ライフサイエンスコーパス: carbo

1 an apex predators (cormorants, Phalacrocorax carbo).

2 2beta-(R)-Carbo-1-fluoro-2-propoxy-3beta-(4-chlorophenyl) tro pane

3 nyl) tro pane ((R)-FIPCT, R-6) and 2beta-(S)-carbo-1-fluoro-2-propoxy-3beta-(4-chlorophenyl) tro pane

4 2Beta-carbo(2-fluoroethoxy)-3beta-(4'-((Z)-2-iodoethenyl)pheny

5 to chemotherapy; 18 (55%) of 33 responded to CARBO; 24 (80%) of 30 responded to CARBO and CARBO-VCR-5

6 Enantiopure carbo[6]helicenyl boronates were synthesized using a pho

7 (700 mg/m(2)), followed by three courses of CARBO (700 mg/m(2)), day 0; 5-FU (1,000 mg/m(2)/d), by c

8 were treated sequentially with one course of CARBO (700 mg/m(2)), followed by three courses of CARBO

9 ponded to CARBO; 24 (80%) of 30 responded to CARBO and CARBO-VCR-5-FU; and nine (75%) of 12 responded

10 /amino-3-arylisoxazoles, bearing unsaturated carbo and heterocyclic substituents at the position 4, g

11 catalytic cascade produces in one operation carbo- and heterobicyclic building blocks for the synthe

12 fide products is also demonstrated in simple carbo- and heterocycle-forming processes.

13 A variety of (arylmethyl)carbo- and heterocycles (N, O) can be synthesized with t

14 Carbo- and heterocycles of five- and six-membered rings

15 an atom-economical approach to five-membered carbo- and heterocycles that contain two new stereogenic

16 ion are shown and lead to highly substituted carbo- and heterocycles with excellent diastereocontrol.

17 uding arylation processes, formation of both carbo- and heterocycles, alpha- and beta-functionalizati

18 lation strategy for the synthesis of various carbo- and heterocycles, based on an intramolecular aryn

19 bene, chalcone, cinnamic acid, various fused carbo- and heterocycles, etc.

20 the synthesis of a wide number of different carbo- and heterocycles.

21 eta-amino ketones and highly enantioenriched carbo- and heterocyclic compounds.

22 ates of [1,5]-hydrogen shifts in a series of carbo- and heterocyclic dihydroaromatic compounds were e

23 ion delivers diverse trans-3,4-disubstituted carbo- and heterocyclic five-membered rings in high yiel

24 nization of a variety of enone acids, giving carbo- and heterocyclic products with high diastereo- an

25 cyclopropanes (ACPs) to afford five-membered carbo- and heterocyclic rings with concomitant intramole

26 ly highly diastereoselective installation of carbo- and heterocyclic substituents at position 1', ort

27 ls and furnishes a diverse and unique set of carbo- and heteropolycyclic ring systems in good yields

28 a general foundation for the definition of "carbo-aromaticity", the relevance of which is surveyed t

29 ional, aromatic, rigid, sigma,pi-macrocyclic carbo-benzene archetypes of various substitution pattern

30 Deleting a C4 edge of the rigid C18 carbo-benzene circuit results in a flexible 'carbo-butad

31 Furthermore, carbo-benzene junctions exhibit field-effect transistor

32 the first examples of direct pi-stacking of carbo-benzene rings, with inter-ring distances very clos

33 methods, molecular units of alpha-graphyne ('carbo-benzene' macrocycles) can be inserted between two

34 sport calculations are carried out on such a carbo-benzene, providing unprecedented single molecule c

35 nd characterization of p-dialkyl-tetraphenyl-carbo-benzenes (n = 2, 8, 14, 20) are thus presented and

36 several types of non-aromatic references of carbo-benzenes are then considered, i.e. freely rotating

37 splay classical UV-vis electronic spectra of carbo-benzenes in solution (lambdamax = 445.5 +/- 1 nm,

38 All alkyl-carbo-benzenes were also found to be highly crystalline.

39 Very preliminary experimental results on a carbo-benzenoid fragment are finally disclosed.

40 the chirality of beta(3) carbon in C-linked-carbo-beta(3)-amino acid (Caa) from R to S.

41 were prepared from (S)-beta-Caa(l) (C-linked carbo-beta-amino acid with D-lyxo furanoside side chain)

42 A new C-linked carbo-beta-amino acid, (R)-beta-Caa((r)), having a carbo

43 onal analysis of beta-peptides from C-linked carbo-beta-amino acids [beta-Caa(l)] with a d-lyxo furan

44 carbo-benzene circuit results in a flexible 'carbo-butadiene' molecule that has a conductance 40 time

45 Therefore, although carbo-cages have enthalpies of formation 1 order of magn

46 ular properties of polyhedranes, a series of carbo-cages is proposed in silico via density functional

47 n Europe from both subspecies (Phalacrocorax carbo carbo and P. c. sinensis) and 84 birds from two in

48 Patients treated sequentially with CARBO, CARBO-VCR-5-FU, and HDDP-ETOP had response rates

49 d then to synthetic rutile, high-temperature carbo-chlorination to produce TiCl4, and batch reduction

50 In the carbo-counterparts, the values of the magnetic response

51 ble, explaining why the similar systems like carbo-cubane have already been synthesized.

52 dienes and flexible sigma-cyclic, pi-acyclic carbo-cyclohexadienes, and to "pro-aromatic" congeners,

53 yne, a carbon-expanded version of graphene ('carbo-graphene') that was recently evidenced as an alter

54 l, optical and mechanical properties of such carbo-materials are surveyed.

55 etic, physical, and theoretical chemistry of carbo-mers and in particular macrocyclic-polycyclic repr

56 With respect to their parent molecules, carbo-mers are constitutionally defined as "carbon-enric

57 It is shown that functional carbo-mers are entering the field of "molecular material

58 Since total or partial carbo-mers of aromatic carbon-allotropes of infinite siz

59 dered, i.e. freely rotating sigma,pi-acyclic carbo-n-butadienes and flexible sigma-cyclic, pi-acyclic

60 -3-([3,5-dimethyl-4-[(4-methylpiperazin-1-yl)carbo nyl]-1H-pyrrol-2-yl]methylene)-N-methyl-2-oxo-2,3-

61 dingly categorized by the number of built-in carbo- or heterocycles.

62 direct enrichment of short-chain carboxylic (CARBO)-OxPLs, whereas detection of aldehydic (ALDO)-OxPL

63 C, while not cost effective compared with IV-CARBO/PAC at 7 years, becomes cost effective if a longer

64 may also be cost effective compared with IV-CARBO/PAC if proven as effective as inpatient IP-CIS/PAC

65 sis, the ICER of IP-CIS/PAC compared with IV-CARBO/PAC was $26,311.

66 f intravenous carboplatin and paclitaxel (IV-CARBO/PAC), intravenous cisplatin and paclitaxel (IV-CIS

67 Compared with IV-CARBO/PAC, IP-CIS/PAC had an incremental cost-effectiven

68 66, 57, 51, and 48 months for IP-CIS/PAC, IV-CARBO/PAC, IV-CIS/PAC (GOG 172), or IV-CIS/PAC (GOG 158)

69 costly and had lower life expectancy than IV-CARBO/PAC.

70 est that this process occurs via a concerted carbo-palladation across the thiophene double bond, foll

71 In the particular case of a carbo-prismane, no structural change is perceived until

72 " congeners, i.e. rigid sigma,pi-macrocyclic carbo-quinoids.

73 EOB)) by preparation of the precursors 2beta-carbo-R-1-mesyloxy-2-propoxy-3beta-(4-chlorop hen yl)tro

74 a-(4-chlorop hen yl)tropane (R-12) and 2beta-carbo-S-1-mesyloxy-2-propoxy-3beta-(4-chlorop hen yl)tro

75 ren whose tumors remained unresectable after CARBO-VCR-5-FU or who demonstrated no response or progre

76 Patients treated sequentially with CARBO, CARBO-VCR-5-FU, and HDDP-ETOP had response rates and EFS

77 and then received two additional courses of CARBO-VCR-5-FU.

78 CARBO; 24 (80%) of 30 responded to CARBO and CARBO-VCR-5-FU; and nine (75%) of 12 responded to HDDP-E

79 CARBO was given on day 1 at an area under the curve of 6

80 th a fixed systemic exposure of carboplatin (CARBO) with or without granulocyte colony-stimulating fa

81 dophenyl)-4-methyl-N-(1-piperidyl)pyrazole-3-carbo xamide].

82 12-hexahydro-10-(R)hydroxy-9-methyl-1-oxo-10-carbo xylate (K-252a) and 2-[N-(2-hydroxyethyl)-N-(4-met

83 H-diazirin-3-yl)phenyl)ethyl)-1H-imidazole-5-carbo xylate (trifluoromethyldiazirinyl-etomidate), or T

84 henyl)-4-(2-ethoxy-2-oxoethyl)-4H-chromene-3-carbo xylate) (CXL017), reveals selective cytotoxicity t