ライフサイエンスコーパス: carboxylase

1 As, and we have named it long-chain acyl-CoA carboxylase.

2 cant change in phosphorylation of acetyl CoA carboxylase.

3 es the second partial reaction of acetyl-CoA carboxylase.

4 sed phosphorylated (p-)AMPK and p-acetyl CoA carboxylase.

5 to form malonyl-CoA, catalyzed by acetyl-CoA carboxylase.

6 e reduced activity of crotonyl-CoA reductase/carboxylase.

7 g Acc1p, the rate-limiting enzyme acetyl-CoA carboxylase.

8 the chloroplast genome, ribulose diphosphate carboxylase.

9 ted protein kinase and its target acetyl-CoA carboxylase.

10 accumulate chloroplastic phosphoenolpyruvate carboxylase.

11 erent from those of related biotin-dependent carboxylases.

12 anslational biotinylation of acyl coenzyme A carboxylases.

13 rent from that of the other biotin-dependent carboxylases.

14 zymes collectively known as biotin-dependent carboxylases.

15 xation reactions by supplying bicarbonate to carboxylases.

16 or multiple metabolic reactions catalyzed by carboxylases.

17 inimal biotin acceptor BCCP fragments of the carboxylases.

18 icity in dictating biotin distribution among carboxylases.

19 otein (BCCP) domain of five biotin-dependent carboxylases.

20 mechanism and evolution of biotin-dependent carboxylases.

21 carbonate, the required substrate of various carboxylases.

22 cell-specific deletion of acetyl coenzyme A carboxylase 1 (ACC1), an enzyme that catalyzes conversio

23 rements of key lipogenic enzymes [acetyl CoA carboxylase 1 (ACC1), fatty acid synthase (FASN), and st

24 By contrast, biotinylation of the acetyl-CoA carboxylase 1 and 2 (ACC1 and ACC2) fragments, both of w

25 ovel series of dual inhibitors of acetyl-CoA carboxylase 1 and 2 (ACC1 and ACC2).

26 nfection, a specific inhibitor of acetyl CoA carboxylase 1, 5-(tetradecyloxy)-2-furoic acid, was admi

27 lipogenesis: fatty acid synthase, acetyl-CoA carboxylase 1, and glycerol-3-phosphate acyltransferase.

28 arly pharmaceutical inhibition of acetyl CoA carboxylase 1, the rate limiting step of FAS, inhibit ge

29 We have shown previously that acetyl-CoA carboxylase 2 (Acc2(-/-)) mutant mice, when fed a high-f

30 ecause malonyl CoA production via acetyl CoA carboxylase 2 (ACC2) inhibits the entry of long chain fa

31 nt abundance via hydroxylation of acetyl-coA carboxylase 2 (ACC2).

32 t of adipose triglyceride lipase, acetyl-CoA carboxylase 2 and AMP-activated protein kinase (AMPK)gam

33 r 1c, fatty acid synthase, acetyl coenzyme A carboxylase 2, and carnitine palmitoyltransferase 1 alph

34 NADPH:2-ketopropyl-coenzyme M oxidoreductase/carboxylase (2-KPCC), an atypical member of the disulfid

35 nservation with the related biotin-dependent carboxylases 3-methylcrotonyl-CoA carboxylase (MCC) and

36 ed by decreased protein levels of acetyl-CoA carboxylase, a key regulator of both lipid oxidation and

37 e lipid synthesis is catalyzed by acetyl-CoA carboxylase, a large complex composed of four subunits.

38 ased abundances of mRNA encoding Acetyl Co-A carboxylase (Acc) (up 25%) and Hsp70 (up 32%) in experim

39 that required phosphorylation of acetyl-CoA carboxylase (ACC) 1 and/or ACC2 at the AMPK sites.

40 ated by the SREBP-SCD pathway, an acetyl-CoA carboxylase (ACC) and certain nuclear hormone receptors

41 Acetyl-CoA carboxylase (ACC) catalyzes the rate-determining step in

42 c, fatty acid synthase (FAS), and acetyl-CoA carboxylase (ACC) gene expression.

43 ice by liver-specific knockout of acetyl-CoA carboxylase (ACC) genes and treat the mice with the hepa

44 Acetyl-CoA carboxylase (ACC) has crucial roles in fatty acid metabo

45 could be used to identify acetyl coenzyme A carboxylase (ACC) in Pseudomonas aeruginosa and human ce

46 biochemical or a genetic block at acetyl-CoA carboxylase (ACC) in S. aureus, confirming that regulati

47 The development of acetyl-CoA carboxylase (ACC) inhibitors for the treatment of metabo

48 of oxo-dihydrospiroindazole-based acetyl-CoA carboxylase (ACC) inhibitors is reported.

49 Acetyl-CoA carboxylase (ACC) inhibitors offer significant potential

50 Acetyl-CoA carboxylase (ACC) is a target of interest for the treatm

51 ent excess, induced both AMPK and acetyl-CoA carboxylase (ACC) phosphorylation.

52 utical inhibition of acetyl-coenzyme A (CoA) carboxylase (ACC), a key fatty acid biosynthetic enzyme,

53 olled by the rate-limiting enzyme acetyl-CoA carboxylase (ACC), an attractive but traditionally intra

54 ymes [fatty acid synthase (FASN), acetyl-CoA carboxylase (ACC), ATP citrate lyase (ACLY)].

55 RNAi silencing of Acetyl Co-A carboxylase (ACC), highly expressed in JGM-treated BPH,

56 olecule inhibitor of acetyl coenzyme A (CoA) carboxylase (ACC), the enzyme that controls the first ra

57 Kalpha and its downstream target, acetyl-CoA carboxylase (ACC), were hyperphosphorylated, indicative

58 AMPK phosphorylates and inhibits acetyl-CoA carboxylase (ACC), which catalyzes carboxylation of acet

59 get is the multifunctional enzyme acetyl-CoA carboxylase (ACC), which catalyzes the first committed s

60 levels of phosphorylated AMPK and acetyl-CoA carboxylase (ACC).

61 lation and inactivation of acetyl coenzyme A carboxylase (ACC).

62 downstream target phospho-acetyl-coenzyme A carboxylase (ACC).

63 2AMPK) and its downstream target, acetyl-CoA carboxylase (ACC).

64 of fatty acid synthase (FAS) and acetyl-CoA carboxylase (ACC).

65 an allosteric inhibitor of acetyl-coenzyme A carboxylases (ACC) ACC1 and ACC2, reduces hepatic de nov

66 reased phosphorylation, decreased acetyl-CoA carboxylase Acc1 phosphorylation, and sterol response el

67 The inhibition of the acetyl-CoA carboxylases ACC1 and ACC2 by AMPK maintains NADPH level

68 ement binding protein (SREBP)-1c, acetyl-CoA carboxylase (ACC1) and lipid uptake genes, such as PPARg

69 s is regulated by the activity of acetyl-CoA carboxylase (Acc1), the first and rate-limiting enzyme o

70 of fatty acid synthase (Fas) and acetyl-CoA carboxylase (Acc1).

71 which together pinpoint plastidic acetyl-CoA carboxylase (ACCase) as the enzymatic target of feedback

72 Acetyl-CoA carboxylase (ACCase) catalyzes the committed step of de

73 C2) that targets homomeric acetyl-coenzyme A carboxylase (ACCase) to plastids.

74 Acetone carboxylases (ACs) catalyze the conversion of substrates

75 s of pyruvate kinase and phosphoenolpyruvate carboxylase activities indicate that pyruvate is supplie

76 olysis, hepatic acetyl CoA content, pyruvate carboxylase activity and hepatic glucose production.

77 evolution, despite its competition with the carboxylase activity necessary for carbon fixation, yet

78 They enhance the carboxylase activity of RuBisCO by increasing the local

79 entrating pathway that helps to maximize the carboxylase activity of the enzyme while suppressing its

80 Ribulose-1,5-bisphosphate carboxylase activity was confirmed in H2/bicarbonate-gro

81 ssing seeds indicated the in vivo acetyl-CoA carboxylase activity was reduced to approximately half t

82 ydroxylase alleviated the reduced acetyl-CoA carboxylase activity, restored the rate of fatty acid sy

83 ate the expression of crotonyl-CoA reductase/carboxylase, an enzyme of the ethylmalonyl-CoA pathway i

84 hosphate synthetase 1 (urea cycle), pyruvate carboxylase (anaplerosis, gluconeogenesis), propionyl-Co

85 ynthesis and consists of two enzymes: biotin carboxylase and carboxyltransferase.

86 biotin acceptor protein of acetyl-coenzyme A carboxylase and catalyzes posttranslational biotinylatio

87 is associated with activation of acetyl-CoA carboxylase and changes in the expression profiles of re

88 kinase, MB inactivates downstream acetyl-CoA carboxylase and decreases cyclin expression.

89 ts and regulators of lipogenesis, acetyl CoA carboxylase and fatty acid synthase.

90 sis, as well as the expression of acetyl-CoA carboxylase and fatty acid synthase.

91 ssion of the mSREBP1 target genes acetyl-CoA carboxylase and fatty-acid synthase was suppressed, alon

92 RNAs for simultaneous repression of pyruvate carboxylase and glutaminase by selecting all seed matche

93 g AMPK-induced phosphorylation of acetyl-CoA carboxylase and in activating the PI3K/AKT pathway throu

94 stimulated flux through phosphoenolpyruvate carboxylase and malic enzyme, altered the balance betwee

95 ng enzyme AMPK, and inhibition of acetyl-CoA carboxylase and mammalian target of rapamycin signaling

96 nslational regulation of phosphoenolpyruvate carboxylase and nitrate reductase.

97 orylate its endogenous substrates acetyl CoA carboxylase and Raptor, and provokes mitochondrial bioge

98 xidation partially occurred through pyruvate carboxylase and rendered NNT knockdown cells more sensit

99 activity of the anabolic factors acetyl-CoA carboxylase and ribosomal protein S6 and inhibiting aero

100 vitro activities of both phosphoenolpyruvate carboxylase and Rubisco were increased.

101 abolic pathway from NaAD using unprecedented carboxylase and sulfur transferase reactions to form the

102 keto acid dehydrogenase E1 component, biotin carboxylase and superoxide dismutase were related to ene

103 a conserved component among biotin-dependent carboxylases and catalyzes the MgATP-dependent carboxyla

104 these proteins likely function as guanidine carboxylases and guanidine transporters, respectively.

105 the expression of proteins annotated as urea carboxylases and multidrug efflux pumps.

106 anaplerosis, gluconeogenesis), propionyl-CoA carboxylase, and 3-methylcrotonyl-CoA carboxylase (branc

107 sed phosphorylation of raptor and acetyl-CoA carboxylase, and decreased phosphorylation of ULK1 (Ser-

108 malic acid inhibition of phosphoenolpyruvate carboxylase, and enzyme kinetics) was simulated.

109 nt-binding protein 1c (SREBP-1c), acetyl-CoA carboxylase, and fatty-acid synthase, three key function

110 enolpyruvate carboxykinase (PEPCK), pyruvate carboxylase, and glucose-6-phosphatase, and the neonate'

111 red the phosphorylations of AMPK, acetyl CoA carboxylase, and glycogen synthase kinase-3, decreased g

112 lement-binding proteins 1c and 2, acetyl-CoA carboxylase, and HMG-CoA reductase mRNAs/proteins and in

113 -CoA content, a potent activator of pyruvate carboxylase, and increased glycerol conversion to glucos

114 oxylases propionyl-CoA carboxylase, pyruvate carboxylase, and methylcrotonoyl-CoA carboxylase is fast

115 strates, including Raptor, acetyl coenzyme A carboxylase, and PGC-1alpha, is attenuated in IRE1alpha-

116 n fatty acid synthesis, including acetyl-CoA carboxylase, and three out of five putative type II digl

117 Biotin-dependent carboxylases are widely distributed in nature and have i

118 Interestingly, pyruvate carboxylase ASO also reduced adiposity, plasma lipid con

119 Pyruvate carboxylase ASO did not alter de novo fatty acid synthes

120 Pyruvate carboxylase ASO had similar effects in Zucker Diabetic F

121 Pyruvate carboxylase ASO reduced plasma glucose concentrations an

122 1-c, SREBP2, fatty-acid synthase, acetyl-CoA carboxylase, ATP citrate lyase, and Glut-1 were signific

123 LmPC), a biotin-dependent enzyme with biotin carboxylase (BC) and carboxyltransferase (CT) activities

124 ACC contains biotin carboxylase (BC) and carboxyltransferase (CT) activities

125 catalyzed by the holo-ACC components, biotin carboxylase (BC) and carboxyltransferase (CT), were simu

126 Biotin carboxylase (BC) is a conserved component among biotin-d

127 PC contains biotin carboxylase (BC), carboxyltransferase (CT) and biotin ca

128 moiety to a specific lysine residue of each carboxylase BCCP domain.

129 h was predicted to inhibit acetyl coenzyme A carboxylase beta, a key fatty acid oxidation enzyme that

130 yl-CoA carboxylase, and 3-methylcrotonyl-CoA carboxylase (branched chain amino acids catabolism).

131 gulation of the model C4 phosphoenolpyruvate carboxylase (C4-Pepc) promoter in maize (Zea mays).

132 x ), the maximum rate of phosphoenolpyruvate carboxylase carboxylation (Vpmax ), and foliar dark resp

133 In human cells, biotin-dependent carboxylases catalyze key reactions in gluconeogenesis,

134 ncoding a plastid-targeted acetyl-coenzyme A carboxylase, cause hypersensitivity to spectinomycin.

135 ioesters catalysed by crotonyl-CoA reductase/carboxylase (CCRC) homologues.

136 e AMPK substrates, p53 and acetyl-coenzyme A carboxylase, changes that correlated with increased miR-

137 on hypotheses by feeding leaves with the PEP carboxylase competitive inhibitors malate and diethyl ox

138 ient and specific interactions with the urea carboxylase component of urea amidolyase.

139 34H encodes a 3-octaprenyl-4-hydroxybenzoate carboxylase (CpsUbiX, UniProtKB code: Q489U8) that is in

140 ulation of plastid-encoded acetyl Coenzyme A carboxylase D proteins accounting for the generation of

141 cle defects, organic acidurias, and pyruvate carboxylase deficiency as a treatable condition in the d

142 host was supported by experiments with a PEP carboxylase-deficient mutant strain in blood and cerebro

143 e for citrate cycling rather than acetyl-CoA carboxylase-dependent fatty acid synthesis.

144 c group must first gain access to the biotin carboxylase domain and become carboxylated and then tran

145 al conformation in the absence of the biotin carboxylase domain and that the carboxyltransferase doma

146 version, consisting of little more than the carboxylase domain of the plastidic accD gene fused to a

147 onments, where heteromeric acetyl-coenzyme A carboxylase encoded in part by the chloroplast genome ca

148 Microorganisms use carboxylase enzymes to form new carbon-carbon bonds by i

149 We confirmed that BPL-1 biotinylates four carboxylase enzymes, and we demonstrate that BPL-1 is re

150 g a ligand-stimulated decrease in acetyl-CoA carboxylase expression.

151 tty acid synthesis genes, namely, acetyl-CoA carboxylase, fatty acid synthase, SREBP1c, chREBP, gluco

152 al citrate synthase flux (V CS) and pyruvate carboxylase flux (V PC) in vivo.

153 ssue (WAT) leading to reductions in pyruvate carboxylase flux.

154 acetyl-CoA allosteric activation of pyruvate carboxylase flux.

155 uvate dehydrogenase and anaplerotic pyruvate carboxylase fluxes.

156 one, the latter required by the enzyme gamma-carboxylase for gamma-carboxylation of all vitamin K-dep

157 ession of genes encoding PEX7 and acetyl-CoA carboxylase further improved fatty alcohol production by

158 Geranyl-CoA carboxylase (GCC) is essential for the growth of Pseudom

159 First, the phosphoenolpyruvate carboxylase gene (ppc) from Klebsiella pneumoniae was ov

160 e dexamethasone system to silence acetyl-CoA carboxylase gene and observed prolific root growth when

161 trix, OCN is gamma-carboxylated by the gamma-carboxylase (GGCX) on three glutamic acid residues, a ce

162 associated with mutations in gamma-glutamyl carboxylase (GGCX) that often has fatal outcomes.

163 tem for studying mutations in gamma-glutamyl carboxylase (GGCX), the enzyme responsible for convertin

164 Eleven spontaneous mutations of acetyl-CoA carboxylase have been identified in many herbicide-resis

165 c (CE) assay for measuring acetyl coenzyme A carboxylase holoenzyme (holo-ACC) activity and inhibitio

166 crystal structure of the long-chain acyl-CoA carboxylase holoenzyme from Mycobacterium avium subspeci

167 and BCCP domains and other biotin-dependent carboxylase holoenzymes are known, there is currently no

168 ain (120 kDa), multi-domain biotin-dependent carboxylase in bacteria.

169 on catalyzed by phosphoribosylaminoimidazole carboxylase in purine metabolism.

170 We assessed the role of pyruvate carboxylase in regulating glucose and lipid metabolism i

171 increased UCP-3 and inhibition of acetyl-CoA carboxylase in skeletal muscle, findings consistent with

172 Carbonic anhydrase and phosphoenolpyruvate carboxylase in vitro activity varied significantly despi

173 [3,4-c]pyridin]-7'(2'H)-one-based acetyl-CoA carboxylase inhibitors is reported.

174 Tissue-specific inhibition of pyruvate carboxylase is a potential therapeutic approach for nona

175 metabolic diseases in humans, and acetyl-CoA carboxylase is a target for drug discovery in the treatm

176 n yeast Saccharomyces cerevisiae, acetyl-CoA carboxylase is encoded by the ACC1 gene.

177 In particular, we demonstrate that pyruvate carboxylase is essential to re-supply the depleted pool

178 yruvate carboxylase, and methylcrotonoyl-CoA carboxylase is fast and limited by the bimolecular assoc

179 ed protein kinase called phosphoenolpyruvate carboxylase kinase (PPCK).

180 ria monocytogenes by inhibiting its pyruvate carboxylase (LmPC), a biotin-dependent enzyme with bioti

181 luding the central metabolic enzyme pyruvate carboxylase (LmPC).

182 -dependent carboxylases 3-methylcrotonyl-CoA carboxylase (MCC) and propionyl-CoA carboxylase (PCC).

183 3-methylcrotonyl CoA carboxylase (MCCase) is a nuclear-encoded, mitochondrial

184 rucial in bicarbonate provision for pyruvate carboxylase-mediated oxaloacetate synthesis.

185 levels of Fatty Acid Synthase and Acetyl CoA Carboxylase mRNAs, enzymes responsible for lipid synthes

186 inus resembles aminoimidazole ribonucleotide carboxylase/mutase, LarC binds Ni and could act in Ni de

187 stinct lineages of biotin-dependent acyl-CoA carboxylases, one carboxylating the alpha carbon of a sa

188 result of enhanced activity of cytosolic PEP carboxylase or by limited supply of energetic and reduct

189 ding form I ribulose-1,5-bisphosphate (RuBP) carboxylase oxygenase (RubisCO) along with a divergently

190 Ribulose 1,5 bisphosphate carboxylase oxygenase (Rubisco) concentrations were quan

191 educed affinity of ribulose-1,5-bisphosphate carboxylase oxygenase (RuBisCO) to CO2 under conditions

192 lvin Cycle enzyme, Ribulose 1,5 bisphosphate carboxylase oxygenase (Rubisco).

193 tosynthesis (e.g., ribulose-1,5-bisphosphate carboxylase oxygenase genes rbcS and rbcL), imply large-

194 Ribulose-1,5-biphosphate-carboxylase-oxygenase (RuBisCO) has a crucial role in ca

195 hybrid type II/III ribulose-1,5-bisphosphate carboxylase-oxygenase (RuBisCO) that couples adenosine m

196 100 genes encoding ribulose-1,5 bisphosphate carboxylase-oxygenase subunit proteins of the Calvin cyc

197 ies of the enzymes ribulose 1,5-bisphosphate carboxylase/ oxygenase and carbonic anhydrase to facilit

198 Ribulose-bisphosphate carboxylase/oxygenase (Rubisco) activase uses the energy

199 boxysomal enzymes, ribulose-1,5-bisphosphate carboxylase/oxygenase (RuBisCO) and carbonic anhydrase (

200 n by concentrating ribulose-1,5-bisphosphate carboxylase/oxygenase (RuBisCO) and its substrate CO2 wi

201 of carbon, ribulose-1,5-bisphosphate (RuBP) carboxylase/oxygenase (Rubisco) catalyzes primary carbon

202 The enzyme ribulose-1,5-bisphosphate carboxylase/oxygenase (Rubisco) catalyzes two competing

203 hibitors from dead-end ribulose-bisphosphate carboxylase/oxygenase (Rubisco) complexes requires the a

204 rbon-fixing enzyme ribulose-1,5-bisphosphate carboxylase/oxygenase (RuBisCO) in a paracrystalline lat

205 Ribulose 1,5-bisphosphate carboxylase/oxygenase (RubisCO) is a critical yet severe

206 Ribulose 1,5-bisphosphate carboxylase/oxygenase (RuBisCO) is a crucial enzyme in c

207 CO2-fixing enzyme ribulose 1,5-bisphosphate carboxylase/oxygenase (rubisco) is inhibited by nonprodu

208 Ribulose-1,5-bisphosphate carboxylase/oxygenase (Rubisco) is the key enzyme involv

209 hetic organisms, D-ribulose-1,5-bisphosphate carboxylase/oxygenase (Rubisco) is the major enzyme assi

210 Ribulose-1,5-biphosphate carboxylase/oxygenase (Rubisco) is the most abundant enz

211 CO2-fixing enzyme ribulose-1,5-bisphosphate carboxylase/oxygenase (Rubisco) often limit plant produc

212 Ribulose-1,5-bisphosphate carboxylase/oxygenase (Rubisco) plays a critical role in

213 ntalize the enzyme ribulose-1,5-bisphosphate carboxylase/oxygenase (RuBisCO) with carbonic anhydrase.

214 om the reaction of ribulose 1,5-bisphosphate carboxylase/oxygenase (Rubisco) with O2 instead of CO2 ,

215 ion at the site of ribulose-1,5-bisphosphate carboxylase/oxygenase (Rubisco), simultaneously enhancin

216 Ribulose-1,5-bisphosphate carboxylase/oxygenase (RuBisCO), the carboxylating enzym

217 ge subunit (LS) of ribulose 1,5-bisphosphate carboxylase/oxygenase (Rubisco), the enzyme catalyzing t

218 alog-bound form II ribulose-1,5-bisphosphate carboxylase/oxygenase (Rubisco).

219 imary carboxylase, ribulose-1,5-bisphosphate carboxylase/oxygenase (Rubisco).

220 on fixing enzyme, ribulose-1,5-bis-phosphate carboxylase/oxygenase (Rubisco).

221 CO2 fixing enzyme ribulose-1,5-bisphosphate carboxylase/oxygenase (Rubisco).

222 e carboxylating enzyme ribulose bisphosphate carboxylase/oxygenase (RuBisCO).

223 hs by sequestering ribulose-1,5-bisphosphate carboxylase/oxygenase and carbonic anhydrase in the micr

224 sulate the enzymes ribulose 1,5-bisphosphate carboxylase/oxygenase and carbonic anhydrase.

225 e small subunit of ribulose-1,5-bisphosphate carboxylase/oxygenase and its reverse peptide with a ser

226 and, by extension, ribulose-1,5-bisphosphate carboxylase/oxygenase and the carbonic anhydrase CcaA, w

227 e dual activity of ribulose-1,5-bisphosphate carboxylase/oxygenase and the resulting loss of CO(2) by

228 refolding of bacterial ribulose-bisphosphate carboxylase/oxygenase but gained this ability when CrCpn

229 Mg(2+) within the ribulose-1,5-bisphosphate carboxylase/oxygenase family of enzymes.

230 imple kinetic model of ribulose bisphosphate carboxylase/oxygenase function.

231 enitrification and ribulose 1,5-bisphosphate carboxylase/oxygenase gene clusters, underscoring its ab

232 Rubisco (ribulose-1,5-bisphosphate carboxylase/oxygenase) catalyses the key reaction in the

233 small subunit of ribulose-1,5-bis-phosphate carboxylase/oxygenase, and ferredoxin, we exposed these

234 ss II aldolase, or ribulose 1,5-bisphosphate carboxylase/oxygenase, large subunit (RuBisCO) superfami

235 ontribution of the ribulose-1,5-bisphosphate carboxylase/oxygenase-bypass to seed storage metabolism

236 d-Ribulose 1,5-bisphosphate carboxylase/oxygenases (RuBisCOs) are promiscuous, catal

237 cid oxidation, activated the AMPK-acetyl-CoA carboxylase pathway, and promoted inefficient metabolism

238 rent correlation with gluconeogenic pyruvate carboxylase (PC) activity in hepatocytes.

239 mine, which require the activity of pyruvate carboxylase (PC) and glutaminase 1 (GLS1), respectively.

240 Pyruvate carboxylase (PC) has important roles in metabolism and i

241 in the structure of the tetrameric pyruvate carboxylase (PC) holoenzyme.

242 Pyruvate carboxylase (PC), a multifunctional biotin-dependent enz

243 ression of the mitochondrial enzyme pyruvate carboxylase (PC), resulting in diminished production of

244 the carboxyl transferase domain of pyruvate carboxylase (PC).

245 onyl-CoA carboxylase (MCC) and propionyl-CoA carboxylase (PCC).

246 The activities of phosphoenolpyruvate (PEP) carboxylase (PEPC) and the PEP-regenerating enzyme, pyru

247 tant functions for phosphoenolpyruvate (PEP) carboxylase (PEPC) in inorganic phosphate (Pi)-starved p

248 Phosphoenolpyruvate carboxylase (PEPC) is a crucial enzyme that catalyzes an

249 Phosphoenolpyruvate carboxylase (PEPC) is a tightly controlled cytosolic enz

250 ymatic rates of Rubisco, phosphoenolpyruvate carboxylase (PEPc), and carbonic anhydrase (CA).

251 e for C4 photosynthesis, Phosphoenolpyruvate Carboxylase (PEPC), evolved from nonphotosynthetic PEPC

252 tion after inhibition of phosphoenolpyruvate carboxylases (PEPCs), and increases in PEPC transcript a

253 le via a stage-dependent phosphoenolpyruvate carboxylase/phosphoenolpyruvate carboxykinase process th

254 ed AMPK activation and downstream acetyl-CoA carboxylase phosphorylation and glucose uptake in isolat

255 vels, and diminished acetyl coenzyme A (CoA) carboxylase phosphorylation than in the wild-type livers

256 Acetyl-CoA carboxylase phosphorylation was increased in gastrocnemi

257 K activity, particularly phosphoenolpyruvate carboxylase (PPC) and PPDK in rNAD-ME1.

258 production of the enzyme phosphoenolpyruvate carboxylase (PPC) and that adventitious overexpression o

259 Phosphoenolpyruvate carboxylase (PPC; EC 4.1.1.31) catalyzes primary nocturn

260 osphate synthase (PpsAB) and phenylphosphate carboxylase (PpcABCD) and syntrophic terephthalate-degra

261 n of the BCCP fragments of the mitochondrial carboxylases propionyl-CoA carboxylase, pyruvate carboxy

262 EPC is phosphorylated by Phosphoenolpyruvate Carboxylase Protein Kinase (PPCK).

263 ecimens and found that only hepatic pyruvate carboxylase protein levels related strongly with glycemi

264 umulated a chloroplastic phosphoenolpyruvate carboxylase protein, albeit at reduced amounts relative

265 or biotin auxotrophs and identified pyruvate carboxylase (Pyc) as required for biotin biosynthesis.

266 low CO2 , including both PEPCs and pyruvate carboxylase (PYC), whereas ME abundance did not change a

267 s in the acetyl-CoA binding site of pyruvate carboxylase (PycA) rescued cefuroxime resistance and res

268 the mitochondrial carboxylases propionyl-CoA carboxylase, pyruvate carboxylase, and methylcrotonoyl-C

269 Maize genes encoding phosphoenolpyruvate carboxylase, pyruvate, orthophosphate dikinase, and the

270 tate exclusively via the phosphoenolpyruvate carboxylase reaction.

271 taacuI::kan mutant phenotype by crotonyl-CoA carboxylase/reductase from R. sphaeroides was attributed

272 a mutation in the gene encoding crotonyl-CoA carboxylase/reductase, demonstrating that acetate produc

273 Many bicarbonate-incorporating carboxylases rely on the organic cofactor biotin for the

274 artment in which algae sequester the primary carboxylase, ribulose-1,5-bisphosphate carboxylase/oxyge

275 d an archaeal-type ribulose-1,5-bisphosphate carboxylase (RubisCO) involved in AMP recycling.

276 lvin cycle enzyme, ribulose 1,5-bisphosphate carboxylase (RubisCO), prevents photoheterotrophic growt

277 ptation is that of ribulose-1,5-bisphosphate carboxylase (RubisCO), the enzyme responsible for fixati

278 of biotinylation suggests that mitochondrial carboxylase sequences evolved to produce fast associatio

279 e, we show that the chloroplastic acetyl-CoA carboxylase subunit (accD) gene that is present in the p

280 in steady-state behavioural assays, acetone carboxylase subunit (acxC) mutant behaviour was altered.

281 protease subunit (clpP)-like and acetyl-CoA carboxylase subunit D (accD)-like open reading frames.

282 translation of the plastid-encoded ACC beta-carboxylase subunit.

283 mide activated AMPK and inhibited acetyl-CoA carboxylase, suggesting activation of fat metabolism in

284 at the otherwise integrative enzyme pyruvate carboxylase (TgPyC) is dispensable not only in glycolysi

285 pic polypeptide (GIP) receptor, and pyruvate carboxylase) that are important regulators of beta-cell

286 ng system provided by a cytosolic acetyl-CoA carboxylase, the mitochondrial AAE13 protein is essentia

287 x mutations on the sensitivity of acetyl-CoA carboxylase to nine herbicides representing the three ch

288 version of lactate to pyruvate, via pyruvate carboxylase to oxaloacetate, and via PCK2 to phosphoenol

289 pathways with varying flux ratio of RubisCO carboxylase to oxygenase may contribute to the adaptive

290 ene that targets homomeric acetyl-coenzyme A carboxylase to plastids, where the multidomain protein c

291 mary downstream targeting enzyme, acetyl-CoA carboxylase, up-regulated gene expression of carnitine p

292 The activity of pyruvate carboxylase was low in muscle, and no PEP carboxykinase

293 tivity in HCS-catalyzed biotinylation to the carboxylases was investigated in single turnover stopped

294 canola endogenous reference gene (acety-CoA-carboxylase) was constructed and used for duplex real-ti

295 os of PEPC and PPDK to ribulose bisphosphate carboxylase were substantially lower than 1, even at low

296 SNF1 phosphorylates and inhibits acetyl-CoA carboxylase, which catalyzes the carboxylation of acetyl

297 Pyruvate carboxylase, which catalyzes the first step of gluconeog

298 ction of new herbicides targeting acetyl-CoA carboxylase will depend on their ability to overcome the

299 e may be fixed via the ribulose bisphosphate carboxylase, Wood-Ljungdahl pathway or reductive TCA cyc

300 of the unusual beta-subunit of the acyl-CoA carboxylase (YCC) responsible for this reaction, alone a