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1 ,5beta,17beta)-3-hydroxy-18-norandrostane-17-carbonitrile).
2 synthetic steroid PCN (pregnenolone-16alpha-carbonitrile).
3 ucleophilic cyclization to the corresponding carbonitrile.
4 uch as dexamethasone or pregnenolone-16alpha-carbonitrile.
5 ifampicin but not with pregnenolone-16 alpha-carbonitrile.
6 high concentrations of pregnenolone 16 alpha-carbonitrile.
7 of 4-imino-3-phenyl-3,4-dihydroquinazoline-2-carbonitrile.
8 but not the PXR ligand pregnenolone 16alpha-carbonitrile.
9 {[(tert-butyldimethylsilyl)oxy]methyl}phenyl)carbonitrile.
10 dition-methylations to 3-oxo-1-cyclohexene-1-carbonitrile.
11 everal 1-anilino-6,7-dimethoxyisoquinoline-4-carbonitriles.
12 , 6,7-dialkoxy-4-oxo-1, 4-dihydroquinoline-3-carbonitriles.
13 midopentanoate and 2, 4-diaminoquinazoline-6-carbonitriles.
14 romophenyl)-4-imino-3,4-dihydroquinazoline-2-carbonitriles.
15 cyclization produces 5,6-dihydroindolizine-5-carbonitriles.
16 tive monoarylation was observed with primary carbonitriles.
17 ative to the preparation of alpha-heteroaryl carbonitriles.
19 midazo[1,2-b][1,2,4]triazin- 7-yl]biphenyl-2-carbonitrile (1), an orally active GABA(A) alpha(2/3)-se
20 oro-4'-(alpha-d-mannopyranosyloxy)biphenyl-4-carbonitrile (10j) a FimH antagonist with an optimal in
21 17(20)-ene modification as in 17(20)-ene-20-carbonitrile (14) did not increase activity in compariso
22 Eight 2-phenyl-3H-imidazo[4,5-b]quinoline-9-carbonitriles 15 are prepared in four steps from N'-aryl
24 mediate 2,4-diaminopyrido[2,3-d]pyrimidine-6-carbonitrile 16 with the appropriate anilines afforded t
26 nyl)piperazine-1-carbonyl)-10H-phenoxazine-3-carbonitrile (16o), showed excellent antiproliferative p
28 mino-7-benzylpyrrolo[2,3-d][1,2,3]triazine-5-carbonitrile (19) and 2-amino-1-benzylpyrrole-3,4-dicarb
29 fected mice with 4-phenyl-1,2,5-oxadiazole-3-carbonitrile-2-oxide led to marked reductions in worm bu
31 bofuranosyl)pyrrolo[2,3-d][1,2,3]t riazine-5-carbonitrile (26) and 2-amino-1-(2,3,5-tri-O-benzoyl-bet
32 hydro-1 H-indol-5-yl)-1-methyl-1 H-pyrrole-2-carbonitrile 27 (WAY-255348), which demonstrated potent
33 7is prepared from either 5-diazoimidazole-4-carbonitrile (28) and methyl isocyanate or by diazotizat
36 phenyl)-furan-2-yl]-imidazo[1,2-a]pyridine-6-carbonitrile (4a), through the bis-O-acetoxyamidoxime fo
38 mines 3, and 6H-pyrazolo[3,4-c]isothiazole-3-carbonitriles 5, together with several minor side produc
39 ituted 4,6-diaminopyrrolo[2,3-d]pyrimidine-5-carbonitrile, -5-carboxamide, and -5-thiocarboxamide ana
40 ubstituted 4-aminopyrrolo[2,3-d]pyrimidine-5-carbonitrile, -5-carboxamide, and -5-thiocarboxamide der
41 4,6-dimethyl-6H-pyrazolo[3,4-c]isothiazole-3-carbonitrile (5a) and helps resolve a previous incorrect
43 opyl-4,7-dihydropyrazolo[1,5-a]p yrimidine-3-carbonitrile 61 significantly raised the circulating lev
44 gives 5H-pyrazolo[3,4-e][1,2,4]dithiazine-3-carbonitriles 7 in good yields (74-85%) and 6H-pyrazolo[
45 methyl-5H-pyrazolo[3,4-e][1,2,4]dithiazine-3-carbonitrile (7a) gave 1,3-dimethyl-6H-pyrazolo[3,4-f][1
46 7-oxo-7,8-dihydro-pyrid o[2,3-d]pyrimidine-6-carbonitrile (7x), was found to be the most active, indu
48 l-6H-pyrazolo[3,4-f][1,2,3,5]trithiazepine-4-carbonitrile (9a), but on prolonged reaction times, it g
49 icaciously activated by pregnenolone 16alpha-carbonitrile, a glucocorticoid receptor antagonist that
52 (+)-3alpha-hydroxy-5alpha-androstane-17beta-carbonitrile [(+)-ACN], a neuroactive steroid, had no ef
54 M), 1-(2-amino-3-methyl-butyryl)-azetidine-2-carbonitrile (AMAC), which has shown efficacy in two est
56 the results obtained with the rigid 17 beta-carbonitrile analogs were analyzed using molecular model
57 sultant 7-phenylaminothieno[3,2-b]pyridine-6-carbonitrile analogues show potent inhibition of Src kin
58 (+)-3alpha-hydroxy-5alpha-androstane-17beta-carbonitrile and (+)-3alpha-hydroxy-5alpha-pregnan-20-on
59 oxyethoxy)methyl]pyrrolo[2,3-d]-pyrimidine-5-carbonitrile and -5-thiocarboxamide derivatives and seve
60 1-phenyl-2,3,5,6,7,8-hexahydroisoquinoline-4-carbonitrile and 1-alkyl-3-oxo-3,5,6,7-tetrahydro-2H-cyc
61 for dexamethasone and pregnenolone 16 alpha-carbonitrile and may explain the mechanism by which low
62 accessible 1,2,3,4-tetrahydroisoquinoline-1-carbonitriles and 1,2-bis(bromomethyl)arenes is describe
63 is applicable to both primary and secondary carbonitriles and a wide range of heteroaryl halides.
64 tosteroids or 3 alpha-hydroxysteroid-17 beta-carbonitriles and which contained various methyl group s
65 3alpha,5alpha,17beta)-3-hydroxyandrostane-17-carbonitrile) and B285 ((3alpha,5beta,17beta)-3-hydroxy-
67 roclor 1254, isoniazid, pregnenolone 16alpha-carbonitrile, and clofibrate) or the general P450 inhibi
68 coupling of 4-(2-bromoanilino)quinazoline-2-carbonitrile; and (3) a nonoxidative Pd(Ar3P)3 [Ar = 3,5
70 propriately substituted 4-anilinoquinoline-3-carbonitriles are potent inhibitors of Src kinase, with
73 , providing the 4-anilinobenzo[g]quinoline-3-carbonitriles as a series with enhanced Src inhibitory p
74 cocorticoid antagonist pregnenolone 16 alpha-carbonitrile at 100 microM blocks dexamethasone binding
75 enylacetones to substituted 2-oxo-2H-pyran-3-carbonitriles at room temperature under alkaline conditi
76 bled monolayers of 1,3,5-tris(4'-biphenyl-4"-carbonitrile)benzene, a large functional trinitrile mole
77 -hydroxy ethyl)-3a-methyl-1H-benz[e]indene-3-carbonitrile (BI-2) using single-channel patch-clamp and
79 (+)-3alpha-hydroxy-5alpha-androstane-17beta-carbonitrile blocked responses to acetylcholine (IC50, 1
80 ipine, clotrimazole, or pregnenolone 16alpha-carbonitrile, but not microsomes from control, dexametha
82 -alkoxyamino-5-(pyridin-2-ylamino)pyrazine-2-carbonitrile CHK1 inhibitors was generated by hybridizat
84 lanilino)-6-pyrrolidin-1-yl-1,3,5-triazine-2-carbonitrile (CP243522), showed a K(i) of 21 nM and was
85 -dimethylamino-3-methyl-butyryl)-azetidine-2-carbonitrile (DAMAC), that does not inhibit DPP IV, was
86 The dexamethasone- and pregnenolone 16alpha-carbonitrile-dependent induction of MRP2 expression was
87 l molecules, including a tetrahydroquinoline carbonitrile derivative (S010-0261), that inhibit the Mt
89 of of 6,7-disubstituted-4-anilinoquinoline-3-carbonitrile derivatives that function as irreversible i
90 w 6,7-disubstituted-4-(arylamino)quinoline-3-carbonitrile derivatives that function as irreversible i
91 ,5,6,7-tetrahydro-2H-cyclopenta[c]pyridine-4-carbonitrile distributes to the brain, indicating that i
93 r, (3beta,5alpha,17beta)-17-hydroxyestrane-3-carbonitrile (ECN), a novel neuroactive steroid and sele
94 f (3beta,5alpha, 17beta)-17-hydroxyestrane-3-carbonitrile [(+)-ECN] on GABAA receptors and Ca2+ chann
95 3-hydroxy-13,24-cyclo-18-norcholan-20-ene-21-carbonitrile, eltanolone, 5beta-pregnan-3alpha,21-diol-2
96 ng-annulation reaction of 2-chloroqunoline-3-carbonitriles enabled the direct synthesis of sulfur-sub
97 on a BN/Cu(111) template by codeposition of carbonitrile-functionalized porphyrin derivatives (2H-TP
98 f Grignard reagents to 3-oxocyclohex-1-ene-1-carbonitrile generates C-magnesiated nitriles whose alky
99 ich shows that the aniline group at C-4, the carbonitrile group at C-3, and the alkoxy groups at C-6
100 r polyphenyl molecular linkers with terminal carbonitrile groups on a smooth Ag(111) noble-metal surf
103 oxidative coupling of 4-anilinoquinazoline-2-carbonitriles in neat trifluoroacetic acid (TFA); (2) a
106 series of 4-anilino-6, 7-dialkoxyquinoline-3-carbonitrile inhibitors of epidermal growth factor recep
107 amino-4-(3-pyridyl)-4H-naphtho(1,2-b)pyran-3-carbonitrile, is a potent antiproliferative compound tha
108 rpholin-4-yl-ethyl)phenylami no]pyrimidine-5-carbonitrile (JNJ-17029259) represents a novel structura
111 proposed 8-oxo-8H-acenaphtho[1,2-b]pyrrol-9-carbonitrile led to a structural revision, and the produ
112 ships for additional thieno[3,2-b]pyridine-6-carbonitriles, modifying the substituents on the C-2 phe
113 4-diazepan-1- yl)sulfonyl)phenyl)quinoline-3-carbonitrile (NEU-924, 83) for T. cruzi and N-(3-chloro-
114 with dexamethasone or pregnenolone-16 alpha-carbonitrile only if consensus II sequences were include
115 given the PXR agonist, pregnenolone-16alpha-carbonitrile, or the herbal medicine, St John's wort, ch
116 ce with the PXR agonist pregnenolone-16alpha-carbonitrile (PCN) activated Akr1b7 gene expression, whe
117 ries to the PXR ligands pregnenolone-16alpha-carbonitrile (PCN) and dexamethasone increased p-glycopr
118 ment with PXR activator pregnenolone 16alpha-carbonitrile (PCN) down-regulated the mRNA levels of car
119 he activation of PXR by pregnenolone 16alpha-carbonitrile (PCN) in AKR/J mice can prevent the develop
120 phenobarbital (PB) and pregnenolone-16alpha-carbonitrile (PCN) occurs via increased hepatic expressi
121 ne X receptor activator pregnenolone-16alpha-carbonitrile (PCN) or the Ah receptor ligand 2,3,7,8-tet
122 Treatment of rats with pregnenolone-16alpha-carbonitrile (PCN), a ligand for the rodent pregnane X r
123 tment with 5-pregnen-3beta-ol-20-one-16alpha-carbonitrile (PCN), followed by an increase in Cyp3a11 m
124 atoxic steroids such as pregnenolone 16alpha-carbonitrile (PCN), which induce cytochrome P450 3A (CYP
125 nd 20-day pregnant, and pregnenolone-16alpha-carbonitrile (PCN)-treated rats using in vivo metabolic-
126 ,5,6,7-tetrahydro-2H-cyclopenta[c]pyridine-4-carbonitrile PREPL inhibitors that are able to block PRE
127 ydroxy-aryl-5,6,7,8-tetrahydroisoquinoline-4-carbonitriles represent interesting chemical scaffolds,
129 of 5-((4-aminopyridin-2-yl)amino)pyrazine-2-carbonitriles resulted in the identification of a potent
130 4-(thiazol-5-yl)-2-(phenylamino)pyrimidine-5-carbonitrile series results from the relative malleabili
131 4-(thiazol-5-yl)-2-(phenylamino)pyrimidine-5-carbonitrile series that bind to both CDK9/cyclin T and
132 roxy-2-methyl-3-phenoxypropanoyl)-indoline-4-carbonitriles showed potent binding to the androgen rece
133 analogously substituted 4-anilinoquinoline-3-carbonitrile SKI-606, which is undergoing evaluation in
137 ntermediate, 6-acetamido-4-chloroquinoline-3-carbonitrile, that involved a safer cyclization step.
138 [(3beta,5beta,17beta)-3-hydroxyandrostane-17-carbonitrile] that was also the most effective blocker o
139 ,3,4-tetrahydrobenzo[b][1,6]naph thyridine-8-carbonitrile, the most potent compound, has an excellent
140 P mice over 7 days with pregnenolone-16alpha-carbonitrile to activate the nuclear receptor pregnane X
142 ats, dexamethasone and pregnenolone-16 alpha-carbonitrile treatment elevated ring hydroxylation up to
143 totypical CYP3A inducer pregnenolone 16alpha-carbonitrile was restricted to constructs containing the
144 (1-(3-(2-chlorophenoxy) propyl)-1H-indole-3-carbonitrile) was identified as a small molecule that bl
146 (-)-3alpha-hydroxy-5alpha-androstane-17beta-carbonitrile were consistent with the hypothesis that po
147 tained or replaced with a 4-aminoquinoline-7-carbonitrile were synthesized in an effort to improve dr
148 halophenyl)-2-benzoylthieno[2,3-b]pyridine-5-carbonitriles were discovered as a new class of PfGSK-3
149 e 8-substituted-4-anilino-6-aminoquinoline-3-carbonitriles were prepared from the appropriate 2-subst
150 -phenyl-7-phenylaminothieno[3,2-b]pyridine-6-carbonitriles were recently reported to be inhibitors of
151 yl-1H-imidazol-4-yl)methylamin o]quinoline-3-carbonitrile, which demonstrated in vitro as well as in
153 dative couplings of 3,4-dihydro-2H-pyrrole-2-carbonitriles with copper(II)-salts furnished 2,2'-bipyr
154 ation of 4-chloro-6-(crotonamido)quinoline-3-carbonitriles with monocyclic or bicyclic anilines.
155 cylation of 6-amino-4-(arylamino)quinoline-3-carbonitriles with unsaturated acid chlorides or by amin
156 cylation of 6-amino-4-(arylamino)quinoline-3-carbonitriles with unsaturated acid chlorides or mixed a
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