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1 eactions (Sonogashira, Suzuki, and reductive carbonylation).
2 th annelation, while the reverse is true for carbonylation.
3 tissue lipid aldehyde production and protein carbonylation.
4 philicity increases upon both annelation and carbonylation.
5 be more influential on the extent of protein carbonylation.
6 omplex attenuated ouabain-stimulated protein carbonylation.
7 eptibility to mitochondrial membrane protein carbonylation.
8 col involves Michael addition and subsequent carbonylation.
9 se secondary structure, oligomerization, and carbonylation.
10 ein amino acids in a reaction termed protein carbonylation.
11 es that do not undergo simple ring-expansion carbonylation.
12 resent alternative reactants to enable (11)C-carbonylation.
13 es reactive oxygen species-dependent protein carbonylation.
14 ed by tandem intramolecular Heck cyclization/carbonylation.
15 l as its ability to suppress ROS and protein carbonylation.
16 A high raffinose level increases ROS and carbonylation.
17 o a Bronsted acid site in the 8MR to undergo carbonylation.
18 cies present in the MOR side pockets undergo carbonylation.
19 uction yields (100 t/y) compared to methanol carbonylation (0.26 pound/kg, 261 pound/t) and ethane di
20 ts activation), malonyl-CoA content, protein carbonylation (a marker of oxidative stress), plasma adi
21 e protocol was set up using Paraquat-induced carbonylation, a model that induces protein aggregation
23 n IP; this correlated with decreased protein carbonylation, a surrogate marker for oxidative stress.
24 proceeds via carbonylation-carbocyclization-carbonylation-alkynylation involving sequential insertio
25 oxidation, total carbonylation, and specific carbonylation (alpha-amino adipic and gamma-glutamic sem
26 days, and protein oxidation was evaluated as carbonylation (alpha-amino adipic and gamma-glutamic sem
27 d cysteine residues, referred to as "protein carbonylation." Although not widely appreciated, reactiv
28 ines via a sequential one-pot multicomponent carbonylation/amination reaction has been developed.
30 t synthesize CL, exhibited increased protein carbonylation, an indicator of reactive oxygen species (
31 uropathies, we predicted that an increase in carbonylation and aggregation of PMP22 may be associated
33 s exhibited significant elevation in protein carbonylation and alterations in protein conformation.
34 tes, complex I protein and activity, protein carbonylation and ATP levels were all fully protected in
40 n the generation of reactive oxygen species, carbonylation and glutathionylation of cellular proteins
41 ction of reactive oxygen species, along with carbonylation and glutathionylation of the cellular prot
45 ptophan and thiols depletion, higher protein carbonylation and more intense formation of protein cros
46 n p38K are associated with increased protein carbonylation and Nrf2-dependent transcription, while ad
48 es (UF) for the extent of protein oxidation (carbonylation and Schiff base formation) and their senso
50 ical examples, such as alcohol oxidation and carbonylation and the asymmetric reduction of ketones.
51 lucose) for their ability to promote protein carbonylation and tryptophan depletion in myofibrillar p
52 and exhibit decreased mitochondrial protein carbonylation and UCP2-dependent reduction in intracellu
53 e and selective for both epoxide and lactone carbonylation, and by the identification of a solvent th
54 drial respiration, tissue nitration, protein carbonylation, and contractile function in the heart dur
56 ocyclization, ring cleavage, hydrogen shift, carbonylation, and decarbonylation contributed to CBZ tr
57 higher levels of lipid peroxidation, protein carbonylation, and DNA oxidative damage even at a young
58 ctive aldehyde 4-hydroxynonenal (HNE) caused carbonylation, and HNE-glutathione adducts were detected
59 hase-2 expression, tissue nitration, protein carbonylation, and mitochondrial morphology and function
61 dinitrogen loss became competitive with N(2) carbonylation, and significant quantities of the zircono
62 tion was evaluated as thiol oxidation, total carbonylation, and specific carbonylation (alpha-amino a
63 D1 pI 6.0 isoform is oxidatively modified by carbonylation, and the pI 5.0 isoform is selectively acc
65 -induced oxidative damage to DNA and protein carbonylation are involved in the observed toxicity of H
68 In the biotechnology industry, oxidative carbonylation as a post-translational modification of pr
70 hat DJ-1 protein is irreversibly oxidized by carbonylation as well as by methionine oxidation to meth
71 lular H(2)O(2) levels as measured by protein carbonylation assays and fluorescence-activated cell sca
73 rphyrins, and lipid peroxidation and protein carbonylation blockers/inhibitors (edaravone and lazaroi
74 of vemurafenib and UVA caused little protein carbonylation but were nevertheless inhibitory to nucleo
75 2) C-H activation (i.e., ortho acylation) or carbonylation by activation of the carbonyl group (i.e.,
76 etailed mechanistic investigation of epoxide carbonylation by the catalyst [(salph)Al(THF)2]+ [Co(CO)
78 rsed the effects of IPC on postischemic Rpt5 carbonylation, cardiac function, morphology and morphome
79 step by PdI(2)/KI-catalyzed direct oxidative carbonylation, carried out in alcoholic media under rela
80 ted by effective activation to a homogeneous carbonylation catalyst [(dtbpx)PdH(L)](+) by addition of
81 rs also demonstrated the practicality of the carbonylation catalyst for complex molecule synthesis as
82 active and selective porphyrin-based epoxide carbonylation catalyst, [(OEP)Cr(THF)2][Co(CO)4] (1; OEP
84 owed to react under PdI2-catalyzed oxidative carbonylation conditions, depending on the nature of the
86 s of 8-oxo-dG-modified DNA and total protein carbonylation corresponded to cardioprotective activity.
90 allmarks of oxidative stress such as protein carbonylation, decreased aconitase activity, and lower l
92 alkylation, halogenation, carboxylation, and carbonylation), each representing a distinct handle for
93 ibited severe lipid peroxidation and protein carbonylation, for oxidative stress damage at the cellul
94 eductive N-O bond cleavage of 40 followed by carbonylation gave cyclic urea 47 in which inversion of
95 ntial and non-overlapping, such that epoxide carbonylation goes to completion before any of the inter
100 was employed to identify specific targets of carbonylation in GSTA4-silenced or overexpressing 3T3-L1
106 istinct advantage over traditional reductive carbonylation in that no carbon monoxide, pressurized ga
107 506 pretreatments markedly increased protein carbonylation in the myocardium despite elevated mangane
109 Ethanol sensitivity and increased protein carbonylation in the taz1Delta mutant but not in crd1Del
110 show significantly lower protein oxidation (carbonylation) in Mexican free-tailed bats (Tadarida bra
112 red adipocytes resulted in increased protein carbonylation, increased mitochondrial ROS, dysfunctiona
113 late stationary phase, mitochondrial protein carbonylation increases in all strains, particularly in
114 earlier reported transition-metal-catalyzed carbonylations involved either toxic carbon monoxide (CO
117 from aryl chlorides via palladium-catalyzed carbonylation is described using atmospheric pressure of
118 n donor solvent, whereas the rate of lactone carbonylation is first-order in lactone and inversely de
119 he stages differ in that the rate of epoxide carbonylation is independent of substrate concentration
126 es and subsequent direct palladium-catalyzed carbonylation/lactonization provide an efficient route t
127 s a target for oxidant-induced PTMs, such as carbonylation, leading to impaired function during epile
128 ich significantly correlated with fibrinogen carbonylation level (r(2)=0.33, P<0.0001), residual beta
129 new procedure reflected an increased protein carbonylation level measuring overall two to fourfold mo
133 ia/reoxygenation hypersomnolence but also to carbonylation, lipid peroxidation injury, and the proinf
134 ylis-Hillman reactions, conjugate additions, carbonylations, methylations, silylations, and brominati
136 ular enolate alkylation, an effective Stille carbonylation/Nazarov cyclization sequence, and a high-r
137 ere, numerous proteins are carbonylated, and carbonylation occurs in both collecting ducts and thin l
138 tannylacrylate is prepared by stereospecific carbonylation of (E)-1,2-difluorovinyl iodide followed b
141 were selectively obtained when the oxidative carbonylation of 2-alkynylbenzamides, bearing a terminal
143 2061) was developed via palladium-catalyzed carbonylation of 2-iodo-5-methoxyaniline (4) with thiazo
144 licon-tethered acrylate; an efficient Stille carbonylation of a sterically encumbered vinyl triflate;
145 Monoselective gamma-C-H olefination and carbonylation of aliphatic acids has been accomplished b
146 nent reaction based on a palladium-catalyzed carbonylation of alpha-chloroketones in the presence of
151 ed that 4-HNE treatment of cells resulted in carbonylation of AMPKalpha/beta, which was not observed
153 (-) catalyst for a late-stage regioselective carbonylation of an enantiomerically pure cis-epoxide to
154 in posterior eyecups of mutant mice, whereas carbonylation of an RPE-specific protein was observed in
158 conducting the palladium-catalyzed reductive carbonylation of aryl iodides and bromides using 9-methy
159 ation has been found to facilitate the rapid carbonylation of aryl iodides into acid chlorides via re
160 omplished using a palladium-catalyzed double carbonylation of aryl iodides with near stoichiometric c
162 general protocol for the palladium-catalyzed carbonylation of aryl tosylates and mesylates to form es
166 t of oxidative modification, we assessed the carbonylation of cytosolic proteins in phagocytic neutro
170 bstrate scope has been demonstrated allowing carbonylation of electron-rich, electron-poor, and heter
173 e stress markers (P<0.001) and with a marked carbonylation of fibrinogen (P<0.001), whose secondary s
174 areful control of reaction conditions in the carbonylation of glycidyl esters, the exclusive producti
175 owever, an effective catalyst for the direct carbonylation of methane to acetic acid, which might ena
176 vehicle for the low-temperature vapor-phase carbonylation of methanol by insertion of CO into the O-
177 ive site in supported gold catalysts for the carbonylation of methanol has been identified as dimers/
178 istic study of the electrochemical oxidative carbonylation of methanol with CO for the synthesis of d
184 Catechin (200ppm) reduced significantly carbonylation of protein spots identified as glycogen ph
186 d evoked Ca(2+) release from the SR, reduced carbonylation of RyR2s, and increased binding of [(3)H]r
187 GSTA4-silenced adipocytes displayed elevated carbonylation of several key mitochondrial proteins incl
189 igand-controlled regioselective Pd-catalyzed carbonylation of styrenes with aminophenols was realized
190 This work reports oxidative N-dealkylation/carbonylation of tertiary amines to tertiary amides by u
192 HepG2 cells with 4-HNE resulted in increased carbonylation of the lipid phosphatase known as "phospha
194 close proximity to the active site of CI and carbonylation of the residue is predicted to induce subs
195 ysis of target proteins revealed significant carbonylation of the S100A9 subunit of calprotectin, a t
196 N-C bond formation was also accomplished by carbonylation of the silylated product, yielding an unpr
198 by hydrogenation and C-H bond activation, as carbonylation of the zirconocene and hafnocene dinitroge
200 atalysts are reported for the regioselective carbonylation of trans-disubstituted epoxides to cis-bet
203 tive Pd/C-catalyzed oxidative N-dealkylation/carbonylation of various aliphatic as well as cyclic ter
204 substrates and represent the first catalytic carbonylations of alkyl bromides with carbon monoxide.
207 s to identify the site and extent of protein carbonylation on a proteome-wide scale has expanded our
209 iples, understanding the impact of oxidative carbonylation on product quality of protein pharmaceutic
210 tates extended characterization of oxidative carbonylation on recombinant monoclonal antibodies and p
211 to investigate the effect of annelation and carbonylation on the electronic and ligand properties of
214 istent with the low or undetectable rates of carbonylation on zeolites without 8-MR channels (H-BEA,
215 both species, the dose-response for protein carbonylation parallels that for fecundity reduction, ma
216 ant activity towards lipid oxidation and the carbonylation pathway at different concentrations under
218 n, quercetin and gallic acid) on the protein carbonylation pathway occurred during the oxidation of m
222 de, among others, Friedel-Crafts alkylation, carbonylation, polymerization, cyclization, olefin metat
224 tes were subjected to the Fe(CO)(5)-mediated carbonylation process under a CO atmosphere, leading to
225 through the development of C-H amination and carbonylation processes, leading to the synthesis of azi
229 This elementary step controls catalytic carbonylation rates of dimethyl ether (DME) to methyl ac
230 s 3, bearing alkyl or aryl substituents, the carbonylation reaction led to a mixture of Boc-protected
238 mackerel (Scomber scombrus) mince to undergo carbonylation reactions during chilled storage, and the
241 sformation proceeds via two tandem catalytic carbonylation reactions mediated by Pd(P(t)Bu3)2 and pro
243 tion complexes as stoichiometric reagents in carbonylation reactions with (11)CO to produce structura
244 thway well known for homogeneously catalyzed carbonylation reactions, such as the synthesis of acetic
248 mulated Na/K-ATPase.c-Src signaling, protein carbonylation, redistribution of Na/K-ATPase and sodium/
251 in adipose tissue leads to increased protein carbonylation, ROS production, and mitochondrial dysfunc
253 Overall, our findings indicate that MyBPC carbonylation serves as a critical determinant of cardio
256 However, comprehensive identification of carbonylation sites has so far remained a very difficult
259 roach were demonstrated by identification of carbonylation sites on both unstressed and oxidized anti
260 he first time the identification of specific carbonylation sites on recombinant monoclonal antibodies
262 oach, which enabled direct identification of carbonylation sites without any fractionation or affinit
264 IR spectroscopy, which reveals that the two carbonylation stages are sequential and non-overlapping,
265 ntally benign process, [Pd]-catalyzed direct carbonylation starting from simple and commercially avai
269 is far more resistant to IR-induced protein carbonylation than is the much more radiosensitive nemat
270 imal-source were more susceptible to protein carbonylation than soy proteins and globular were more s
272 also be transformed through direct oxidative carbonylation to acetic acid, which is commercially obta
273 tured CI identified specific metal catalyzed carbonylation to Arg76 within the 75 kDa subunit concomi
274 reaction occurs in tandem through an initial carbonylation to generate an aroyl halide, which undergo
275 lcohols undergo W(CO)(6)-catalyzed oxidative carbonylation to the corresponding hydroxyalkylureas wit
278 rotein that showed a significant increase in carbonylation under Dox-induced cardiotoxic conditions i
282 g amino amides employing oxidative catalytic carbonylation using W(CO)(6) as the catalyst, I(2) as th
287 ctedly, the oxidative DNA damage and protein carbonylation was more severe in the DeltatrxC mutant th
292 Because aldehydes are important mediators of carbonylation, we explored the immunomodulatory properti
294 ass (i.e., cardiolipin content), and protein carbonylation, were assessed at various time points (8,
295 d loss of CcO activity and increased protein carbonylation, which was accompanied by a decline in the
297 clopride, for the dopamine D2/D3 receptor by carbonylation with excellent radiochemical purity and yi
298 N-(o-bromoaryl)amides by palladium-catalyzed carbonylation with paraformaldehyde as the carbonyl sour
300 es to delineate the physiochemical impact of carbonylation yielded channels with enhanced or reduced
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