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1 determines enzyme activity of chloroplastic carbonic anhydrase.
2 ts reveal that the pH gradient is created by carbonic anhydrase.
3 ly converted to H2S by the ubiquitous enzyme carbonic anhydrase.
4 iochemical function for Cd, an unusual Cd/Zn carbonic anhydrase.
5 luding human serum albumin, beta-casein, and carbonic anhydrase.
6 e 1,5-bisphosphate carboxylase/oxygenase and carbonic anhydrase.
7 - by first converting it to CO2 via external carbonic anhydrase.
8 cy to be competitive with the native enzyme, carbonic anhydrase.
9 ed urea channel, UreI; and periplasmic alpha-carbonic anhydrase.
10 onstants for proton transfer in catalysis by carbonic anhydrase.
11 ription of the urease gene cluster and alpha-carbonic anhydrase.
12 porters ae1 and pendrin, and two isoforms of carbonic anhydrase.
13 art through the action of a shell-associated carbonic anhydrase.
14 on state similar to that at the zinc site in carbonic anhydrase.
15 ulfide, which is rapidly converted to H2S by carbonic anhydrase.
16 osphate carboxylase/oxygenase (RuBisCO) with carbonic anhydrase.
17 eature not previously observed in alpha-type carbonic anhydrases.
18 on of CO2-controlled stomatal development by carbonic anhydrases.
20 globin, Apolipoprotein E, Apolipoprotein A1, Carbonic anhydrase 1, and Hemoglobin subunit alpha upon
21 on of NP markers FoxF1, Pax-1, keratin-8/18, carbonic anhydrase-12, and NC markers brachyury, galecti
22 ubiquitin (8.6 kDa), myoglobin (17 kDa), and carbonic anhydrase (29 kDa) upon higher energy collision
23 of plasma creatine kinase M-type (CK-M) and carbonic anhydrase 3 (CA-3) in the blood, more than 90%
24 s, anti-salivary gland protein 1 (SP1), anti-carbonic anhydrase 6 (CA6) and anti-parotid secretory pr
25 s, anti-salivary gland protein 1 (SP1), anti-carbonic anhydrase 6 (CA6) and parotid secretory protein
29 ion of hypoxia-regulated genes (for example, carbonic anhydrase 9 (CA9) and vascular endothelial grow
34 ations, photosynthetic attributes along with carbonic anhydrase activity whereas its higher concentra
35 cable for rapid and simple quantification of carbonic anhydrase activity which is very important to p
36 half-saturation constants for CO2 fixation, carbonic anhydrase activity, CO2 /HCO3 (-) uptake, delta
37 in zinc deficiency, probably due to reduced carbonic anhydrase activity, validated by quantitative p
40 well-defined system of protein and ligands--carbonic anhydrase and a series of structurally homologo
43 is dependent on H(+) V-ATPase, together with carbonic anhydrase and five further transporters or chan
46 c carbon into the cell and colocalization of carbonic anhydrase and RuBisCO inside proteinaceous micr
47 CO2 better than any small molecule model of carbonic anhydrase and with an efficiency within 1400-fo
49 consist of inorganic carbon transporters and carbonic anhydrases (and other supporting components) th
50 This paper describes a synthetic dimer of carbonic anhydrase, and a series of bivalent sulfonamide
52 BisCO reaction, staying below saturation for carbonic anhydrase, and avoiding wasteful oxygenation re
54 genes including: green fluorescent proteins, carbonic anhydrase, and oxidative stress proteins; and f
55 ctive inorganic carbon transport components, carbonic anhydrases, and aggregation of Rubisco in the c
57 revisiae as the folding modulators and human carbonic anhydrase as a model protein, we demonstrate th
60 This study examined the effects of bovine carbonic anhydrase (BCA) and CO2-rich gas streams on the
61 y measuring the affinity of unlabeled bovine carbonic anhydrase (BCA) for a variety of ligands (most
62 g: ribonuclease (Rnase) A, myoglobin, bovine carbonic anhydrase (BCA) II, hemoglobin (Hb), and the he
65 cs of CO(2) hydration, we first measured the carbonic anhydrase (CA) activity of the bladder epitheli
68 in interactions of these inhibitors into the carbonic anhydrase (CA) catalytic site, thus highlightin
70 intraocular pressure (IOP) by inhibiting the carbonic anhydrase (CA) enzyme to reduce aqueous humor p
74 hough many inhibitors are reported for human carbonic anhydrase (CA) enzymes, few may be considered u
75 ective inhibition of cancer-associated human carbonic anhydrase (CA) enzymes, specifically CA IX and
76 es, which act as effective inhibitors of the carbonic anhydrase (CA) from Trypanosoma cruzi (TcCA).
78 , pepsin, maltose binding protein (MBP), and carbonic anhydrase (CA) in the presence of hundreds of n
79 : see text] Finally, we show that the enzyme carbonic anhydrase (CA) increases the dissolution rate a
81 g of the possibility of developing selective carbonic anhydrase (CA) inhibitors, interactions between
84 mplementary DNAs encoding four distinct beta-carbonic anhydrase (CA) isoforms were characterized from
86 eft protons: (1) generation by extracellular carbonic anhydrase (CA), (2) release from acidic synapti
87 hosphate carboxylase/oxygenase (RuBisCO) and carbonic anhydrase (CA), in an engineered protein cage b
89 This enhancement was completely abolished in carbonic anhydrase (CA)-deficient antisense lines of bot
92 iency only ~100-fold less than that of human carbonic anhydrase (CA)II and at least 550-fold better t
94 cloned, purified, and characterized an alpha-carbonic anhydrase (CA, EC 4.2.1.1) from the human patho
96 ized from three established aminosulfonamide carbonic anhydrase (CA, EC 4.2.1.1) inhibitor pharmacoph
97 nging to the underexposed sulfamate class of carbonic anhydrase (CA, EC 4.2.1.1) inhibitors was gener
98 rimary/secondary amines and COS as potential carbonic anhydrase (CA, EC 4.2.1.1) inhibitors, using th
104 re thus obtained, which showed an increasing carbonic anhydrase (CA, EC 4.2.1.1) inhibitory action wi
105 ity/selectivity against the tumor associated carbonic anhydrase (CA, EC 4.2.1.1) isoforms hCA IX and
106 gent of Chagas disease, encodes for an alpha-carbonic anhydrase (CA, EC 4.2.1.1) possessing high cata
111 ged from the immunohistochemical analysis of carbonic anhydrases (CA) IX and XII expression in thyroi
113 f four human (h) isoforms of the zinc enzyme carbonic anhydrase, CA (EC 4.2.1.1), hCA I, II, IX, and
114 ncorporating 6- and 7-substituted coumarins (carbonic anhydrase, CA inhibitors) derivatized with clin
117 esults suggest that intra- and extracellular carbonic anhydrases can work in concert to ensure rapid
121 on between different Ci species catalyzed by carbonic anhydrases (CAs) are key components in the CCM,
123 mechanisms (CCMs) involving transporters and carbonic anhydrases (CAs) are well known, but the contri
128 cotransporter, suggesting that inhibition of carbonic anhydrases (CAs) confers the beneficial thiazid
129 version between CO2 and HCO3(-) catalyzed by carbonic anhydrases (CAs), and active inorganic carbon (
133 5-bisphosphate carboxylase/oxygenase and the carbonic anhydrase CcaA, whereas the C-terminal peptide
139 en alga Chlamydomonas reinhardtii, a luminal carbonic anhydrase, CrCAH3, was suggested to improve pro
140 For comparison we assayed recessive ca1ca4 carbonic anhydrase double mutant plants, based on their
141 recently isolated Arabidopsis thaliana beta-carbonic anhydrase double mutants (ca1 ca4) exhibit an i
142 Many microalgae induce an extracellular carbonic anhydrase (eCA), associated with the cell surfa
144 Clostridium perfringens strain 13, the only carbonic anhydrase encoded in the genome, was characteri
145 ing atmospheric CO2 elevation, including the carbonic-anhydrase-encoding genes CA1 and CA4 and the se
147 hloroplast are achieved by the activity of a carbonic anhydrase enzyme combined with the maintenance
149 possible clinical benefits of inhibitors of carbonic anhydrase enzymes and the water channel Aquapor
150 a subcomplex, containing the ancestral gamma-carbonic anhydrase (gamma-CA), gamma-carbonic anhydrase-
151 onic anhydrase gene (ca19) beyond the single carbonic anhydrase gene (ca18) that was known previously
153 LCI1, CCP1, CCP2 and LCIA) and mitochondrial carbonic anhydrase genes (CAH4 and CAH5) are up regulate
154 alysis and synteny studies suggest that both carbonic anhydrase genes form one or two independent gen
156 defined system of protein and ligands--human carbonic anhydrase (HCA) and a series of benzothiazole s
157 oldamer 2 was synthesized and bound to human carbonic anhydrase (HCA) using a nanomolar active site l
158 ss-coupling reactions and evaluated as human carbonic anhydrase (hCA, EC 4.2.1.1) inhibitors against
159 lly and pharmacologically relevant human (h) carbonic anhydrase (hCA, EC 4.2.1.1) isoforms, the cytos
163 against four physiologically relevant human carbonic anhydrases (hCAs, EC 4.2.1.1), isoforms hCA I,
164 Arg160His mutation of Haemophilus influenzae carbonic anhydrase (HICA), which mimics the endogenous m
167 Tryptic digestion of differentially labeled carbonic anhydrase I and hemoglobin allowed the identifi
168 ng these proteins, the strict association of carbonic anhydrase I and S100A8 with ECM was verified by
170 s, which was demonstrated by modification of carbonic anhydrase I with electrochemically generated re
173 of residual mobility in complexes of bovine carbonic anhydrase II (BCA) and para-substituted benzene
177 ts to analyze the direct interaction between carbonic anhydrase II (CAII) and MCT1, MCT2, and MCT4, r
180 f MCT1 and MCT4 is enhanced by the cytosolic carbonic anhydrase II (CAII) independent of its catalyti
186 onic acid, TPMA) to the active site of human carbonic anhydrase II (hCAII) has been investigated.
187 ione (1,2-HOPTO) in the active site of human carbonic anhydrase II (hCAII) has been investigated.
188 e corresponding inhibitor complexes of human carbonic anhydrase II (HCAII) indicated that HpalphaCA p
190 nvestigation of the CD spectrum of the Human Carbonic Anhydrase II (HCAII), with main focus on the ne
191 This paper uses the binding pocket of human carbonic anhydrase II (HCAII, EC 4.2.1.1) as a tool to e
193 res rapid conversion between CO2 and HCO3(-) Carbonic anhydrase II facilitates this reversible reacti
194 K, tartrate-resistant acid phosphatase, and carbonic anhydrase II in bone marrow macrophages (BMMs),
196 lls arise mainly from extrainsular PDX-1(+), carbonic anhydrase II(-) (mature ductal), elastase 3a (a
198 of the selected scFvs was shown to recognize carbonic anhydrase II, an up-regulated enzyme involved i
200 lated known genes, whereas Srpx2, Cd200, and carbonic anhydrase III (CAIII) were identified as novel
202 Carbonic anhydrase XII (CA12) is the key carbonic anhydrase in epithelial fluid and HCO3 (-) secr
203 resolved kinetics for dansylamide binding to carbonic anhydrase in solutions crowded with polyethylen
205 roportion of Rubisco and the thylakoid lumen carbonic anhydrase in the pyrenoid rose substantially, c
206 we investigate the repertoire of cytoplasmic carbonic anhydrases in the sea lamprey (Petromyzon marin
208 ich was sensitive to Na(+)withdrawal, to the carbonic anhydrase inhibitor acetazolamide and to H2DIDS
209 tment of B. pertussis-infected mice with the carbonic anhydrase inhibitor acetazolamide reduced lung
216 In this connection, we report a new class of carbonic anhydrase inhibitors, based on the thiopyrano-f
217 ation, use of topical beta blockers, topical carbonic anhydrase inhibitors, daily dose of BAK, and gl
218 Other glaucoma medications (beta blockers, carbonic anhydrase inhibitors, parasympathomimetics, and
219 the dye were more potent agents with higher carbonic anhydrase inhibitory action than the parent dye
220 ished nitrite bioactivation, but the role of carbonic anhydrase is abrogated when physiological conce
221 H(+)-extrusion mechanisms and extracellular carbonic anhydrase, is responsible for active transport-
222 was also observed, in line with patterns of carbonic anhydrase isoform expression in those tissues.
224 n efficiency within 1400-fold of the fastest carbonic anhydrase isoform, CAII, and 11-fold of CAIII.
226 luated as inhibitors of the ubiquitous human carbonic anhydrase isoforms I, II, IX, XII, and XIV usin
227 t that the human genome encodes 15 different carbonic anhydrase isoforms that have a high degree of h
228 rs (encoded by Slc26a4, Slc4a8, and Slc4a9), carbonic anhydrase isoforms, and V-type H(+)-ATPase subu
230 -the-haystack" screen for inhibitors against carbonic anhydrase isozyme II is performed, in which kno
238 n of hypoxic tumors is possible by targeting carbonic anhydrase IX (CA IX), an enzyme overexpressed i
242 of tumor hypoxia is activated expression of carbonic anhydrase IX (CA9), a regulator of pH and tumor
243 chemical technique, using antibodies against carbonic anhydrase IX (CAIX) and copper pumps (Ctr1 and
244 body-mediated therapy with the chimeric anti-carbonic anhydrase IX (CAIX) antibody girentuximab (cG25
249 CC tumors, which also express high levels of carbonic anhydrase IX (CAIX), a HIF1-dependent protein.
250 o facilitate the intraoperative detection of carbonic anhydrase IX (CAIX)-expressing tumor lesions wi
253 armacodynamics from tumor biomarkers such as carbonic anhydrase IX and topoisomerase I by immunohisto
255 is a chimeric monoclonal antibody that binds carbonic anhydrase IX, a cell surface glycoprotein ubiqu
256 escribed a novel acetazolamide derivative, a carbonic anhydrase ligand with high affinity for the tum
257 ty to CO(2), native extra- and intracellular carbonic anhydrase-like activities, the non-CO(2)/HCO(3)
258 l gamma-carbonic anhydrase (gamma-CA), gamma-carbonic anhydrase-like, and 20.9-kDa subunits, had a si
259 valent system comprising synthetic dimers of carbonic anhydrase linked chemically through thiol group
264 Contrastingly, transcripts of chloroplast carbonic anhydrases namely CAH6, CAH3 and LCIB are up re
267 D-ME cycle via an aspartate-alanine shuttle, carbonic anhydrase, phosophoenolpyruvate carboxylase, al
269 of incubation at 750 microatm pCO2, reduced carbonic anhydrase protein activity and shell growth occ
270 ient CO2 We identified CAH1 as an alpha-type carbonic anhydrase, providing a biochemical role in CCM
271 rey metamorphosis resulting in distinct gill carbonic anhydrases reflecting the contrasting life mode
272 aria susceptibility in the murine model, and carbonic anhydrase, reflecting the blood's abnormal acid
274 munoisolated from mouse brain, we identified carbonic anhydrase-related proteins CA10 and CA11, two h
275 ditions we find dorzolamide (an inhibitor of carbonic anhydrase) results in diminished nitrite bioact
276 showed reduced expression of colonic villin, carbonic anhydrase, secretory mucin muc2, and increased
277 beta-lactoglobulin (five peptides), 25% for carbonic anhydrase (six peptides), and 51% for bovine se
278 e, biotin, mannose) against matched targets (carbonic anhydrase, streptavidin, concanavalin A) to ide
280 ely conserved proteins containing domains of carbonic anhydrase, Sushi, Von Willebrand factor type A,
283 M) approximately 10(5)-10(8) M(-1) s(-1) for carbonic anhydrase, the most efficient catalyst of CO(2)
285 1,5-bisphosphate carboxylase/ oxygenase and carbonic anhydrase to facilitate carbon fixation in cyan
287 68 and mannose receptor-positive, expressing carbonic anhydrase type II, but relatively low levels of
290 cyclen, a small molecule mimic of the enzyme carbonic anhydrase, was evaluated under rigorous conditi
291 died: ribonuclease A, trypsin inhibitor, and carbonic anhydrase, where the latter had impurities of s
292 larly sodium bicarbonate co-transporters and carbonic anhydrases, which were also expressed in LAM lu
294 robenzoarylsulfonamide ligands bind to human carbonic anhydrase with a conserved binding geometry, an
298 n of one specific gene in the FLC signature, carbonic anhydrase XII (CA12), at the protein level by w
299 Here we describe variants in CA12 encoding carbonic anhydrase XII in two pedigrees exhibiting CF-li
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