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4 the general acid-assisted rate constants for carbonic acid and bicarbonate ion were estimated for the
7 -H2CO3 adds a new aspect to the chemistry of carbonic acid in astrophysical environments, especially
8 have succeeded in isolation of undecomposed carbonic acid in the matrix and recondensation after rem
10 fixed carbon includes respiratory CO(2) and carbonic acid that propagate to the base of the critical
11 Twenty years ago two different polymorphs of carbonic acid, alpha- and beta-H2CO3, were isolated as t
12 n potential generated by the dissociation of carbonic acid, colloidal particles move either away from
14 bon dioxide system, previously identified as carbonic acid, was observed in the high-pressure diamond
15 ransition of bicarbonate into nondissociated carbonic acid, which reduces the total concentration of
20 ubiquitin (8.6 kDa), myoglobin (17 kDa), and carbonic anhydrase (29 kDa) upon higher energy collision
21 This study examined the effects of bovine carbonic anhydrase (BCA) and CO2-rich gas streams on the
22 y measuring the affinity of unlabeled bovine carbonic anhydrase (BCA) for a variety of ligands (most
23 g: ribonuclease (Rnase) A, myoglobin, bovine carbonic anhydrase (BCA) II, hemoglobin (Hb), and the he
24 cs of CO(2) hydration, we first measured the carbonic anhydrase (CA) activity of the bladder epitheli
26 in interactions of these inhibitors into the carbonic anhydrase (CA) catalytic site, thus highlightin
28 intraocular pressure (IOP) by inhibiting the carbonic anhydrase (CA) enzyme to reduce aqueous humor p
32 hough many inhibitors are reported for human carbonic anhydrase (CA) enzymes, few may be considered u
33 ective inhibition of cancer-associated human carbonic anhydrase (CA) enzymes, specifically CA IX and
34 es, which act as effective inhibitors of the carbonic anhydrase (CA) from Trypanosoma cruzi (TcCA).
36 , pepsin, maltose binding protein (MBP), and carbonic anhydrase (CA) in the presence of hundreds of n
37 : see text] Finally, we show that the enzyme carbonic anhydrase (CA) increases the dissolution rate a
39 g of the possibility of developing selective carbonic anhydrase (CA) inhibitors, interactions between
42 mplementary DNAs encoding four distinct beta-carbonic anhydrase (CA) isoforms were characterized from
44 eft protons: (1) generation by extracellular carbonic anhydrase (CA), (2) release from acidic synapti
45 hosphate carboxylase/oxygenase (RuBisCO) and carbonic anhydrase (CA), in an engineered protein cage b
47 This enhancement was completely abolished in carbonic anhydrase (CA)-deficient antisense lines of bot
50 iency only ~100-fold less than that of human carbonic anhydrase (CA)II and at least 550-fold better t
52 cloned, purified, and characterized an alpha-carbonic anhydrase (CA, EC 4.2.1.1) from the human patho
54 ized from three established aminosulfonamide carbonic anhydrase (CA, EC 4.2.1.1) inhibitor pharmacoph
55 nging to the underexposed sulfamate class of carbonic anhydrase (CA, EC 4.2.1.1) inhibitors was gener
56 rimary/secondary amines and COS as potential carbonic anhydrase (CA, EC 4.2.1.1) inhibitors, using th
61 re thus obtained, which showed an increasing carbonic anhydrase (CA, EC 4.2.1.1) inhibitory action wi
62 ity/selectivity against the tumor associated carbonic anhydrase (CA, EC 4.2.1.1) isoforms hCA IX and
63 gent of Chagas disease, encodes for an alpha-carbonic anhydrase (CA, EC 4.2.1.1) possessing high cata
74 a subcomplex, containing the ancestral gamma-carbonic anhydrase (gamma-CA), gamma-carbonic anhydrase-
75 defined system of protein and ligands--human carbonic anhydrase (HCA) and a series of benzothiazole s
76 oldamer 2 was synthesized and bound to human carbonic anhydrase (HCA) using a nanomolar active site l
77 ss-coupling reactions and evaluated as human carbonic anhydrase (hCA, EC 4.2.1.1) inhibitors against
78 lly and pharmacologically relevant human (h) carbonic anhydrase (hCA, EC 4.2.1.1) isoforms, the cytos
81 Arg160His mutation of Haemophilus influenzae carbonic anhydrase (HICA), which mimics the endogenous m
84 beta-lactoglobulin (five peptides), 25% for carbonic anhydrase (six peptides), and 51% for bovine se
87 globin, Apolipoprotein E, Apolipoprotein A1, Carbonic anhydrase 1, and Hemoglobin subunit alpha upon
88 of plasma creatine kinase M-type (CK-M) and carbonic anhydrase 3 (CA-3) in the blood, more than 90%
89 s, anti-salivary gland protein 1 (SP1), anti-carbonic anhydrase 6 (CA6) and anti-parotid secretory pr
90 s, anti-salivary gland protein 1 (SP1), anti-carbonic anhydrase 6 (CA6) and parotid secretory protein
93 ion of hypoxia-regulated genes (for example, carbonic anhydrase 9 (CA9) and vascular endothelial grow
96 ations, photosynthetic attributes along with carbonic anhydrase activity whereas its higher concentra
97 cable for rapid and simple quantification of carbonic anhydrase activity which is very important to p
98 half-saturation constants for CO2 fixation, carbonic anhydrase activity, CO2 /HCO3 (-) uptake, delta
99 in zinc deficiency, probably due to reduced carbonic anhydrase activity, validated by quantitative p
104 is dependent on H(+) V-ATPase, together with carbonic anhydrase and five further transporters or chan
107 c carbon into the cell and colocalization of carbonic anhydrase and RuBisCO inside proteinaceous micr
108 CO2 better than any small molecule model of carbonic anhydrase and with an efficiency within 1400-fo
110 revisiae as the folding modulators and human carbonic anhydrase as a model protein, we demonstrate th
114 5-bisphosphate carboxylase/oxygenase and the carbonic anhydrase CcaA, whereas the C-terminal peptide
116 For comparison we assayed recessive ca1ca4 carbonic anhydrase double mutant plants, based on their
117 recently isolated Arabidopsis thaliana beta-carbonic anhydrase double mutants (ca1 ca4) exhibit an i
118 Clostridium perfringens strain 13, the only carbonic anhydrase encoded in the genome, was characteri
121 possible clinical benefits of inhibitors of carbonic anhydrase enzymes and the water channel Aquapor
122 onic anhydrase gene (ca19) beyond the single carbonic anhydrase gene (ca18) that was known previously
124 LCI1, CCP1, CCP2 and LCIA) and mitochondrial carbonic anhydrase genes (CAH4 and CAH5) are up regulate
125 alysis and synteny studies suggest that both carbonic anhydrase genes form one or two independent gen
129 Tryptic digestion of differentially labeled carbonic anhydrase I and hemoglobin allowed the identifi
130 ng these proteins, the strict association of carbonic anhydrase I and S100A8 with ECM was verified by
132 s, which was demonstrated by modification of carbonic anhydrase I with electrochemically generated re
134 of residual mobility in complexes of bovine carbonic anhydrase II (BCA) and para-substituted benzene
138 ts to analyze the direct interaction between carbonic anhydrase II (CAII) and MCT1, MCT2, and MCT4, r
141 f MCT1 and MCT4 is enhanced by the cytosolic carbonic anhydrase II (CAII) independent of its catalyti
146 onic acid, TPMA) to the active site of human carbonic anhydrase II (hCAII) has been investigated.
147 ione (1,2-HOPTO) in the active site of human carbonic anhydrase II (hCAII) has been investigated.
148 e corresponding inhibitor complexes of human carbonic anhydrase II (HCAII) indicated that HpalphaCA p
150 nvestigation of the CD spectrum of the Human Carbonic Anhydrase II (HCAII), with main focus on the ne
151 This paper uses the binding pocket of human carbonic anhydrase II (HCAII, EC 4.2.1.1) as a tool to e
153 res rapid conversion between CO2 and HCO3(-) Carbonic anhydrase II facilitates this reversible reacti
154 K, tartrate-resistant acid phosphatase, and carbonic anhydrase II in bone marrow macrophages (BMMs),
156 lls arise mainly from extrainsular PDX-1(+), carbonic anhydrase II(-) (mature ductal), elastase 3a (a
158 of the selected scFvs was shown to recognize carbonic anhydrase II, an up-regulated enzyme involved i
160 lated known genes, whereas Srpx2, Cd200, and carbonic anhydrase III (CAIII) were identified as novel
162 Carbonic anhydrase XII (CA12) is the key carbonic anhydrase in epithelial fluid and HCO3 (-) secr
164 roportion of Rubisco and the thylakoid lumen carbonic anhydrase in the pyrenoid rose substantially, c
166 ich was sensitive to Na(+)withdrawal, to the carbonic anhydrase inhibitor acetazolamide and to H2DIDS
167 tment of B. pertussis-infected mice with the carbonic anhydrase inhibitor acetazolamide reduced lung
171 In this connection, we report a new class of carbonic anhydrase inhibitors, based on the thiopyrano-f
172 ation, use of topical beta blockers, topical carbonic anhydrase inhibitors, daily dose of BAK, and gl
173 Other glaucoma medications (beta blockers, carbonic anhydrase inhibitors, parasympathomimetics, and
174 the dye were more potent agents with higher carbonic anhydrase inhibitory action than the parent dye
175 ished nitrite bioactivation, but the role of carbonic anhydrase is abrogated when physiological conce
176 was also observed, in line with patterns of carbonic anhydrase isoform expression in those tissues.
178 n efficiency within 1400-fold of the fastest carbonic anhydrase isoform, CAII, and 11-fold of CAIII.
180 luated as inhibitors of the ubiquitous human carbonic anhydrase isoforms I, II, IX, XII, and XIV usin
181 t that the human genome encodes 15 different carbonic anhydrase isoforms that have a high degree of h
182 rs (encoded by Slc26a4, Slc4a8, and Slc4a9), carbonic anhydrase isoforms, and V-type H(+)-ATPase subu
184 -the-haystack" screen for inhibitors against carbonic anhydrase isozyme II is performed, in which kno
191 n of hypoxic tumors is possible by targeting carbonic anhydrase IX (CA IX), an enzyme overexpressed i
195 of tumor hypoxia is activated expression of carbonic anhydrase IX (CA9), a regulator of pH and tumor
196 chemical technique, using antibodies against carbonic anhydrase IX (CAIX) and copper pumps (Ctr1 and
197 body-mediated therapy with the chimeric anti-carbonic anhydrase IX (CAIX) antibody girentuximab (cG25
201 CC tumors, which also express high levels of carbonic anhydrase IX (CAIX), a HIF1-dependent protein.
202 o facilitate the intraoperative detection of carbonic anhydrase IX (CAIX)-expressing tumor lesions wi
205 armacodynamics from tumor biomarkers such as carbonic anhydrase IX and topoisomerase I by immunohisto
207 is a chimeric monoclonal antibody that binds carbonic anhydrase IX, a cell surface glycoprotein ubiqu
208 escribed a novel acetazolamide derivative, a carbonic anhydrase ligand with high affinity for the tum
213 of incubation at 750 microatm pCO2, reduced carbonic anhydrase protein activity and shell growth occ
215 1,5-bisphosphate carboxylase/ oxygenase and carbonic anhydrase to facilitate carbon fixation in cyan
217 68 and mannose receptor-positive, expressing carbonic anhydrase type II, but relatively low levels of
221 robenzoarylsulfonamide ligands bind to human carbonic anhydrase with a conserved binding geometry, an
224 n of one specific gene in the FLC signature, carbonic anhydrase XII (CA12), at the protein level by w
225 Here we describe variants in CA12 encoding carbonic anhydrase XII in two pedigrees exhibiting CF-li
227 ditions we find dorzolamide (an inhibitor of carbonic anhydrase) results in diminished nitrite bioact
228 This paper describes a synthetic dimer of carbonic anhydrase, and a series of bivalent sulfonamide
230 BisCO reaction, staying below saturation for carbonic anhydrase, and avoiding wasteful oxygenation re
232 genes including: green fluorescent proteins, carbonic anhydrase, and oxidative stress proteins; and f
233 ncorporating 6- and 7-substituted coumarins (carbonic anhydrase, CA inhibitors) derivatized with clin
234 en alga Chlamydomonas reinhardtii, a luminal carbonic anhydrase, CrCAH3, was suggested to improve pro
235 H(+)-extrusion mechanisms and extracellular carbonic anhydrase, is responsible for active transport-
236 ient CO2 We identified CAH1 as an alpha-type carbonic anhydrase, providing a biochemical role in CCM
237 aria susceptibility in the murine model, and carbonic anhydrase, reflecting the blood's abnormal acid
238 showed reduced expression of colonic villin, carbonic anhydrase, secretory mucin muc2, and increased
239 e, biotin, mannose) against matched targets (carbonic anhydrase, streptavidin, concanavalin A) to ide
241 ely conserved proteins containing domains of carbonic anhydrase, Sushi, Von Willebrand factor type A,
242 cyclen, a small molecule mimic of the enzyme carbonic anhydrase, was evaluated under rigorous conditi
243 died: ribonuclease A, trypsin inhibitor, and carbonic anhydrase, where the latter had impurities of s
244 on of NP markers FoxF1, Pax-1, keratin-8/18, carbonic anhydrase-12, and NC markers brachyury, galecti
249 ty to CO(2), native extra- and intracellular carbonic anhydrase-like activities, the non-CO(2)/HCO(3)
250 l gamma-carbonic anhydrase (gamma-CA), gamma-carbonic anhydrase-like, and 20.9-kDa subunits, had a si
251 munoisolated from mouse brain, we identified carbonic anhydrase-related proteins CA10 and CA11, two h
266 ing atmospheric CO2 elevation, including the carbonic-anhydrase-encoding genes CA1 and CA4 and the se
268 consist of inorganic carbon transporters and carbonic anhydrases (and other supporting components) th
269 ged from the immunohistochemical analysis of carbonic anhydrases (CA) IX and XII expression in thyroi
272 on between different Ci species catalyzed by carbonic anhydrases (CAs) are key components in the CCM,
274 mechanisms (CCMs) involving transporters and carbonic anhydrases (CAs) are well known, but the contri
279 cotransporter, suggesting that inhibition of carbonic anhydrases (CAs) confers the beneficial thiazid
280 version between CO2 and HCO3(-) catalyzed by carbonic anhydrases (CAs), and active inorganic carbon (
284 against four physiologically relevant human carbonic anhydrases (hCAs, EC 4.2.1.1), isoforms hCA I,
286 esults suggest that intra- and extracellular carbonic anhydrases can work in concert to ensure rapid
287 we investigate the repertoire of cytoplasmic carbonic anhydrases in the sea lamprey (Petromyzon marin
288 Contrastingly, transcripts of chloroplast carbonic anhydrases namely CAH6, CAH3 and LCIB are up re
290 rey metamorphosis resulting in distinct gill carbonic anhydrases reflecting the contrasting life mode
291 ctive inorganic carbon transport components, carbonic anhydrases, and aggregation of Rubisco in the c
293 larly sodium bicarbonate co-transporters and carbonic anhydrases, which were also expressed in LAM lu
297 ogic markers of tumor hypoxia (pimonidazole, carbonic anydrase 9 [CA9]) and vascular perfusion (Hoech
298 ophobic interactions between the analyte and carbonic chain of surfactant, the retention of cationic
299 odelling daily anthocyanin extraction during carbonic maceration, particularly from the sixth day.
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