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3 The inhibitory domain has been mapped to the carboxyl acidic domain of TSPX, truncation of which rend
5 neous modification of carbon electrodes with carboxyl-amine functionalities offers protection against
7 a coated QDs (QD@SiO2), modified with amino, carboxyl and epoxy groups and stabilized with polyethyle
8 rieties of nanotubes, carrying predominantly carboxyl and hydroxyl functionalities, respectively, fac
10 r binding properties may, in addition to the carboxyl and phenolic groups, be influenced by the molec
11 ns the allowed distance between the backbone carboxyl and the amide carbon of any L-ASP substrate.
13 deposition had not altered the abundance of carboxyl, aryl, alkyl, or O/N-alkyl C in forest floor, b
14 deposition had not altered the abundance of carboxyl, aryl, alkyl, or O/N-alkyl C in forest floor, b
18 e BADC isoforms interact with the two biotin carboxyl carrier protein (BCCP) isoforms of A. thaliana
19 iotinylation reaction of the acceptor biotin carboxyl carrier protein (BCCP), through the expected bi
20 ene families, including P450 monooxygenases, carboxyl/cholinesterases, glutathione-S-transferases, an
22 nd slower rates were observed with increased carboxyl concentration and oxygen, heteroaliphatic, and
23 een eight characteristics (molecular weight, carboxyl concentration, and carbon, oxygen, nitrogen, al
27 acid anion adsorption increased with surface carboxyl content, despite electrostatic repulsion from t
29 main (46-290) for memory suppression whereas carboxyl domain (598-854) and the amino-terminal residue
32 ble number of tandem repeat (VNTR) domain of carboxyl ester lipase (CEL) presents an opportunity to s
33 nes favoring the production of R-9-PAHSA and carboxyl ester lipase (CEL), a PAHSA degradative enzyme,
34 n of the structure of AF-Est2 with the human carboxyl esterase 1, which has CoA thioesterase activity
36 rivative (DEAdcCE) for the protection of the carboxyl function at the side chain of the aspartic acid
37 In addition, we have conjugated hydroxyl or carboxyl function groups on the ICG-NPs for future molec
39 , aliphatic C), a relative increase in amide/carboxyl functional groups and a significant increase in
43 ombined with iron oxide precipitation afford carboxyl functional groups suitable for immobilization o
44 nzoylglycine (H3L), which bears catechol and carboxyl functionalities in tandem, on to the surface of
45 on; thus, we propose that these nitrogen and carboxyl functionalities of aromatic compounds may also
46 tic approach, it is herein demonstrated that carboxyl functionalization of poly(lactic-co-glycolic ac
49 work demonstrates the excellent potential of carboxyl-functionalized graphene oxide (GO-COOH) composi
53 ethylaminophenyl (4), 4-nitrophenyl (5), and carboxyl group (6) as substituents at the exocyclic doub
54 additional polar functional group such as a carboxyl group (as in 3x) or a monosaccharide (as in 4x
56 ree arginines that accommodates the terminal carboxyl group and a dedicated cavity that facilitates b
58 ly attached biotin as a vector to transfer a carboxyl group between donor and acceptor molecules duri
60 dation of proteins (FPOP), and site-specific carboxyl group footprinting to investigate the HOS of pr
61 show that the ethylamido derivative of the 5-carboxyl group from 5-carboxy-fluorescein diacetate or f
62 y line the proton inlet path to an essential carboxyl group in the c-subunit in the proton uptake sit
63 nyl)ethoxy-1,3,2-dioxaphospholane, bearing a carboxyl group in the gamma-position with respect to the
66 s buried within the protein, and the exposed carboxyl group is bound by a Ser-93-fatty acid carboxyl-
67 tem, such as the biphenyl system, and a free carboxyl group leads to highly potent and selective GIVA
68 ealing specific hydrogen bonds between the 5-carboxyl group of 5caC and the conserved epi-DNA recogni
70 residue is enzymatically linked to the gamma-carboxyl group of a glutamate in the primary sequence of
74 the threonine and glycine residues, and the carboxyl group of threonine is amide-linked to the side
76 eractions between active site residues and a carboxyl group on the Pchlide molecule result in a polar
77 iate involves early proton transfer from the carboxyl group to water along with C-C bond cleavage, pr
78 luorescein diacetate, still possesses a free carboxyl group whose ionization constant is such that th
79 antiradical moieties (catechol, guaiacyl and carboxyl group) and molecular conformation in antioxidat
80 purpose as the proton can be carried on the carboxyl group, whereas the basicity of the tropylium io
81 Helix stabilization requires the protonated carboxyl group; unexpectedly, this stabilization could n
82 rmation from primary amines with hydroxyl or carboxyl groups (amino acids), but not from secondary am
83 iwalled carbon nanotubes functionalized with carboxyl groups (MWCNTf) was developed to modify glassy
84 d a fluorescent oxazole (5) having amine and carboxyl groups approximately the same distance apart as
85 bination of readily functionalized amine and carboxyl groups attached to a chiral central core along
86 e of hydrophobic acetyl groups, carbonyl and carboxyl groups caused a partial disorganization and dep
89 s of GAX, followed by more moderate PREs for carboxyl groups in homogalacturonan and rhamnogalacturon
90 fers functionalized products with acetyl and carboxyl groups in one step, in good yields, and with sh
91 -exchange kinetics for individual side-chain carboxyl groups in proteins has been achieved in only a
92 enefited from the reactive functional groups-carboxyl groups of Alb NPs, p19 protein, a viral protein
93 groups of N-terminal residues but also gamma-carboxyl groups of internal (non-N-terminal) Asp and Glu
95 tably trapped within the PAA brushes and the carboxyl groups of PAA can serve as internal proton sour
96 covalently conjugated ICG-NH2 to the pendant carboxyl groups of poly (ethylene glycol)-block-poly(2-m
97 cium-driven electrostatic interactions among carboxyl groups of the AGPs and the pectic acids give ri
99 n binding assays indicated that the retained carboxyl groups of the fatty acids helped maintain a tig
101 via diimide-activated amidation between the carboxyl groups on the CNT surface and amine groups on t
104 ca-coated UCNPs (50 nm in diameter) exposing carboxyl groups on the surface were conjugated to a seco
105 latform for the DNA-c by the large number of carboxyl groups present on the functionalized gold nanop
106 lysis suggests that mechanisms involving two carboxyl groups result in the most stable bond to the mi
107 CNTs used in our studies were derivatized by carboxyl groups to facilitate their dispersion in water.
111 Observations support the deprotonation of carboxyl groups with low acid dissociation constants (pK
112 Substrates having functionalities such as carboxyl groups, alcohols, or heterocycles in the vicini
113 yl-aliphatic ketones, aliphatic and aromatic carboxyl groups, phenol, and methoxy phenyl ethers.
118 turated acyl tail and the negatively charged carboxyl head group are required for PUFAs to open Kv7.1
119 s with ubiquitin involving (i) the ubiquitin carboxyl hydrolase catalytic domain of BAP1, which inter
121 ster carbonyl hydration, suggesting that the carboxyl is linked to more extended H-bond clusters than
122 amates are then sequentially added via alpha-carboxyl-linkages to the growing glutamate side chain.
124 CCP5, we confirmed that it metabolized gamma-carboxyl-linked glutamate of synthetic substrates and tu
125 ereas most CCPs catalyze hydrolysis of alpha-carboxyl-linked glutamates, CCP5 uniquely metabolizes th
126 nmethylated phosphatases to show that PP6 is carboxyl-methylated and that LCMT-1 is the major methylt
128 ggest that LCMT-1 coordinately regulates the carboxyl methylation of PP2A-related phosphatases and, c
131 ulated by the opposing activities of leucine carboxyl methyltransferase 1 (LCMT-1) and protein phosph
132 he results of in vitro characterization of a carboxyl methyltransferase encoded in the cluster, Her8,
134 E-1), or the PP2A methyltransferase, leucine carboxyl methyltransferase-1 (LCMT-1), and examined the
136 th environmentally-sensitive probes Laurdan, carboxyl-modified Laurdan (C-Laurdan), Di-4-ANEPPDHQ, an
140 solution is even more surprising because the carboxyl moiety is not a good electrophile due to the ne
141 ditions where a ureido group is added to the carboxyl moiety to form a cyclic amide, regenerating SP
142 and amine groups NDandante or amine NDamine, carboxyl NDvox or hydroxyl groups NDH and drop-casted or
143 in Acetobacteria: amidation at the alpha-(l)-carboxyl of meso-diaminopimelic acid and the presence of
144 ng (1)H and (13)C PREs were observed for the carboxyls of GAX, followed by more moderate PREs for car
146 action because only compounds that contain a carboxyl or hydroxyl group and have moderate steric hind
147 n most cases, consists of negatively charged carboxyl or hydroxyl groups that limit attractive forces
148 functional groups (any one of primary amino, carboxyl, or primary hydroxyl) enables identification of
152 to the anti-fouling effect conferred by the carboxyl-PEG layer, we could directly detect as little a
153 he development of a microarray platform with carboxyl-polyethylene glycol (PEG) as a functional layer
154 poly (ethylene glycol)-block-poly(2-methyl-2-carboxyl-propylene carbonate) (PEG-PCC) copolymer using
155 poly(ethylene glycol)-block-poly(2-methyl-2-carboxyl-propylene carbonate-graft-dodecanol; PEG-PCD) t
156 oly (ethylene glycol)-block-poly (2-methyl-2-carboxyl-propylene carbonate-graft-SMART-graft-dodecanol
158 decarboxylation of 1: transfer of the second carboxyl proton to the adjacent phenyl carbon and C-C cl
160 ort on the combination of poly [pyrrole-co-3-carboxyl-pyrrole] copolymer and aptamer for the developm
161 rinsic conjugation of the poly [pyrrole-co-3-carboxyl-pyrrole] copolymer and subsequently on its elec
164 on of carboxylates leads to the formation of carboxyl radicals, which upon rapid CO2-extrusion and F(
165 ccharide and their chemically desulfated and carboxyl-reduced derivatives revealed that the sulfate e
168 cationic substrates, LmrP contains catalytic carboxyl residues on the surface of a large interior cha
170 thetic polymers have been shown to mimic the carboxyl-rich surface motifs of non-collagenous proteins
171 a new hypothesis that the substrate's alpha-carboxyl serves as a proton acceptor and activates one o
172 te constants (kon and koff, respectively) of carboxyl side chains, based on (13)C NMR relaxation meas
173 principally when a glycyl residue is at the carboxyl side of Asn and leads to formation of aspartyl
174 dergoes both amino terminal (N-terminal) and carboxyl terminal (C-terminal) proteolytic modifications
175 hiols with a length of 11 carbon atoms and a carboxyl terminal group can efficiently block the charge
176 on of surface electrostatic potential at the carboxyl terminal of the alpha1-helix of HLA class I all
178 aking place at the amino-terminal (FERM) and carboxyl-terminal (FAT) domains and that both domains ar
180 ORF33-binding domain to the highly conserved carboxyl-terminal 19 amino acids (aa) of ORF45 and the U
182 modifies the nascent polypeptide by adding a carboxyl-terminal alanine and threonine (CAT) tail throu
184 4, (ii) the amino-terminal cysteine-rich and carboxyl-terminal basic domains of ORF31 mediate the ORF
185 s-associated speck-like protein containing a carboxyl-terminal caspase-recruitment domain, and caspas
186 nnels are characterized by the presence of a carboxyl-terminal cyclic nucleotide-binding domain (CNBD
187 such as addition of an isoprenyl lipid to a carboxyl-terminal cysteine in proteins that terminate wi
190 Mutational analyses have indicated that the carboxyl-terminal domain (CTD) of hepadnavirus core prot
191 Mutational analyses have suggested that the carboxyl-terminal domain (CTD) of hepadnavirus core prot
193 oes not absolutely require the non-conserved carboxyl-terminal domain (CTD), which is necessary for r
195 gating process, channels lacking the distal carboxyl-terminal domain are no longer regulated by the
196 ding and catalytic motifs, the isolated TlyA carboxyl-terminal domain exhibits no detectable affinity
197 ally occurring DLX3 mutant that disrupts the carboxyl-terminal domain leading to tricho-dento-osseous
199 one H3 at Ser(10) In addition, targeting the carboxyl-terminal domain of CS-GRP78 with a mAb suppress
202 ts revealed that the Ssu72 RNA polymerase II carboxyl-terminal domain phosphatase, a critical determi
206 ) and PHD (plant homeo domain) fingers and a carboxyl-terminal domain that directly binds the largest
207 me interface includes the RNAP subunit alpha carboxyl-terminal domain, which is required for RNAP-rib
209 served common docking (CD) domain within the carboxyl-terminal domains of ERK3 and ERK4 and the conse
212 that the HD together with the DLX3 amino- or carboxyl-terminal domains was required for maximal inhib
214 inantly labeling only single residues in the carboxyl-terminal end of ECL2 and the amino-terminal end
215 with Astn2 TM2 leads to the appearance of a carboxyl-terminal fragment consistent with intramembrane
217 g as well as generation of a cell-associated carboxyl-terminal fragment with potential oncogenic func
218 Cys(6)-sec labeling multiple residues in the carboxyl-terminal half of ECL2 and throughout ECL3, Cys(
223 of MUC16 are ascribed to the cell-associated carboxyl-terminal MUC16 (MUC16-Cter), the exact biochemi
224 Through binding of Erk2 to the second of its carboxyl-terminal NPXY motifs, LRP1 beta-chain positivel
226 study, the data demonstrate that within the carboxyl-terminal portion of mouse TG, T3 is formed de n
228 ng proteins, including E2f, interact through carboxyl-terminal protein interaction domains, but genet
229 protein lacking N-terminal myristoylation, a carboxyl-terminal pX extension of VP1, VP2 late domains
232 ipitation studies showed the alpha-actinin-4 carboxyl-terminal region specifically interacted with th
233 mong known TRP structures, together with the carboxyl-terminal region, forms a large two-layered cyto
236 he amino-terminal region of the protein, and carboxyl-terminal tail identity both contribute to MLO a
237 ons and that alterations affecting the ATP7A carboxyl-terminal tail induce release of the copper tran
239 ction with a beta2-adrenoceptor fused to the carboxyl-terminal tail of the vasopressin type 2 recepto
240 (362), Ser(363) and Thr(366) residues at the carboxyl-terminal tail were primarily responsible for ss
241 ared with AVR1, A-L is shorter and lacks the carboxyl-terminal tail, the T-region that is crucial for
245 protein-SlGGB1 fusion protein as well as the carboxyl-terminal yellow fluorescent protein-SlGGB1/amin
246 ransition coupled the phosphorylation of the carboxyl-terminal-domain (CTD) of RNA polymerase II (RNA
247 oth hydroxyl-terminated 'neutral' (D-OH) and carboxyl-terminated 'anionic' (D-COOH) Polyamidoamine (P
249 nine dimer spokes radiate, placing the Sas-6 carboxyl termini at the outer edge of the approximately
251 imately 4-5 nm, revealing that the amino and carboxyl termini of Ana2 are located in the outer cartwh
252 The results indicate that the amino and carboxyl termini of PHO1 are both oriented toward the cy
253 cted cells, we determined that the amino and carboxyl termini reside in the extracellular space and a
254 y conserved among different Cxs, whereas the carboxyl termini, often called the cytoplasmic tails, ar
258 tion of a helix extending toward the peptide carboxyl terminus and docking within the receptor amino
259 y receptor phosphorylation, primarily in the carboxyl terminus but also in the cytoplasmic loops, and
260 d V166E rClC-K1 demonstrated that the distal carboxyl terminus is necessary for slow cooperative gati
264 molecular interaction assay reveals that the carboxyl terminus of APC interacts with the matrix regio
265 in bacterial proteasomal ATPases, buries the carboxyl terminus of each protomer in the central channe
271 luorescent protein (YFP) was tethered to the carboxyl terminus of the alpha2A adrenergic receptor (al
273 f Gbetagamma-specific scavengers-namely, the carboxyl terminus of the G protein-coupled receptor kina
275 h an unexpected epsilon-glycinylglycinyl-Lys carboxyl terminus when the site of linkage is Lys48.
276 h the exclusion of exon 3 generates a unique carboxyl terminus with specific anti-apoptotic functions
277 e identify the HECT (homologous to the E6-AP carboxyl terminus) family E3 ubiquitin ligase, UBR5, as
278 g new gene) and HECT (homologous to the E6AP carboxyl terminus) types shed light on their enzymatic a
279 ane helices followed by a long intracellular carboxyl terminus, and earlier work demonstrated that th
282 p53 is subject to lysine methylation at its carboxyl terminus, which has been shown to repress p53's
283 s it has an exceptionally long intracellular carboxyl terminus, which is predicted to be mainly disor
284 sphorylation of AQP2 at various sites in its carboxyl terminus, with Ser-256 phosphorylation critical
290 ing Cx43 with ACT1, a peptide mimetic of the carboxyl-terminus of Cx43, accelerates fibroblast migrat
291 somal activity, suggesting that the extended carboxyl-terminus of this cofactor confers suboptimal bi
292 Intriguingly, the truncation of the PafE carboxyl-terminus resulted in the robust binding of PafE
295 terminal groups, an amino, a hydroxyl, and a carboxyl, were investigated using two different molecule
298 hermore, myocardial-specific deletion of the carboxyl zinc-finger of Gata6 alters atrioventricular co
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