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1 vities of the full-length protein, while the carboxy-terminal 143 residues contain a nuclear localiza
4 we use knock-in mice expressing NLRC4 with a carboxy-terminal 3xFlag tag to identify phosphorylation
7 biquitin-like (Ubl) proteins in two steps by carboxy-terminal adenylation and thioester bond formatio
8 tment and the tagging of nascent chains with carboxy-terminal Ala and Thr extensions ("CAT tails").
9 ditionally, Rqc2 modifies stalled NCs with a carboxy-terminal, Ala- and Thr-containing extension-the
10 -dependent ubiquitination and Rqc2p-mediated Carboxy-terminal Alanine and Threonine (CAT) tail elonga
11 the beta(2)AR and Gs involve the amino- and carboxy-terminal alpha-helices of Gs, with conformationa
13 the finding that the removal of merely three carboxy-terminal amino acids compromised Nab3's function
14 underscoring, in particular, the role of the carboxy-terminal amino acids in the folding of thioredox
15 from classical IgE by the replacement of two carboxy-terminal amino acids with eight novel residues t
16 d just N-terminal to the basic domain, and a carboxy-terminal amphipathic alpha-helix referred to as
17 s a metalloproteinase catalytic domain and a carboxy-terminal ancillary domain, the latter determinin
18 s to protein storage vacuoles is mediated by carboxy terminal and internal sorting determinants (ISDs
19 citrullination of the resulting peptides at carboxy-terminal arginine residues, which were identifie
23 hotspots, requiring the repair functions of carboxy-terminal binding protein (CtBP)-interacting prot
24 ion between MRN and the tandem breast cancer carboxy-terminal (BRCT) repeats in 53BP1, and is accompa
25 s of post-translational modifications of the carboxy-terminal CAAX motifs (where C is cysteine, A is
26 S effector TRP120 is conjugated to SUMO at a carboxy-terminal canonical consensus SUMO conjugation mo
32 ted to impaired bone metabolism as increased carboxy-terminal collagen cross-link-1 levels and alkali
33 pha), and bone metabolism (osteocalcin [OC], carboxy-terminal collagen crosslinks [CTX], and N-termin
38 SAMP1 and SAMP2, with a beta-grasp fold and carboxy-terminal diglycine motif similar to ubiquitin, t
42 and show that this interaction requires the carboxy-terminal DNA-binding/dimerization domain of Z an
43 ces encoding the signal peptide (SS) and the carboxy-terminal domain (CT) of beta-lactamase, and clon
44 purified CDK8 in vitro for RNA polymerase II carboxy-terminal domain (CTD) and histone H3 substrates.
45 ng seven alpha-helices and a beta-hairpin, a carboxy-terminal domain (CTD) comprising four alpha-heli
47 isomerizing peptide bonds within the pol II carboxy-terminal domain (CTD) heptapeptide repeat (YSPTS
48 n and processing, and the role of the Pol II carboxy-terminal domain (CTD) in regulating these proces
49 man immunodeficiency virus type 1 (HIV-1) CA carboxy-terminal domain (CTD) is essential for CA-CA int
51 dentified SEM-5 as able to interact with the carboxy-terminal domain (CTD) of EGL-15, a domain that i
54 i-subunit complex stably associated with the carboxy-terminal domain (CTD) of RNA polymerase II (RNAP
57 the failure to phosphorylate serine 2 in the carboxy-terminal domain (CTD) of the large subunit of RN
58 2)-Pro(3)-Thr(4)-Ser(5)-Pro(6)-Ser(7) in the carboxy-terminal domain (CTD) of the largest RNA polymer
61 , polymerase II (Pol II), and phospho-Ser(2) carboxy-terminal domain (CTD) Pol II to the IFN-stimulat
62 inase 9 (CDK9) recruitment and phospho-Ser 2 carboxy-terminal domain (CTD) RNA polymerase (Pol) II fo
63 mplekin in a ternary complex with the Pol II carboxy-terminal domain (CTD) Ser 5 phosphatase Ssu72 an
64 its, a core that binds UPF1 and a protruding carboxy-terminal domain (CTD) that binds the SMG1 kinase
65 n of the amino-terminal domain (NTD) and the carboxy-terminal domain (CTD) was found to be essential
69 nteracting transactivator, with Glu/Asp-rich carboxy-terminal domain 2 (CITED2), a gene that mediates
71 using a recombinant OcXII harboring only the carboxy-terminal domain and this part did not exhibit an
73 eletions in the highly conserved hydrophobic carboxy-terminal domain disrupted both protein function
74 emical and functional studies, that the Srs2 carboxy-terminal domain harbours tandem receptor motifs
75 and involving a region of the middle domain/carboxy-terminal domain interface previously suggested t
78 present data suggesting that the cytoplasmic carboxy-terminal domain of amphiregulin plays an importa
81 ding of activated CheY to FliM displaces the carboxy-terminal domain of FliG (FliGC) from FliM, modul
82 between FMRP and Ca(V)2.2 occurs between the carboxy-terminal domain of FMRP and domains of Ca(V)2.2
84 owed selective competitive inhibition of the carboxy-terminal domain of human somatic ACE providing e
85 We determined the crystal structure of the carboxy-terminal domain of human SRAP and found that it
86 onse (UPR) and autophagy in B cells, and the carboxy-terminal domain of LMP1 activates cellular signa
87 lls, the apoptosis required the UPR, and the carboxy-terminal domain of LMP1 blocked this apoptosis.
89 ruited to origins by an essential, conserved carboxy-terminal domain of Mcm3 that interacts with and
92 is model suggested that POA binds within the carboxy-terminal domain of ribosomal protein S1 (RpsA) a
94 Sub1 influences Spt5 phosphorylation of the carboxy-terminal domain of RNAPII largest subunit by the
95 t the Na(+)-K(+)-ATPase, upon binding to the carboxy-terminal domain of the alpha subunit of the chan
97 juxtaposes transcription factor IIH and the carboxy-terminal domain of the largest subunit of Pol II
101 binding motifs and instead is similar to the carboxy-terminal domain of the yeast spliceosome protein
103 tion results in premature termination of the carboxy-terminal domain of VIR, resembling McClintock's
105 n with an amino-terminal GTPase domain and a carboxy-terminal domain predicted to be embedded in the
106 tructed an HCMV recombinant virus encoding a carboxy-terminal domain truncation mutant of US28, FLAG-
113 s secreted by T9SSs typically have conserved carboxy-terminal domains (CTDs) belonging to the TIGRFAM
114 cretion of numerous other proteins that have carboxy-terminal domains associated with targeting to th
115 catalytic core domain flanked by amino- and carboxy-terminal domains essential for the concerted int
118 arged regions conserved in the J-domains and carboxy-terminal domains of each J-protein class, and ar
121 These include rotation of the amino- and carboxy-terminal domains relative to each other, and a m
122 of phosphorylation in the amino-terminal and carboxy-terminal domains that are positioned to alloster
123 l as alpharetroviruses by providing critical carboxy-terminal domains to the intasome core that canno
124 and STING interacted directly, through their carboxy-terminal domains, to promote STING dimerization,
126 ing of peptides for MHC class I loading, but carboxy-terminal editing is thought to be due to proteas
129 amino-terminal end and hexahistidine at the carboxy-terminal end to generate CPD-MAGE-A3 in a pQE-70
130 -381 and serine-382, located in the C-linker carboxy-terminal end, which prevent KAT2 surface express
132 ge, positive-strand RNA viral genome and the carboxy-terminal endodomain of the membrane protein (M).
133 Similar acidic sequences are present in the carboxy-terminal ends of all yeast lipin orthologues.
137 ents, proIGF-IA and proIGF-IB have different carboxy-terminal extensions called the E-peptides (EA an
139 ee energy (DeltaG) of PDZ1 and PDZ2 with the carboxy-terminal, five-amino acid residues that form the
141 retase of the amyloid precursor protein beta-carboxy-terminal fragment (APP-betaCTF) constitutes the
143 n increase of the degradation of APP and its carboxy-terminal fragment (CTF) by activation of the lys
147 spite its type II transmembrane topology and carboxy-terminal glycosylphosphatidylinositol (GPI) anch
153 7) in an atypical manner, occupying only the carboxy-terminal half of the I-A(g7) peptide-binding gro
154 on depends on a beta-propeller domain in the carboxy-terminal half of the protein, which is fused to
155 Three layers of hydrophobic residues on the carboxy-terminal half of the TM1 helices form a bottlene
158 proaches, we investigated interaction of the carboxy-terminal helicase module, in particular the carb
160 ween alpha helices 1 and 2 is displaced, the carboxy-terminal helix 9 is mobilized for membrane trans
161 ay across the membrane bilayer, a latch-like carboxy-terminal helix that caps the cytoplasmic gate, a
162 the "immunodominant region" (cluster I), the carboxy-terminal heptad repeat (cluster II), and the mem
163 1-associated protein-1 (Bap1) is a ubiquitin carboxy-terminal hydrolase and is frequently mutated in
167 mposed of a four-helix bundle connected to a carboxy-terminal immunoglobulin (Ig)-like domain through
168 s N-SH2 domain and a previously unrecognized carboxy-terminal immunoreceptor tyrosine-based activatio
170 age and intracellular Ca(2+), with the large carboxy-terminal intracellular portion being responsible
172 ved by caspases at D1510, disassociating the carboxy-terminal kinase domain from the pore without dis
175 a parallel 3-helix coiled-coil domain of the carboxy-terminal leucine zipper region of CNGA1 subunits
178 sortase-like system for proteolysis-coupled, carboxy-terminal lipid modification exists in bacteria (
179 18-60) showed four rimantadines bound to the carboxy-terminal lipid-facing surface of the helices, su
180 o acids between the leucine-rich repeats and carboxy-terminal low-complexity acidic region domains.
181 member of the SNF2 ATPase superfamily with a carboxy-terminal macrodomain, is encoded by an oncogene
183 larify a regulatory role for the Akt-binding carboxy-terminal modulator protein (CTMP), which has bee
184 stinct from SGR in genomic location, encoded carboxy-terminal motif, and expression through plant and
185 tional requirement in vivo for the AMPKalpha carboxy-terminal NES, as transgenic Drosophila expressin
187 es, chimeric proteins consisting of amino or carboxy-terminal of p85alpha and/or p85beta do not rescu
188 ontains an amino-terminal pyrin domain and a carboxy-terminal oligonucleotide/oligosaccharide-binding
192 1 adaptor protein (NOS1AP), which encodes a carboxy-terminal PDZ ligand of neuronal nitric oxide syn
193 hat target the degradation of p53 and have a carboxy-terminal PDZ ligand that is required for stable
195 eceptor (beta2-AR), through their respective carboxy-terminal PDZ-recognition motifs, individually in
196 ex with a fully phosphorylated 29-amino-acid carboxy-terminal peptide derived from the human V2 vasop
197 al sequence, the protein was identified as a carboxy-terminal peptide of the acute phase protein seru
198 tsZ, referred to here as the CCTP (conserved carboxy-terminal peptide), is required for the interacti
199 d in place through interactions with the two carboxy-terminal periplasmic domains of FimD, a binding
203 n active-like state, bound to NTS(8-13), the carboxy-terminal portion of NTS responsible for agonist-
206 This clearly shows that ArtA is involved in carboxy-terminal post-translational processing of the S-
207 M148, M149, and M150, all of which include a carboxy-terminal PRANC domain which closely resembles a
210 e tissue growth factor (CTGF), procollagen I carboxy-terminal propeptide (PICP), amino-telopeptide of
211 is intensity (assessed by procollagen type I carboxy-terminal propeptide [PICP]), impaired insulin se
212 he characterization of two novel enzymes for carboxy-terminal protein modification provides novel ins
214 ralizing epitopes have been found within the carboxy-terminal receptor binding domains (RBDs) of TcdA
215 ntains an amino-terminal oxygenase domain, a carboxy-terminal reductase domain, and an intervening ca
217 AS) domain and a PAS-cap domain, whereas the carboxy-terminal region contains a cyclic nucleotide-bin
218 cleolar (NoLS) localization signals near the carboxy-terminal region of AAP2 (amino acid positions 14
219 rowth inhibitory activity resides within the carboxy-terminal region of CdiA (CdiA-CT), and that CdiI
220 inus, or deletion of regions in the internal carboxy-terminal region of E protein, led to virus atten
223 activities or interactions specified by the carboxy-terminal region of ICP0 significantly contribute
225 an extended alpha-helix from the disordered carboxy-terminal region of nucleoprotein-core links nucl
227 s that a lipid is covalently attached to the carboxy-terminal region of the S-layer glycoprotein, our
229 e positional homology across species for the carboxy terminal regions and relative positional homolog
231 ns or deletions in the amino-terminal or the carboxy-terminal regions of the E protein were generated
232 function, distinct roles for the amino- and carboxy-terminal regions of the ExbD periplasmic domain
236 y to phosphorylated DOR (pDOR) at the SER363 carboxy-terminal residue, and demonstrated its response
238 fs in Slx5 to aid in substrate targeting and carboxy-terminal RING domains in both Slx5 and Slx8 for
239 calized to their biological substrate when a carboxy-terminal RNA recognition motif domain binds tigh
240 -terminal helicase module, in particular the carboxy-terminal Sec63-2 domain, with the splicing RNA h
241 ) is 35% identical in sequence with a 31-mer carboxy-terminal sEGFR peptide and exhibits an approxima
242 d with Bacillus subtilis spores expressing a carboxy-terminal segment (TcdA26-39) of C. difficile tox
243 odification entails duplicating an amino- or carboxy-terminal segment of the protein and appending it
244 hesis in a transient-transfection assay, the carboxy-terminal segment was crucial for virus replicati
248 roxisomal targeting signal-1 (PTS1), a short carboxy-terminal sequence specifically recognized by the
251 family showed decreased phosphorylation at a carboxy-terminal serine which is predicted to cause clos
252 m substrates have been proposed to contain a carboxy-terminal signal sequence that is necessary and s
253 Several PPR proteins in plants harbor a carboxy-terminal small-MutS-related (SMR) domain, but th
254 a novel tyrosine phosphorylation site in the carboxy-terminal Src Homology 3 (SH3) (SH3C) domain of t
256 itioned in the groove between the amino- and carboxy-terminal subdomains of RCK1, whereas the low-aff
257 residues for DNA binding in cGAS as well as carboxy terminal tail domain for transducing signals in
259 ying its FAD-binding pocket with a conserved carboxy-terminal tail and burying its PER-binding interf
260 lf-driven through interactions between K14's carboxy-terminal tail domain and two regions in the cent
261 large number of multiple KSP repeats in the carboxy-terminal tail domain, which are phosphorylation
262 Here we investigate the negatively charged carboxy-terminal tail domains (CTTs) of alpha- and beta-
266 demonstrate that the connecting segment and carboxy-terminal tail of the beta4 cytoplasmic domain in
267 dentify serine residue 1166 (Ser1166) in the carboxy-terminal tail of the NMDAR subunit GluN2B to be
270 oth alpha- and beta-tubulin proteins possess carboxy-terminal tail regions (CTTs) that are negatively
273 (CP) in the mature proteasome, with the Rpt carboxy-terminal tails inserting into pockets of the alp
275 investigate the inhibition effect of tubulin carboxy-terminal tails using peptide sequences of alpha-
277 Uric acid, C-reactive protein, galectin-3, carboxy-terminal telopeptide of collagen type I, and end
278 nd VSV-DeltaM-Mtc) encoding M protein with a carboxy-terminal tetracysteine tag (Mtc) in place of the
280 e-pair region in the final exon of the gene, carboxy-terminal to the phosphatase catalytic domain.
281 action with Rb1 maps to a domain immediately carboxy-terminal to the T-box and enhances Tbx2 DNA bind
284 ane proteins are 'tail-anchored' by a single carboxy-terminal transmembrane domain that cannot access
288 rane-proximal domain relative to that of the carboxy-terminal transpeptidase domain indicate interdom
289 We found that unlike full-length SAA2.2, the carboxy-terminal truncated SAA2.2 (SAA2.2DeltaC) did not
292 levels, and overexpression of PC1 but not a carboxy-terminal truncation mutant increased ciliary PC2
293 ease domain of P3 and the domains within the carboxy-terminal two-thirds of PB2 are completely rearra
295 is initiated by an E1 enzyme that catalyzes carboxy-terminal Ub adenylation, thioester bond formatio
296 ith STAT3 and p300 to transactivate, whereas carboxy-terminal unphosphorylated Smad3 interacts with S
298 plex interacts with tubulin monomers via the carboxy-terminal winged-helix domain of Ska1, providing
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