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1 er in another step, likely hydrolysis of the carbinolamine.
2 arbinolamine nitrogen to give the protonated carbinolamine.
3 ble of existing in equilibrium with a cyclic carbinolamine.
4 -1, respectively, in dehydrating the neutral carbinolamine.
5 roups and give rise to 5- or 6-membered ring carbinolamines.
6 m constant K1 = 1.87 x 10(3) M(-1)) with the carbinolamine 2-chloro-1-(chloroamino)ethanol.
7  such that the oxygen atoms analogous to the carbinolamine and beta-hydroxyl oxygens are positioned n
8 ambiguously identify the postulated covalent carbinolamine and Schiff base intermediates in the aldol
9  species result in the formation of both the carbinolamine and the hydrazone derivatives.
10 ial formation of alpha-iminoglutarate, alpha-carbinolamine, and alpha-ketoglutarate-reduced coenzyme
11 ls of solvation that would otherwise inhibit carbinolamine, and thus imine, formation.
12 e derived aldehydes to form 5- or 6-membered carbinolamines are critical determinants of biologic pot
13                           We have identified carbinolamines as a new class of alternate substrate.
14 ve stability of the interconvertible N10-C11 carbinolamine, carbinolamine methyl ether, and imine for
15 ) and the ultrared as the enzyme-NADPH-alpha-carbinolamine complex (ERC).
16 -alpha-iminoglutarate and enzyme-NADPH-alpha-carbinolamine complexes at concentrations whose sum acco
17 ent forms of the known alpha-imino and alpha-carbinolamine complexes in which the active site cleft i
18  alpha-iminoglutarate and highly red-shifted carbinolamine complexes observed in both reactions, the
19              In contrast, dehydration of the carbinolamine cross-link to an imine (Schiff base) cross
20 amino group established unambiguously that a carbinolamine cross-link was not formed.
21                      These sequence-specific carbinolamine cross-links are anticipated to interfere w
22 otein with distant homology to pterin-4alpha-carbinolamine dehydratase (PCD) enzymes.
23                                    Pterin-4a-carbinolamine dehydratase (PCD) is a highly conserved en
24 s encoding phenylalanine hydroxylase (PhhA), carbinolamine dehydratase (PhhB), and aromatic aminotran
25 ion has been found, supporting the idea that carbinolamine dehydratase activity is not required for H
26 oH2 forms a tetramer, displays pterin-4alpha-carbinolamine dehydratase activity, and binds HNF1alpha
27                                    Pterin 4a-carbinolamine dehydratase is bifunctional in mammals.
28 osa PhhA plus the recycling enzyme pterin 4a-carbinolamine dehydratase, PhhB, rescues tyrosine auxotr
29 ting assays further indicated that pterin-4a-carbinolamine dehydratase, which regenerates the AAH cof
30 atalase, glutathione peroxidase, and 4 alpha-carbinolamine dehydratase.
31 tivity of the bifunctional protein pterin-4a-carbinolamine dehydratase/dimerization cofactor for hepa
32 ed a novel deletion in PCBD1 (pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepat
33 tocyte nuclear factor 1 (DCoH)/pterin-4alpha-carbinolamine dehydratases (PCD)-like protein is the cau
34                                    Pterin-4a-carbinolamine dehydratases (PCDs) recycle oxidized pteri
35                                          The carbinolamine dehydration step was found to be acid/base
36 amino group may also enhance the rate of the carbinolamine dehydration step.
37 ition reaction resulting in formation of the carbinolamine derivative.
38 um 40% of the DNA was cross-linked, with the carbinolamine form of the cross-link predominating.
39 ase, which allowed the rates of both initial carbinolamine formation (as part of the imination step)
40 ion by acting as a proton shuttle during the carbinolamine formation step, which enables diamines to
41                        MTOX oxidation of the carbinolamine formed with L-tryptophan and formaldehyde
42 ith N-methyl-L-tryptophan, sarcosine, or the carbinolamine formed with L-tryptophan and formaldehyde.
43 s tentatively assigned to protonation of the carbinolamine guanidinium system.
44 y the same group accepting a proton from the carbinolamine hydroxyl to generate alpha-Kg and lysine.
45  in protonation of the hydroxyl group of the carbinolamine in the dehydration step, catalyzing Schiff
46 evidence is presented for the formation of a carbinolamine interchain cross-link in 5'-CpG-3' sequenc
47 esidue or position in the protonation of the carbinolamine intermediate and dehydration of the Schiff
48  strongly for the N-dealkylation of 2a via a carbinolamine intermediate formed by a conventional C-hy
49 to facilitate formation and breakdown of the carbinolamine intermediate to give the Schiff base and t
50 -hexanoic acid, which seems to form a stable carbinolamine intermediate with Lys263.
51 catalyzed step, most likely protonation of a carbinolamine intermediate, is also significantly rate c
52 ction proceeds with C-N bond cleavage in the carbinolamine intermediate, shows excellent functional g
53 hiff base carbon of saccharopine to form the carbinolamine intermediate.
54 acilitate proton transfer from Lys-53 to the carbinolamine intermediate.
55 ) at C-H bonds in 1-4 leads to nonrearranged carbinolamine intermediates and thereby to "ordinary" N-
56  part, explain the thermal stability of this carbinolamine interstrand cross-link and the stereochemi
57 ally stable surrogates for the corresponding carbinolamine interstrand cross-links arising from the c
58                              Collapse of the carbinolamine is then facilitated by the same group acce
59        Molecular modeling suggested that the carbinolamine linkage should be capable of maintaining W
60  is the dG linked to the alpha-carbon of the carbinolamine linkage, and Y(19) is the dG linked to the
61  is the dG linked to the gamma-carbon of the carbinolamine linkage; the cross-link is in the 5'-CpG-3
62  the interconvertible N10-C11 carbinolamine, carbinolamine methyl ether, and imine forms of PBDs.
63 p is likely protonation/deprotonation of the carbinolamine nitrogen formed as an intermediate in imin
64 s a general acid and donates a proton to the carbinolamine nitrogen to give the protonated carbinolam
65  isotope effects reveal that collapse of the carbinolamine (or gem-diamine) to give the final product
66 ct of chain length, oxygen substitution, and carbinolamine ring size on analogue potency.
67 m (3aS)-N8-benzylnoresermethole (-)12 by the carbinolamine route.
68 hat the cross-link is a mixture of imine and carbinolamine structures.
69 hat it can act as a nucleophile in forming a carbinolamine upon attack of the carbonyl of AASA.
70 ve of 1b, which cannot give rise to a cyclic carbinolamine, was 2 orders of magnitude less potent tha
71 ues capable of forming 7-, 8-, or 9-membered carbinolamines were markedly less active.

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