ライフサイエンスコーパス: carbapenemase

1 , 90 (47.9%; 95% CI, 40.6%-55.1%) produced a carbapenemase.

2 nsistent feature of strains producing OXA-48 carbapenemase.

3 uctures of carbapenem complexes of a class A carbapenemase.

4 bapenem hydrolysis, performed with a class A carbapenemase.

5 , particularly variants of the K. pneumoniae carbapenemase.

6 Only BD Phoenix CPO Detect classified carbapenemases.

7 teriaceae that produce Klebsiella pneumoniae carbapenemases.

8 isolate collection (n = 48), with a range of carbapenemases.

9 bapenemase tests, and classification of most carbapenemases.

10 carbapenemases were misclassified as class A carbapenemases.

11 XA-23-like, -24-like, -51-like, and -58-like carbapenemases.

12 cted isolates with KPC and most with metallo-carbapenemases.

13 ctive site alterations that are unique among carbapenemases.

14 ducing bacteria in light of the emergence of carbapenemases.

15 tes submitted isolates that produced class A carbapenemases.

16 sults across multiple sites for detection of carbapenemases.

17 umannii isolates producing acquired OXA-type carbapenemases.

18 cing P. aeruginosa isolates produced class B carbapenemases.

19 amily Enterobacteriaceae that do not produce carbapenemases.

20 id, accurate detection and classification of carbapenemases.

21 ss A, 72.4% of class B, and 88.6% of class D carbapenemases.

22 solates were included, of which 29% produced carbapenemases.

23 most frequent carbapenemase was K pneumoniae carbapenemase (329 [75%]; 253 [74%] vs 76 [81%]).

24 lla pneumoniae and 74 harbored K. pneumoniae carbapenemase (56.1%), 54 metallo-beta-lactamase (40.9%)

25 Is the emergence of carbapenemase a problem waiting to happen?

26 has also been shown that enzymes with feeble carbapenemase activity (e.g. AmpC types and some SHV enz

27 d specificity of meropenem and ertapenem for carbapenemase activity among non-Enterobacteriaceae were

28 Unfortunately, class D beta-lactamases with carbapenemase activity are resistant to beta-lactamase i

29 Current methods to detect carbapenemase activity are suboptimal, requiring prolong

30 g and selected reaction monitoring to detect carbapenemase activity from pathogenic microorganisms in

31 zone diameter of </= 23 mm as a predictor of carbapenemase activity had a sensitivity of 99% and a sp

32 accurate, objective phenotypic detection of carbapenemase activity in Enterobacteriaceae In this iss

33 ity test using faropenem (10 mug) to predict carbapenemase activity in Enterobacteriaceae.

34 ture of KPC-2 provides key insights into the carbapenemase activity of emerging class A beta-lactamas

35 ility but does not play a direct role in the carbapenemase activity of the GES family of beta-lactama

36 he emergence of class D beta-lactamases with carbapenemase activity presents an enormous challenge to

37 tive and specific assay for the detection of carbapenemase activity using ertapenem and liquid chroma

38 ed disulfide bridge is responsible for their carbapenemase activity, but this has not yet been valida

39 ance of these bacteria on the basis of their carbapenemase activity, suggesting the great potential o

40 To investigate the molecular basis of this carbapenemase activity, we have determined the structure

41 d cephalosporinase activity, as well as weak carbapenemase activity.

42 ion by KPC-2 and its unique cephalosporinase/carbapenemase activity.

43 ead of extended-spectrum beta-lactamases and carbapenemases among common bacterial pathogens are thre

44 ass D carbapenemases were the most prevalent carbapenemases among the carbapenemase-producing A. baum

45 d 2 A. baumannii isolates) producing non-MBL carbapenemases, AmpC beta-lactamases, and extended-spect

46 ative pathogens that produce a transmissible carbapenemase and are typically resistant to most (somet

47 ity against Gram-negative bacteria including carbapenemase and carbacephalosporinase producing strain

48 OXA-48 is a highly prevalent carbapenemase and has been isolated worldwide.

49 KPC beta-lactamases are serine carbapenemases and are a subclass of class A beta-lactam

50 ly described limitations with blaOXA-48-like carbapenemases and blaOXA carbapenemases associated with

51 ended-Spectrum BLs (ESBL), KPC- and OXA-type carbapenemases and metallo-beta-lactamases (MBL).

52 f carbapenem resistant Klebsiella pneumoniae carbapenemases and monitored by end point detection of f

53 Comparison of the KPC-2 structure with non-carbapenemases and previously determined NMC-A and SME-1

54 ICT) for the detection of OXA-48/OXA-48-like carbapenemases and the development of an algorithm for r

55 t geographical regions now report KPC serine carbapenemases and the metallo-beta-lactamases VIM, IMP,

56 "low-level" production of the K. pneumoniae carbapenemase, and rep-PCR indicated that all bla(KPC-3)

57 -M family of ESBLs, the KPC family of serine carbapenemases, and the VIM, IMP, and NDM-1 metallo-beta

58 BLs), transferable AmpC beta-lactamases, and carbapenemases are associated with laboratory testing pr

59 n-bonding networks in NMCA, SFC-1, and SME-1 carbapenemases are less intensive, and as a consequence,

60 Enterobacteriaceae, while OXA- and metallo- carbapenemases are of growing importance in Acinetobacte

61 t prevalent beta-lactamases, and chromosomal carbapenemases are restricted to Stenotrophomonas maltop

62 OXA-48 has emerged as a major carbapenemase associated with the Enterobacteriaceae in

63 ith blaOXA-48-like carbapenemases and blaOXA carbapenemases associated with Acinetobacter baumannii w

64 A few acquired carbapenemases belonging to molecular class A also have

65 Weak carbapenemases belonging to molecular class D are emergi

66 esistance mechanisms were KPC (K. pneumoniae carbapenemases) beta-lactamases encoded by blaKPC2, blaK

67 CPOs carrying the Klebsiella pneumoniae carbapenemase (bla KPC ) gene have caused outbreaks glob

68 tamase (bla(ESBL)) and Klebsiella pneumoniae carbapenemase (bla(KPC)) genes.

69 assay for detection of Klebsiella pneumoniae carbapenemase (blaKPC) and New Delhi metallo-beta-lactam

70 reads characterized as beta-lactamases, the carbapenemase blaOXA was dominant in most of the effluen

71 ruption of the disulfide bridge in the GES-5 carbapenemase by the C69G substitution results in only m

72 Analysis of carbapenemases by PCR revealed that imipenem resistance

73 ae expressing IMP, VIM, KPC, NDM, and/or OXA carbapenemases, by using imipenem, meropenem, and ertape

74 aries significantly when compared to the non-carbapenemase class D member OXA-1/doripenem complex.

75 Culture of a PCR-confirmed, carbapenemase-containing organism, or history of coloniz

76 Both tests exhibited high sensitivity of carbapenemase detection (>97%).

77 We compared carbapenemase detection among 271 Gram-negative bacilli

78 d a method comparison study of 11 phenotypic carbapenemase detection assays to evaluate their accurac

79 clinical performance of Check-Direct CPE for carbapenemase detection directly from 301 perirectal swa

80 ce areas or in outbreak settings where rapid carbapenemase detection is critical for infection contro

81 provides novel advantages such as automated carbapenemase detection, inclusion in susceptibility pan

82 atory in parallel with molecular methods for carbapenemase detection.

83 blaKPC and blaNDM, two of the most important carbapenemases, directly from culture in less than 90 mi

84 A carbapenemase-encoding gene was found in 81.7% (94/115)

85 Carbapenemase-encoding genes bla(OXA-23) and/or ISAba1-b

86 of a molecular epidemiological survey of 15 carbapenemase-encoding genes from a recent collection of

87 We describe the phenotype, clonality, and carbapenemase-encoding genes present in CRE isolated fro

88 GNB) from positive blood cultures and all 14 carbapenemase enzymes tested.

89 goal of finding a potent inhibitor of serine carbapenemase enzymes that are currently compromising th

90 This carbapenemase exhibits k(cat)/K(m) of 3 x 10(5) m(-1)s(-

91 racteristics of chromID CARBA and HardyCHROM Carbapenemase for the detection of carbapenemase-produci

92 lo-beta-lactamase (VIM) were the most common carbapenemases found.

93 ng identified 1,493 isolates that harbored a carbapenemase gene (1,485 ertapenem-nonsusceptible isola

94 umoniae isolates harboring the K. pneumoniae carbapenemase gene (bla(KPC)) are creating a significant

95 Detection of a carbapenemase gene at a C(T) cutoff value of </=35 was c

96 bla NDM-1 was the only carbapenemase gene detected.

97 olate with primers specific for the bla(KPC) carbapenemase gene produced an amplicon of the expected

98 ase, we retrospectively tracked the bla(KPC) carbapenemase gene-bearing pKpQIL plasmid responsible fo

99 ith the presence of bla(KPC), a transferable carbapenemase gene.

100 R (qPCR) assay that detects five families of carbapenemase genes (blaIMP, blaKPC, blaNDM, blaOXA-48,

101 -lactamase (bla) NDM, VIM, IMP, KPC, and OXA carbapenemase genes (e.g., blaOXA-23, blaOXA-24/40, and

102 -lactamase (bla) NDM, VIM, IMP, KPC, and OXA carbapenemase genes (e.g., blaOXA-23, blaOXA-24/40, and

103 Thus, the acquisition of carbapenemase genes by these organisms increases the ris

104 Rapid methods for tracking plasmids carrying carbapenemase genes could greatly benefit infection cont

105 ocols might not correctly reflect the HGT of carbapenemase genes in vivo.

106 to carbapenems in vitro for the presence of carbapenemase genes remains controversial and requires f

107 ype were assessed for the presence of common carbapenemase genes using a Check-MDR CT101 microarray (

108 Carbapenemase genes were detected by polymerase chain re

109 Carbapenemase genes were embedded in isoforms of Tn4401

110 Carbapenemase genes were most frequently identified in K

111 argeted PCR as to the presence or absence of carbapenemase genes were tested for carbapenemase produc

112 obacteriaceae The most frequently identified carbapenemase genes were the KPC (n = 794), OXA-48-like

113 with polymerase chain reaction analysis for carbapenemase genes, and isolates with the blaOXA-232 ge

114 ged to sequence type (ST) 88 and carried two carbapenemase genes, bla(KPC-18) and bla(VIM-1).

115 at (i) 60% of the isolates harbored multiple carbapenemase genes; (ii) the blaDIM-1 gene, which has p

116 This would likely apply to all other class A carbapenemases given the high degree of their structural

117 tion of metallo-beta-lactamase with KPC-type carbapenemase has implications for the use of next-gener

118 Enterobacteriaceae (CRE) producing acquired carbapenemases have created a global public health crisi

119 nem-hydrolyzing beta-lactamases (also called carbapenemases), however, can confer bacterial resistanc

120 henotypic methods exist for the detection of carbapenemases; however, clinical laboratories have stru

121 from carbapenem-nonsusceptible isolates for carbapenemase identification.

122 This is the first such structure of a carbapenemase in complex with a clinically important bet

123 OXA-48 is the most prevalent carbapenemase in Enterobacteriaceae in Europe and the Mi

124 lasmid-mediated AmpC beta-lactamases and KPC carbapenemases in Enterobacteriaceae, while OXA- and met

125 eta-lactamases in Klebsiella pneumoniae, and carbapenemases in Enterobacteriaceae.

126 The increasing dissemination of carbapenemases in Gram-negative bacteria has threatened

127 n included 87 isolates that produced class A carbapenemases (including KPC-2, -3, -4, -5, -6, and -8,

128 tential for use in the specific detection of carbapenemases, including metallo-beta-lactamases in act

129 enzymes, collectively referred to as class A carbapenemases, is a disulfide bridge between invariant

130 detection of Enterobacteriaceae carrying the carbapenemase KPC has been problematic.

131 tes, CRE producing the Klebsiella pneumoniae carbapenemase (KPC) are increasingly common and are ende

132 ae strains tested positive for K. pneumoniae carbapenemase (KPC) genes by real-time PCR and had eleva

133 neumoniae strains that produce K. pneumoniae carbapenemase (KPC) have spread globally in the last dec

134 m (ETP) resistance and Klebsiella pneumoniae carbapenemase (KPC) in 47 Klebsiella pneumoniae isolates

135 the production of the Klebsiella pneumoniae carbapenemase (KPC) is an important mechanism of carbape

136 Klebsiella pneumoniae carbapenemase (KPC) production in Gram-negative bacilli

137 nfirmatory testing for Klebsiella pneumoniae carbapenemase (KPC) production or other beta-lactamases

138 The Klebsiella pneumoniae carbapenemase (KPC) was detected in carbapenem-resistant

139 Imipenemase (IMP), Klebsiella pneumoniae carbapenemase (KPC), and Verona integron-encoded metallo

140 bla KPC, encoding a transmissible carbapenemase (KPC), has historically largely been assoc

141 ases, particularly the Klebsiella pneumoniae carbapenemase (KPC), with no inhibition of mammalian ser

142 a(KPC) responsible for Klebsiella pneumoniae carbapenemase (KPC)-mediated carbapenem resistance and w

143 ed infection caused by Klebsiella pneumoniae carbapenemase (KPC)-producing Enterobacter gergoviae.

144 In the United States, Klebsiella pneumoniae carbapenemase (KPC)-producing Enterobacteriaceae are inc

145 Klebsiella pneumoniae carbapenemase (KPC)-producing K. pneumoniae has become e

146 wo clinical strains of Klebsiella pneumoniae carbapenemase (KPC)-producing K. pneumoniae were studied

147 in a collection of 14 Klebsiella pneumoniae carbapenemase (KPC)-producing non-Klebsiella pneumoniae

148 d for the detection of Klebsiella pneumoniae carbapenemase (KPC)-type beta-lactamases.

149 bacteriaceae producing Klebsiella pneumoniae carbapenemase (KPC)-type carbapenemases, using 806 stool

150 pread dissemination of Klebsiella pneumoniae carbapenemase (KPC).

151 ples and 77 (19%) of 402 E coli samples were carbapenemase (KPC, NDM, OXA-48-like, or VIM) producers.

152 the production of the Klebsiella pneumoniae carbapenemase (KPC-2) class A beta-lactamase.

153 The K. pneumoniae carbapenemases (KPC) (ESBL-type enzymes that confer resi

154 s to identify specific Klebsiella pneumoniae carbapenemases (KPC) and additional beta-lactamases.

155 iated by plasmid-borne Klebsiella pneumoniae carbapenemases (KPC) is an emerging problem of significa

156 llo-beta-lactamases or Klebsiella pneumoniae carbapenemases (KPC), no specific inhibitor is available

157 Production of a serine carbapenemase, KPC, is increasing alarmingly in the Unit

158 me PCR assay to detect Klebsiella pneumoniae carbapenemases (KPCs) and used this assay to screen clin

159 Klebsiella pneumoniae carbapenemases (KPCs) are considered a serious threat to

160 Detection of Klebsiella pneumoniae carbapenemases (KPCs) can be nonspecific, especially whe

161 niae (Kp) strains that produce K. pneumoniae carbapenemases (KPCs) has become a significant problem,

162 Klebsiella pneumoniae carbapenemases (KPCs) have recently been described in Ch

163 Klebsiella pneumoniae carbapenemases (KPCs) were first identified in 1996 in t

164 Klebsiella pneumoniae carbapenemases (KPCs) were originally identified in the

165 resistance, especially due to K. pneumoniae carbapenemases (KPCs).

166 S70 residue renders the active sites of the carbapenemases more shallow, likely allowing easier acce

167 e reveal that PenA is an inhibitor-resistant carbapenemase, most similar to KPC-2 (the most clinicall

168 bapenemases (n = 84) or Ambler class A and B carbapenemases (n = 41) and carbapenemase-negative isola

169 luding isolates producing OXA-48/OXA-48-like carbapenemases (n = 84) or Ambler class A and B carbapen

170 er class A and B carbapenemases (n = 41) and carbapenemase-negative isolates (n = 41).

171 and 232 were produced by 243 isolates and 51 carbapenemase-negative isolates included porin mutants a

172 Due to the highly challenging carbapenemase-negative isolates, specificities were lowe

173 mCIM; isolates with Ambler class A, B, and D carbapenemases, non-CP-CRE isolates, and carbapenem-susc

174 ed that these isolates produce IMP-4, an MBL carbapenemase not previously published as present among

175 stigated the impact of ancillary testing for carbapenemase of isolates that met the CDC CPE surveilla

176 Outer membrane proteins OmpA and YiaD, and carbapenemase Oxa-23 are hubs of the identified interact

177 ent variants (K84D and V130D) of the class D carbapenemase OXA-24 with doripenem bound as a covalent

178 The probe binds the class D carbapenemase OXA-24/40 with close to the same affinity

179 on of the blaOXA48 gene, which codes for the carbapenemase OXA-48, in lysate samples from Klebsiella

180 is on the identification of beta-lactamases (carbapenemases OXA-48 and KPC in particular) in bacteria

181 hic lateral flow assay to detect OXA-48-like carbapenemases (OXA-48 K-SeT) in Enterobacteriaceae (n =

182 CRE are increasing in California, and carbapenemases, particularly KPC, are a common mechanism

183 identified with potent inhibition of serine carbapenemases, particularly the Klebsiella pneumoniae c

184 performance of this definition, compared to carbapenemase PCR, for a collection of 125 Enterobacteri

185 the presence of OXA-48 and KPC in all of the carbapenemase positive samples, independent of species a

186 ceptible to imipenem were not uncommon among carbapenemase-positive isolates (9.4%, 141/1,493) and mo

187 Among the carbapenemase-positive isolates, 66.7% (2/3), 37.0% (111

188 faropenem disc correctly identified 84 of 86 carbapenemase producers (98% sensitivity), with a specif

189 271 Gram-negative bacilli (of which 131 were carbapenemase producers) using a novel chromogenic rapid

190 m-negative bacillary isolates, including 134 carbapenemase producers.

191 alysed in 40 epidemiologically-related NDM-1 carbapenemase producing Klebsiella pneumoniae isolates i

192 Carbapenemase producing organisms (CPOs) represent an ur

193 aring 14-day mortality between patients with carbapenemase-producing (CP)-CRE compared with non-CP-CR

194 CP isolates (Ambler class A, B, and D), non-carbapenemase-producing (non-CP) carbapenem-resistant is

195 ducing A. baumannii strains, with 60% of the carbapenemase-producing A. baumannii isolates producing

196 the most prevalent carbapenemases among the carbapenemase-producing A. baumannii strains, with 60% o

197 ays achieved >90% specificity in identifying carbapenemase-producing A. baumannii, no assays achieved

198 assays may be necessary to accurately detect carbapenemase-producing A. baumannii.

199 producing Pseudomonas aeruginosa (CP-PA) and carbapenemase-producing Acinetobacter baumannii (CP-AB)

200 nce in the community and in hospitals, while carbapenemase-producing Acinetobacter spp., mostly from

201 infer carbapenem resistance mechanisms in 39 carbapenemase-producing and 16 other carbapenem-resistan

202 Detecting colonization of patients with carbapenemase-producing bacteria can be difficult.

203 The emergence and spread of carbapenemase-producing carbapenem-resistant Enterobacte

204 microbiology laboratories to reliably detect carbapenemase-producing carbapenem-resistant Enterobacte

205 streptomycin, was associated with an OXA-23 carbapenemase-producing clone, which has spread rapidly

206 95% CI: 1.10-7.41) were associated with non-carbapenemase-producing CRE (NCPE) (n = 88) compared wit

207 oice--are needed because of the emergence of carbapenemase-producing enterobacteria.

208 A collection of 166 isolates of carbapenemase-producing Enterobacteriaceae (CPE) and 82

209 Four chromogenic media for carbapenemase-producing Enterobacteriaceae (CPE) and two

210 formation that enhances our understanding of carbapenemase-producing Enterobacteriaceae (CPE) and whi

211 Carbapenemase-producing Enterobacteriaceae (CPE) are a s

212 Carbapenemase-producing Enterobacteriaceae (CPE) are eme

213 last 2 decades, but global dissemination of carbapenemase-producing Enterobacteriaceae (CPE) is a mo

214 Early identification of carbapenemase-producing Enterobacteriaceae (CPE) is esse

215 The best available treatment against carbapenemase-producing Enterobacteriaceae (CPE) is unkn

216 Rapid detection of carbapenemase-producing Enterobacteriaceae (CPE) represe

217 ardyCHROM Carbapenemase for the detection of carbapenemase-producing Enterobacteriaceae (CPE).

218 All specimens were analyzed for ESBL- and carbapenemase-producing Enterobacteriaceae (CPE).

219 , 108 (43%) were female, and 161 (64.7%) had carbapenemase-producing Enterobacteriaceae (CPE).

220 Klebsiella pneumoniae carbapenemase-producing Enterobacteriaceae (hereafter "K

221 Carbapenemase-producing Enterobacteriaceae are an emergi

222 Infections caused by carbapenemase-producing Enterobacteriaceae are increasin

223 Here, we quantified the effects of carbapenemase-producing Enterobacteriaceae carriage on p

224 Carbapenemase-producing Enterobacteriaceae colonization

225 tios and subdistribution hazard ratios, with carbapenemase-producing Enterobacteriaceae colonization

226 lonized at admission, and 96 (9.5%) acquired carbapenemase-producing Enterobacteriaceae colonization

227 Carbapenemase-producing Enterobacteriaceae colonization

228 ge on patient outcome in two Greek ICUs with carbapenemase-producing Enterobacteriaceae endemicity.

229 Patients colonized with carbapenemase-producing Enterobacteriaceae have on avera

230 the first two clinical cases of OXA-48-type carbapenemase-producing Enterobacteriaceae in the United

231 extended-spectrum-beta-lactamase (ESBL)- and carbapenemase-producing Enterobacteriaceae is a major co

232 and Prevention for detection and control of carbapenemase-producing Enterobacteriaceae is discussed,

233 Of 132 carbapenemase-producing Enterobacteriaceae isolates, 125

234 Three travelers (0.5%) acquired carbapenemase-producing Enterobacteriaceae.

235 nt, and highly predictive screening test for carbapenemase-producing Enterobacteriaceae.

236 dards in Europe make it difficult to contain carbapenemase-producing Enterobacteriaceae.

237 nent-wide enhanced sentinel surveillance for carbapenemase-producing Enterobacteriaeceae can be overc

238 nent-wide enhanced sentinel surveillance for carbapenemase-producing Enterobacteriaeceae can be overc

239 Accurate detection of carbapenemase-producing glucose-nonfermenting Gram-negat

240 Carbapenemase-producing K pneumoniae isolates showed hig

241 results and categorical interpretations for carbapenemase-producing K. pneumoniae differ by methodol

242 istant enterococci and Klebsiella pneumoniae carbapenemase-producing K. pneumoniae followed a similar

243 reating 24 of 26 (92%) Klebsiella pneumoniae carbapenemase-producing K. pneumoniae infectious episode

244 ent of infections caused by highly resistant carbapenemase-producing K. pneumoniae.

245 h polymyxin B against 12 clinical strains of carbapenemase-producing K. pneumoniae.

246 issible CPE worldwide, Klebsiella pneumoniae carbapenemase-producing K. pneumoniae; and present strat

247 cal interpretation of susceptibility against carbapenemase-producing Klebsiella pneumoniae (KPC).

248 first structured survey on the occurrence of carbapenemase-producing Klebsiella pneumoniae and Escher

249 Since carbapenemase-producing Klebsiella pneumoniae strains we

250 mmended phenotypic test for the detection of carbapenemase-producing members of the family Enterobact

251 Carbapenemase-producing organisms (CPO) have been identi

252 ification of patients who are colonized with carbapenemase-producing organisms (CPO) is included in m

253 were the most sensitive for the detection of carbapenemase-producing organisms (CPOs) (100%; all blaK

254 The accurate detection of carbapenemase-producing organisms is a major challenge f

255 id identification of patients colonized with carbapenemase-producing organisms using multiplex PCR ma

256 Carbapenemase-producing organisms, or CPOs, are Gram-neg

257 est, had specificities of >90% for detecting carbapenemase-producing P. aeruginosa Class D carbapenem

258 A total of 86% of the carbapenemase-producing P. aeruginosa isolates produced

259 nt sensitivity and specificity for detecting carbapenemase-producing P. aeruginosa isolates.

260 h a sensitivity of >90% for the detection of carbapenemase-producing P. aeruginosa, including all rap

261 e is threatened by the growing prevalence of carbapenemase-producing pathogens.

262 ctivation method (mCIM) for the detection of carbapenemase-producing Pseudomonas aeruginosa (CP-PA) a

263 oniae (hypermucoviscous K1, research K2, and carbapenemase-producing ST258) strains, the absence of C

264 0 mul was required for reliable detection of carbapenemase production among P. aeruginosa and A. baum

265 arba NP test to be accurate for detection of carbapenemase production among P. aeruginosa isolates an

266 Carbapenemase production could be confirmed with the mod

267 d Kirby Bauer disk diffusion tests to detect carbapenemase production in a collection of 14 Klebsiell

268 ays required an increased inoculum to detect carbapenemase production in isolates with blaNDM, blaIMP

269 sence of carbapenemase genes were tested for carbapenemase production using the mCIM; isolates with A

270 their performance of a test for detection of carbapenemase production, the Carba NP test.

271 cific phenotypic method for the detection of carbapenemase production, the carbapenem inactivation me

272 lineating procedures for identifying CRE and carbapenemase production.

273 we present crystal structures of the class A carbapenemase SFC-1 from Serratia fonticola and of compl

274 xtended-spectrum beta-lactamases (ESBLs) and carbapenemases, specifically the CTX-M family of ESBLs,

275 nes by these organisms increases the risk of carbapenemase spread in general.

276 es and previously determined NMC-A and SME-1 carbapenemase structures shows several active site alter

277 Carbapenemases such as KPC, NMC-A, IMI, SME, NDM, SPM, I

278 mpermeable strains; counterwise, even potent carbapenemases, such as IMP-1, may only give a small red

279 example is increasing multi-AR due to mobile carbapenemases, such as NDM-1 protein (coded by blaNDM-1

280 an alternative phenotypic test, the indirect carbapenemase test, for the detection of blaKPC-producin

281 minate delays and subjectivity in initiating carbapenemase tests, and classification of most carbapen

282 The GES-2 beta-lactamase is a class A carbapenemase, the emergence of which in clinically impo

283 Recently a second group of acquired metallo-carbapenemases, the VIM types, has been recorded from P.

284 earing in multiple combinations of ESBLs and carbapenemases, thereby conferring resistance to virtual

285 ance upon carbapenems, but the expression of carbapenemases threatens to limit the utility of these d

286 the epidemiology, clinical characteristics, carbapenemase types, risk factors, treatment, and outcom

287 ebsiella pneumoniae carbapenemase (KPC)-type carbapenemases, using 806 stool samples and rectal swabs

288 inappropriate therapy) and the most frequent carbapenemase was K pneumoniae carbapenemase (329 [75%];

289 Detection of carbapenemases was performed phenotypically, with confir

290 ere reviewed and molecular typing for common carbapenemases was performed.

291 y/specificity values for "flagging" a likely carbapenemase were 100%/0% (BD Phoenix), 82 to 85%/6 to

292 No class B or D carbapenemases were detected.

293 ns such as ceftazidime/avibactam, no class B carbapenemases were misclassified as class A carbapenema

294 arbapenemase-producing P. aeruginosa Class D carbapenemases were the most prevalent carbapenemases am

295 The most common carbapenemases were the OXA-23-type, found in 107 isolat

296 PC-2 (the most clinically significant serine carbapenemase), whereas PenI is an extended spectrum bet

297 r are the first structures of native class-A carbapenemases with a clinically used carbapenem antibio

298 Carbapenemases with either serine-based or zinc-facilita