ライフサイエンスコーパス: carbonic anhydrase II

1 rker tartrate-resistant acid phosphatase, or carbonic anhydrase II.

2 ibrary of fluoroaromatic inhibitors of F131V carbonic anhydrase II.

3 nhibitor (K(d) approximately 30 pM) of human carbonic anhydrase II.

4 nding of Zn(II), Cu(II), and Co(II) to human carbonic anhydrase II.

5 ding of the crystal lattice of Phe-131-->Val carbonic anhydrase II.

6 t kinase and a panel of compounds binding to carbonic anhydrase II.

7 from the large subunit of Rubisco and human carbonic anhydrase II.

8 ton transfers in two solution systems and in Carbonic Anhydrase II.

9 ted expression of the differentiation marker carbonic anhydrase II.

10 fer, who used this method to renature bovine carbonic anhydrase II.

11 is associated with mutations in cytoplasmic carbonic anhydrase II.

12 ithm was used to design inhibitors for human carbonic anhydrase II.

13 of the selected scFvs was shown to recognize carbonic anhydrase II, an up-regulated enzyme involved i

14 trated diminished or no immunoreactivity for carbonic anhydrase II and calretinin in the retinal laye

15 Four doubly spin-labeled variants of human carbonic anhydrase II and corresponding singly labeled v

16 Human carbonic anhydrase II and rat liver arginase serve as we

17 his approach using the 29 kDa protein, human carbonic anhydrase II and the 30 kDa protein, calbindin

18 chemistry using antibodies against vimentin, carbonic anhydrase II, and glutamine synthetase.

19 Human carbonic anhydrase II, and possibly carbonic anhydrase I

20 Y64H/F65A murine CAV, wild-type human alpha-carbonic anhydrase II, and the gamma-carbonic anhydrase

21 far, autoantibodies against lactoferrin and carbonic anhydrase II are most frequently detected in se

22 Using carbonic anhydrase II as a model system, we characterize

23 We have reported previously that carbonic anhydrase II augments transport activity of MCT

24 uted benzenesulfonamide inhibitors to bovine carbonic anhydrase II (BCA II), the observed thermodynam

25 of residual mobility in complexes of bovine carbonic anhydrase II (BCA) and para-substituted benzene

26 the thermodynamics of association of bovine carbonic anhydrase II (BCA) and para-substituted benzene

27 of the lysine epsilon-NH3+ groups of bovine carbonic anhydrase II (BCA).

28 to follow a globular metalloprotein--bovine carbonic anhydrase II (BCA, EC 4.2.1.1)--on unfolding up

29 A (RNaseA), cyclophilin A (CypA), and bovine carbonic anhydrase II (BCAII).

30 A (RNaseA), cyclophilin A (CypA), and bovine carbonic anhydrase II (BCAII).

31 ntly identified as a weak inhibitor of human carbonic anhydrase II by Iyer et al.

32 ne-rich proteins, lactoferrin, lysozyme, and carbonic anhydrase II by probing in vivo pellicle with s

33 ent homology, using the crystal structure of carbonic anhydrase II (CA II) and the sequence of CA IX,

34 Others report that carbonic anhydrase II (CA II) binds to the C termini of

35 We present a new approach to carbonic anhydrase II (CA II) inhibitor design that enab

36 s investigators suggested that intracellular carbonic anhydrase II (CA II) interacts at high affinity

37 a covalently attached sulfonamide ligand to carbonic anhydrase II (CA II) resulted in the inhibition

38 these assays, we determined the affinity of carbonic anhydrase II (CA II), a prototypical zinc enzym

39 r binding affinity to the zinc metalloenzyme carbonic anhydrase II (CA II).

40 a fragment screening campaign against human carbonic anhydrase II (CA II).

41 ed cells was confirmed by immunodetection of carbonic anhydrase II (CA-II), cellular retinaldehyde-bi

42 ed cells was confirmed by immunodetection of carbonic anhydrase II (CA-II), cellular retinaldehyde-bi

43 g topiramate ( 1) is a moderate inhibitor of carbonic anhydrase-II (CA-II) ( K i or K d = 0.3-0.6 mic

44 Binding experiments for a model system of carbonic anhydrase-II (CA-II) analyte and immobilized 4-

45 ulfamide derivatives for inhibition of human carbonic anhydrase-II (CA-II) by using a direct binding

46 e and sulfamide groups for the inhibition of carbonic anhydrase-II (CA-II).

47 ), sodium-bicarbonate transporter (NBC), and carbonic anhydrase II (CA2) increased 5- to 10-fold.

48 ted by the AE1 anion exchanger is reduced by carbonic anhydrase II (CA2) inhibition or by prevention

49 ts to analyze the direct interaction between carbonic anhydrase II (CAII) and MCT1, MCT2, and MCT4, r

50 P1 has two acidic motifs homologous to known carbonic anhydrase II (CAII) binding sequences.

51 We have recently shown that carbonic anhydrase II (CAII) binds in vitro to the C-ter

52 The three-dimensional structure of human carbonic anhydrase II (CAII) complexed with the sulfonam

53 Carbonic anhydrase II (CAII) deficiency in humans is ass

54 In nature, the zinc metalloenzyme carbonic anhydrase II (CAII) efficiently catalyzes the c

55 s surrounding the zinc binding site of human carbonic anhydrase II (CAII) in determining the metal io

56 f MCT1 and MCT4 is enhanced by the cytosolic carbonic anhydrase II (CAII) independent of its catalyti

57 ic residues in the hydrophobic core of human carbonic anhydrase II (CAII) influence metal ion binding

58 The catalytic zinc ion of human carbonic anhydrase II (CAII) is coordinated by three his

59 e generated transgenic mice expressing human carbonic anhydrase II (CAII) promoter: Cre recombinase (

60 In carbonic anhydrase II (CAII) residues Phe93, Phe95, and

61 A65F, A65L, A65H, A65T, A65S, and A65G human carbonic anhydrase II (CAII) variants have been solved b

62 Carbonic anhydrase II (CAII)(Cre);Pdx1(Fl) mice were eug

63 factors that dictate the proton transfer in carbonic anhydrase II (CAII), an enzyme that has been us

64 ctivity of a prototypical zinc enzyme, human carbonic anhydrase II (CAII), and a number of active sit

65 Immunohistochemical staining for NHE3, carbonic anhydrase II (CAII), and aquaporin-I (AQP1) was

66 ed with doxorubicin induce the expression of carbonic anhydrase II (CAII), inhibitor of differentiati

67 However, E117 of human carbonic anhydrase II (CAII), which is part of the E117-

68 TFGs containing CB[6]- and carbonic anhydrase II (CAII)-binding domains were synthe

69 terminus of the anion exchanger AE1 binds to carbonic anhydrase II (CAII).

70 4, a biomarker in esophageal tumorigenesis), carbonic anhydrase II (CAII, a regulator of acid-base ho

71 rase I (CAI, approximately 7 amol/cell), and carbonic anhydrase II (CAII, approximately 0.8 amol/cell

72 tive stabilities of noncovalent complexes of carbonic anhydrase II (CAII, EC 4.2.1.1) and benzenesulf

73 ct complexes detected in lysed RBCs included carbonic anhydrase II (CAII-Zn at approximately 0.8 amol

74 Acetazolamide (222 g/mol) binding to carbonic anhydrase II (CAII; 30000 Da) was chosen as a m

75 fied by positive staining for H+ -ATPase and carbonic anhydrase II constituted 35% to 40% of all cell

76 s to search for tight binding inhibitors for carbonic anhydrase II (EC 4.2.1.1).

77 When the technique was applied to bovine carbonic anhydrase II, even combining data from several

78 etric stretching vibration of azide bound to carbonic anhydrase II exhibits a pronounced evolution of

79 ) other than laminin-1 that can sustain both carbonic anhydrase II expression and, possibly, the capa

80 estingly, there appeared to be a decrease in carbonic anhydrase II expression over time when the epit

81 specific cytodifferentiation, in the form of carbonic anhydrase II expression, is not necessarily cou

82 res rapid conversion between CO2 and HCO3(-) Carbonic anhydrase II facilitates this reversible reacti

83 The kinetics of refolding of carbonic anhydrase II following transfer from a buffer c

84 owns (melittin, ubiquitin, GroES, myoglobin, carbonic anhydrase II), from more than 1000 possible dat

85 The rat carbonic anhydrase II gene was characterized and found t

86 med on was sections using antibodies against carbonic anhydrase II, H+ -ATPase and Band 3 protein.

87 ites of human carbonic anydrase I and bovine carbonic anhydrase II have been targeted for cleavage by

88 te kinase (PK), lactate dehydrogenase (LDH), carbonic anhydrase II, Hb, and band 3 (AE1).

89 Human carbonic anhydrase II (HCA II) catalyzes the reversible

90 Histidine 64 in human carbonic anhydrase II (HCA II) functions in the catalyti

91 nt in the site-specific mutant N67L of human carbonic anhydrase II (HCA II) has been examined by kine

92 Human carbonic anhydrase II (HCA II) is a monomeric zinc-conta

93 Human carbonic anhydrase II (HCA II) is a zinc-metalloenzyme t

94 Histidine at position 64 (His64) in human carbonic anhydrase II (HCA II) is believed to be the pro

95 The catalysis of CO(2) hydration by human carbonic anhydrase II (HCA II) is limited in maximal vel

96 Catalysis by the zinc metalloenzyme human carbonic anhydrase II (HCA II) is limited in maximal vel

97 Human carbonic anhydrase II (HCA II) is one of the fastest kno

98 The crystal structure of human carbonic anhydrase II (HCA II) obtained at 0.9 A resolut

99 all molecule rescue of mutant forms of human carbonic anhydrase II (HCA II) occurs by participation o

100 ity of catalysis of CO(2) hydration by human carbonic anhydrase II (HCA II) requires proton transfer

101 Human carbonic anhydrase II (HCA II) uses a Zn-bound OH(-)/H2O

102 Variants of human carbonic anhydrase II (HCA II) with amino acid replaceme

103 13C and 1H(N)/15N chemical shifts for human carbonic anhydrase II (HCA II), a 259 residue 29 kDa met

104 xide and dehydration of bicarbonate by human carbonic anhydrase II (HCA II), a histidine residue (His

105 Human carbonic anhydrase II (HCA II), among the fastest enzyme

106 In human carbonic anhydrase II (HCA II), the mutation of position

107 have utilized the recombinant form of human carbonic anhydrase-II (hCA-II) as the enzyme source and

108 interaction energy between the protein human carbonic anhydrase II (HCAII) and the fluorine-substitut

109 onic acid, TPMA) to the active site of human carbonic anhydrase II (hCAII) has been investigated.

110 ione (1,2-HOPTO) in the active site of human carbonic anhydrase II (hCAII) has been investigated.

111 e corresponding inhibitor complexes of human carbonic anhydrase II (HCAII) indicated that HpalphaCA p

112 The binding of sulfonamides to human carbonic anhydrase II (hCAII) is a complex and long-deba

113 te derivatives against steroid sulfatase and carbonic anhydrase II (hCAII) was also observed, and the

114 nvestigation of the CD spectrum of the Human Carbonic Anhydrase II (HCAII), with main focus on the ne

115 This paper uses the binding pocket of human carbonic anhydrase II (HCAII, EC 4.2.1.1) as a tool to e

116 H2Ph)NH3+) bound at the active site of human carbonic anhydrase II (HCAII; E.C. 4.2.1.1).

117 23 is nonestrogenic and potently inhibits carbonic anhydrase II (IC(50) 86 nM).

118 seizures, with very weak inhibition of human carbonic anhydrase-II (IC(50) = 110 microM).

119 K, tartrate-resistant acid phosphatase, and carbonic anhydrase II in bone marrow macrophages (BMMs),

120 alpha methylacyl racemase in papillary RCC, carbonic anhydrase II in chromophobe RCC and K19 in TCC.

121 te crystal growth and inducing expression of carbonic anhydrase II in monocytic cells and promoting a

122 ohistochemistry demonstrated the presence of carbonic anhydrase II in these cells.

123 nd was observed in a site-specific mutant of carbonic anhydrase II in which a prominent proton shuttl

124 mino acids of varying size at position 65 in carbonic anhydrase II (including four amino acids found

125 yzed by a Co(II)-substituted mutant of human carbonic anhydrase II is analyzed to show the rate of re

126 Deprotonation of zinc-bound water in carbonic anhydrase II is the rate-limiting step in the c

127 These include mutations of genes encoding carbonic anhydrase II, kidney anion exchanger 1, and dif

128 lls arise mainly from extrainsular PDX-1(+), carbonic anhydrase II(-) (mature ductal), elastase 3a (a

129 a negatively charged transition state in the carbonic anhydrase II mechanism, whereas a neutral trans

130 he model proteins in this study (calmodulin, carbonic anhydrase II, RmlB, Bcl-xL) were chosen to test

131 zed benezenesulfonamide complexed with human carbonic anhydrase II shows how an encapsulated xenon at

132 above background) against albumin, amylase, carbonic anhydrase II, sIgA, IgG, IgM, lactoferrin, lyso

133 on catalyzed by the zinc-metalloenzyme human carbonic anhydrase II, the binding of substrate CO(2), f

134 Proteolipid protein and carbonic anhydrase-II transcripts, measured by real-time

135 sulfonamide inhibitors binding to the enzyme carbonic anhydrase II using Biacore optical biosensors.

136 selective labeling of purified HCA II (human carbonic anhydrase II) was achieved.

137 t of small-molecule inhibitors of the enzyme carbonic anhydrase II, we tested the reproducibility, se

138 cidic protein or oligodendrocytes expressing carbonic anhydrase II were found to co-express Kir6.2 mR

139 A series of charge ladders of bovine carbonic anhydrase II were synthesized and the relative

140 three proteins (ubiquitin, cytochrome c, and carbonic anhydrase II) were investigated.

141 ants were provided with reagents (the enzyme carbonic anhydrase II, which was immobilized onto the se

142 mponent that specifically binds and inhibits carbonic anhydrase II with nanomolar affinity.

143 ncreatic duct cell-specific differentiation (carbonic anhydrase II) without ductal morphogenesis was