gene.

3 identified Cd14 as a potentially protective candidate gene.

4 s GIIbeta, GANAB is a strong ADPKD and ADPLD candidate gene.

5 iology of tooth agenesis while revealing new candidate genes.

6 ariations in patients, resulting in numerous candidate genes.

7 ches, and have explored the role of specific candidate genes.

8 Most loci harbor biologically plausible candidate genes.

9 d efficient system for testing craniocardiac candidate genes.

10 tive polymerase chain reaction (qPCR) for 21 candidate genes.

11 inversely correlated with mRNA levels of the candidate genes.

12 these regulatory elements can be considered candidate genes.

13 proteins and that they have potential target candidate genes.

14 the approximately 5 kb regions away from the candidate genes.

15 ay (CMA), and targeted resequencing (TRS) of candidate genes.

16 genome-wide association analyses to identify candidate genes.

17 lotype analysis to fine-map this locus to 12 candidate genes.

18 onformation data and reports the most likely candidate genes.

19 ative real-time PCR was employed to validate candidate genes.

20 ards understanding disease mechanisms of the candidate genes.

21 f apomixis, to an 80-kb region containing 11 candidate genes.

22 es highlights RNASET2, SECISBP2L and NRG1 as candidate genes.

23 r protein 220; chromosome 4) were considered candidate genes.

24 were not driven by variation in dopaminergic candidate genes.

25 ysregulated and therefore, considered as CKD candidate genes.

26 single nucleotide polymorphisms (SNPs) on 12 candidate genes.

27 isequilibrium block comprising two promising candidate genes AAP8 and 2 S albumin, which might contri

28 As a result, we have identified several candidate genes, among others three calcium channel gene

29 Genetic and candidate gene analyses in an Il10-deficient IBD mouse m

30 An in silico candidate gene analysis and bioinformatics review led us

31 Using a candidate gene analysis approach, we also identified sin

32 ditional approaches using genetic linkage or candidate gene analysis have often been limited, costly,

33 family, homozygosity mapping with subsequent candidate gene analysis was performed.

34 Although candidate gene and genome-wide association studies have

35 Candidate gene and genome-wide linkage studies have not

36 is, we identify associations between several candidate genes and agronomically important traits.

37 ncorporated 38 inherited arrhythmia syndrome candidate genes and another 33 genes not previously inve

38 INTERPRETATION: Identification of new candidate genes and associated pathways will inform futu

39 These candidate genes and associated SNPs provide valuable res

40 d with other sources of evidence to identify candidate genes and biomarkers that would contribute sub

41 expression of genes in a set of curated ADHD candidate genes and five a priori selected, biological p

42 d, and thus, results provide a set of useful candidate genes and markers to be evaluated for more eff

43 ti under salt stress vs. control to identify candidate genes and pathways involved in salt response.

44 e functional involvement of several of these candidate genes and physiological control points in regu

45 ere, we used proteogenomics to determine the candidate genes and proteins that have a role in resista

46 ntal function in vitro by measuring relevant candidate genes and proteins.

47 arative transcriptomics analyses to identify candidate genes and relevant pathways common to KT and S

48 e, model to find the logic by which a set of candidate genes and their associated transcription facto

49 amilies with Sanger sequencing of positional candidate genes and with exome sequencing a homozygous m

50 Our findings provide additional candidate-gene annotation for 37 disease susceptibility

51 ene mutations were initially discovered by a candidate gene approach based on their known roles in en

52 We used a positional cloning-candidate gene approach to identify molecular bases for

53 e Drosophila melanogaster model system and a candidate gene approach to identify novel components req

54 Using this method in combination with a candidate gene approach, we were able to identify linked

55 t combines agnostic GWAS with a well-powered candidate-gene approach has the potential to discover no

56 ultiple discoveries made with genome-wide or candidate gene approaches that have revealed significant

57 Candidate-gene approaches and recent genome-wide associa

58 bitors (DNMTi and HDACi), primarily based on candidate-gene approaches.

59 Furthermore, we identified that 53 candidate genes are associated with more than one disord

60 that variants within historic schizophrenia candidate genes are associated with schizophrenia at lev

61 tigate whether variants within schizophrenia candidate genes are enriched for association with schizo

62 ic databases revealed that a majority of the candidate genes are expressed by astrocytes and neurons

63 Candidate genes are preferentially expressed in neural t

64 olecular mechanisms of pathogenesis for most candidate genes are unknown.

65 transcription factor PRRX1 could be a strong candidate gene as it is expressed in the pulmonary veins

66 In total, we identified 46 candidate genes associated with caste-specific biosynthe

67 s (GWAS) have provided a collection of novel candidate genes associated with complex diseases, such a

68 ication, and fruit size evolution as well as candidate genes associated with important agronomic trai

69 script profiling experiments have identified candidate genes associated with QTL.

70 Here we characterized candidate genes associated with rainfall gradients, temp

71 To identify candidate genes associated with variation in susceptibil

72 The field of ARDS genomics has cycled from candidate gene association studies to bias-free approach

73 first systematic review and meta-analysis of candidate gene association studies, pharmacogenetic and

74 neuroscience, with particularly low power in candidate gene association studies.

75 nd evidence strength evaluation of published candidate-gene association studies in lung cancer up to

76 More than 1000 candidate-gene association studies on genetic susceptibi

77 Multiple candidate gene-association studies of non-HLA single-nuc

78 Instead, candidate gene associations with striatal D2R were dimin

79 provide several lines of evidence supporting candidate genes at many loci and highlight some pathways

80 inversion probe technologies to sequence 208 candidate genes at scale in this impressive resource has

81 uantitative trait analyses suggest plausible candidate genes at these regions that may contribute to

82 Candidate gene AT3G32930 with in the detected region and

83 first comprehensive reference collection of candidate genes based on the recently released tomato ge

84 blished associations between variants within candidate genes (BDNF, OXTR, RORA, GRM8, CHRNA4, IL-1A,

85 identify altered regulation of schizophrenia candidate genes by DISC1 and its core Interactome as an

86 a-analyses to document enrichment of DNMs in candidate genes by leveraging our WGS dataset with those

87 e intraocular pressure, and identifies a new candidate gene, Cacna2d1, that modulates intraocular pre

88 ss of studying exposure metabolism for which candidate genes can be identified.

89 n on de novo mutations (DNMs) and identified candidate genes containing such variants.

90 ed likely pathogenic variants in three novel candidate genes (DENND5A, NEMF and DNHD1) each of which

91 While a small subset of candidate genes did appear to be significantly associate

92 Autoimmune candidate genes displayed greater expression specificity

93 icted transcription factor, IKZF2, and other candidate genes (e.g. WDFY4) through asQTL mapping using

94 icant effects on nodule production for three candidate genes, each validated in two independent mutan

95 ndidate genes, whereas for FTD we detected 1 candidate gene (ELP2).

96 ion correlation analysis to identify several candidate genes encoding putative trans-chrysanthemol an

97 Silencing of orthologues of these candidate genes enhanced the DeltaF508-CFTR functional e

98 er psychiatric traits; and to reevaluate the candidate gene era data through the Broad Antisocial Beh

99 h DNMs or rare inherited mutations in the 67 candidate genes exhibited significantly lower intelligen

100 se-atherosclerotic disease-identification of candidate genes explaining the associations of these loc

101 physical 3-dimensional interaction with 326 candidate genes expressed in at least 1 of these cell ty

102 Next, we selected 101 candidate genes expressed only in pig RMEC, but not in p

103 nctival fibrosis after glaucoma surgery with candidate gene expression tissue biomarkers of fibrosis.

104 iance in MPB and highlight several plausible candidate genes (FGF5, IRF4, DKK2) and pathways (melaton

105 e neuronal RNA binding protein, Rbfox1, as a candidate gene for autism spectrum disorders.

106 taining transcription factor identified as a candidate gene for CLP in human populations, with target

107 Our results suggest NCAN as a new candidate gene for DD and indicate that NCAN variants af

108 Our findings identify RCL1 as a novel candidate gene for depression and offer insights into me

109 ype VII collagen, has been identified as the candidate gene for dystrophic epidermolysis bullosa.

110 We identified HvCERK1 as a candidate gene for FHB resistance, which is functional i

111 regulation, and identify ZPO2 as a possible candidate gene for future diagnostic and therapeutic str

112 henotypes, highlighting AMTN as an excellent candidate gene for human AI.

113 It points to NHE8 as a candidate gene for human globozoospermia and a possible

114 ing studies identified filamin C (FLNC) as a candidate gene for hypertrophic cardiomyopathy (HCM).

115 n IBD, and we have identified MAGI3 as a new candidate gene for IBD.

116 these findings indicate that SOX5 is a novel candidate gene for LOAD with an important role in neuron

117 r diaphanous-related formin 1 (DIAPH1), as a candidate gene for MTP using exome sequencing, ontologic

118 amily of proteins, was first discovered as a candidate gene for muscular dystrophy and cardiomyopathy

119 And as such, our study reveals COL15A1 as a candidate gene for orphan neuromuscular disorders.

120 DSS1, a candidate gene for split hand/split foot syndrome, provi

121 ne receptor (nAChR), has been suggested as a candidate gene for the phenotypes observed.

122 Here, focusing on potential candidate genes for angiogenesis, we performed a morphol

123 gions under differential selection contained candidate genes for bill morphology and used genetic arc

124 e identify NUP37, NUP43, and NUP188 as novel candidate genes for cardiovascular disease, and suggest

125 often up-regulated during carcinogenesis and candidate genes for causing the major single-base substi

126 KD GWAS and kidney eQTL results can identify candidate genes for CKD.

127 We identified 113 candidate genes for congenital heart defects within thes

128 As an example, we describe GWAB-boosted candidate genes for coronary artery disease and supporti

129 tors such as SRp55, that may cross talk with candidate genes for diabetes.

130 nsights into the genetic basis and potential candidate genes for differences in the IgG responses to

131 designed NGS panel that covers 412 known and candidate genes for epilepsy.

132 architecture of heart rate, and indicate new candidate genes for follow-up functional studies.

133 These results provide candidate genes for further investigation of their poten

134 might contribute to nsCPO risk and suggests candidate genes for further investigation.

135 n throughout the genus and identify a set of candidate genes for future functional analyses of sex-sp

136 6 mouse knockout strains and identify 52 new candidate genes for genetic hearing loss.

137 de association SNPs identifies 60 functional candidate genes for heart phenotypes, representing 20% o

138 to annotate susceptibility loci and identify candidate genes for human atherosclerotic disease based

139 Besides identifying candidate genes for IVSC resistance in groundnut, the st

140 We show that across all traits the candidate genes for mean phenotype values and plasticity

141 les and genotyped for 71 polymorphisms in 29 candidate genes for periodontitis.

142 ach, we can quickly test human craniocardiac candidate genes for phenocopy as a critical first step t

143 for specific local eQTLs that could harbour candidate genes for phenotypic QTLs, or detect gene-by-e

144 Candidate genes for punicalagin biosynthesis were identi

145 Identification of candidate genes for resistance to this pathogen is of gr

146 lator, CAT4 orthologs could be considered as candidate genes for seed quality biofortification in cro

147 tnnb1-mutant mouse colon adenomas identified candidate genes for subsequent evaluation of human TCGA

148 Together these resources provide a list of candidate genes for targeted engineering of CAM into C3

149 iption factor genes in these modules allowed candidate genes for the control of wall metabolism durin

150 m sativum), leading to the identification of candidate genes for the regulation of globulin abundance

151 ) of mitochondriopathy patients and identify candidate genes for the remainder.

152 Candidate genes for these traits in pigeonpea have seque

153 Putative candidate genes [for example, PHYTOALEXIN DEFFICIENT 4 (

154 We evaluated ten candidate genes found in six clusters of strongly associ

155 Seven associated SNPs hit directly on candidate genes; four SNPs were in high linkage disequil

156 We sequenced 208 candidate genes from >11,730 cases and >2,867 controls.

157 her neurodegenerative conditions, as well as candidate genes from exome sequencing in 3 index cases w

158 Candidate genes from these pathways were validated at th

159 r for gene-gene interactions that identified candidate gene-gene relations within an input sentence.

160 we also found likely pathogenic variants in candidate genes GPC4 and RAC3, both linked to the Wnt si

161 Many more candidate genes had been selected within the Ningyou7 pe

162 Several of the underlying candidate genes have been implicated in important plant

163 Additional candidate genes have been prioritized in silico by their

164 However, many studies identifying candidate genes have lacked replication, and their resul

165 findings indicate that the most investigated candidate gene hypotheses of schizophrenia are not well

166 Our candidate gene identification suggests that nutrient upt

167 hesis development and testing in addition to candidate gene identification.

168 When a significant variant or a candidate gene identified by GWAS is also an eQTL or eGe

169 To validate candidate genes identified by the screen, we further des

170 Genomic regions and candidate genes identified in the present study provide

171 Functional analyses of candidate genes identified in this study will improve ou

172 One candidate gene implicated in influencing learning is the

173 ing specific functional domains and synaptic candidate genes important in NDD pathology.

174 IBD patient and subsequent sequencing of the candidate gene in 12 additional IO IBD patients revealed

175 adhesion, making it a biologically plausible candidate gene in ARVC pathogenesis.

176 ployed to investigate the possible role of a candidate gene in certain biological process under study

177 encing, were used to confirm the role of the candidate gene in determining spot position.

178 We identified mutations in a candidate gene in eight individuals from five families p

179 PTPRO is a novel candidate gene in emphysema with severe airflow obstruct

180 Sanger sequencing of this candidate gene in independent allelic vrs3 mutants revea

181 Here, we investigated a candidate gene in the 21q22.3 risk locus-UBASH3A, which

182 The one obvious candidate gene in the mapped intervals, HMA3, is unlikel

183 this approach allowed us to uncover a novel candidate gene in the regulation of NK cell maturation,

184 EPAS1 is known to be the major selection candidate gene in Tibetans.

185 Functional validation of top 61 candidate genes in 4 IPA networks indicated down regulat

186 ration sequencing to screen for mutations in candidate genes in 547 additional hereditary and/or earl

187 rocesses with DNA methylation patterns of 60 candidate genes in boys at early school age.

188 We inactivated these candidate genes in cell line models to show that loss of

189 linically relevant application to prioritize candidate genes in disease susceptibility loci identifie

190 lective sweep analyses, a number of loci and candidate genes in the two populations were scanned inde

191 ng time and oil metabolism, and revealed new candidate genes in these networks.

192 To confirm a cardiovascular role for these candidate genes in vivo, we used morpholinos to reduce S

193 ding genes known to be involved in CAKUT and candidate genes, in a cohort of 204 unrelated patients w

194 Candidate genes, including cell type-specific transcript

195 ealed six associated loci harboring numerous candidate genes, including EDAR, SP5, MRPS22, ADGRG6 (GP

196 cancer genomes uncovered several pan-cancer candidate genes, including IRS4, SMARCA1 and TERT.

197 evelopmental delay and lethality revealed 40 candidate genes, including sms-1, which encodes a sphing

198 The screen revealed several candidate genes, including those involved in Golgi traff

199 which recruitment was stratified, and other candidate genes, including TRPV1 and GSTM1.

200 Candidate genes indicative of AMI were nominated from mi

201 esearch should serve as a cautionary tale to candidate gene investigators examining other phenotypes:

202 actions associated with SSR resistance, with candidate genes involved in a wide range of processes in

203 e-specific and shared data sets of known and candidate genes involved in cancer.

204 But, our work points to several strong candidate genes involved in mechanisms and biochemical p

205 We identified a number of candidate genes involved in the ABA signaling pathway, a

206 ulations, and targeted SNP analyses of other candidate genes involved in the immune response to malar

207 lian defects is low, the number of potential candidate genes is high, and interventional evidence is

208 Comprehensive genetic testing of the candidate genes is warranted.

209 ns and GWA for mapping Mendelian traits to a candidate-gene level in melon.

210 n studies revealed 28 GWAS hits in potential candidate genes likely to affect traits of agricultural

211 and demonstrate the successful use of a CHD candidate gene list to allow for a more streamlined appr

212 resistance to CaLCuV and the lack of obvious candidate genes near the gip-1 locus suggest that a nove

213 Of these, half do not impact the candidate gene of interest; the other half correlate wit

214 To identify additional candidate genes of CS and potentially DTC, we analysed a

215 ing problems of function prediction, finding candidate genes of diseases, protein-protein interaction

216 oak outer bark, which unveils new regulatory candidate genes of phellem development.

217 association results from large consortia of candidate gene or genome-wide association studies, inclu

218 ave investigated DNA methylation of selected candidate genes or a very small fraction of genomic CpG

219 n in several species; to determine promising candidate genes/pathways/organs for further empirical re

220 A recent analysis of 25 historical candidate gene polymorphisms for schizophrenia in the la

221 Results revealed several candidate genes positively selected in Ankole cattle in

222 Absence of candidate genes previously implicated with longevity ind

223 plus 1457 controls) to optimize the power of candidate-gene prioritization.

224 ultiple known NMD factors and numerous human candidate genes, providing a platform for discovery of a

225 ched for these associated SNPs - one was the candidate gene regions and the other was the approximate

226 We identified key a priori candidate genes regulating root growth and development a

227 To identify candidate genes related to different mechanism defense i

228 Moreover, we identified several important candidate genes related to drought and heat stress, and

229 rols (n = 193), which resulted in 14 and 224 candidate genes, respectively.

230 ome analyses were used to identify potential candidate genes responsible for spot formation.

231 Three new candidate genes revealed by two associated SNPs were sup

232 Additional candidate genes revealed in this study may eventually se

233 ensus semantic similarity of phenotypes in a candidate gene's signaling neighborhood.

234 Hence, this study was aimed at identifying candidate gene(s) and elucidating resistance mechanisms

235 Genome wide association studies and candidate gene screens have identified members of the co

236 ucted and used for gene function prediction, candidate gene selection, and improving understanding of

237 ing (WES) in an sbds-negative SDS family and candidate gene sequencing in additional SBDS-negative SD

238 Genome-wide association studies and candidate gene studies implicate a series of genes invol

239 ere identified in filaggrin (FLG) and HLA in candidate gene studies, and loci in HLA were identified

240 allow precise estimates of effect sizes for candidate gene studies.

241 likely pathologic variants in several novel candidate genes such as GABRE, MYH1, and CLCN6.

242 organism can be efficiently constructed and candidate genes, such as Xa21 in rice, can be accurately

243 Other suggestive candidate genes, such as ZNF816, are of interest for fut

244 andidate genes were identified, including 10 candidate genes supported by previous QTL studies and fi

245 strains have identified a heart regeneration candidate gene that modulates the contractile sarcomeric

246 he literature is enriched with 52 convincing candidate genes that are awaiting confirmation in indepe

247 e comparison of the two clades and found 151 candidate genes that are conserved in the Listeria sensu

248 this study, we have identified and validated candidate genes that are required for MPXV infection, sp

249 scriptome under high light exposure revealed candidate genes that could be involved in critical yet m

250 study identified other variants within those candidate genes that demonstrated genome-wide significan

251 Mutations in candidate genes that encode for a ligand (NDP) and recep

252 As a result, we prioritized 67 ASD-candidate genes that exhibited significantly higher prob

253 leading to the identification of a number of candidate genes that may have played important roles in

254 most studies identify only small numbers of candidate genes that pass the conventional significance

255 (31.6%), 52 convincing recessive variants in candidate genes that were not previously reported in reg

256 Five candidate genes that were potentially subject to selecti

257 esulted in the identification of a set of 26 candidate genes that were resequenced in 132 independent

258 In order to identify additional candidate genes the Cd responses of Col-0 and Bur-0 were

259 ade searching for risk-causative variants in candidate genes; therefore, more complex genetic and epi

260 seeds at the malting stage, we identified a candidate gene, TLP8 (thaumatin-like protein 8), which w

261 Here we tested the potential of 60 of those candidate genes to alter leaf anatomy in rice.

262 with resistance, and (3) determine putative candidate genes to elucidate the mode of resistance.

263 firm gene-expression changes for a couple of candidate genes to exemplify the utility of our analysis

264 Our study also highlighted seven novel candidate genes (TRAPPC3, EXOC3L2, FAM98C, C17orf61, LRR

265 Further analyses indentified 132 candidate genes under selection.

266 us to suggest hypotheses for mechanisms and candidate genes underlying each QTL.

267 n as G9a)-activated the maternal (m) copy of candidate genes underlying PWS, including the SnoRNA clu

268 ification is essential for the imprinting of candidate genes underlying PWS.

269 in-depth molecular investigation to validate candidate genes underlying rice stem NSC and informs fut

270 The candidate gene was subsequently knocked down in human he

271 Targeted resequencing of candidate genes was performed in an independent 70 patie

272 To assess the pathogenic profiles of candidate genes, we conducted Pathway Enrichment, Sub-Ne

273 In canvassing potentially redundant candidate genes, we identified developmentally early exp

274 Among 21 candidate genes, we identified multiple genes (gp130, CC

275 Further candidate genes were detected from long-range regulatory

276 quality polymorphisms within several malaria candidate genes were examined in a sample of 8096 indivi

277 Variants within the 20 candidate genes were extracted from exome-sequencing dat

278 Ninety percent of candidate genes were functionally validated with targete

279 kely causal variants in previously published candidate genes were identified (ASTN1, HELZ, THOC6, WDR

280 In total, 18 candidate genes were identified, including 10 candidate

281 Transcriptional expression levels of candidate genes were measured in peripheral blood sample

282 As a group, variants in the most-studied candidate genes were no more associated with schizophren

283 oss genes, but the vast majority, 52, of the candidate genes were novel.

284 To mimic the situation in T2D islets, candidate genes were overexpressed or silenced in cultur

285 Candidate genes were subsequently validated for function

286 For internal verification of MACE data, candidate genes were tested via RT-qPCR and a strong pos

287 Candidate genes were validated by bisulfite pyrosequenci

288 he model lead to a plausible prioritizing of candidate genes when analyzing multiple genomic variable

289 For FTD-ALS, this resulted in 9 potential candidate genes, whereas for FTD we detected 1 candidate

290 alysis and allele mining identified possible candidate genes which may modulate the content of metabo

291 c order to the linear order in the number of candidate genes, while overcoming the difficulty of mode

292 five autoimmune diseases, we prioritised 245 candidate genes with a median distance from peak signal

293 nd reliable tool that can infer dominance of candidate genes with high sensitivity and specificity, m

294 This analysis highlights several candidate genes with variation that alter protein functi

295 st QTLs detected reside within the region of candidate genes with various functions, thus confirming

296 NPs were in high linkage disequilibrium with candidate genes within 366 kb.

297 ficit stress), and 233 (plasticity) a priori candidate genes within linkage disequilibrium blocks for

298 Candidate genes within these regions included few genes

299 of the few techniques that can help identify candidate genes without relying on our currently incompl

300 A top candidate gene, ZNF804A, was robustly replicated in diff