ライフサイエンスコーパス: candidemia

1 of Candida in urine (candiduria) and blood (candidemia).

2 ed with Klebsiella pneumoniae bacteremia and candidemia.

3 tients with invasive bacterial infections or candidemia.

4 Only 4.6% of patients developed candidemia.

5 g isolate, but it caused only 7% of cases of candidemia.

6 emia are risk factors for the development of candidemia.

7 81%, and 71% of these deaths were related to candidemia.

8 magnetic resonance (T2MR), for diagnosis of candidemia.

9 ified in 18% of 72 patients with C. glabrata candidemia.

10 ocandins are recommended for Candia glabrata candidemia.

11 psilosis is the third most frequent cause of candidemia.

12 n TLR signaling influences susceptibility to candidemia.

13 udied were associated with susceptibility to candidemia.

14 tween infants with candiduria and those with candidemia.

15 ogy and burden of early-onset, nonnosocomial candidemia.

16 explained risk factor for the development of candidemia.

17 acing diagnostic uncertainty, or after prior candidemia.

18 n Als3p (rAls3p-N) protects mice from lethal candidemia.

19 ns and was associated with susceptibility to candidemia.

20 an active, population-based surveillance for candidemia.

21 bation, resulting in four missed episodes of candidemia.

22 Of 2176 episodes of candidemia, 128 were CUTS (5.88%).

23 The tests were similar in diagnosing candidemia (59% vs 68%; P = .77), but PCR was more sensi

24 We detected 773 cases of candidemia, 752 of which were included in the overall co

25 Sixty-one patients had candidemia alone and 38 patients had combined bloodstrea

26 r patients (P = 0.02) and caused over 25% of candidemias among persons 65 years of age or older.

27 BDG levels were 73.4 pg/ml in patients with candidemia and <10 pg/ml in patients without candidemia

28 ite, 93 African American, 8 other race) with candidemia and 351 noninfected controls (263 white, 88 A

29 nazole is associated with a low incidence of candidemia and attributable mortality, despite colonizat

30 tive was to identify factors associated with candidemia and candidemia-related death among adult live

31 echinocandins in treatment and prevention of candidemia and invasive candidiasis.

32 used for primary treatment and prevention of candidemia and invasive candidiasis.

33 linical trials to be efficacious in treating candidemia and invasive candidiasis.

34 rvention period for the incidence density of candidemia and MDR BSI (+0.018 cases per 1000 OBDs per q

35 ence and mortality rate of hospital-acquired candidemia and MDR BSI through sustained reduction in an

36 C. albicans is the most important cause of candidemia and remains highly susceptible to available a

37 More than 70% of patients with candidemia and septic shock were in multiple organ failu

38 differentiation between patients with early candidemia and those without candidemia (ICU patients, i

39 scedosporium, zygomycosis, etc.), those with candidemia, and control patients.

40 s, such as Staphylococcus aureus bacteremia, candidemia, and hepatitis C virus infection.

41 azole (FLC) remains a first-line therapy for candidemia; and voriconazole (VRC), an expanded-spectrum

42 Twenty percent to 70% of all candidemias are associated with this biofilm process.

43 in the rapid identification of 31 out of 72 candidemias as C. albicans and resulted in a significant

44 zole did not statistically alter the rate of candidemia, as this was low across the studies and devel

45 We performed prospective surveillance for candidemia at 16 hospitals in the State of Iowa from 1 J

46 ase chain reaction (PCR) assays can diagnose candidemia before blood cultures and show promising sens

47 We examined the incidence of candidemia, Candida species distribution, and antifungal

48 Plasma BDG levels were undetectable in 18 candidemia cases.

49 g/dl, respectively, for the 11 patients with candidemia compared to 1.14 and 1.23 microM/mg/dl, respe

50 Between December 1985 and December 1992, candidemia developed in 1.4% of adult liver transplant r

51 When candidemia develops shortly after abdominal surgery and

52 However, prevalence of candidemia did not differ significantly in two groups (1

53 nt a case report of invasive candidiasis and candidemia due to a Candida glabrata isolate that develo

54 We present the first case of candidemia due to Candida quercitrusa in a pediatric pat

55 We describe marked shifts in candidemia epidemiology over the past 2 decades.

56 In 2010, C. kefyr caused 16.7% of candidemia episodes.

57 ortality between days 3 to 30, or persistent candidemia for >/=72 hours after initiation of therapy)

58 d, resulting in up to six missed episodes of candidemia (four Candida glabrata isolates, one C. albic

59 We identified 301 episodes of candidemia from 2001 to 2010 inclusive.

60 Delayed treatment of candidemia has previously been shown to be an important

61 ents with early candidemia and those without candidemia (ICU patients, including Candida-colonized pa

62 y and December 1997 detected 306 episodes of candidemia in 34 medical centers (22 in the United State

63 1997 through 1999 detected 1,184 episodes of candidemia in 71 medical centers (32 in the United State

64 n (BDG) detection assay for the diagnosis of candidemia in children.

65 Candidemia in ICU patients is caused by non-albicans spe

66 nator, we calculated the annual incidence of candidemia in Iowa to be 6.0 per 100,000 of population.

67 e factors associated with the development of candidemia in liver transplant recipients.

68 , was recently approved for the treatment of candidemia in nonneutropenic patients.

69 n, may help to explain the increased risk of candidemia in patients receiving LE via medical catheter

70 The Prospective Population Study on Candidemia in Spain (CANDIPOP) is a prospective multicen

71 From 2,675 identified cases of candidemia in the current surveillance, 2,329 Candida is

72 ed cytokine responses, and predisposition to candidemia in whites.

73 re (defined by 7-day mortality or persistent candidemia) in patients treated with either an echinocan

74 We calculated candidemia incidence and antifungal drug resistance comp

75 ted blood culture system to detect simulated candidemia, including both Candida albicans and non-albi

76 early incidence of C. kefyr colonization and candidemia increased over the study period (P < 0.01), p

77 Candidemia is a severe invasive fungal infection with hi

78 Candidemia is an important cause of morbidity and mortal

79 Candidemia is common and associated with high morbidity

80 Surveillance for candidemia is necessary to detect trends in species dist

81 Although candidemia is not always found during invasive candidias

82 tibility to infections, but its relevance in candidemia is unknown.

83 Patients with IC had candidemia (n = 17), deep-seated candidiasis (n = 33), o

84 The rate of early-onset candidemia nearly doubled between 2000 and 2003 (p < .00

85 on of patients enrolled in a recent study of candidemia, no such clear-cut correlation was present.

86 ia treated with insulin up to 2 weeks before candidemia (odds ratio [OR], 16.15; p = 0.002), and 2) e

87 Whether echinocandins could be used to treat candidemia of a urinary tract source (CUTS) is unknown.

88 the 245 patients in the primary analysis had candidemia only.

89 ntravenous antibiotics before development of candidemia (OR, 11.15; p = 0.005).

90 candidemia and <10 pg/ml in patients without candidemia (P < 0.001).

91 nd potentially antifungal resistant cause of candidemia, particularly among the elderly.

92 A cohort of 338 candidemia patients and 351 noninfected controls were ge

93 s are associated with persistent fungemia in candidemia patients.

94 Following candidemia, production of specific fungal exotoxins coin

95 ntify factors associated with candidemia and candidemia-related death among adult liver transplant re

96 ominal surgery performed up to 1 week before candidemia (relative risk [RR], 7.25; p = 0.02), high wh

97 Candidemia remains a significant problem in intensive ca

98 udy population with 5% and 10% prevalence of candidemia, respectively.

99 (RR, 0.99; p = 0.02), and elevated AST with candidemia (RR, 1.001; p = 0.01).

100 Early-onset candidemia seems to be a distinct entity, which is incre

101 ion between IL-17A and kynurenine levels and candidemia suggests their potential as biomarkers for an

102 2000, making this the first population-based candidemia surveillance conducted over multiple time poi

103 Between 2008 and 2011, population-based candidemia surveillance was conducted in Atlanta, GA, an

104 The association of SNPs with both candidemia susceptibility and outcome were assessed.

105 N, I602S) were significantly associated with candidemia susceptibility in whites.

106 Crude in-hospital mortality was higher for candidemia than for bacterial bloodstream infection (28.

107 idering voriconazole therapy for C. glabrata candidemia that occurs in patients with extensive prior

108 One C. albicans-colonized infant developed candidemia; the colonizing and infecting strains had ide

109 sceptibility testing for timely tailoring of candidemia therapy.

110 The blood of four patients with candidemia, three patients with mixed fungal infections,

111 Outcome for 105 patients with candidemia treated with amphotericin B was correlated wi

112 ntation activity, higher annual incidence of candidemia, uncontrolled use of fluoroquinolones, and ro

113 at 7 and 30 days after the first episode of candidemia was 16.5% and 47%, respectively.

114 days); median voriconazole exposure prior to candidemia was 48 days.

115 e overall mortality rate among patients with candidemia was 81%, and 71% of these deaths were related

116 nd after controlling for other risk factors, candidemia was associated with increased mortality risk

117 A multicenter study of adult patients with candidemia was conducted in 9 hospitals.

118 The epidemiology of C. kefyr candidemia was evaluated in another hospital in Montreal

119 Simulated candidemia was produced with 20 Candida isolates at thre

120 ood culture, and 52 control patients without candidemia was reported.

121 In the multivariable model, persistent candidemia was significantly associated with (odds ratio

122 Candidemia was simulated with 15 Candida spp. by using a

123 nced the development of azole resistance and candidemia, weekly mouthwashings were done, and fluconaz

124 The variables predictive of death related to candidemia were abdominal surgery performed up to 1 week

125 f treatment success and 30-day mortality for candidemia were each 51%.

126 A total of 501 patients with bacteremia or candidemia were included in the final analysis: 245 pati

127 terial bloodstream infections, patients with candidemia were more likely to have been admitted within

128 = 264) bloodstream infections, patients with candidemia were more likely to have solid tumors (p < .0

129 No associations with susceptibility to candidemia were observed for SNPs in TLR2, TLR4, TLR6, T

130 In the United States, 45% of candidemias were due to non-C. albicans species.

131 the most common species detected, but 43% of candidemias were due to species other than C. albicans.

132 e systems detected all episodes of simulated candidemia when specialized mycology media were used.

133 re timely institution of targeted therapy in candidemia, which can improve patient outcomes.

134 tched case-control study of 26 patients with candidemia, which was defined as the isolation of Candid

135 was used to identify factors associated with candidemia, which were 1) hyperglycemia treated with ins

136 were recovered from 4 patients who developed candidemia while receiving fluconazole and three patient

137 fluconazole and three patients who developed candidemia while receiving voriconazole.

138 Controls were patients without candidemia who were randomly selected in a ratio of 5:1

139 We identified 2675 cases of candidemia with 2329 isolates during 3 years of surveill

140 CUTS was defined as a candidemia with concomitant candiduria by the same organ

141 on with the C. albicans clinical isolate vs. candidemia with its agerminative mutant, although serum

142 Candidemia with septic shock is infrequent in nonimmunoc

143 cubated for 5 days, an additional episode of candidemia would have remained undetected.