ライフサイエンスコーパス: capacitative

1 f internal Ca(2+) stores (i.e. they are 'non-capacitative').

2 family of cation channels are candidates for capacitative and non-capacitative Ca2+ entry channels.

3 We conclude that the non-capacitative ARC channels share, with voltage-gated Ca(2

4 erous examples of label free impedimetric or capacitative assaying of biomolecules, these are rarely

5 ly-MTAPc enabled a high faradaic (signal) to capacitative (background) current during NO electro-oxid

6 We studied the properties of capacitative Ca 2+ entry in astrocytes by means of singl

7 We found that, in astrocytes, capacitative Ca 2+ entry is not attributable to TRPC ope

8 novel form of Ca 2+ signaling, distinct from capacitative Ca 2+ entry, which suggests a specific sign

9 Sr2+ and Ba2+ do not enter astrocytes during capacitative Ca 2+ entry.

10 a 2+ stores depletion, a phenomenon known as capacitative Ca 2+ entry.

11 ced release of Ca from internal stores or by capacitative Ca entry.

12 he animal hemisphere of the oocyte, but that capacitative Ca influx occurs over the entire oocyte mem

13 eriments were performed to determine whether capacitative Ca(2+) entry (CCE) can be activated in cani

14 Although the molecular identity of capacitative Ca(2+) entry (CCE) channels remains elusive

15 -sensitive adenylyl cyclases (ACs) depend on capacitative Ca(2+) entry (CCE) for their regulation.

16 Store-operated cation (SOC) channels and capacitative Ca(2+) entry (CCE) play very important role

17 Capacitative Ca(2+) entry (CCE) was enhanced in PASMCs f

18 SMCs) showed that the TRPC1 channel mediates capacitative Ca(2+) entry (CCE), but the molecular signa

19 ed cardiomyocytes suggest the involvement of capacitative Ca(2+) entry (CCE), the influx of Ca(2+) th

20 ellular calcium stores, a mechanism known as capacitative Ca(2+) entry (CCE).

21 tage-gated Ca(2+) channels, a process termed capacitative Ca(2+) entry (CCE).

22 es sustained Ca(2+) signaling dependent upon capacitative Ca(2+) entry (CCE).

23 acellular Ca(2+) stores, hence activation of capacitative Ca(2+) entry (CCE).

24 ating from intracellular pools (MHA) or from capacitative Ca(2+) entry (EHA).

25 resting B cells with specific inhibitors of capacitative Ca(2+) entry (SK&F 96365) or PKC (Go6850).

26 easuring the cytosolic Ca(2+) response after capacitative Ca(2+) entry activation and Ca(2+) dynamics

27 I of C6-2B glioma cells is regulated only by capacitative Ca(2+) entry and not by a substantial eleva

28 on was completely prevented by inhibitors of capacitative Ca(2+) entry and only partially abrogated b

29 mate colocalization of adenylyl cyclase with capacitative Ca(2+) entry channels is an intrinsic prope

30 In these cells, a modest degree of capacitative Ca(2+) entry could be discerned in the face

31 However, the role of capacitative Ca(2+) entry in EGF-mediated Ca(2+) mobiliz

32 ly, PI(3,4,5)P(3)-sensitive Ca(2+) entry and capacitative Ca(2+) entry represent major Ca(2+) influx

33 Capacitative Ca(2+) entry stimulates cAMP synthesis in m

34 EHA was more sensitive to Ca(2+) influx via capacitative Ca(2+) entry than intracellular release, wh

35 xcitable cells, overwhelms the effect of any capacitative Ca(2+) entry that may occur.

36 he Ca(2+) release process from the ER or the capacitative Ca(2+) entry through the plasma membrane.

37 Inhibition of capacitative Ca(2+) entry with EGTA or LaCl(3) or low ex

38 constrictor-stimulated Ca(2+) store release, capacitative Ca(2+) entry, and noncapacitative Ca(2+) en

39 ological processes, including store-operated capacitative Ca(2+) entry, Ca(2+)-induced Ca(2+) release

40 h domains to be susceptible to regulation by capacitative Ca(2+) entry.

41 tored the sensitivity of adenylyl cyclase to capacitative Ca(2+) entry.

42 eterologously, were regulated exclusively by capacitative Ca(2+) entry.

43 a stage downstream of ER Ca(2+) release and capacitative Ca(2+) entry.

44 blated the regulation of adenylyl cyclase by capacitative Ca(2+) entry.

45 adenylyl cyclase activity and did not affect capacitative Ca(2+) entry.

46 nt of their plasma membranes and more robust capacitative Ca(2+) entry.

47 hol and thapsigargin (Tg)) known to activate capacitative Ca(2+) entry.

48 a membrane Ca(2+) channels, a process termed capacitative Ca(2+) entry.

49 Cbeta activation, Ca(2+) store release, and capacitative Ca(2+) entry.

50 DES effectively inhibited TG-induced capacitative Ca(2+) influx in a dose-dependent manner wi

51 mycin, a mitochondrial inhibitor that blocks capacitative Ca(2+) influx in other systems.

52 ore-operated cation channels can account for capacitative Ca(2+) influx in SMC and can play an import

53 ion of intracellular Ca(2+) stores activates capacitative Ca(2+) influx in smooth muscle cells, but t

54 or activation of store-operated channels and capacitative Ca(2+) influx in wide variety of cell types

55 Ca(2+) influx via a mechanism distinct from capacitative Ca(2+) influx induced by carbachol and Tg.

56 Capacitative Ca(2+) influx induced by thapsigargin was a

57 ull functions of eNOS and aequorin, and that capacitative Ca(2+) influx is the principle stimulus for

58 +)](i) to levels higher than those caused by capacitative Ca(2+) influx, the LAMP assay revealed that

59 effect of DES on store-operated channels and capacitative Ca(2+) influx, we used rat basophilic leuke

60 CRAC) currents and thapsigargin (TG)-induced capacitative Ca(2+) influx.

61 lease from internal stores does not activate capacitative Ca(2+) influx.

62 upport our previous proposal that TRPCs form capacitative Ca-entry channels.

63 In intact platelets, maximal capacitative Ca2+ and Mn2+ influx developed rapidly (wit

64 NO (1 micromol/L) inhibited capacitative Ca2+ and Mn2+ influx independently of the t

65 and caveolae, which contribute to increased capacitative Ca2+ entry (CCE) and DNA synthesis.

66 2 overexpression results in up-regulation of capacitative Ca2+ entry (CCE) and that SKF-96365, an inh

67 Capacitative Ca2+ entry (CCE) has been speculated to con

68 Capacitative Ca2+ entry (CCE) is Ca2+ entering after sti

69 R) Ca2+ stores activates Ca2+ influx via the capacitative Ca2+ entry (CCE) pathway.

70 Local Ca2+ release caused activation of capacitative Ca2+ entry (CCE).

71 irect activation of PKC, thus generating non-capacitative Ca2+ entry alongside that evoked following

72 s, but they were robustly stimulated only by capacitative Ca2+ entry and not al all by a substantial

73 undertaken to investigate the regulation of capacitative Ca2+ entry by phorbol ester-sensitive prote

74 rise generated by ionophore, Ca2+ entry via capacitative Ca2+ entry channels was solely responsible

75 to the suggestion that adenylyl cyclases and capacitative Ca2+ entry channels were localized in the s

76 nels are candidates for capacitative and non-capacitative Ca2+ entry channels.

77 in blunting the regulation of the cyclase by capacitative Ca2+ entry defined the intimacy between the

78 d conditions were devised that distinguished capacitative Ca2+ entry from both internal release and n

79 role in the regulation of SOCs by monitoring capacitative Ca2+ entry in 3T3-like embryonic fibroblast

80 a small G protein, is linked functionally to capacitative Ca2+ entry in human embryonic kidney 293 ce

81 gous channel proteins that appear to mediate capacitative Ca2+ entry in species from worms and files

82 The level of capacitative Ca2+ entry in Src- cells is restored to nea

83 s been suggested that this store-mediated or capacitative Ca2+ entry is brought about by a physical a

84 Although the mechanism of capacitative Ca2+ entry is not known, evidence suggests

85 e we provide evidence for an additional, non-capacitative Ca2+ entry mechanism in human platelets.

86 data indicate that the inhibitory action on capacitative Ca2+ entry of glucosamine is distinct from

87 ited AVP-evoked Sr2+ entry without affecting capacitative Ca2+ entry or release of Ca2+ stores.

88 es but also provide a physiological role for capacitative Ca2+ entry other than store refilling.

89 bility of T cells to maintain a high rate of capacitative Ca2+ entry over prolonged periods of >10 mi

90 The capacitative Ca2+ entry pathway in J774 macrophages is r

91 bition of phosphatase type 1/2A inhibits the capacitative Ca2+ entry pathway in rat thymic lymphocyte

92 Importantly, the capacitative Ca2+ entry pathway in rat thymic lymphocyte

93 tive calcium channels (VSCCs) as well as the capacitative Ca2+ entry pathway.

94 Ca2+ influx occurs predominantly through the capacitative Ca2+ entry pathway.

95 d, phase I appears to be mainly dependent on capacitative Ca2+ entry related to release of thapsigarg

96 e was also able to reverse the inhibition of capacitative Ca2+ entry seen following other treatments

97 essed Ca2+-inhibitable adenylyl cyclase with capacitative Ca2+ entry sites but also provide a physiol

98 n of Ca(2+)-sensitive adenylyl cyclases with capacitative Ca2+ entry sites, even when expressed heter

99 ntimacy between the adenylyl cyclase and the capacitative Ca2+ entry sites.

100 ses might display the strict requirement for capacitative Ca2+ entry that is shown by the Ca(2+)-inhi

101 [Ca2+]i inhibited the ability of subsequent capacitative Ca2+ entry to further increase [Ca2+]i.

102 The present study compared the regulation by capacitative Ca2+ entry versus ionophore-mediated Ca2+ e

103 to determine whether glucosamine's effect on capacitative Ca2+ entry was also due to ATP depletion, a

104 Selective inhibition of capacitative Ca2+ entry with Gd3+ revealed that the non-

105 concentrations of Gd3+ irreversibly blocked capacitative Ca2+ entry without affecting AVP-evoked Sr2

106 activation of store-operated Ca2+ channels (capacitative Ca2+ entry).

107 ariously as store-operated Ca2+ entry (SOC), capacitative Ca2+ entry, and Ca2+ release-activated chan

108 -induced intracellular Ca2+ store depletion (capacitative Ca2+ entry, CCE) represents the preferentia

109 y expressed, are preferentially regulated by capacitative Ca2+ entry, compared with other means of el

110 poorly understood cellular mechanism, termed capacitative Ca2+ entry, is activated [3,4]; this permit

111 cells was inhibited by two drugs that block capacitative Ca2+ entry, La3+ and SK&F 96365.

112 rom internal stores followed by a sustained, capacitative Ca2+ entry, which is mediated by store-oper

113 clopiazonic acid or carbachol also activates capacitative Ca2+ entry.

114 luorescence by Mn2+ was used as a measure of capacitative Ca2+ entry.

115 rease in the rate of Mn2+ influx, suggesting capacitative Ca2+ entry.

116 cumulation, comparable with that elicited by capacitative Ca2+ entry.

117 by 1 microM Gd3+ which completely inhibited capacitative Ca2+ entry.

118 lay an active role in modulating the rate of capacitative Ca2+ entry.

119 2+ release from intracellular stores and for capacitative Ca2+ entry.

120 tracellular Ca2+ stores and thereby activate capacitative Ca2+ entry.

121 yed attenuation of the Ca2+ signal evoked by capacitative Ca2+ entry.

122 nzoyl-S-farnesyl-S-cysteine had no effect on capacitative Ca2+ entry.

123 inin-8 was observed only during the phase of capacitative Ca2+ influx and was blocked by zero Ca2+.

124 However, the inhibition of capacitative Ca2+ influx in the presence of glucosamine

125 Additionally, our results suggest that capacitative Ca2+ influx may be mediated by both conform

126 tiate Ca2+ signaling through activation of a capacitative Ca2+ influx pathway.

127 stores while inhibiting their refilling via capacitative Ca2+ influx that results in partial emptyin

128 ic reticulum (ER) and the channels mediating capacitative Ca2+ influx through the plasma membrane.

129 n addition, the 2dGlc-mediated inhibition of capacitative Ca2+ influx was reversed by staurosporine,

130 d by depletion of intracellular Ca2+ stores (capacitative Ca2+ influx) was enhanced 3 h after injury.

131 lgernyl-L-cysteine blocked the activation of capacitative Ca2+ influx, whereas N-benzoyl-S-farnesyl-S

132 Capacitative Ca2+ influx, which occurs in response to mo

133 elease of Ca2+ from intracellular stores and capacitative Ca2+ influx.

134 id induced [Ca2+]i elevation consistent with capacitative Ca2+ influx.

135 rm expression (ET-1, ET-2, and ET-3) through capacitative Ca2+ influx.

136 the actions of farnesyl-cysteine analogs on capacitative Ca2+ influx.

137 The amplitudes of the capacitative Ca2+ signals decreased at lower extracellul

138 se of intracellular Ca2+ stores followed by "capacitative" Ca2+ entry due to emptying of these stores

139 mitochondria to modulate store-operated or "capacitative" Ca2+ entry in Jurkat leukemic T cells and

140 Capacitative calcium entry (CCE) describes CA2+ influx i

141 We examined capacitative calcium entry (CCE) in Jurkat and in L6 ske

142 on the elucidation of the molecular basis of capacitative calcium entry (CCE) into cells.

143 In animal cells, capacitative calcium entry (CCE) mechanisms become activ

144 standing extensive efforts, the mechanism of capacitative calcium entry (CCE) remains unclear.

145 f the presenilins (PS1 and PS2) in governing capacitative calcium entry (CCE), a refilling mechanism

146 l cells stimulates proliferation by inducing capacitative calcium entry (CCE).

147 global block in T cell receptor-independent capacitative calcium entry (CCE).

148 or by intracellular calcium store depletion [capacitative calcium entry (CCE)].

149 cells also showed significant impairments in capacitative calcium entry (CCE, also known as store-ope

150 dy, we have examined the interaction between capacitative calcium entry and arachidonic acid-activate

151 and inositol 1,4,5-trisphosphate (IP(3)) in capacitative calcium entry and calcium release-activated

152 , 2-aminoethoxydiphenyl borane, blocked both capacitative calcium entry and I(crac).

153 study, we examined the influence of 2-APB on capacitative calcium entry and intracellular Ca2+ concen

154 nduced calcium transients via enhancement of capacitative calcium entry and is associated with a spat

155 ol 12-myristate 13-acetate and inhibitors of capacitative calcium entry and most likely reflects the

156 esicular trafficking could lead to decreased capacitative calcium entry and subsequent apoptosis of c

157 ears to be due, at least in part, to reduced capacitative calcium entry at the plasma membrane.

158 annel openings are completely blocked by the capacitative calcium entry blocker, 2-aminoethoxydipheny

159 al of extracellular calcium or inhibition of capacitative calcium entry by 2-APB prevented ciglitazon

160 racellular calcium stores to plasma membrane capacitative calcium entry channels.

161 of Ca(2+) stores, or entry of Ca(2+) through capacitative calcium entry channels.

162 The potentiation of capacitative calcium entry in astrocytes or muscle cells

163 in immature B cells and they exhibit greater capacitative calcium entry in response to Ag.

164 Trpm5 may be responsible for capacitative calcium entry in taste receptor cells that

165 n, the S170F and DeltaE9 cells showed larger capacitative calcium entry indicating a direct effect on

166 hat a discrete step in the pathway signaling capacitative calcium entry interacts with and inhibits t

167 That is, capacitative calcium entry is potently inhibited by arac

168 ver, influx of extracellular calcium through capacitative calcium entry may be an unrecognized compon

169 originally thought, and may involve neither capacitative calcium entry nor a role for PLA2 and arach

170 Capacitative calcium entry or store-operated calcium ent

171 lations occurs through the store-operated or capacitative calcium entry pathway.

172 Thus we investigated whether inhibition of capacitative calcium entry per se could reduce endoplasm

173 When capacitative calcium entry was blocked with Gd3+, 2-APB

174 Capacitative calcium entry was not altered under these c

175 In addition, capacitative calcium entry was potentiated severalfold b

176 -dependent or UTP dose-dependent increase in capacitative calcium entry when calcium was added to the

177 on of vesicular transport results in reduced capacitative calcium entry which in turn results in apop

178 entry is inhibited by the pre-activation of capacitative calcium entry with thapsigargin.

179 re-operated Ca(2+) influx (SOCI; also called capacitative calcium entry) in glomerular mesangial cell

180 romoter in a Jurkat T-cell line defective in capacitative calcium entry, a signaling mechanism involv

181 2-APB was found to inhibit capacitative calcium entry, but at concentrations greate

182 fect of two well characterized inhibitors of capacitative calcium entry, Gd3+ and 2-aminoethoxydiphen

183 affect agonist-induced calcium transients or capacitative calcium entry, indicating that 4-AP effects

184 and further understand the role of hTRPC3 in capacitative calcium entry, we examined the effect of tw

185 lar trafficking as a mechanism of regulating capacitative calcium entry, we investigated whether disr

186 t mechanism for regulated entry of Ca(2+) is capacitative calcium entry, whereby depletion of intrace

187 itivity to these inhibitors is indicative of capacitative calcium entry.

188 ms of intracellular calcium oscillations and capacitative calcium entry.

189 n calcium feedback regulation of I(crac) and capacitative calcium entry.

190 acellular calcium stores, a process known as capacitative calcium entry.

191 calcium stores with regard to the control of capacitative calcium entry.

192 pancreatic acinar cells, a process known as capacitative calcium entry.

193 e plasma membrane calcium influx channels or capacitative calcium entry.

194 TRPC) are involved in agonist-stimulated and capacitative calcium entry.

195 antly greater permeability to Ba2+ than does capacitative calcium entry.

196 imulation with neurotransmitters, and during capacitative calcium entry.

197 for polyphosphoinositides for activation of capacitative calcium entry.

198 increasing basal [Ca(2+)](i) to potentiating capacitative calcium entry.

199 store loading and abrogated the desensitized capacitative calcium influx associated with bortezomib t

200 In BCEC, capacitative calcium influx is involved in mediating a p

201 ibiting phosphoinositide 3-kinase, impairing capacitative calcium influx, and inhibiting cyclooxygena

202 tive adenylyl cyclases detect and respond to capacitative cation entry rather than global cytosolic c

203 icinity of these enzymes as a consequence of capacitative cation entry to partially regulate both of

204 application and completely disappeared when capacitative cation influx reached its maximum.

205 influx of Ca(2+) through the plasma membrane capacitative channels.

206 eripheral plasma membrane such that a single capacitative component can account for the biophysical p

207 Thus, the capacitative current in cultured skeletal muscle cells w

208 The development of the skeletal muscle capacitative current was inhibited by genistein, a tyros

209 ak channel and for a channel that mediates a capacitative current.

210 These results indicate that the non-capacitative divalent cation entry pathway is regulated

211 sustained elevation of cytosolic Ca2+ due to capacitative entry is not required for induction of apop

212 an that of sup- II cells, demonstrating that capacitative entry is reduced in sup+ I cells.

213 gesting that cytosolic Ca2+ elevation due to capacitative entry may be required for optimal ER pool f

214 ionophore ionomycin, we found evidence for a capacitative entry mechanism in mouse oocytes.

215 essential for stimulation of activity by the capacitative entry of Ca(2+) in the intact cell.

216 ut was specifically dependent on the induced capacitative entry of Ca(2+).

217 bitor thapsigargin (TG) but does not prevent capacitative entry of extracellular calcium.

218 more effectively attenuated by inhibitors of capacitative entry than of L-type channels.

219 duced an accumulation of vesicles, decreased capacitative entry, and induced apoptosis.

220 e [Ca2+]i originated from internal stores or capacitative entry.

221 factor MEK1 was unaffected by inhibitors of capacitative entry.

222 ntly reduces cytosolic Ca(2+) levels under a capacitative influx model and ER re-uptake of calcium, i

223 tion of Ca2+ from internal stores triggers a capacitative influx of extracellular Ca2+ across the pla

224 Capacitative influx of extracellular Ca2+ was inhibited

225 e to all stimuli examined is controlled by a capacitative mechanism and sets the frequency of spiking

226 n-excitable cells is generally ascribed to a capacitative mechanism in which the activation of the en

227 a2+ entry in nonexcitable cells focus on the capacitative mechanism where entry is activated as a dow

228 f activating Ca(2+) entry via the so-called "capacitative" mechanism, recent evidence suggests that C

229 re inconsistent with current versions of the capacitative model.

230 2+) does not conform to the widely accepted "capacitative" model and, instead, reflects the activity

231 Ca(2+) entry is usually thought to occur via capacitative or store-operated Ca(2+) channels.

232 The process of capacitative or store-operated Ca(2+) entry has been ext

233 +) influx activated by store depletion (i.e. capacitative or store-operated Ca(2+) influx).

234 ar Ca2+ into the cytoplasm, a process termed capacitative or store-operated Ca2+ entry.

235 ross the plasma membrane, a process known as capacitative or store-operated Ca2+ entry.

236 We have recently questioned whether the capacitative or store-operated model for receptor-activa

237 reciprocal regulation of noncapacitative and capacitative (or store-operated) Ca2+ entry in nonexcita

238 suppress NFAT signaling by interfering with "capacitative" or "store-operated" calcium mobilization,

239 The cells therefore express a capacitative pathway activated by empty stores and a non

240 an increase in [Ca2+]i rapidly inhibits the capacitative pathway and more slowly activates mechanism

241 ient to maximally activate Ca2+ entry by the capacitative pathway and that products of phosphatidylin

242 in cytosolic [Ca2+], confirming that the non-capacitative pathway can evoke a significant increase in

243 trations of AVP is mediated largely by a non-capacitative pathway directly regulated by arachidonic a

244 s that distinguish it from the corresponding capacitative pathway in the same cells and therefore is

245 e Ca2+ entry with Gd3+ revealed that the non-capacitative pathway is the major route for the Ca2+ ent

246 pathway activated by empty stores and a non-capacitative pathway stimulated by receptors; only the f

247 l cyclase for Ca(2+) entry occurring via the capacitative pathway to attempt to discriminate between

248 After inhibition of the capacitative pathway with Gd3+, AVP evoked a substantial

249 ptors are required for activation of the non-capacitative pathway, because microinjection of cells wi

250 id not mediate the effects of AVP on the non-capacitative pathway.

251 tore refilling nor of desensitization of the capacitative pathway.

252 strating a rapid partial inactivation of the capacitative pathway.

253 art, on formulating a suitable model for the capacitative response of the channel and double layer at