ライフサイエンスコーパス: carbocyclic

1 inhibitors built as conformationally locked, carbocyclic 1,3-diazepinone nucleosides to determine the

2 Asymmetric syntheses of L-carbocyclic 2',3'-didehydro-2',3'-dideoxy- and 2',3'-did

3 It was found that L-carbocyclic 2',3'-didehydro-2',3'-dideoxyadenosine (34)

4 -2',3'-dideoxy-3'-thiacytidine (3TC-TP), and carbocyclic 2',3'-didehydro-ddGTP (CBV-TP) indicated inc

5 imidine-2'-deoxyribose was synthesized using carbocyclic 2'-deoxyuridine as starting material.

6 te (T-dGTP), carbovir 5'-triphosphate, and D-carbocyclic-2'-deoxyguanosine 5'-triphosphate (D-CdG-TP)

7 As reported here, Carbocyclic 3-deazaadenosine is the first compound demon

8 Carbocyclic 4'-methyl and 4'-cyano nucleoside analogues

9 Carbocyclic 9-deazapurine nucleosides (1-4), a spiranic

10 (where X is the alpha- or beta-anomer of the carbocyclic abasic site analogue) were determined by NMR

11 exes having the alpha- or beta-anomer of the carbocyclic abasic site by human AP endonuclease showed

12 2'-Fluoro-6'-methylene carbocyclic adenosine (FMCA) is a potent and selective i

13 was inhibited by incubation of cells with a carbocyclic adenosine analog, 3-deazaaristeromycin, resu

14 The biological versatility of aristeromycin (carbocyclic adenosine) is limited by accompanying cytoto

15 tion that the side effects of aristeromycin (carbocyclic adenosine) were reduced by removing the meth

16 ng of the heterocyclic bases with the chiral carbocyclic alcohol 6 [(1R,2S,4R,5S)-1-[(benzyloxy)methy

17 d contrast to the reactions of the analogous carbocyclic allylic alcohols with tert-butyl hydroperoxi

18 This reaction is compatible with carbocyclic amides containing alpha-tertiary as well as

19 e 10 that was necessary for the synthesis of carbocyclic amine 15.

20 tyl analogue 5 was linearly constructed from carbocyclic amine 17, and the final target 6 was similar

21 rule constraint results in the production of carbocyclic amino ketones, key alkaloid building blocks.

22 enediyne is more reactive than corresponding carbocyclic analog and produces good yield of the Bergma

23 Duplexes containing a carbocyclic analog of dA were not cleaved.

24 Several carbocyclic analogs of glycinamide ribonucleotide, inclu

25 The carbocyclic analogue (C-BCNA) of the highly potent and s

26 The carbocyclic analogue had enhanced agonist efficacy, and

27 the ethylene glycol ketal of hydrocodone; a carbocyclic analogue of bisnorhydrocodone was also prepa

28 domain resulting in the identification of a carbocyclic analogue that possesses a KIapp value of 2.3

29 The carbocyclic analogues (26a,b) of D4FC demonstrated weak

30 stereoselective syntheses of the hydrindane carbocyclic analogues 95, 96, 100, and 104 are presented

31 Although these carbocyclic analogues appeared to be more stable than ze

32 s have been carried out then so as to access carbocyclic analogues of an important series of anticanc

33 gn and development of efficient syntheses of carbocyclic analogues of DPD, which are locked in the cy

34 Carbasugars, the carbocyclic analogues of sugars, constitute an important

35 A number of carbocyclic analogues of the fructose-derived ketone 1 h

36 ic site repair has been examined using novel carbocyclic analogues.

37 The preparation of acyclic, carbocyclic and azacyclic alpha-aminoboronic acid deriva

38 ates couple with enol triflates derived from carbocyclic and heterocyclic (i.e., piperidinones) beta-

39 s with log(k(az)/k(s)) for a wide variety of carbocyclic and heterocyclic amine mutagens including Ph

40 iflate and reacted in situ with 21 different carbocyclic and heterocyclic aromatic compounds.

41 n is a valuable method for synthesis of both carbocyclic and heterocyclic bridged bicyclo[5.3.1]undec

42 Both carbocyclic and heterocyclic C2-aryl substituents have b

43 oieties should lead to highly functionalized carbocyclic and heterocyclic compounds.

44 own to be robust across a range of different carbocyclic and heterocyclic D-ring precursors, proceedi

45 rm a diverse array of omega-oxonitriles into carbocyclic and heterocyclic five- and six-membered alke

46 d to the synthesis of densely functionalised carbocyclic and heterocyclic frameworks that are otherwi

47 a broad substrate scope, providing access to carbocyclic and heterocyclic ring systems in good to exc

48 zed as versatile methods for construction of carbocyclic and heterocyclic scaffolds.

49 e of synthetically and medicinally important carbocyclic and heterocyclic systems.

50 A general and efficient synthesis of carbocyclic and hexenopyranosyl nucleosides has been dev

51 A variety of heterocyclic, carbocyclic, and acyclic alkenes react with good to exce

52 We tested cyclohexyl-substituted isochroman, carbocyclic, and chroman bicyclic dopamine analogs and f

53 On the ribose moiety, 2'-hydroxy, 4'-thio, carbocyclic, and six-membered anhydrohexitol ring modifi

54 cross-coupling between electron-rich hetero-/carbocyclic arenes and electron-poor arenes bearing rela

55 of the shikimate pathway for biosynthesis of carbocyclic aromatic compounds in plants, bacteria, fung

56 The reduction of a series of hetero- and carbocyclic aromatic compounds under ammonia free condit

57 microm), aza-AdoMet (IC(50) 100 microm), and carbocyclic aza-AdoMet (IC(50) 35 microm).

58 ilt from the corresponding benzoyl-protected carbocyclic bis-allyl ureas by ring-closing metathesis.

59 Newly prepared carbocyclic C-analog of tubercidine, profiled in MCF7 (b

60 Carbocyclic C-nucleosides are quite rare.

61 reduction with Bu3SnH and then converted to carbocyclic C-ribonucleosides 1, 3, and 4.

62 the phosphaethene TSs are much less than the carbocyclic cases.

63 The isolation of carbocyclic coformycin as the herbicidally active compon

64 we report that the primary mode of action of carbocyclic coformycin has been identified as inhibition

65 tic radiolabeled marker, rapid conversion of carbocyclic coformycin to the 5'-phosphate analog could

66 The 5'-phosphate analog of the carbocyclic coformycin was synthesized and shown to be a

67 um L. var Onward) seedlings are treated with carbocyclic coformycin, there is a very rapid and dramat

68 ine nucleosides (1-4), a spiranic pyrimidone carbocyclic compound (5), and an unusual carbocyclic iso

69 Carbocyclic compounds with high stereochemical and funct

70 es of natural and unnatural heterocyclic and carbocyclic compounds.

71 ntaining a tetrahydropyran ring (1a) and its carbocyclic congener (1b).

72 rmolecular Diels-Alder reaction to forge the carbocyclic core in a concise and stereoselective manner

73 The resulting 6-step synthesis of the carbocyclic core of the berkeleyone natural products has

74 With access to the carbocyclic core of the family of natural products, wilf

75 A flexible strategy toward the carbocyclic core of the naturally occurring sphingomyeli

76 The carbocyclic core structure was assembled using a tandem

77 conditions, expediently generated its [7,5]-carbocyclic core, afforded a unique sequence for dihydro

78 and ring-closing metathesis to construct its carbocyclic core.

79 reacted somewhat less efficiently than their carbocyclic counterparts, the fragmentation provided 11-

80 ontaining a 2',3'-unsaturation in its planar carbocyclic deoxyribose ring that acts on HIV-1 reverse

81 To address carbocyclic fatty acid synthesis in plants, a cDNA libra

82 nd the pathway in higher plants that produce carbocyclic fatty acids was defined as by transfer of C(

83 uct of cumbiasin B that possesses an unusual carbocyclic framework named seco-cumbiane.

84 ployed, for the first time, to construct the carbocyclic framework of aminoyclitols, while bis-Wittig

85 c cycloadducts that map onto the alternative carbocyclic frameworks of both himandravine and GB17.

86 underwent cyclizations to provide different carbocyclic frameworks.

87 oxides, achieved through the combination of carbocyclic-fused di-Grignard reagents and readily avail

88 ethod was used to synthesize three different carbocyclic[g]indole scaffolds as inhibitors of human no

89 However, the O-phosphonate analog of carbocyclic glycinamide ribonucleotide did support enzym

90 ide, including the phosphonate derivative of carbocyclic glycinamide ribonucleotide, did not serve as

91 erted to the conformationally locked (north)-carbocyclic guanosine (+)-17 identical to the one obtain

92 on alterations of macrocycles, made of four carbocyclic/heterocyclic subunits, which resemble the st

93 Several carbocyclic ions show similar behavior.

94 one carbocyclic compound (5), and an unusual carbocyclic isonucleoside (6) were prepared as enantiome

95 or stereospecific preparation of a versatile carbocyclic key intermediate, D-2'-fluoro-6'-methylene c

96 (ProTide) technology to the antiviral agent carbocyclic L-d4A (L-Cd4A).

97 With related but less symmetrical carbocyclic ligands, however, the magnetic properties of

98 1c)] by a formal 4-electron oxidation of the carbocyclic ligands.

99 inding affinity and biological activity with carbocyclic LNA (cLNA) analogs by replacing the 2'-oxyge

100 yielding hydroxylation products analogous to carbocyclic lyxosides.

101 Here we report the synthesis of a new carbocyclic mechanism-based covalent inhibitor of an alp

102 We report the first structural analysis of a carbocyclic mechanism-based GH inactivator, the results

103 We report that a carbocyclic modification of the ribose moiety incorporat

104 The methods for synthesising the carbocyclic moiety mainly focus on the construction of t

105 ond to the pyrrole rings on each side of the carbocyclic moiety, gave 4J(Me,H) = 0.9-1.0 Hz.

106 ether moiety and the [2.2.1] camphor-derived carbocyclic moiety.

107 A carbocyclic N(6)-methyl-2'-deoxyadenosine bisphosphate a

108 t in the total synthesis of heterocyclic and carbocyclic natural products.

109 By virtue of its carbocyclic nature, N-MCD4T (2) is a more robust molecul

110 y follow patterns previously established for carbocyclic nitrenium ions, but the reactions with AcO(-

111 are comparable to those of highly selective carbocyclic nitrenium ions.

112 assembly of five- and six-membered oxa- and carbocyclic nitriles demonstrating the utility of omega-

113 For the preparation of a carbocyclic nitrogen analogue of S-adenosylmethionine (c

114 Carbocyclic nucleoside analogues are catabolically stabl

115 A new class of carbocyclic nucleoside analogues built on a bicyclo[4.1.

116 clopentylamine precursors for 5'-substituted carbocyclic nucleoside analogues was developed.

117 xane scaffold can lock the conformation of a carbocyclic nucleoside into one of the two antipodal (no

118 of a carboxyl group at the alpha position of carbocyclic nucleoside phosphonate analogues leads to a

119 the efficient conversion of 3 into the novel carbocyclic nucleoside spironoraristeromycin 4.

120 D-carba T is a carbocyclic nucleoside that has a 3' hydroxyl on the pse

121 ficient asymmetric synthesis of an antiviral carbocyclic nucleoside, noraristeromycin 5.

122 rba-T, 13) was used as a reference, flexible carbocyclic nucleoside.

123 A series of four structurally related carbocyclic nucleosides (6a, 6b, 10a, and 10b) were synt

124 nd L-2',3'-dideoxy-2',3'-didehydro-2'-fluoro-carbocyclic nucleosides (D- and L-2'F-C-d4Ns) were synth

125 Carbocyclic nucleosides are nucleoside analogues in whic

126 [reaction: see text] Carbocyclic nucleosides are of considerable interest for

127 The triphosphates (27a,b) of the carbocyclic nucleosides demonstrated potent inhibitory a

128 oro substitution on the 2',3'-double bond in carbocyclic nucleosides has provided biologically intere

129 Carbocyclic nucleosides have received much attention due

130 rivileged rigid template for sculpting other carbocyclic nucleosides to meet the demands of specific

131 The syntheses of target carbocyclic nucleosides were accomplished via a converge

132 The target D- and L-carbocyclic nucleosides were both stereospecifically syn

133 agents, D- and L-2',3'-unsaturated 3'-fluoro carbocyclic nucleosides were synthesized and evaluated a

134 s of synthesis of 3-, 4- and 6-membered ring carbocyclic nucleosides, a selection of the more relevan

135 versatile intermediates for the synthesis of carbocyclic nucleosides, have been developed via a ring-

136 zed for the synthesis of biologically active carbocyclic nucleosides.

137 of unnatural five-membered ring heterocyclic carbocyclic nucleosides.

138 s of carbocycles related to the synthesis of carbocyclic nucleosides.

139 itution reactions after the synthesis of the carbocyclic nucleosides.

140 es a group of analogues known generically as carbocyclic nucleosides.

141 Thus, we identified uncharged carbocyclic nucleotide analogues that represent potentia

142 Thus, we have greatly expanded the range of carbocyclic nucleotide analogues that represent potentia

143 bicyclic cyclopentenones fused with either a carbocyclic or a heterocyclic ring system in good yield.

144 Kabachnik-Fields reactions of various carbocyclic or heterocyclic acetylenic aldehydes togethe

145 demonstrating how covalently bonding, soft, carbocyclic organometallic ligands provide an excellent

146 metric epoxidation of various styrenes using carbocyclic oxazolidinone-containing ketone 3 has been i

147 where phosphorylation occurs, derivatives of carbocyclic oxetanocin A (4a), oxetanocin G (4b), and 2-

148 f cyclopentane and cyclopentene and a chiral carbocyclic phosphonate.

149 an convert symmetrical ketoesters to complex carbocyclic products bearing multiple stereocentres with

150 nes or alkynes and diaryliodonium salts form carbocyclic products in a single step.

151 lic product is distinct from the more common carbocyclic products of synthetic and biosynthetic [4+2]

152 e array of different heterocyclic as well as carbocyclic products.

153 NRTIs based on the carbocyclic pseudosugar may offer an effective approach

154 s with dicarbonyls provides rapid entry into carbocyclic reaction products.

155 ucts that can be converted into analogues of carbocyclic ribosides.

156 that allow the construction of more than one carbocyclic ring at a time have proven valuable, in part

157 Modifications of the substituents on the carbocyclic ring did not perturb the inhibition pattern

158 acrocyclic ring reduction, lactamization and carbocyclic ring formation.

159 a Mur ligase homolog forms the six-membered carbocyclic ring in the final step of the pathway.

160 The conformation of the carbocyclic ring in these nucleosides was found to be le

161 ng phosphorylation at the 5' hydroxyl on the carbocyclic ring in vivo.

162 Indole fused with a seven-membered carbocyclic ring is a commonly observed structural featu

163 or beta-hydroxyl substituent at C-5' of the carbocyclic ring is detailed.

164 In these products, the size of the carbocyclic ring is varied widely (5-12 membered); howev

165 The presence of a carbocyclic ring on the new drug, cis-amminedichloro(2-m

166 (tetracyclic molecules with a linear 6-6-6-5 carbocyclic ring system) ring systems and properly subst

167 ricyclic compounds with a linear 6-6-5 fused carbocyclic ring system.

168 rovides a new method for the construction of carbocyclic ring systems bearing versatile organoboronic

169 carbon bonds, thus providing these important carbocyclic ring systems in a single synthetic step.

170 e generation of quaternary carbon centers in carbocyclic ring systems is sparse.

171 can be controlled to afford a range of novel carbocyclic ring systems through an intramolecular allyl

172 useful route to a number of heterocyclic and carbocyclic ring systems.

173 placing the ribose moiety with a constrained carbocyclic ring.

174 carbaporphyrin that is unsubstituted on the carbocyclic ring.

175 es that depend intimately on the size of the carbocyclic ring: 5-membered oxonitriles generate magnes

176 We have introduced constrained carbocyclic rings (to explore the role of sugar puckerin

177 Fatty acids containing three-member carbocyclic rings are found in bacteria and plants.

178 ive cyclizations to form 10- and 12-membered carbocyclic rings in the key steps of the biosynthesis o

179 , two new C-C bonds, and establishes two new carbocyclic rings is also described.

180 e ability of PikC to hydroxylate a series of carbocyclic rings linked to the desosamine glycoside via

181 beta-methylene C(sp(3) )-H bonds of various carbocyclic rings were also successfully alkynylated.

182 ively functionalized within each of the four carbocyclic rings, a synthetic ent-steroid has been prep

183 s secondary C(sp(3))-H bonds in a variety of carbocyclic rings, including cyclopropanes, cyclobutanes

184 ), three compounds with incrementally larger carbocyclic rings.

185 Extensions toward the synthesis of carbocyclic sinefungin 7 document the importance of real

186 s work describes a synthetic approach to the carbocyclic skeleton of isospongian diterpenes that uses

187 Hosomi-Sakurai cyclizations to construct the carbocyclic skeleton of the targets.

188 ative containing the 2,8-ethanonoradamantane carbocyclic skeleton, whose key-step consists of an intr

189 The carbocyclic skeletons of the cumbiasins are unprecedente

190 or-diterpenoid, all of which possess unusual carbocyclic skeletons, were isolated from the hexane sol

191 ne (PCP) analogues possessing a highly rigid carbocyclic structure and an attached piperidine ring wh

192 a unique family of fundamental [n]-membered carbocyclic structures with radiating alkenes, which hav

193 place in a single operation to access novel carbocyclic structures.

194 While simple carbocyclic substitution of adenosine agonists greatly d

195 og, while another duplex contains a central, carbocyclic substrate analog (carba-8-oxo-dG).

196 Subtle changes in the carbocyclic substrate led to the discovery of a heretofo

197 th DNA containing a south-constrained abasic carbocyclic sugar at the target site in the presence of

198 ion of a macrocycle between the base and the carbocyclic sugar moiety, via ring-closing metathesis, a

199 A key intermediate for carbocyclic sugar production, (1S,2S,3R, 4R,5S)-1-(tert-

200 A synthesis of carbocyclic sugars from carbohydrate-derived dialdehydes

201 substitution; and a variety of aromatic and carbocyclic surrogates for phenyl.

202 Formal expansion of (4n + 2)-pi carbocyclic systems by insertion of NSN motifs in every

203 mistry is also extended from heterocyclic to carbocyclic systems, with computational guidance used to

204 itu generated nitrosoalkenes to form bridged carbocyclic systems.

205 tionality amenable to the preparation of the carbocyclic target molecule by suitable postrearrangemen

206 (cPGI(2); a stable prostacyclin analog), and carbocyclic thromboxane (cTXA(2)) were administered at c

207 We use carbocyclic thromboxane A2 (CTA2) to convert the TXAS he

208 Carbocyclic thymidine (carba-T, 13) was used as a refere

209 showed that DPTL binds with high affinity to carbocyclic TXA(2), TXA(2) mimetic (U-46619), TXB(2), PG

210 Carbocyclic uracil polyoxin C (+)-2 and its alpha-epimer

211 Carbocyclic uracil polyoxin C analogs are prepared from

212 However, stable carbocyclic versions of these analogues are less effecti