ライフサイエンスコーパス: cap structure

1 are induced to fold upon recognition of the cap structure.

2 on factor (eIF) 4G, bridging the 5' terminal cap structure.

3 nding of an initiation factor, eIF4E, to the cap structure.

4 anslation of cellular mRNAs utilizing the 5' cap structure.

5 ite that is a considerable distance from the cap structure.

6 ranslated efficiently in the absence of a 5' cap structure.

7 was contributed by the interaction with the cap structure.

8 position 10-15 nucleotides downstream of the cap structure.

9 he 5' diphosphate end of RNA to form a GpppN cap structure.

10 in the affinity of eIF4E for the mRNA m7GTP cap structure.

11 in a heterodimeric complex to bind the mRNA cap structure.

12 hich are involved in the modification of RNA cap structure.

13 p in vitro due to its ability to bind the 5' cap structure.

14 Y14 is critical for its binding to the mRNA cap structure.

15 in (PAB1) gene deletion, stabilizes the mRNA cap structure.

16 F4F (of which eIF4G is a subunit) for the 5' cap structure.

17 ay that is stimulated by removal of the mRNA cap structure.

18 synthesized BTV ssRNA transcripts to form a cap structure.

19 GTP to the 5' end of mRNA to form the GpppN cap structure.

20 y require a 3' OH or interaction with the 5' cap structure.

21 hotoreactive moiety is brought closer to the cap structure.

22 ric, coiled coil with a small, alpha-helical cap structure.

23 in synthesis by binding the 5' terminal mRNA cap structure.

24 at eIF4F binds mRNAs primarily at the 5' m7G cap structure.

25 protein in 2'-O and G-N-7 methylation of the cap structure.

26 is responsible for methylating the viral RNA cap structure.

27 f a transcript independent of its 5' end and cap structure.

28 lent enzyme-GMP intermediate to generate the cap structure.

29 bypassing the host cell requirement of a 5' cap structure.

30 iation and separately formation of the GpppA cap structure.

31 r by competing with eIF4E for binding to the cap structure.

32 oth eIF4E-2 and eIF4E-3 can bind to the mRNA cap-structure.

33 on of higher order PIMs that possess mannose cap structures.

34 nd increases interactions of eIF4E with mRNA cap structures.

35 was developed for the two distinct types of cap structures.

36 o synthesize viral mRNAs methylated at their cap structures.

37 at the distal end, often with the help of a capping structure.

38 of which is covered by a novel T:A:T triple capping structure.

39 iolate protecting layer, consisting of Ag2S5 capping structures.

40 ase-paired thymines that are involved in the capping structures.

41 r loop arrangements, strand orientations and capping structures.

42 m(7)GDP; however, it did not function on the cap structure alone.

43 itiation factor 4E (eIF4E) also binds to the cap structure, an interaction that is critical for initi

44 Communication between the 5' cap structure and 3' poly(A) tail of eukaryotic mRNA res

45 n of a reporter mRNA lacking the 5' (7)mGppp cap structure and 3' poly(A) tail.

46 e consistent with ribosomal tethering at the cap structure and clustering at internal sites.

47 viral RNAs that are capped by binding to the cap structure and depurinating the RNAs downstream of th

48 at the barbed end are intimately related to cap structure and dynamics.

49 r by a mechanism which is independent of the cap structure and in this case ribosomes are directed to

50 f many positive strand RNA viruses lack a 5' cap structure and instead rely on cap-independent transl

51 endoplasmic reticulum, colocalizing with the cap structure and interacting with the ribosomal protein

52 of stable snRNPs, hypermethylation of the 5' cap structure and nuclear import of the resultant partic

53 ise our current knowledge on the role of the cap structure and of the cap-binding protein complex in

54 The 5'-cap structure and poly(A) tail of eukaryotic mRNAs funct

55 esis, the mRNA 5'-terminal 7-methylguanosine cap structure and several recognition proteins play a pi

56 mRNA requires direct interaction between the cap structure and the eukaryotic translation initiation

57 L-BC Gag also covalently binds to the cap structure and the mutation H156R, which corresponds

58 Although the cap structure and the poly(A) tail are on opposite ends

59 The 5'-terminal cap structure and the poly(A) tail at the 3' terminus se

60 accharomyces cerevisiae is stimulated by the cap structure and the poly(A) tail through the binding o

61 Both the cap structure and the spliced leader (SL) sequence affec

62 The VHS RNase binds both to mRNA cap structure and to tristetraprolin, an inducible host

63 RNAs into Xenopus oocytes and examined their cap structures and translational activities during meiot

64 e loop plays a central role for the specific capping structures and in stabilizing the most favored f

65 The distinct capping structures appear to be crucial for the favored

66 Thus, changes in the telomere cap structure are sufficient to affect the rate of senes

67 First, as cap structures are usually required for translation of m

68 the identification of the absence of the 5' cap structure as a primary molecular determinant of part

69 contain an unusual 2,2,7-trimethylguanosine cap structure as a result of trans-splicing onto the 5'

70 The dual role of the cap structure as a target of mRNA degradation and as the

71 reaction with free GDP, yielding the same 5'-capped structure as is formed by protein GTP:RNA guanyly

72 The 7-methylguanosine cap structure at the 5' end of eukaryotic messenger RNAs

73 ic mRNA turnover is the removal of the m(7)G cap structure at the 5' end of the message.

74 ly degraded, presumably due to the lack of a cap structure at the 5' end of the mRNA.

75 ctors recruit the 40S ribosomal subunit to a cap structure at the 5' end of the mRNA.

76 ly dependent upon the presence of an m7GpppN cap structure at the 5' end of the transcript.

77 ncer RNAs did not appear to contain a normal cap structure at the 5' ends.

78 g protein synthesis independent of the m(7)G cap structure at the 5'-end of an mRNA molecule.

79 of a triphosphate or a 7-methyl 3'G5'ppp5' G cap structure at the 5'-end of the RNA does not affect c

80 ase (L) protein of VSV methylates viral mRNA cap structures at the guanine-N-7 (G-N-7) and ribose-2'-

81 ellum and three constituents of the axonemal capping structure at the tips of both assembling and mat

82 The assembly is closed by specific capping structures at either end, which we propose to pl

83 We propose that mRNAs lacking a cap structure become exposed to RdRp to initiate or main

84 ith a natural competition existing at the 5' cap structure between PARN and eIF4E that may be regulat

85 y ISG15 and ISGylated 4EHP has a much higher cap structure-binding activity.

86 4EHP is an mRNA 5' cap structure-binding protein and acts as a translation

87 terminal Strep tag appears buried within the cap structure, blocking effector transport even in Y. pe

88 , like L-A viral mRNA, lack 3'-poly(A) or 5'-cap structures but can normally express mRNA with both c

89 etoplastid mRNA acquire a hypermethylated 5'-cap structure, but its function has been unclear.

90 RNA virus furnishes its transcript with a 5' cap structure by a novel cap-snatching mechanism in whic

91 ic activity and subsequent hydrolysis of the cap structure by a scavenger decapping activity.

92 ation of clustered lesions in the chromosome capping structure can result in the unfolding of existin

93 Telomeres form protective capping structures composed of telomeric DNA complexed w

94 Telomeres are protected by capping structures consisting of core protein complexes

95 tro indicated that the 7-methyl group of the cap structure contributes to the enzyme's substrate spec

96 tail, followed either by cleavage of the 5' cap structure (decapping) and 5'->3' exonucleolytic dige

97 lation of 4EHP may play an important role in cap structure-dependent translation control in immune re

98 U3 and U8 RNAs containing alternative cap structures did not localize in nucleoli nor did U3 o

99 ase activity that can also remove the entire cap structure dinucleotide from an mRNA.

100 les during phagocytosis and to the posterior cap structure during surface receptor shedding for immun

101 ry, most eukaryotic cellular mRNAs have a 5' cap structure [e.g. m7G(5')ppp(5')N].

102 ught to be required for interaction with the cap structure, eIF4G, and 4E-BPs, it fails to interact w

103 e methyltransferases sequentially modify the cap structure, first at the guanine-N-7 (G-N-7) position

104 pyrophosphatase that hydrolyzes the residual cap structure following 3' to 5' decay of an mRNA.

105 g enzyme DcpS functions to clear the cell of cap structure following decay of the RNA body by catalyz

106 cpS is known for its role in hydrolyzing the cap structure following mRNA degradation.

107 x with only two G-tetrads but multiple-layer capping structures formed by loop residues.

108 In addition, the capping structures formed by the extended flanking segme

109 ed decapping enzyme Dcp2 that removes the 5' cap structure from eukaryotic mRNA and thereby efficient

110 DCPS decaps the cap structure generated by 3' to 5' exonucleolytic degra

111 nt enzyme-pRNA intermediate to generate a 5'-cap structure (GpppA).

112 hate end of poly(A) to form a tetraphosphate cap structure, GppppA.

113 eport that the L protein produces an unusual cap structure, guanosine(5')tetraphospho(5')adenosine (G

114 esence of translational control elements and cap structures has not been carefully investigated for m

115 The cap structures have the potential to be of considerable

116 hat T. vaginalis mRNAs are protected by a 5' cap structure, however, contrary to that typical for euk

117 lves three mRNA structural features: (i) the cap structure, (ii) the context of the Kozak sequences t

118 d woodchuck, behaved as if it contained a 5'-cap structure; (ii) in the infected liver there were add

119 be controlled by access of the enzyme to the cap structure in a competition with the translation init

120 These results define an additional 5' RNA cap structure in eukaryotes and raise the possibility th

121 er IRES domains substitute for a 5' terminal cap structure in protein synthesis.

122 ndings underscore the importance of a proper cap structure in the synthesis of functional messenger R

123 The SL RNA cap structure in Trypanosoma brucei is unique among euka

124 The only known RNA cap structure in unicellular protists is the unusual Cap

125 iruses, FluB PB2 recognizes a wider range of cap structures including m(7)GpppGm-, m(7)GpppG-, and Gp

126 Addition of a 12-nucleotide chain to the cap structure increased affinity at high ionic strength

127 les increase, the stability of the spherical cap structure increases with respect to the alternative

128 Direct analysis of the mRNA cap structure indicated no alteration of cap processing

129 te-terminated substrates shows that that the cap structure inhibits the action of the enzyme.

130 The N7-methylguanine portion of the mRNA cap structure interacts with cap-binding proteins via an

131 The 2,2,7-trimethylguanosine (TMG) cap structure is characteristic of certain eukaryotic sm

132 The decapping enzyme that removes the 5' cap structure is encoded by the DCP1 gene.

133 The cap structure is formed by several activities and comple

134 A cis-diol containing cap structure is present at the 5' end of the U2 homolog

135 ts argue that dissociation of eIF4E from the cap structure is required before decapping.

136 g mechanism in which m(7)Gp from a host mRNA cap structure is transferred to the 5'-diphosphate termi

137 f how the flavivirus MTase protein binds RNA cap structures is presented.

138 In eukaryotes, the 5'-methylguanosine (cap) structure is principally removed by the Nudix famil

139 bonding and hydrophobic interactions in this capping structure is -1.2 kcal/mol, evaluated from therm

140 NA-binding motif no longer binds to the mRNA cap structure, is localized in the cell nucleus, does no

141 The SL cap is the most elaborate cap structure known in nature and has been shown to cons

142 ing protein that binds to capped RNA but not cap structure lacking an RNA.

143 The presence of the 5' cap structure m(7)G(5')ppp(5')Nm is a general feature of

144 e only plant mRNAs known to naturally lack a cap structure (m(7)GpppN) are viral in origin.

145 Eukaryotic mRNA bears a cap structure (m(7)GpppX-) at the 5' terminus crucial fo

146 eIF4F (4F) complex that assembles at the 5' cap structure (m(7)GTP) of mRNA to initiate ribosomal sc

147 d of the mRNA can affect the state of the 5' cap structure, m7G(5')ppp(5')G.

148 eIF4E linkage to cap structures mediates the recruitment of other transla

149 A polymerase synthesizes viral mRNAs with 5'-cap structures methylated at the guanine-N7 and 2'-O-ade

150 this and the 38-year-old cartilage the three capping structures: NeuAc(alpha2-3)-Gal-GlcNAc6S-Gal-Glc

151 forms the distinctive gamma-methylphosphate cap structure of 7SK, a noncoding RNA that regulates Cdk

152 MTases and can target only the N7-methylated cap structure of adenylate-primed RNA substrates.

153 Binding of the cap structure of AlMV4 by the polymerase activated RNA s

154 iral heterotrimeric RNA polymerase binds the cap structure of cellular pre-mRNA to promote its cleava

155 The m7GpppN cap structure of eukaryotic mRNA is formed cotranscripti

156 nd of three steps in the synthesis of the 5'-cap structure of eukaryotic mRNA.

157 he enzyme responsible for methylating the 5' cap structure of eukaryotic mRNA.

158 nformational change after the binding of the cap structure of host cell heterogeneous nuclear RNA by

159 The 5'-cap structure of most spliceosomal small nuclear RNAs (s

160 initiation factor 4E (eIF4E) binds to the 5' cap structure of mRNA and is critical for cap-dependent

161 plants have two complexes that bind the m7G-cap structure of mRNA and mediate interactions between m

162 eIF4E, eIF4G, and eIF4A, binds to the m(7)G cap structure of mRNA and stimulates recruitment of the

163 einitiation complex to eIF4F bound at the 5'-cap structure of mRNA are necessary for preventing eIF5-

164 Recognition of the 5'-cap structure of mRNA by eIF4E is a critical step in the

165 plex, Eu(THED)3+, effectively cleaves the 5' cap structure of mRNA in solution by nucleophilic attack

166 The 5' cap structure of mRNA is a N7 methylated guanosine resid

167 Binding of the 5' -terminal cap structure of mRNA to eIF4E is a critical event durin

168 The cap-binding complex (CBC) binds to the cap structure of mRNA to protect it from exonucleases as

169 es contain a small subunit that binds the 5'-cap structure of mRNA, and a large subunit, eIF4G or eIF

170 Through its interaction with the 5' cap structure of mRNA, eIF4E functions to recruit mRNAs

171 Recognition of the cap structure of mRNA, m(7)GpppN, where N is any nucleot

172 Moreover, Y14 binds the cap structure of mRNAs and inhibits the activity of the

173 ly with the decapping factor Dcp2 and the 5' cap structure of mRNAs via different but overlapping dom

174 in vitro, specifically interacts with the 5' cap structure of RNA substrates, and this interaction is

175 Consequently, the cap structure of the gammaTuRC is distal to the base of

176 t role in mRNA translation by binding the 5'-cap structure of the mRNA and facilitating the recruitme

177 karyotic initiation factor 4E (eIF4E) to the cap structure of the mRNA.

178 incorporates the GDP moiety of GTP into the cap structure of transcribing mRNAs.

179 Methylation of the 5'-cap structure of viral RNAs plays important roles in gen

180 ine RNA caps to the 2,2,7-trimethylguanosine cap structures of small nuclear and small nucleolar RNAs

181 ntose is linked to a terminal mannose in the cap structures of these oligosaccharides as evidenced by

182 her 5' capping or 2'-O-methylation of the 5' cap structures of viral transcripts, and in this way pro

183 poly(A)-specific ribonuclease, binds the 5' cap-structure of mRNA and initiates deadenylation-depend

184 y to integrate into telomeres, the essential capping structures of chromosomes that play roles in can

185 ecognition of the methyl-7-guanosine (m(7)G) cap structure on mRNA is an essential feature of mRNA me

186 ylation-independent repression requires a 5' cap structure on the mRNA; however, deadenylation does n

187 The effects of the cap structure on these different processes is mediated b

188 ron microscopy revealed the formation of new cap structures on broken filaments that re-grew.

189 uiting the 40S ribosomal subunit to the mRNA cap structure or internal ribosome entry site (IRES) ele

190 ut did not block translation mediated by the cap structure or other viral IRESs.

191 d as the high-affinity substrate but not the cap structure or RNA alone.

192 ion from RIG-I, explaining the complexity of cap structures over evolution.

193 s pathway is decapping, since removal of the cap structure permits 5'-->3' exonucleolytic digestion.

194 Since the cap structure plays a critical role in the assembly of t

195 ne residue closely resembles the 5' terminal cap structure present on all eukaryotic mRNA molecules.

196 transcript, thus forming on it an authentic cap structure (referred to as cap0) in the budding yeast

197 Analysis of the mRNA cap structure revealed that alterations to the predicted

198 ification of the diverse range of beta-helix cap structures reveals subtle commonalities in structura

199 Unlike the cap structures seen in U-snRNAs and mRNAs it is neither

200 and their initial 7-methylguanosine (m7G) 5' cap structures subsequently become converted to 2,2,7-tr

201 their poly(A) tail but contain an intact 5' cap structure, suggesting that Dhh1 is required for effi

202 more distal, toward the tip of the gammaTuRC-cap structure, than that of gamma-tubulin.

203 a reverse turn that is consistent with the C-cap structure that has been previously reported for the

204 The cap structure that is characteristic of all polymerase-I

205 sential step in the formation of the m7GpppN cap structure that is characteristic of eukaryotic mRNA

206 Their plus-strand RNA genome contains a 5'-cap structure that is methylated at the guanine N-7 and

207 hat Xgrip210 is a component of the gammaTuRC cap structure that is required for the assembly of the g

208 e with a deep cavity for binding the m7GpppN cap structure that is required for viral RNA transcripti

209 Eukaryotic RNAs typically contain 5' cap structures that have been primarily studied in yeast

210 glec-5, bind to NeuAcalpha2,3Gal, a terminal capping structure that can also be displayed on the lipo

211 In addition to lacking a cap structure, the full-length I transcripts synthesized

212 Given the functions of the 5' cap structure throughout mRNA metabolism, antisense olig

213 , and act independently of a 7mG(5')ppp(5')G cap structure to deadenylate an exogenous mRNA substrate

214 s use 5' caps or other mechanisms to mimic a cap structure to limit detection of viral RNAs by intrac

215 The lack of a cap structure typical of eukaryotic mRNA and absence of

216 e distinctive 2,2,7-trimethylguanosine (TMG) cap structure usually found on snRNAs and snoRNAs is pro

217 ) tail complex on mRNA can interact with the cap structure via eIF-4G.

218 cell sorter analysis confirmed that the 7mG cap structure was critical for efficient infectivity, al

219 BioServe Fluid Processing Apparatus and root cap structure was examined at both light and electron mi

220 A unique capping structure was shown to form in this 1:4:1 G-quad

221 nded to reduce the ability of PB2 to bind to cap structures, was stable in all three assays, whereas

222 on of existing repeats and de novo design of capping structures, we designed leucine-rich repeats (LR

223 RNAs lacking 2'-O-methylated 5' cap structures were also detected in the in vivo 6 hr la

224 Human U3 and U8 RNAs with various cap structures were generated by in vitro transcription,

225 The ManLAM mannose cap structures were necessary in limiting P-L fusion, an

226 ation of N-glycans in EBs, whereas alpha-Gal-capped structures were more prevalent in ExE cells.

227 tidic acid can be induced to reversibly form cap structures when exposed to an asymmetry in ionic str

228 ols the half-life of mRNA by cleaving the 5' cap structure, which exposes a monophosphate that is eff

229 The N7-methylated guanosine (m7G) cap structure, which is found at the 5' ends of mature e

230 ses, such as VSV, possess a fully methylated cap structure, which is required for mRNA stability, eff

231 structure derived from the standard m7GpppN cap structure, with 2'-O methylations on the first four

232 each thymine position provided evidence of a capping structure within the top loop region of the i-mo