ライフサイエンスコーパス: carbonyl oxygen

1 ing also forms a strong hydrogen bond with a carbonyl oxygen.

2 ction is stabilized by delocalization to the carbonyl oxygen.

3 ng the reformation of a hydrogen bond to the carbonyl oxygen.

4 from the o-methyl group to the excited state carbonyl oxygen.

5 on distribution to the benzoyl-CoA thioester carbonyl oxygen.

6 ino substituents led to sulfonylation of the carbonyl oxygen.

7 be either the amino nitrogen or the carboxy carbonyl oxygen.

8 between the head group choline and the sn-2 carbonyl oxygen.

9 in a direct hydrogen bond with either of the carbonyl oxygens.

10 ains form intrahelical H-bonds with upstream carbonyl oxygens.

11 trongly with both lipid headgroup and linker carbonyl oxygens.

12 n the center of the helix and bonding to the carbonyl oxygens.

13 that rocks in a PSI domain socket lined with carbonyl oxygens.

14 he metal in the holo-enzyme by the C3 and C4 carbonyl oxygens.

15 carbonyl carbon (13k = 1.028 +/- 0.001), the carbonyl oxygen (18k = 0.9945 +/- 0.0009), the nucleophi

16 raction between copper and the Gly45 peptide carbonyl oxygen [2.6 A for Cu(II)] than had been recogni

17 different probes: a charged NH+3nitrogen, a carbonyl oxygen, a hydroxyl oxygen and a methyl carbon a

18 ogen-bonding relaxation times at the favored carbonyl oxygen acceptor sites also have the largest ord

19 epoxide hydrolase active site, and each urea carbonyl oxygen accepts hydrogen bonds from the phenolic

20 In one enzyme-inhibitor complex, the urea carbonyl oxygen additionally interacts with Gln(382).

21 equally between the peptide nitrogen and the carbonyl oxygen also reduces the correlation to the expe

22 l chemical motif: hydrogen bonding between a carbonyl oxygen and an aromatic hydrogen atom.

23 imal interaction of distal residues with the carbonyl oxygen and another, acidic form in which the ox

24 m a hydrogen bonding interaction between the carbonyl oxygen and dG.

25 s are direct interactions of the beta-lactam carbonyl oxygen and nitrogen with the zinc ions and of t

26 ing dimer interact respectively with the C-2 carbonyl oxygen and one C-1 carboxylate oxygen of the ad

27 ydrogen bonds to five residues, three to the carbonyl oxygen and one for each--NH group.

28 or K+ by dual coordination with the backbone carbonyl oxygen and side chain hydroxyl of the same resi

29 - and/or HO-) occurs at the Asn47 side chain carbonyl oxygen and that an Asn47-Cys112 hydrogen bond p

30 step by forming a hydrogen bond between its carbonyl oxygen and the C4a-hydroperoxyflavin.

31 nt at a minor steric interaction between the carbonyl oxygen and the flanking phenyl group.

32 drogen bond appears to occur between the POB carbonyl oxygen and the partner dC's second amino proton

33 at the placement of H-bonds to the inhibitor carbonyl oxygen and the positioning of the catalytic bas

34 show strong hydrogen bonding between urea's carbonyl oxygen and the positively charged solute.

35 ted distance of 2.78 A between the carbamate carbonyl oxygen and the proton to be removed are favorab

36 ion that involves initial interaction at the carbonyl oxygen and which has the effect of polarizing t

37 uch as the regular H-bonding pattern between carbonyl oxygens and amide H(+)s four residues apart in

38 dimers as well as hydrogen bonds to benzoyl carbonyl oxygens and lattice water molecules.

39 in primarily by hydrogen bonds with backbone carbonyl oxygens and peptidic NH groups.

40 bonding interactions between the glutathione carbonyl oxygens and the amide protons of thioredoxin re

41 ngth of hydrogen bonding between the quinone carbonyl oxygens and the urea N-hydrogens.

42 the divalent metal ion by C1-carboxyl and C2-carbonyl oxygens and water molecule W4 that is within cl

43 Determination of the carbonyl carbon, carbonyl oxygen, and formyl hydrogen isotope effects was

44 s in Ca(2+) coordination with its main-chain carbonyl oxygen, and this function is not expected to be

45 ediated through backbone peptidic NH groups, carbonyl oxygens, and/or solvents.

46 contact with the putative oxyanion or ligand carbonyl oxygen appears in most complexes involving a be

47 actions between the formyl C-H and the amide carbonyl oxygen are considered negligible.

48 a larger increase in electron density at the carbonyl oxygen are predicted.

49 The methoxyamide NH and carbonyl oxygen are within H-bonding distance of Glu71 a

50 n residues become covalently linked, and two carbonyl oxygens are added to the indole ring of betaTrp

51 helical path following the positions of the carbonyl oxygens around the channel pore.

52 er noncovalent bonds between uranium and the carbonyl oxygen as the extent of ligation increases.

53 All structures identify the Trp 147 carbonyl oxygen as the hydrogen bond acceptor for the ag

54 of the pterin closest to the iron is the O-4 carbonyl oxygen at a distance of 3.6 A.

55 ido group in thiocolchicine is replaced by a carbonyl oxygen at C(7), was obtained from deacetythioco

56 When U or C is present at -1, the carbonyl oxygen at C2 on the nucleobase contributes to t

57 e residues that form hydrogen bonds with the carbonyl oxygen at C4, a conserved threonine residue tha

58 Addition of carbonyl oxygen at the alpha-position and formation of C

59 n selectivity in NaDC-1, indicating that the carbonyl oxygen at this position may play a role in the

60 gen-bonding probes - NH(+)(3) nitrogen atom, carbonyl oxygen atom and hydroxyl oxygen atom - the aver

61 often occupies the nest may be a main-chain carbonyl oxygen atom as in the paperclip, also called th

62 ic acid methyl ester (PABAOMe) occurs at the carbonyl oxygen atom both in isolation and when one wate

63 e relative stabilities of protonating at the carbonyl oxygen atom for PABAH(+).(H(2)O)(0-6) and PABAO

64 This inhibitor is positioned with its carbonyl oxygen atom forming the fourth ligand of the ca

65 In this intermediate, the acetamido carbonyl oxygen atom forms a covalent bond to C1' of N-a

66 either the GXXXG or GXXXA motif contacts the carbonyl oxygen atom from the first glycyl residue of th

67 A main-chain carbonyl oxygen atom from Tyr115 in the ordered loop for

68 side chain of the active site Ser70, and the carbonyl oxygen atom in an oxyanion hole.

69 dithiolane sulfur atom in the former, and a carbonyl oxygen atom in the latter.

70 Interestingly, the backbone carbonyl oxygen atom of bestatin is coordinated to Znl a

71 bond between the side-chain of Tyr51 and the carbonyl oxygen atom of Glu77 and the presence of two we

72 strong hydrogen bonding interaction with the carbonyl oxygen atom of Gly48 of protease as examined in

73 between the hydroxyl moiety of Tp-THF and a carbonyl oxygen atom of Gly48 was newly identified.

74 The amide forms a hydrogen bond to the carbonyl oxygen atom of Ser214.

75 that, compared with wild-type hevamine, the carbonyl oxygen atom of the N-acetyl group of the -1 sug

76 r(217) forms a strong hydrogen bond with the carbonyl oxygen atom of Tyr(154) to lock the cofactor S-

77 acile cyclization onto the neighboring amide carbonyl oxygen atom to generate seven-membered carbonyl

78 chelate ring with a weak donor bond from the carbonyl oxygen atom to the tin center.

79 platin residue is attached to the N7, N3, or carbonyl oxygen atom, (O6), of guanine and to the N7, N3

80 probes: a charged NH(+)(3) nitrogen atom, a carbonyl oxygen atom, a hydroxyl oxygen atom and a methy

81 e juxtaposition to a threonine residue and a carbonyl oxygen atom, along with conservation of the cat

82 he peptide bond through interaction with the carbonyl oxygen atom.

83 ctrophilic addition of diaminocarbene to the carbonyl oxygen atom.

84 spartate residue is replaced by a main-chain carbonyl oxygen atom.

85 ABAOMeH(+) in stabilizing protonation at the carbonyl oxygen atom.

86 articipates in three H-bonds: two main-chain carbonyl oxygen atoms (from R194 itself and from C95 of

87 posed that three slightly negatively charged carbonyl oxygen atoms (O of T135, O of C168, and O(B) of

88 tracellular side, is made of four main-chain carbonyl oxygen atoms and four threonine side-chain hydr

89 these proteins and determined that, when the carbonyl oxygen atoms are cis-coplanar, the compounds de

90 ode of Ca(2+) chelation, using only backbone carbonyl oxygen atoms from residues in the selectivity f

91 Main chain carbonyl oxygen atoms from the K+ channel signature sequ

92 h two -0.5 charges located where the nearest carbonyl oxygen atoms of the acceptor would reside in th

93 In the minor groove the cytosine carbonyl oxygen atoms of the GpC and CpG steps are cross

94 interactions between the VPU helices and the carbonyl oxygen atoms of the lipid molecules, particular

95 atoms at C2 and C8 interacted with backbone carbonyl oxygen atoms of the peptide strand.

96 nsistent with a biliverdin radical where the carbonyl oxygen atoms on both the A and the D pyrrole ri

97 acetanilide undergo diprotonation at the two carbonyl oxygen atoms to form distonic superelectrophile

98 e selectivity filter provide a ring of three carbonyl oxygen atoms with a radius of approximately 3.6

99 Carbonyl oxygen atoms within the selectivity filter form

100 clization and force the G67 nitrogen and S65 carbonyl oxygen atoms within van der Waals contact in pr

101 o the different electronic properties of its carbonyl oxygen atoms, a directed binding of the substra

102 ons and valine amide protons compete for the carbonyl oxygen atoms, converting NH(Val)...O=C hydrogen

103 lar side, are made of exclusively main-chain carbonyl oxygen atoms.

104 ion through the hydroxamic acid hydroxyl and carbonyl oxygen atoms.

105 tween Zn(2+) and OT is lowest in energy with carbonyl oxygens being the primary ligation sites.

106 that the latter forms via the sharing of the carbonyl oxygen between the MCPA carboxylate group and a

107 Replacement of the amide carbonyl oxygen by a sulfur atom had a detrimental effec

108 mple nonredox substitution of the C2-uridine carbonyl oxygen by sulfur is catalyzed by tRNA thiouridi

109 surveyed the bridging of pairs of main chain carbonyl oxygens by cations or by delta(+) hydrogens wit

110 at halogen bonding with the pi-system of the carbonyl oxygen can become competitive with the commonly

111 Both structures show a main chain carbonyl oxygen closer to the active site serine as expe

112 raction has not previously been discussed, a carbonyl oxygen contact with the putative oxyanion or li

113 the Ala305 (and possibly Val304 and Ile307) carbonyl oxygen, contribute to site 2.

114 (18)O(2) or H(2)(18)O showed that the amide carbonyl oxygen derived exclusively from molecular oxyge

115 show the fused pyrrolo ring as the source of carbonyl oxygen electron density.

116 interaction of Arg(41) with the acyl-CoA C1 carbonyl oxygen explains the effects of Arg(41) mutation

117 ated with a nucleophilic water and the ester carbonyl oxygen facilitates the near-attack geometry in

118 takes place via addition of CF(3)(+) to the carbonyl oxygen followed by transposition via a four-mem

119 s a rapid pre-equilibrium protonation of the carbonyl oxygen, followed by the formation of at least o

120 the result of fragmentation initiated at the carbonyl-oxygen for both isomers.

121 The backbone carbonyl oxygen from residues 337 through 342 on the non

122 ion interacting with the amine nitrogen and carbonyl oxygen from the amino acid backbone and the ami

123 tracellular) that are built mainly using the carbonyl oxygens from the protein backbone.

124 of the gamma-phosphoryl group of ATP to the carbonyl oxygen, generating phosphoenol acetone as the a

125 able of simultaneously interacting with both carbonyl oxygens give large shifts in the redox potentia

126 hydrogen bonds to the lone-pair electrons of carbonyl oxygens have been examined to reveal the influe

127 ction between O-methyl protons and a thymine carbonyl oxygen helps stabilize T.O6MeG pairs bound to D

128 anine specificity is provided by two peptide carbonyl oxygens hydrogen-bonded to the exocyclic amino

129 The effect of replacing the beta-lactam carbonyl oxygen in cephalosporins by sulfur on their rea

130 Glu376 shows the importance of the thioester carbonyl oxygen in modulating key properties of the medi

131 ) between the aldehydic oxygen and the amide carbonyl oxygen in the diastereomeric, disfavored transi

132 the same Lys is also hydrogen bonded with a carbonyl oxygen in the DNA binding module.

133 raction between vanadium and the hydroxamate carbonyl oxygen in the enzyme complex than in free solut

134 A and class C carbapenem complexes, the acyl carbonyl oxygen in the OXA-1-doripenem complex is bound

135 proteins optimally expose the two contiguous carbonyl oxygen in the proline-mimetic chain for FKBP do

136 as identified by the interaction between the carbonyl oxygen in the R1 side chain of beta-lactams and

137 77 A) between the aldehydic hydrogen and the carbonyl oxygen in transition state 13 is beyond the sum

138 ich are involved in interactions with the C2 carbonyl oxygen in uracil or xanthine, cause substantial

139 ntial values, whereas the regions around the carbonyl oxygens in CBs are significantly negative, whic

140 /beta interface on the 2-fold axis with four carbonyl oxygens in the coordination sphere.

141 rol experiments established retention of the carbonyl oxygens in the enzymatic products during the tr

142 ihood of a Na(+) ion coordinated to the four carbonyl oxygens in the major groove for these G.U pairs

143 binding at low pH is proposed to be between carbonyl oxygens in the nonhelical part of the fourth me

144 re protonated by trifluoroacetic acid at the carbonyl oxygen, in spite of the reverse order of basici

145 nteractions of cations with protein backbone carbonyl oxygens, in particular, play a critical role in

146 is identical to PS except that it contains a carbonyl oxygen instead of an acetyl group at C17 on the

147 entify an alpha-helical switch that shifts a carbonyl oxygen into the active site to coordinate a met

148 tease activity by movement of the equivalent carbonyl oxygen into the active site.

149 s involving the iron ligated to Cys17, whose carbonyl oxygen is a hydrogen bond acceptor to the Cys21

150 cycloundecanone complex shows that the guest carbonyl oxygen is directed into a binding pocket define

151 The structure reveals that the C2 carbonyl oxygen is directly coordinated with the metal i

152 bifurcated hydrogen bonds where the uracil 2-carbonyl oxygen is hydrogen-bonded to both G,H1 and G,H2

153 ndicating that in the E.S complex the formyl carbonyl oxygen is not coordinated with the metal ion.

154 romophore formation and suggest that the T62 carbonyl oxygen is the base that initiates the dehydrati

155 The carbonyl-oxygen KIE (18kobs = 0.996) points to attack of

156 al deformation implies that Na+ moves to the carbonyl oxygens lining the pore of this channel for sol

157 on-activated aldehyde and the ester or amide carbonyl oxygen lone pair is found to play a major role

158 interaction between monovalent cations and a carbonyl oxygen (most likely at C6) in TTQ.

159 erpendicular, involving the pi-system of the carbonyl oxygen (N-C horizontal lineO...X dihedrals ca.

160 In the computed structures, the amide carbonyl oxygen nearest the nucleobase (O7') forms an in

161 nd Na(+) are coordinated to the nitrogen and carbonyl oxygen (NO coordination), whereas K(+) coordina

162 dium ion coordinates to the nitrogen and the carbonyl oxygen (NO-coordination), whereas Maiba forms a

163 ngstrom and 1.60 +/- 0.04 Angstrom, from the carbonyl oxygens O(1) and O(4) to the NH group of Ala M2

164 ggests a significant covalent O-H binding of carbonyl oxygen O1 that is a characteristic of a neutral

165 G, another between the imino proton of G and carbonyl oxygen O2 of U.

166 ate is observed bound to subunit I, with its carbonyl oxygen, O4, lying 2.9 A from the beta-metal ion

167 nd sites within the PNA backbone display the carbonyl oxygen (O7') and the amide proton (n + 1)H1' di

168 s assisted by Arg228 hydrogen bonding to the carbonyl oxygen of >C5[double bond]O.

169 hat the overall hydrogen bonding between the carbonyl oxygen of (-)-cocaine benzoyl ester and the oxy

170 en and the distance from the nitrogen to the carbonyl oxygen of 2.38+/-0.13A.

171 by a tethered nucleophile, which may be the carbonyl oxygen of a ketone, ester, or carbonate, or a t

172 n addition to forming a hydrogen bond with a carbonyl oxygen of a neighboring loop may also favorably

173 is one in which the base coordinates to the carbonyl oxygen of a nonzwitterionic form of valine and

174 After labeling the reducing carbonyl oxygen of a series of disaccharides with 18O to

175 pecifically, whether H264 interacts with the carbonyl oxygen of acetoacetyl-CoA's thioester, turnover

176 re, after nicotinamide-ribosyl cleavage, the carbonyl oxygen of acetylated substrate attacks the C-1'

177 reaction proceeds, the distance between the carbonyl oxygen of ACh and NH group of Ala204 becomes sm

178 ly two hydrogen bonds are formed between the carbonyl oxygen of ACh and the peptidic NH groups of Gly

179 rboxylates of Asp12 and Asp186, the backbone carbonyl oxygen of Ala14, and a water that forms a hydro

180 ears to be a hydrogen bond with the backbone carbonyl oxygen of Ala318, suggesting that this atom is

181 sine Y(D) may be structurally coupled to the carbonyl oxygen of an alanine-derived peptide carbonyl g

182 de chain oxygens of Asp(13) and Asp(57), the carbonyl oxygen of Asn(59), and two water molecules.

183 At the back of the cavity, the side-chain carbonyl oxygen of Asn-97' interacts with the phenolic h

184 ive site has been identified, the main chain carbonyl oxygen of Asn39.

185 ns of Asp8, Glu169, Asp170, and the backbone carbonyl oxygen of Asp10 along with one oxygen from the

186 The ligands are Glu105, His106, the carbonyl oxygen of Cys102, and a water molecule.

187 roup (H(3)C- and/or HO-) near the main chain carbonyl oxygen of Cys153 and that Phe88 (analogous to T

188 that the C-H donors transfer hydrogen to the carbonyl oxygen of DDQ while Sn-H and B-H hydride donors

189 ydrogen bonding between the amido proton and carbonyl oxygen of ester group provides the extra stabil

190 wed no detectable exchange of (18)O into the carbonyl oxygen of FTC or the product, formate, under an

191 one between the 2'-hydroxyl proton of U and carbonyl oxygen of G, another between the imino proton o

192 between the hydroxyl group and the backbone carbonyl oxygen of Glu(89).

193 s, one between the alpha-amino group and the carbonyl oxygen of Gly 216 and the other between the car

194 drogen bonding of the arylamine group to the carbonyl oxygen of Gly(243).

195 The carbonyl oxygen of Gly48 showed two alternative conforma

196 hree conformations: trans O-up, in which the carbonyl oxygen of Gly57 (O57) points toward the flavin

197 2)O(-); (iii) cofactor-binding domain: amide carbonyl oxygen of I318 with amide N of H67; and (iv) co

198 ha-helix 2, hydrogen bonds to the main chain carbonyl oxygen of Ile-259 on TM alpha-helix 3.

199 Hydrogen bonding between the carbonyl oxygen of isoleucine-100 and the 4-amino group

200 igate the catalytic zinc through the glycine carbonyl oxygen of its scissile G approximately VV tripl

201 (iv) cofactor domain: C(alpha) of T178 with carbonyl oxygen of L141.

202 h carboxanilide NH- group and the main-chain carbonyl oxygen of Lys101.

203 ed intramolecular I...O interaction with the carbonyl oxygen of only one of the two carboxylic groups

204 he amino group of Asp is 2.9 A away from the carbonyl oxygen of PAM, positioned correctly for the nuc

205 The carbonyl oxygen of Phe-65 is almost 90 degrees out of th

206 by a hydrogen bond, first with the backbone carbonyl oxygen of Phe161 then with the hydroxyl group o

207 n the -NH(2) group of nucleobase G17 and the carbonyl oxygen of serine 56.

208 e main chain carbonyl of Pro132, between the carbonyl oxygen of SHA and the side chain guanadinium gr

209 -substituted aminoalkylindenes that lack the carbonyl oxygen of the AAIs.

210 mediate negative charge that develops on the carbonyl oxygen of the acetyl group during both the form

211 , transfer of an 18O label from water to the carbonyl oxygen of the acetyl group in OAADPr is consist

212 ructure in which Thr-181 was acetylated; the carbonyl oxygen of the acyl-enzyme complex was located i

213 at the alpha-hydrogen, carbonyl carbon, and carbonyl oxygen of the amino acid, the O2' and O3' of th

214 ide chain, the free alpha-amino nitrogen and carbonyl oxygen of the amino-terminal Ser residue coordi

215 His-98, in the plane of PGH, approaches the carbonyl oxygen of the analogue.

216 Tyr158 directly interacts with the thioester carbonyl oxygen of the C16 fatty acyl substrate and ther

217 jacent nucleophilic atom, in the form of the carbonyl oxygen of the C7 tert-butyloxycarbonyl group.

218 4 is within hydrogen bonding distance to the carbonyl oxygen of the carbonyl-CoA moiety of the substr

219 In the crystal lattice, the carbonyl oxygen of the central glycyl residue in two gly

220 ctone carbonyl oxygen of the E-ring, and the carbonyl oxygen of the D-ring).

221 hydroxyl hydrogen of the E-ring, the lactone carbonyl oxygen of the E-ring, and the carbonyl oxygen o

222 In the "oxyanion hole", the amide carbonyl oxygen of the inhibitor interacts through a wat

223 Consistent with previous work, the carbonyl oxygen of the inhibitors interacts directly wit

224 zine ring, and between alpha H286 and the C2-carbonyl oxygen of the isoalloxazine ring, may play a ro

225 nd waters, and the proximity of the backbone carbonyl oxygen of the n - 3 residues before the quenche

226 3 contribute to catalysis by positioning the carbonyl oxygen of the N-acetyl group near to the C1 ato

227 ed to solvent, and both the amide proton and carbonyl oxygen of the peptide backbone are exposed to s

228 om an intramolecular interaction between the carbonyl oxygen of the platinated guanine base and a cis

229 The carbonyl oxygen of the scissile bond in the substrate is

230 For example, the carbonyl oxygen of the side chain of Gln-412 rotated awa

231 do not donate hydrogen bonds directly to the carbonyl oxygen of the substrate, but they stabilize the

232 te, acetoacetyl-CoA, by interacting with the carbonyl oxygen of the thioester functionality.

233 dino group bends over to form an H-bond with carbonyl oxygen of the Thr-183, thus occluding the chann

234 raction is dominated by ligation between the carbonyl oxygen of the ureido ring of biotin and the Mg2

235 However, solvent exchange into the thioester carbonyl oxygen of these acetyl-S-enzyme intermediates i

236 the chemical shift properties of the Leu(10) carbonyl oxygen of transmembrane pore-forming peptide gr

237 the active site but that O2' of rCTP and the carbonyl oxygen of Tyr-271 or Ala-271 are unusually clos

238 nhibitors that interacts with the main-chain carbonyl oxygen of Tyr188.

239 e amide oxygen of Asn-300 and the main-chain carbonyl oxygen of Val-229 to act as the general base.

240 x by interacting favorably with the unpaired carbonyl oxygen of Val206(5.45).

241 ed to the iron, as well as to the main chain carbonyl oxygens of Ala322, Gly247, and Leu249 and the m

242 tween the N-delta of His386 and the backbone carbonyl oxygens of Asn382 and Gln383.

243 Na+ and K+ are coordinated to the carbonyl oxygens of beta Phe-306, beta Ser-308, and beta

244 Cs+ is coordinated to the carbonyl oxygens of beta Phe-306, beta Ser-308, beta Gly

245 ch binding site potassium interacts with the carbonyl oxygens of both the loop thymine residues and t

246 oup of an ethanol molecule, and the backbone carbonyl oxygens of Glu-17, Asn-18, and Met-20.

247 sp-189 (chymotrypsin numbering) and with the carbonyl oxygens of Gly-219 and Ogamma of Ser-190.

248 en subunits, with ligands contributed by the carbonyl oxygens of Gly52 and Asn262 from one chain and

249 and NH(2) of Arg(363) are hydrogen-bonded to carbonyl oxygens of P1 and P1' of the substrate analog a

250 bonds with amides, whereas the corresponding carbonyl oxygens of the other two polymorphs form intera

251 that tightly fits K(+) ions and is lined by carbonyl oxygens of the polypeptide backbone.

252 , with two K+ ions each coordinated by eight carbonyl oxygens of the protein and separated by a water

253 he geometry of the hydrogen bonds to the two carbonyl oxygens of the semiquinone Q(A)(.-) in the reac

254 e investigated the hydrogen bonds to the two carbonyl oxygens of the semiquinone QA*- in the well-cha

255 ining ester linkages, demonstrating that the carbonyl oxygens of the sn-1 and -2 ester linkage are no

256 ing studies and is notable for including two carbonyl oxygens of the thrombin main chain.

257 We find that the carbonyl oxygen on the backbone of the arginine finger s

258 te which encounters a nucleophilic attack by carbonyl oxygen on the electrophilic amine to produce is

259 ysis is achieved through the rotation of the carbonyl oxygen on the N-terminal of the prolyl peptide

260 ion by substrate, an amino group displaces a carbonyl oxygen on TTQ, and that this significantly alte

261 e-derived amino group which displaces the C6 carbonyl oxygen on TTQ.

262 F; one comes from rhenium oxide, and the two carbonyl oxygens originate from the carboxylic acid and

263 ms a bicyclic aromatic intermediate with its carbonyl oxygen pointing out of the oxyanion hole and fo

264 the bicyclic aromatic intermediate with its carbonyl oxygen positioned outside of the oxyanion hole

265 rom hydroxyl or other proton-donor groups to carbonyl oxygens potentially can facilitate intermolecul

266 MMs occur through the phosphorylation of the carbonyl oxygen preceding the cyclized residue.

267 triple bond, and solid K3PO4 interacts with carbonyl oxygen, promoting intermolecular nucleophilic a

268 sfy the helices unpaired amide nitrogens and carbonyl oxygens, respectively.

269 Li(+) and Ca(2+) binding to the carbonyl oxygen sites of a model peptide system has been

270 The amide carbonyl oxygen solvates charge in both the SB and CS fo

271 arge oxygen; and 2) amide dipoles with their carbonyl oxygen surface exposed and amine proton buried

272 ing of Arg(180) (P1) by interacting with its carbonyl oxygen that displaces the nucleophilic water.

273 His331 with the negatively charged thioester carbonyl oxygen, that breaks down to generate bicarbonat

274 ve sp(3) nitrogen and hydrogen, and negative carbonyl oxygen), the last probe is least distinctive.

275 dified by the polarization of the thiolester carbonyl oxygen through hydrogen bonding to the 2'-OH of

276 Lewis acid interaction with the carbonyl oxygen thus weakens the N-CO(2)(-) bond and fun

277 ould be expected to clash with the preceding carbonyl oxygen (thus accounting for its frustrated ener

278 Conversion of the 6-carbonyl oxygen to a 6-amino group (ImmH to ImmA) increa

279 7d may increase the directing ability of the carbonyl oxygen to metalate the 2-position of the arylse

280 anine residue contacts the proteasome Gly-19 carbonyl oxygen to stabilize the open conformation.

281 planar structure due to attraction of the 3-carbonyl oxygen to the sulfur of the distal ring.

282 These residues lie beyond the carbonyl oxygen tunnel thought to form the channel selec

283 arbon atom in gamma-position relative to the carbonyl oxygen, undergo a rapid rearrangement resulting

284 bond attached to an ammonium nitrogen and a carbonyl oxygen was evaluated by ab initio calculations

285 iation constant of the cation with the amide carbonyl oxygen was no tighter than approximately 8.5 M.

286 on the C=O is a "pull" of electrons onto the carbonyl oxygen, which, in turn, polarizes the electron

287 ngs involve formation of hydrogen bonds with carbonyl oxygens, which have a significant out-of-plane

288 rve as an "oxyanion hole" in stabilizing the carbonyl oxygen, while the Zn(2) ion acts as an electrop

289 e being a single atom: the substitution of a carbonyl oxygen with a sulfur atom.

290 ate, which does not appreciably exchange its carbonyl oxygen with the solvent (kh/kex = 55).

291 ate of hydrolysis to that of exchange of the carbonyl oxygen with water (k(h)/k(ex) = 11.3), give a d

292 Aldehydes readily exchange their carbonyl oxygen with water, making oxygen labeling exper

293 The effect of replacing carbonyl oxygens with sulfur in a series of orotidine 5'