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1 usions that are formed by loops of the major capsid protein.
2 ns, structure, and interactions of the viral capsid protein.
3 d region in the protruding (P) domain of the capsid protein.
4 RNA and so controls expression of the HPV L1 capsid protein.
5 er, Th17-polarized cells produced more viral capsid protein.
6 ed within the highly diverse P domain of the capsid protein.
7 ein bound at only one conformer of the major capsid protein.
8 mited by functional constraints on the viral capsid protein.
9 ly or prevent association with the VP2 minor capsid protein.
10 e of the infectious particle-associated ORF2 capsid protein.
11 interacts with the cytoskeleton via its p24 capsid protein.
12 thin the carboxyterminal domain (CTD) of the capsid protein.
13 rom the protruding (P) domain of the NoV VP1 capsid protein.
14 severity, is a soluble variant of the viral capsid protein.
15 enome encodes 3 proteins, including the ORF2 capsid protein.
16 dissociated pb10 to the 120 hexamers of the capsid protein.
17 ntre of the 120 hexamers formed by the major capsid protein.
18 Vs from a KSHV mutant defective in the small capsid protein.
19 his case, it is the chlorovirus PBCV-1 major capsid protein.
20 nner shell is different from all other known capsid proteins.
21 rotein NP1 is required for the expression of capsid proteins.
22 S1 to -4) are not required for expression of capsid proteins.
23 lomavirus contains major (L1) and minor (L2) capsid proteins.
24 han those that took the entire exposed viral capsid proteins.
25 g structure function relationships for viral capsid proteins.
26 licivirus mRNAs, enabling synthesis of minor capsid proteins.
27 ete against non-cognate RNAs for assembly by capsid proteins.
28 lution structures of the two main astrovirus capsid proteins.
29 activity of Hsp90 for the stability of their capsid proteins.
30 embly through specific interactions with the capsid proteins.
31 onment and its in vivo interactions with the capsid proteins.
32 exact orientation and interactions with the capsid proteins.
33 the flexible C-terminal domain (CTD) of the capsid proteins.
34 than the value of approximately 3 found for capsid proteins.
35 in regulating lytic replication, but lacked capsid proteins.
36 ct, and no degradation was observed on VLPs' capsid proteins.
38 For purity analysis, only 25 ng of total AAV capsid proteins (4.3 femtomole virus particles) were loa
39 Multiple peptides were identified from HAV capsid proteins (53.7% coverage), but none from nonstruc
40 d the interaction of the E2 protein with the capsid protein, a critical step in virus budding, and wa
41 rkable global conformational polymorphism of capsid proteins, a network formed by extended N arms, mo
44 te and efficient and results in both soluble capsid protein and conical or tubular capsid assemblies,
45 ction of IFN-lambda was governed by the MNoV capsid protein and correlated with diminished enteric pe
47 ed a plausible model for compound binding to capsid protein and inhibition by a distinct resistance m
48 rus (KSHV) mutant that is defective in small capsid protein and is unable to produce mature virions.
49 We determined the C terminus of the mature capsid protein and reproducibly detected low levels of t
50 e discovered a novel interaction between HCV capsid protein and the nucleoporin Nup98 at cytosolic li
53 human adenovirus (HAdV) in vitro by binding capsid proteins and blocking endosomal escape of virus.
54 es specific human adenoviruses by binding to capsid proteins and blocking endosomal escape of virus.
55 ainst autophagic destruction by sequestering capsid proteins and coordinating particle assembly and s
56 ted to model the cooperative effects between capsid proteins and genomic RNA that would occur in a pa
57 eroviruses depends on an interaction between capsid proteins and nonstructural protein 2C(ATPase) In
58 ained particle-based computational model for capsid proteins and RNA that represents protein-RNA inte
59 RNA viruses can involve interactions between capsid proteins and secondary structures in the viral ge
60 tide sequences at the interfaces between the capsid proteins and the genomic RNA of bacteriophage MS2
62 ell epitope, derived from feline calicivirus capsid protein, and a well characterized B-cell epitope
63 fibrillarin, whereas BaMV movement proteins, capsid protein, and BaMV RNA are recruited with HV coinf
64 inds to the HIV-1 core, which is composed of capsid protein, and this interaction leads to inhibition
65 igner" AAV, AAV2/Anc80L65, in which the main capsid proteins approximate the ancestral sequence state
67 fluorescent tags fused to the VP26 and pUL25 capsid proteins are available, neither of these componen
68 ramatic transformation demonstrates that the capsid proteins are capable of undergoing substantial qu
69 neutralising antibodies to L2, the minor HPV capsid protein, are also being developed both as simple
71 stone Lake ecosystem using a conserved major capsid protein as a phylogenetic anchor for assembly of
73 apsid protein-expressing gene that expresses capsid proteins as efficiently as pHBoV1NSCap does, and
74 oplasm as mRNAs encoding the Gag and Gag-Pol capsid proteins as well as genomic RNAs (gRNAs) packaged
76 This is often achieved through the viral capsid protein associating with or integrating into intr
77 igh rates of amino acid substitutions in the capsid proteins at exposed sites not previously identifi
79 ing possible when repulsive forces among the capsid proteins become large enough, which is known to b
80 anscription, extending the activities of the capsid protein beyond its presumed role as an inert comp
81 studies have revealed that herpesvirus small capsid proteins bind to capsids via their amino terminus
82 A typically encodes only the major and minor capsid proteins, but in murine norovirus (MNV), the subg
83 ase to cleave the P1 polyprotein into mature capsid proteins, but the FMDV 3C protease is toxic to ho
84 e, studies of the processing of WNV and DENV capsid proteins by the WNV protease identified an unexpe
85 ng inhibitors that block recognition of VEEV capsid protein (C) by the host importin (IMP) alpha/beta
86 final cleavage step at the site between the capsid protein (CA) and spacer peptide 1 (SP1), apparent
88 iven maturation process, the orthoretroviral capsid protein (CA) assembles to form the convex shell t
89 agnetic resonance (NMR) experiments on HIV-1 capsid protein (CA) assemblies with three different morp
92 plex with the N-terminal domain of the HIV-1 capsid protein (CA) has been known for nearly two decade
93 molecular interactions between native HIV-1 capsid protein (CA) hexamers that shield the viral genom
94 s study, the hexagonal lattice formed by the capsid protein (CA) of human immunodeficiency virus (HIV
95 ess, which is essential for infectivity, the capsid protein (CA) reassembles into a conical core.
97 HIV-1, shares its binding site in the viral capsid protein (CA) with the host factors CPSF6 and NUP1
101 ic promoter at levels similar to that of the capsid protein-coding mRNA and is essential for replicat
102 and 20,014 protein-protein interfaces in non-capsid protein complexes from the Protein Data Bank foun
104 ged reconstructions and the roles of the RNA-capsid protein contacts, to analyse cryo-electron tomogr
105 t abundant PCs in the metaproteome represent capsid proteins containing the HK97-like protein fold pr
108 ive proteolytic processing of the astrovirus capsid protein (CP) both inside and outside the host cel
114 lding protein (SP) for a binding site on the capsid protein (CP), and works by altering the angle bet
115 ahedral symmetry formed by 180 copies of the capsid protein (CP), which undergoes proteolytic maturat
118 and overgrown, containing more than the 120 capsid protein dimers needed to form a perfect T = 4 ico
119 candidate based on recombinant dengue virus capsid proteins, efficiently produced in Escherichia col
120 However, the structure of the viral major capsid protein, elucidated at near-atomic resolution usi
124 pective residues 98, 145, and 164 in the VP1 capsid protein, exhibited neutralization reduction again
125 pressing mRNA, we constructed a simple HBoV1 capsid protein-expressing gene that expresses capsid pro
126 n as internal polyadenylation signals in the capsid protein-expressing mRNA, we constructed a simple
133 d a 55-kDa protein consistent with the viral capsid protein from 1 to 72 h and increasing de novo syn
135 virus-like particles (VLPs) of the L1 major capsid protein from HPV-2, -4, or -9, including the AS04
136 ntified this PC as a previously unidentified capsid protein from multiple uncultivated tailed virus f
137 virus-like particles (VLPs) of the L1 major capsid protein from two, four, or nine different HPVs.
138 eraction between sorting nexin 17 and the L2 capsid proteins from a variety of papillomavirus types.
140 ificially tethering viral mRNAs encoding Gag capsid proteins (gag-pol mRNAs) to distinct non-PM subce
141 hain reaction amplification of the EhV major capsid protein gene and immunoreactivity to flotillin an
142 s on the noncoding control region, the major capsid protein gene VP1, and the large T antigen gene.
143 way that parvoviruses govern access to their capsid protein genes, namely, at the RNA level, by regul
144 decameric portal assembly interacts with the capsid protein gp23 at the special pentameric vertex.
146 These results demonstrate that the pUL25 capsid protein has a critical role in releasing viral DN
147 echanism that generates these VLVs lacking a capsid protein has remained a mystery for over 20 years.
151 n Nup214 is a binding site for the major AdV capsid protein, hexon, and that this interaction is requ
152 e most abundant adenovirus serotype 5 (AdV5) capsid protein, hexon, directly recruits the motor prote
154 ids on the surface of the Rous sarcoma virus capsid protein in the assembly of appropriately formed i
155 d reduced in their ability to expose a minor capsid protein in the host cell endoplasmic reticulum.
157 nts, suggest asymmetric packing of the major capsid protein in the virion, which supports previous ep
158 ss of the higher-order organization of viral capsid proteins in the virosphere, we explored the quest
160 m patients, HEV produced 3 forms of the ORF2 capsid protein: infectious/intracellular ORF2 (ORF2i), g
162 e breakages among neighboring capsomers, RNA-capsid protein interaction prevents the release of capsi
163 of the HIV-1 life cycle.IMPORTANCE The HIV-1 capsid protein is an attractive but unexploited target f
164 human immunodeficiency virus type 1 (HIV-1) capsid protein is an attractive therapeutic target, owin
165 ain (CTD) of hepatitis B virus (HBV) core or capsid protein is highly dynamic and plays multiple role
166 fe cycle but that the stability of the viral capsid protein is integrally linked to Hsp90 activity.
172 t in a dissociation of a subset of the major capsid protein L1 from the minor capsid protein L2, whic
174 pillomavirus (HPV) vaccines consist of major capsid protein (L1) virus-like particles (VLP) and are h
175 facilitate the release of most of the major capsid protein, L1, from the minor capsid protein L2 and
177 nrecognized interaction partner of the minor capsid protein L2 and was identified as a proviral host
178 We previously demonstrated that the minor capsid protein L2 assumes a transmembranous conformation
179 an important role for the cleavage of minor capsid protein L2 by cellular furin, direct cleavage of
181 Studies have suggested that the virus minor capsid protein L2 can interact with the endosomal recycl
184 ral protein in infectious entry is the minor capsid protein L2, which engages different components of
185 f the major capsid protein L1 from the minor capsid protein L2, which remains in complex with the vir
187 into the host cell by retention of the minor capsid protein, L2, and the viral genome instead of traf
188 bosome entry site structure, a truncated VP4 capsid protein lacking N-terminal myristoylation, a carb
189 state, and subsequent assembly of the mature capsid protein lattice, which encloses viral RNA in the
192 ture consisting of the herpesvirus-conserved capsid proteins MCP, Tri1, Tri2, and SCP and the HCMV-sp
193 With just one eighth the size of the major capsid protein (MCP), the smallest capsid protein (SCP)
196 e, we characterize the functional effects of capsid protein mutations that result in the loss of viru
197 me of electrolyte displaced by the volume of capsid protein, not the volume of the entire capsid.
198 ts suggest that the P17 protein is the minor capsid protein of Bam35 and P24 is the penton protein, w
202 high-resolution X-ray structure of the major capsid protein of JCPyV has been solved, the importance
204 riation within the major (L1) and minor (L2) capsid proteins of human papillomavirus genotype 45 (HPV
206 riation within the major (L1) and minor (L2) capsid proteins of oncogenic human papillomavirus (HPV)
207 r an inhibitor of the function of oligomeric capsid proteins of poliovirus, the expression of drug-su
208 ive antigenic sites on the VP1, VP2, and VP3 capsid proteins of SAT2/Zimbabwe (ZIM)/7/83 (topotype II
210 ot give useful cross-protection, despite the capsid proteins of the two viruses sharing about 80% seq
211 nd virus-like particle) of recombinant viral capsid proteins of two NoV strains, VA387 (GII.4) and VA
212 hedral asymmetric unit: a dimer of the major capsid protein, one turret protein, and one clamp protei
213 eficient in assembly, packaging of the minor capsid proteins, or binding to cells or in transport to
215 nt evidence that a truncated form of the Gag capsid protein (p22) or its processed form (p18) is nece
216 hibiting the final protease cleavage between capsid protein p24 and spacer protein-1, producing immat
218 this analysis to examine the effects of p24 capsid protein (p24(CA)) mutations and cellular environm
220 protein complex, along with its constitutive capsid protein, plays essential roles at virtually every
222 basis for developing strategies to regulate capsid protein production in the infected epithelium and
223 motifs in the parechovirus genome that bind capsid proteins, providing approximately 60 specific int
224 nts, we investigated the effect of the minor capsid proteins pUL17 and pUL25 on the structural stabil
225 o the capsid vertices and involves two minor capsid proteins, pUL17 and pUL25, and the large inner te
226 uclear pore complex (NPC) is mediated by the capsid protein pUL25 and the capsid-tethered tegument pr
227 tions, specifically, phosphorylation, on the capsid protein regulate the capsid-RNA interaction and t
228 e highly charged C-terminal domains (CTD) of capsid proteins regulate the nucleocapsid formation.
229 emonstrate that both the MNV-1 and the HuNoV capsid proteins require Hsp90 activity for their stabili
231 -1 isolates bearing defined mutations in the capsid protein revealed differences in their cytoplasmic
232 n of a single RNA packaging signal (PS) with capsid protein(s) (most +ssRNA viruses so far studied);
233 , either (a) by specific recognition between capsid protein(s) and replication proteins (poliovirus),
234 the major capsid protein (MCP), the smallest capsid protein (SCP) of human tumor herpesviruses--Kapos
235 main of Venezuelan equine encephalitis virus capsid protein, SD1, plays a critical role in the nucleo
237 r results demonstrate that ST-148 stabilizes capsid protein self-interaction, thereby likely perturbi
240 icle (24-mer of the protruding domain of the capsid protein), serves to demonstrate the reliability a
241 ine (G) difference at position 91 of the VP1 capsid protein shifts the profile of tumors induced by M
243 sid is stabilized by 660 copies of the outer capsid protein, Soc, which clamp adjacent gp23 hexamers.
244 We determined the crystal structure of the capsid protein spike domain from one of these HAstV stra
245 region of the genome that encodes the major capsid protein stretches over 17,000 bp and contains a l
246 ought to occur by the sequential addition of capsid protein subunits to a nucleus, with the final ste
247 The similar domain structures of alphavirus capsid proteins suggest that this new knowledge can be a
248 on by blocking positive-strand viral RNA and capsid protein synthesis but also protects against HAstV
250 acid substitutions in the domain of the VP1 capsid protein that binds the sialic acid moiety of glyc
251 identify and characterize a mutation in the capsid protein that confers resistance to the inhibitor.
252 igma1 are influenced by the nature of mu1, a capsid protein that does not physically interact with si
253 These constructs encode a noncytopathic VEEV capsid protein that is incapable of interfering with the
254 vage event found in approximately 10% of the capsid proteins that also was shown to alter capsid stab
257 ions have been assigned to each of the minor capsid proteins, the role of UL32 in encapsidation has r
258 gets nonassembled and virus particle-forming capsid proteins to mediate their autophagy-dependent deg
260 s) produced by recombinant expression of the capsid protein, using cryogenic electron microscopy.
263 of JCPyV is composed primarily of the major capsid protein virus protein 1 (VP1), and pentameric arr
264 ot efficient, because mutations in the major capsid protein VP1 caused reduced CD4(+) T-cell response
265 ed a panel of mutations arising in the viral capsid protein VP1 during persistent infection of mice.
268 tein VP4 and the N-terminal extension of the capsid protein VP1, both of which become inserted into t
269 he protruding domain of the murine norovirus capsid protein VP1, specifically residue 296 of VP1, reg
272 ur high-resolution X-ray structures of major capsid proteins VP1 from HPyV6 and from HPyV7 reveal cri
278 he BPV capsid assembled from its predominant capsid protein VP2, known to be involved in a myriad of
279 o acid substitutions at exposed sites in the capsid proteins VP2, VP3, and VP1 tend to be elevated in
280 otein fusions to the amino terminus of small capsid protein VP26 are the most widely used method to v
281 by fluorescent protein fusions to the small capsid protein VP26, which are incorporated into capsids
283 HHs bind to a site on the top surface of the capsid protein VP3, which is hidden in the native virus.
284 in the externalization of the myristoylated capsid protein VP4 and the N-terminal extension of the c
285 gD2) to stimulate humoral immunity and UL19 (capsid protein VP5) and UL47 (tegument protein VP13/14)
286 d whether adding the T cell immunogens UL19 (capsid protein VP5) and UL47 (tegument protein VP13/14)
289 A limit of detection of 0.2 ng/mL (3.3 pM) capsid proteins was achieved with convenient UV absorban
290 mens from both patients, and HPyV7 early and capsid proteins were abundantly expressed in affected ti
291 RV is largely unknown, T cell epitopes of RV capsid proteins were analyzed, and cognate T cells were
292 ugh B capsids containing wild-type levels of capsid proteins were synthesized, these procapsids were
293 strategy involved modifications of the viral capsid proteins where specific surface-exposed tyrosine
294 contacts mediated by N-terminal arms of VP2 capsid proteins, which result in the expansion of the ca
296 roviruses, is dependent on an interaction of capsid proteins with the multifunctional nonstructural p
297 lieve that a deeper understanding of how the capsid protein works during infection will create opport
300 he latter system, nucleolar presence of ZIKV capsid protein (ZIKV-C) was associated with ribosomal st
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