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1 reviously found that the 4-[4-(N-substituted carbamoyl)-1-piperazinyl]-6,7-dimethoxyquinazolines can
2 481,715 (quinoxaline-2-carboxylic acid [4(R)-carbamoyl-1(S)-(3-fluorobenzyl)-2(S),7-dihydroxy-7-methy
3 n produced the corresponding N-substituted C-carbamoyl-1,2,3-triazoles 7a-12a in good to excellent yi
7 tetramethyl-1-piperidynyloxyl (Tempol) and 3-carbamoyl-2,2,5,5-tetramethylpyrrolidine-1-oxyl (3CP), a
8 ified via LC-LTQ-Orbitrap MS and NMR as N-(4-carbamoyl-2-imino-5-oxoimidazolidin)formamido-N-methoxya
9 ine aminopeptidase type 2 inhibitor, [(1R)-1-carbamoyl-2-methyl-propyl]-carbamic acid-(3R,4S,5S,6R)-5
10 iota, and its synthetic derivative, the N-(1-carbamoyl-2-phenyl-ethyl) butyramide, FBA, have been dem
11 /- 0.03 nM) > 4-{3-[6-amino-9-(5-cyclopropyl-carbamoyl-3,4-dihydroxytetrahydrofuran-2-yl )-9H-purin-2
14 ibitors, URB597 (cyclohexyl carbamic acid 3'-carbamoyl-3-yl ester) and URB694 (6-hydroxy-[1,1'-biphen
15 The beta1-adrenoceptor antagonist 1-[2-((3-Carbamoyl-4-hydroxy)phenoxy)ethylamino]-3-[4-(1-methyl-4
16 oprolol, bisoprolol, and CGP-20712 [1-[2-((3-carbamoyl-4-hydroxy)phenoxy)ethylamino]-3-[4-(1-methyl-4
18 nel of beta1-AR antagonists, including [2-(3-carbamoyl-4-hydroxyphenoxy)-ethylamino]-3-[4-(1-methyl-4
21 ntigen (PSMA), N-[N-[(S)-1,3-dicarboxypropyl]carbamoyl]-4-(18)F-fluorobenzyl-l-cysteine ((18)F-DCFBC)
22 e cancer using N-[N-[(S)-1,3-dicarboxypropyl]carbamoyl]-4-(18)F-fluorobenzyl-L-cysteine ((18)F-DCFBC)
23 onstrated that N-[N-[(S)-1,3-dicarboxypropyl]carbamoyl]-4-(18)F-fluorobenzyl-L-cysteine ((18)F-DCFBC)
24 = 3 nM); its prodrug amino-acetic acid 4-[2-carbamoyl-5-(6,6-dimethyl-4-oxo-3-trifluoromethyl-4,5,6,
25 fied compound 35 (cyclohexylcarbamic acid 3'-carbamoyl-5-hydroxybiphenyl-3-yl ester) as the most pote
28 -aminophenyl)-1, 2-dihydro-1-methyl-2-propyl-carbamoyl-6,7-methylenedioxyphthalazine++ +, suppressed
29 ibitor URB937 (3, cyclohexylcarbamic acid 3'-carbamoyl-6-hydroxybiphenyl-3-yl ester) is extruded from
30 unds of most interest were found to have a 5-carbamoyl-8-fluoro-3-amino-3,4-dihydro-2 H-1-benzopyran
32 ietane-2-ylidene)-2-[N-(4-methylthiazol-2-yl)carbamoyl]acet ate (YH439)]-treated and suspension cells
33 for a universal tRNA modification, threonyl carbamoyl adenosine (t6A), found in all tRNAs that pair
34 , vinyl, cyano, aryl and N-heteroaryl, acyl, carbamoyl, alkoxycarbonyl, imidoyl, boryl, silyl, phosph
35 tions from N-Boc pyrrolidine via an alpha-(N-carbamoyl)alkylcuprate vinylation reaction followed by N
36 yields obtained in the reactions of alpha-(N-carbamoyl)alkylcuprates [i.e., N-Boc-protected alpha-ami
38 es or perfluorobenzoates react with alpha-(N-carbamoyl)alkylcuprates to afford scalemic alpha-(N-carb
39 y treatment with CuCN.2LiCl affords alpha-(N-carbamoyl)alkylcuprates which react with propargyl halid
40 te adducts obtained via coupling of alpha-(N-carbamoyl)alkylcuprates with alpha,beta-ynoates, alpha-a
41 lfonates, and phosphates give good yields of carbamoyl allenes, while the acetates afford low yields.
43 tes, acetates, and epoxides to give alpha-(N-carbamoyl) allenes via an anti-S(N)2' substitution proce
44 yl)alkylcuprates to afford scalemic alpha-(N-carbamoyl) allenes which undergo N-Boc deprotection and
46 gue 16-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)hexadecanoic acid (13b) decreased prolif
47 phenyl region of compound 3, focusing on the carbamoyl and hydroxyl groups in the distal and proximal
55 the pH-rate profiles for the condensation of carbamoyl aspartate to dihydroorotate showed that a sing
57 .2.3) catalyze the reversible cyclization of carbamoyl aspartate to form dihydroorotate in de novo py
58 se) catalyzes the reversible condensation of carbamoyl aspartate to form dihydroorotate in de novo py
61 re has citrate, a near isosteric analogue of carbamoyl aspartate, bound to the active sites of both e
63 f an electron-withdrawing group (i.e., acyl, carbamoyl) at this position increased the stability of t
65 (7-diethylaminocoumarin-3-carboxamido)propyl]carbamoyl}ATP), which was hydrolyzed to the diphosphate.
66 phenylethyl)amino)-1-oxo-3-phenylpropan-2-yl)carbamoyl) benzoic acid (11) was the most effective whil
67 nd 2-((9,10-dioxo-9,10-dihydroanthracen-2-yl)carbamoyl) benzoic acid (H2L5828102), novel nonlipid and
68 143), 4,5-dichloro-2-((9-oxo-9H-fluoren-2-yl)carbamoyl)benzoic acid (H2L5547924), and 2-((9,10-dioxo-
69 yielded compounds 2-((9-oxo-9H-fluoren-2-yl)carbamoyl)benzoic acid (NSC12404), 2-((3-(1,3-dioxo-1H-b
72 the FAAH inhibitor cyclohexylcarbamic acid 3-carbamoyl biphenyl-3-yl ester (URB597) on mechanically e
73 ndamide (AEA) and cyclohexylcarbamic acid 3'-carbamoyl-biphenyl-3-yl ester (URB597), an inhibitor of
75 hanism involving oxidative addition into the carbamoyl chloride bond to generate a high valent Pd(IV)
76 rivative, but rather gives (N-ethoxycarbonyl)carbamoyl chloride upon thermolysis, or (N-ethoxycarbony
78 gen chloride being formed as coproducts, and carbamoyl chlorides or isocyanates generated as yield-di
79 loromethylene)oxindoles from alkyne-tethered carbamoyl chlorides using PdCl2(PhCN)2 as the catalyst.
80 ic lipid 3beta-[N-(N',N'-dimethylaminoethane)carbamoyl]cholesterol (DC-Chol), two potent adjuvants, d
84 ingle-crystal X-ray analysis or studies with carbamoyl derivatives of amines of known configuration.
87 are reported for the title (chlorocarbonyl)(carbamoyl)disulfane; for (methoxycarbonyl)(N-ethoxycarbo
89 chloro-2-methox y-acridin-9-ylamino)-propyl]-carbamoyl]-ethyl)-carbamic acid tert-butyl ester, showed
90 iogenesis inhibitors, such as O-(chloracetyl-carbamoyl) fumagillol (TNP-470), are thus emerging as a
91 the angiogenesis inhibitor O-(N-chloroacetyl-carbamoyl)-fumagillol (TNP-470) and the alkylating agent
92 iogenesis inhibitor, AGM-1470,O-chloroacetyl-carbamoyl-fumagillol (TNP-470), after two-thirds hepatec
94 des, ether glucuronides, N-glucuronides, and carbamoyl glucuronides, have been shown to be substrates
95 s 14 and 24 commenced with removal of the 10-carbamoyl group from MC, followed by reductive conversio
96 es indicate that FeIIiso-PEPLM, in which the carbamoyl group is shifted on the mannose sugar, forms t
97 cluded hydroxylation, ring cleavage, loss of carbamoyl group, and decarboxylation, as well as O-methy
98 roxylation, ring contraction, or loss of the carbamoyl group, followed by conjugation to glucose or c
99 nosubstituted in the 3-position by alkyl and carbamoyl groups undergo nucleophilic ring opening by ar
103 to cover enantioselective methods based on N-carbamoyl imines, focusing on synthetically useful proto
104 ch previously have not been reported using N-carbamoyl-imines with simple ketone enolates, became our
106 yl-1-[[2-[(2-methyl-3-pyridyl)oxy]-5-pyridyl]carbamoyl]-in doline), or vehicle were microinjected bil
110 that conversion of l-aspartate (l-Asp) to N-carbamoyl-l-aspartate by PyrB may reduce the amount of l
111 5-Difluoro-4-[bis(2-chloroethyl)amino]phenyl]carbamoyl-l-glutamic acid gave a differential of >227 in
113 al-D4Cpa-D3Pal-Ser-4Aph(L-hydroorotyl)-D4Aph(carbamoyl)-Leu-ILys-Pro -DAla-NH2 (acetate salt is FE200
115 -hydroxyllup-20(29)-en-28-oyl]-7-aminoheptyl]carbamoyl]methane (A43D, 4) was a potent HIV-1 entry inh
116 accumulation of the unwanted intermediate D-carbamoyl-methionine was reduced fourfold compared to ce
117 Here, we report a class of propynoic acid carbamoyl methyl amides (PACMAs) that are active against
118 in, we discovered a series of propynoic acid carbamoyl methyl-amides (PACMAs) with potent cytotoxicit
119 (R5 = Me, Ph, CH2Ph), and different acyl and carbamoyl moieties (R7) were appended on the 7-amino gro
120 receptor (Y1R) antagonist BIBP3226, bearing carbamoyl moieties at the guanidine group, revealed subn
122 Sn ligands, 9-N-(4H-thieno[3,2-c]chromene-2-carbamoyl)-Neu5Acalpha2-3Galbeta1-4GlcNAc ((TCC)Neu5Ac),
124 y-3-oxopropyl)-4-(((4-methoxyphenyl)(methyl) carbamoyl)oxy)indolin-1-ium hydrochloride) with IC50s of
125 gen mustard analog of [4-[[N-(3-chlorophenyl)carbamoyl]oxy]-2-butynyl]trimethylammonium chloride (McN
126 transfers (ATP), acyl transfers (acetyl-CoA, carbamoyl-P), methyl transfers (SAM), prenyl transfers (
128 o-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylmethyl)carbamoyl]p yrazolo[1,5-a]pyrimidine-7-carbonyl}amino)in
130 or the human epidermal cell line A-431 with carbamoyl-PAF or ultraviolet B radiation resulted in int
131 he metabolically stable PAF receptor agonist carbamoyl-PAF resulted in increased interleukin-8 mRNA a
132 with PAF receptor antagonists inhibited both carbamoyl-PAF-induced and ultraviolet-B-induced interleu
133 An additional two series of (-)- and (+)-O-carbamoyl phenols of pyrroloindole and furoindole were o
134 M for BChE), with the exception of the (+)-O-carbamoyl phenols of pyrroloindole, which lacked activit
135 inhibitors of cholinesterase: (-)- and (+)-O-carbamoyl phenols of tetrahydrofurobenzofuran and methan
136 ic acid-Schiff staining, urea production via carbamoyl phosphatase synthetase I staining, and cell vi
137 ucleotide biosynthesis, the reaction between carbamoyl phosphate (CP) and l-aspartate to form N-carba
138 responds to the position of the phosphate of carbamoyl phosphate (CP) and the position of the phospho
141 vity and decreased substrate affinity toward carbamoyl phosphate and aspartate compared to the corres
142 ropic cooperativity, and the binding of both carbamoyl phosphate and aspartate were extremely comprom
144 ing established that the natural substrates, carbamoyl phosphate and L-aspartate, do not induce in th
145 identify the enzymatic synthesis of N-amino carbamoyl phosphate and N-hydroxy carbamoyl phosphate fr
147 of the mutants were unable to synthesize any carbamoyl phosphate and the rest were severely crippled.
149 lex with citric acid bound in the postulated carbamoyl phosphate binding site, was determined in two
150 l change that interferes with the binding of carbamoyl phosphate but has little effect once carbamoyl
151 The carboxy phosphate (residues 1-400) and carbamoyl phosphate domains (residues 553-933) also cont
152 e the absolute requirement of the binding of carbamoyl phosphate for the creation of the high-affinit
153 oyl-phosphate synthetase 1 activity produces carbamoyl phosphate for urea synthesis, and deficiency r
155 of the partial reactions, the diminution of carbamoyl phosphate formation, and the percentage of the
156 Escherichia coli catalyzes the formation of carbamoyl phosphate from 2 mol of ATP, bicarbonate, and
157 of CPS.A and CPS.B proteins that synthesized carbamoyl phosphate from ATP, bicarbonate, and ammonia.
158 Escherichia coli catalyzes the formation of carbamoyl phosphate from bicarbonate, glutamine, and two
159 Escherichia coli catalyzes the formation of carbamoyl phosphate from bicarbonate, glutamine, and two
160 of N-amino carbamoyl phosphate and N-hydroxy carbamoyl phosphate from hydroxylamine and hydrazine.
161 y 118 kDa) and catalyzes the biosynthesis of carbamoyl phosphate from MgATP, bicarbonate, and glutami
162 channeling ensures the efficient transfer of carbamoyl phosphate from the active site of CPSase to th
163 gh rapidly degraded at high temperature, the carbamoyl phosphate generated in situ by A. aeolicus car
164 hosphate synthetase-1 (CPS1), which produces carbamoyl phosphate in the mitochondria from ammonia and
165 d-type enzyme is required for the binding of carbamoyl phosphate in the proper orientation so as to i
166 must perform during the overall synthesis of carbamoyl phosphate in the wild type enzyme and the spec
167 ontrast to the wild-type enzyme, addition of carbamoyl phosphate induced a significant alteration in
168 nally, the data indicate that the binding of carbamoyl phosphate induces conformational changes that
170 miting step for the steady-state assembly of carbamoyl phosphate is either the formation, migration,
172 the catalytic cysteine residue, can generate carbamoyl phosphate only in the presence of free ammonia
173 ng the altered CAD with the ATCase substrate carbamoyl phosphate or the bisubstrate analogue N-phosph
174 the catalytic activity for the synthesis of carbamoyl phosphate relative to the wild type CPS, respe
176 ioxin resulted in concomitant recruitment of carbamoyl phosphate synthase 1 (CPS1) to the NC-XRE.
177 ed to increase the level of succinylation on carbamoyl phosphate synthase 1, which is a known target
178 erence-mediated knockdown of a mitochondrial carbamoyl phosphate synthase impairs the response of nit
184 alues of K(m) for glutamine, but the overall carbamoyl phosphate synthesis reaction is unperturbed.
185 5L exhibited a substantially reduced rate of carbamoyl phosphate synthesis, but the rate of ATP turno
187 imiting step in this pathway is catalysed by carbamoyl phosphate synthetase (CPS II), part of the mul
194 rt of carbamate through the large subunit of carbamoyl phosphate synthetase (CPS) from Escherichia co
197 st three enzymes in pyrimidine biosynthesis, carbamoyl phosphate synthetase (CPS), aspartate transcar
198 individual mutant lines deficient in either carbamoyl phosphate synthetase (CPS), the first enzyme i
199 l phosphate generated in situ by A. aeolicus carbamoyl phosphate synthetase (CPSase) was channeled to
200 a large multifunctional protein that carries carbamoyl phosphate synthetase (CPSase), aspartate trans
203 the mitochondrial matrix and interacts with carbamoyl phosphate synthetase 1 (CPS1), an enzyme, cata
205 ylates and activates a mitochondrial enzyme, carbamoyl phosphate synthetase 1, which mediates the fir
206 proteins 70 and 90 (HSP-70; HSP-90), and the carbamoyl phosphate synthetase 2/aspartate transcarbamyl
207 he inhibitor UTP and the activator PRPP, the carbamoyl phosphate synthetase activity is controlled by
212 x-ray crystal structure of the heterodimeric carbamoyl phosphate synthetase from Escherichia coli has
213 arginine serum levels on chromosome 2 at the carbamoyl phosphate synthetase I locus, on chromosome 5
214 ine nucleotide synthesis is catalyzed by the carbamoyl phosphate synthetase II (CPSase) domain of CAD
216 the virulence of T. gondii mutants that lack carbamoyl phosphate synthetase II (uracil auxotrophs) to
217 mately 25 A in length, whereas the tunnel in carbamoyl phosphate synthetase is nearly 100 A long.
218 mensional structures of tryptophan synthase, carbamoyl phosphate synthetase, glutamine phosphoribosyl
219 n some cases, such as biotin carboxylase and carbamoyl phosphate synthetase, the B-domains move signi
224 ned a 240 kDa protein that was identified as carbamoyl phosphate synthetase/aspartate transcarbamoyla
225 l phosphate synthetase II (CPSII) is part of carbamoyl phosphate synthetase/aspartate transcarbamoyla
229 phate synthetase catalyzes the production of carbamoyl phosphate through a reaction mechanism requiri
230 tase from E. coli catalyzes the synthesis of carbamoyl phosphate through a series of four reactions o
234 l-molecule phosphodonors acetyl phosphate or carbamoyl phosphate under conditions in which a control
237 teady-state time course for the formation of carbamoyl phosphate was linear with an overall rate cons
240 bsaturating amounts of PALA or succinate and carbamoyl phosphate) caused a hyperbolic increase and de
241 of ligands, in the presence of the substrate carbamoyl phosphate, and in the presence of the bisubstr
242 xaloacetate, the phosphorylation of MgADP by carbamoyl phosphate, and the bicarbonate-dependent ATPas
243 less negatively charged than its precursors, carbamoyl phosphate, aspartate, or carbamoyl aspartate.
244 topped-flow experiments, using aspartate and carbamoyl phosphate, confirm that the change in excimer
245 gue succinate, in the presence of saturating carbamoyl phosphate, to the pyrenelabeled enzyme caused
246 our other metabolites, S-adenosylmethionine, carbamoyl phosphate, UDP-glucose, and Delta(2)-isopenten
247 y two long interdomain helices: the putative carbamoyl phosphate-binding domain and a binding domain
255 he lead variant on 2q24 (rs715) localizes to carbamoyl-phosphate synthase 1 (CPS1), which encodes a m
256 y facilitating pyrimidine synthesis via CAD (carbamoyl-phosphate synthase 2, aspartate transcarbamyla
257 xpression profile of the c-Myc target genes, carbamoyl-phosphate synthase-aspartate carbamoyltransfer
258 bited complex I of the respiratory chain and carbamoyl-phosphate synthase-I (CPS-I), with an EC(50) a
260 hyperthermophile, has neither a full-length carbamoyl-phosphate synthetase (CPSase) resembling the e
263 which directly phosphorylates S1859 on CAD (carbamoyl-phosphate synthetase 2, aspartate transcarbamo
264 hatidylinositol 4-kinases (PI4KA and PI4KB), carbamoyl-phosphate synthetase 2, aspartate transcarbamy
267 uted to altered allosteric regulation of the carbamoyl-phosphate synthetase activity of CAD (carbamoy
270 ferential plasma proteins detected by iTRAQ, carbamoyl-phosphate synthetase I (CPSI, related to urea
272 skewed distribution of the genotypes for the carbamoyl-phosphate synthetase variants at position 1405
273 trations of amino acids and genotypes of the carbamoyl-phosphate synthetase variants were determined
274 e thioester intermediate of Escherichia coli carbamoyl-phosphate synthetase, indicates that the subst
275 for threonine at position 1405 [T1405N]) in carbamoyl-phosphate synthetase, which controls the rate-
276 urea cycle--in particular, the efficiency of carbamoyl-phosphate synthetase--may contribute to the av
277 bamoyl-phosphate synthetase activity of CAD (carbamoyl-phosphate synthetase-aspartate carbamoyltransf
278 ession of mature hepatocytic markers such as carbamoyl-phosphate synthetase1 and several cytochrome P
279 oning was used to identify a mutation in the carbamoyl-phosphate synthetase2-aspartate transcarbamyla
281 with antagonist ethyl 6-(4-((benzylsulfonyl)carbamoyl)piperidin-1-yl)-5-cyano-2-methylnicotinate (AZ
282 ne-porphyrin bears an S-acetyl or S-(N-ethyl)carbamoyl-protected thiol moiety, thereby avoiding handl
283 inoalanine is an FeII ligand and the mannose carbamoyl provides either a ligand to the FeII or signif
286 tivity studies evolved a tricyclic series of carbamoyl pyridines that demonstrated properties indicat
288 ing fusion stereocenter within the tricyclic carbamoyl pyridone scaffold led to a critical substrate
290 ough group-transfer cyclization reactions of carbamoyl radicals, undergo a Chugaev-like thermal elimi
291 modified by a 43-Da substituent (possibly a carbamoyl substituent) suggests that the lysines in this
292 ethyl 2-(N-((4-iodo-6-methoxypyrimidin-2-yl)carbamoyl)sulfamoyl)benzoate (10c), which has a K(i) val
294 Alkoxycarbonyl-, (alkylthio)carbonyl- and carbamoyl thiocyanates are isolable and have higher calc
295 amino acid residues, including an uncommon 3-carbamoyl threonine, and a phosphoserine residue in cele
297 a combined metalation-addition of a carbonyl-carbamoyl transfer to reveal in situ stereodefined alpha
299 From this enhanced set, we identified the carbamoyl triazole TCMDC-134379 (1), a known serine prot
300 we demonstrate that modification of the C13-carbamoyl unit can be accommodated in the binding site o
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