ライフサイエンスコーパス: carbamyl

1 t protein kinase, (8R,9S, 11S)-(-)-9-methoxy-carbamyl-8-methyl-2,3,9,10-tetrahydro-8, 11-epoxy-1H,8H,

2 sed PKG inhibitors (8R,9S,11S)-(-)-9-methoxy-carbamyl-8-methyl-2,3,9,10-tetrahydro-8,11-epoxy -1H,8H,

3 t the ureido moiety of the DHOase substrate, carbamyl-aspartate (Ca-asp).

4 dimetal TnDhp in complexes with hydantoin, N-carbamyl-beta-alanine, and N-carbamyl-beta-amino isobuty

5 th hydantoin, N-carbamyl-beta-alanine, and N-carbamyl-beta-amino isobutyrate as well as apo-TnDhp in

6 Both basal cytosolic [Ca2+]i and carbamyl choline-induced increases of [Ca2]i were unaffe

7 s(-)(1)), indicating hydrolysis of a common carbamyl-enzyme form.

8 of inhibitor cleavage to generate a covalent carbamyl-enzyme intermediate rather than a tetrahedral c

9 tion of a hydrazide-containing product and a carbamyl-enzyme intermediate that is sufficiently stable

10 activity is observed when the length of the carbamyl function is n = 6 and n = 7 for porcine and rat

11 termined from analysis of the N and C of the carbamyl group after hydrolysis.

12 loyl) GTP (mantGTP), 2'(3')-O-[(2-aminoethyl)carbamyl] GTP (edGTP), and adducts of fluorescein 5-isot

13 In the pyrimidine biosynthetic pathway, N-carbamyl-L-aspartate (CA-asp) is converted to L-dihydroo

14 ia coli ligated to products (phosphate and N-carbamyl-l-aspartate) has been determined at 2.37 A reso

15 plexed with products, phosphate (P(i)) and N-carbamyl-L-aspartate.

16 We show here that the rate of CAD (carbamyl-P synthetase/aspartate transcarbamylase/dihydro

17 as, and the tissue was incubated with 125 nM carbamyl PAF (cPAF), an analogue of PAF.

18 e incubated in organ culture with or without carbamyl PAF (cPAF, 100 nM).

19 nonhydrolyzable PAF receptor agonist methyl carbamyl PAF (mc-PAF) on the unidirectional in vitro mig

20 Pellets containing carbamyl-PAF (cPAF) were implanted in corneas of wild-ty

21 pecific (A23187) and specific (endothelin-1, carbamyl-PAF) stimulation, suggesting a role for this in

22 and the nonhydrolyzable PAF receptor agonist carbamyl-PAF.

23 Levels of carbamyl-palmitoyl transferase 1a and ATP synthase subun

24 distance is 45.2 A) when ATCase is bound to carbamyl phosphate (CP) and to L-alanosine (an analogue

25 at 5-N of glutamine is directly channeled to carbamyl phosphate (CP) synthesis.

26 roduction of L-citrulline and phosphate from carbamyl phosphate and L-ornithine in L-arginine biosynt

27 f this novel transcarbamylase complexed with carbamyl phosphate and N-succinyl-L-norvaline, as well a

28 e of Escherichia coli ATCase maintained with carbamyl phosphate and succinate, phosphonoacetamide and

29 ytic subunit (c3) and holoenzyme (c6r6) with carbamyl phosphate are different.

30 to the synthetase domain (CPS domain), where carbamyl phosphate formation is catalyzed in three conse

31 enzyme, was 2 mol of ATP utilized per mol of carbamyl phosphate formed.

32 sfers ammonia to the synthetase domain where carbamyl phosphate is formed in a three-step reaction se

33 other ligands (N-phosphonacetyl-L-aspartate, carbamyl phosphate plus malonate, phosphonoacetamide plu

34 nthesis reaction of biotin carboxylase where carbamyl phosphate reacted with ADP by holoBCCP87 was 5-

35 minimal medium and can suppress mutations in carbamyl phosphate synthase-aspartate carbamyl transfera

36 omains of CAD stimulates glutamine-dependent carbamyl phosphate synthesis and abolishes the ammonia-d

37 e enzyme can also catalyze ammonia-dependent carbamyl phosphate synthesis if provided with exogenous

38 utant not only catalyzed glutamine-dependent carbamyl phosphate synthesis, but was activated 10-fold

39 of reactions involved in glutamine-dependent carbamyl phosphate synthesis.

40 he E. coli enzyme was also found to catalyze carbamyl phosphate synthesis.

41 e 150-kDa band revealed sequence identity to carbamyl phosphate synthetase I (CPS I) and a high degre

42 rotein induced the activity of mouse hepatic carbamyl phosphate synthetase I (CpsI) 5-fold.

43 alogue of molecular changes in patients with carbamyl phosphate synthetase I (CPSI) deficiency to dev

44 Human carbamyl phosphate synthetase I (CPSI) is an essential h

45 In animals, UTP feedback inhibition of carbamyl phosphate synthetase II (CPSase) controls pyrim

46 on the hydrolysis of glutamine catalyzed by carbamyl phosphate synthetase of Escherichia coli.

47 lated trifunctional enzyme known as CAD (for carbamyl phosphate synthetase, aspartate transcarbamylas

48 d-Ala d-Ala ligase, glutathione synthetase, carbamyl phosphate synthetase, N(5)-carboxyaminoimidazol

49 However, ammonia-dependent synthesis of carbamyl phosphate was abolished, indicating that ammoni

50 The K(m) values for N-acetylornithine and carbamyl phosphate were 1.05 mM and 0.01 mM, respectivel

51 lyzes the conversion of metabolic ammonia to carbamyl phosphate, the rate-limiting step in urea biosy

52 In UV difference and 31P-NMR spectra, carbamyl phosphate-induced effects associated with wild-

53 o subunits that act in concert to synthesize carbamyl phosphate.

54 ate, whereas CPS.B uses a second ATP to form carbamyl phosphate.

55 l-L-citrulline from N-acetyl-L-ornithine and carbamyl phosphate.

56 nzymes, ornithine transcarbamylase (OTC) and carbamyl-phosphate synthase (CPS), as well as dibasic am

57 Escherichia coli carbamyl-phosphate synthetase consists of two subunits t

58 glutaminase domain (GLN domain) of mammalian carbamyl-phosphate synthetase II (CPSase II) catalyzes g

59 midotransferase domain (GLNase) of mammalian carbamyl-phosphate synthetase II hydrolyzes glutamine an

60 s was deleted and the sequences encoding the carbamyl-phosphate synthetase subunits were fused in fra

61 ammonia that arises by the action of PDG to carbamyl-phosphate synthetase.

62 ons in carbamyl phosphate synthase-aspartate carbamyl transferase within the pyrimidine pathway; the

63 ns catalytic specificity for hydrolysis of N-carbamyl versus the peptide bond in exopeptidases.