ライフサイエンスコーパス: carboxylated

1 contribute to secreted fIX being more fully carboxylated.

2 gamma-carboxyglutamic acid (Gla) domain are carboxylated.

3 erage only 32% of the protein is fully gamma-carboxylated.

4 rboxylase substrate, conantokin G, is poorly carboxylated.

5 mic reticulum, where it is extensively gamma-carboxylated.

6 egion of thrombin that is not normally gamma-carboxylated.

7 s nevertheless confirmed that Glu36 is gamma-carboxylated.

8 w herein that Lys302 is post-translationally carboxylated.

9 MCl2 complexes of a new p-carboxylated 1,2-bis(diphenylphosphino)benzene ligand ar

10 dium salts and the ethyl esters of the three carboxylated 1,4-bis(aminostyryl)-2,5-bis(phenylethynyl)

11 Fully carboxylated 1.3S can be prepared in vitro using 1.3S, M

12 r peaks are absent in the 1D spectrum of non-carboxylated 1.3S due to exchange between two or more co

13 For the carboxylated 1.3S, the difference spectra provided the v

14 ssure method was demonstrated for a range of carboxylated 200 nm polystyrene nanoparticles with diffe

15 is carboxylase showed that it preferentially carboxylated acetyl-CoA (1.1 nmol/mg/min) over propionyl

16 e Mg content in biogenic ACC is regulated by carboxylated (acidic) proteins and other macromolecules,

17 Using carboxylated agarose gels as a screening platform, we de

18 screening platform, we demonstrate that soft-carboxylated agarose provides a unique environment for t

19 the considerably softer hydrogels made from carboxylated agarose use a scaffold of unpaired beta-str

20 Self-assembled monolayers (SAMs) of carboxylated alkanethiolates (-S(CH(2))(n-1)CO(2)(-)) on

21 ce functionalization of a silicon wafer with carboxylated alkyltrichlorosilane has been developed.

22 uld make the sturgeon protein the most gamma-carboxylated among known MGPs.

23 We examined the actions of a carboxylated analogue of pregnanolone ((3alpha,5beta)-20

24 Here we show in a simplified food web that carboxylated and biotinylated quantum dots can be transf

25 Protein S D95A was, however, gamma-carboxylated and bound phospholipids with an apparent di

26 cle, we investigated the degradation of both carboxylated and pristine SWNTs with HRP and compared th

27 to the biotin carboxylase domain and become carboxylated and then translocate to the carboxyltransfe

28 ing heterotopic (hepatic) expression of both carboxylated and uncarboxylated osteocalcin through gene

29 s of osteocalcin (total, uncarboxylated, and carboxylated) and insulin resistance in older men and wo

30 rt SWNT seed was a polymer-wrapped SWNT, end-carboxylated, and further tethered with Fe salts at its

31 the secreted proteins were almost completely carboxylated, and in microsomes from each cell line the

32 to the propeptide, at least seven were fully carboxylated as demonstrated by direct gamma-carboxyglut

33 VSMC-derived protein S was found to be gamma-carboxylated as it was precipitated by barium citrate an

34 the future dorsal side and that fluorescent carboxylated beads injected into the vegetal pole are tr

35 presence of nucleophilic catalysts to give C-carboxylated benzofurans with variable dr.

36 The transfer is achieved via carboxylated biotin bound to a 1.3S subunit within the m

37 In these systems a Ru(II) complex having two carboxylated bipyridyl ligands is covalently linked to p

38 One such Ab (mAb GB3.1) was inhibited by carboxylated bovine lung glycopeptides and other multica

39 (n)-b-bPEI can be modified into (PLGA)(n)-b-(carboxylated bPEI) via carboxylation of the primary amin

40 Much of the remaining RuBP-enediol is carboxylated but forms pyruvate, rather than 3-phospho-D

41 he factor X of such a cell line was only 52% carboxylated but that the fraction of carboxylated facto

42 fIX in the fIX-carboxylase complex was fully carboxylated by 10 min, but 95% was still complexed with

43 These substrates are not efficiently carboxylated by the bovine microsomal gamma-glutamyl car

44 Although the model substrate FLEEL is carboxylated by the enzyme, a substrate containing the p

45 the bone extracellular matrix, OCN is gamma-carboxylated by the gamma-carboxylase (GGCX) on three gl

46 e-derived alpha-ketoglutarate is reductively carboxylated by the NADPH-linked mitochondrial isocitrat

47 The skeletal protein osteocalcin is gamma-carboxylated by vitamin K.

48 ormed by CYP4F2 and one hydroxylated and one carboxylated C19:0 were tentatively identified after inc

49 the effect of base washing on the removal of carboxylated carbon fractions, which are generated by th

50 lectrochemical nanosensor based on assembled carboxylated carbon nanotubes (COOH-CNTs) and poly-L-lys

51 A homogeneous mixture containing carboxylated carbon nanotubes was dispersed in carbon in

52 the efficient biofunctionalization of other carboxylated carbon-based polymer composite materials wi

53 hat (*)OH initially reacted with the surface carboxylated carbonaceous fragments, resulting in their

54 s and a 3-6-fold increase in the affinity of carboxylated catechol derivatives for the switch mutant

55 The same aliphatic linear carboxylated chain was introduced as spacer arm in all o

56 Each AT domain has two substrates, an alpha-carboxylated CoA thioester (e.g., malonyl-CoA or methylm

57 Carboxylated (COOH) and aminated (NH2) polystyrene micro

58 form infrared spectra showed the presence of carboxylated (-COOH) and acid sulfonated (-SO(2).OH or -

59 The hydroxylated QDs are prepared from carboxylated (-COOH) dots via a hydroxylation and cross-

60 Carboxylated corroles 3 and 4, which exhibited about 10-

61 biofilm-coated sand (alpha = 0.10) than its carboxylated counterpart (alpha = 0.04).

62 These carboxylated dendrimers did not detectably adsorb to sil

63 eted liposomes were developed to deliver the carboxylated derivative, 5(6)-carboxy-DCFH2, to hepatocy

64 gold nanoparticles with the versatility that carboxylated dextran offers for further functionalizatio

65 tionalized probe DNA strands are attached to carboxylated dextran-based magnetic particles.

66 JC-1 and carboxylated dichlorodihydrofluorescein diacetate were u

67 A variation of these donors bearing a carboxylated donor on O3 is a highly alpha-selective man

68 n in nonspecific binding relative to that of carboxylated dots and a still significant 10-20-fold red

69 rated for a sodium salt of a representative, carboxylated drug molecule.

70 ensive preactivated dyes and instead employs carboxylated dyes activated by large amounts of coupling

71 orted that we could increase the fraction of carboxylated factor X by reducing the affinity of the pr

72 ly 52% carboxylated but that the fraction of carboxylated factor X could be increased to 92% by coexp

73 fIX carboxylation and the extent of secreted carboxylated fIX approximately 2-fold, which shows that

74 Interestingly, the carboxylated fIX product was not efficiently released fr

75 e turnover in vitro is limited by release of carboxylated fIX.

76 de of factor IX (proFIX18), FIXproGla41, and carboxylated FIXproGla41, the Kd values were 50, 2.5, an

77 To accomplish this, carboxylated fluorescent microspheres (MSs) were conjuga

78 reticulum and preferential secretion of the carboxylated form contribute to secreted fIX being more

79 -specific antibodies (which bind only to the carboxylated form of prothrombin lacking the propeptide)

80 iver and matrix gla protein, which, in fully carboxylated form, is able to prevent ectopic mineraliza

81 dues to appear in the 1D NMR spectrum of the carboxylated form.

82 rothrombin:Mg(II) antibodies (which bind the carboxylated forms of proprothrombin and prothrombin) st

83 We conclude that carboxylated gallium corroles are promising chemotherape

84 We prepared the fully carboxylated Gla domain of Factor IX by solid phase pept

85 GP requires four amino acids which are gamma-carboxylated (gla residues).

86 Both carboxylated (GlaMGP) and uncarboxylated (GluMGP) forms

87 e gamma-glutamyl carboxylase converts Glu to carboxylated Glu (Gla) to activate a large number of vit

88 e converts clusters of Glu residues to gamma-carboxylated Glu residues (Glas) in VKD proteins, which

89 the VKD carboxylase, which converts Glu's to carboxylated Glu's (Gla's) in their Gla domains.

90 ependent (VKD) carboxylase converts Glu's to carboxylated Glu's in VKD proteins to render them functi

91 their propeptide and converts Glu's to gamma-carboxylated Glu's, or Gla's, in the Gla domain.

92 min K to convert glutamyl residues (Glus) to carboxylated Glus (Glas) in VKD proteins, rendering them

93 carboxylation of glutamyl residues (Glus) to carboxylated Glus in VKD proteins.

94 equently attacks CO(2), generating the gamma-carboxylated glutamate product.

95 MGP binds calcium ions through gamma-carboxylated glutamates (Gla residues) and inhibits bone

96 n that causes glycine substitution for gamma-carboxylated glutamic acid at position 7.

97 S/MS) of 28 residue peptides harboring gamma-carboxylated glutamic acid residues, a posttranslational

98 g of S100A8/A9 binding to MDSC using an anti-carboxylated glycan Ab reduces MDSC levels in blood and

99 dependent binding to immobilized bovine lung carboxylated glycans and recognized a subset of mannose-

100 These results suggest that the carboxylated glycans play important roles in leukocyte t

101 A9 blocked neutrophil binding to immobilized carboxylated glycans.

102 Syzygium cumini leaves was immobilized onto carboxylated gold coated magnetic nanoparticles (Fe(3)O(

103 ne novel step of the exfoliated accompanying carboxylated graphene sheet from pristine is achieved vi

104 Since carboxylated GRs have a higher density of active sites,

105 ne-functionalized CdSe quantum dots (QDs) on carboxylated GRs via carbodiimide coupling chemistry, fo

106 elationship (SAR) studies led to a series of carboxylated, heteroaryl-substituted chalcone derivative

107 l)-3-(mercaptododecyl)-imidazoliumbromide, a carboxylated IL (IL-COOH), was used to immobilize anti-I

108 The side chain amine of K70 remains fully carboxylated in the acyl structure, and the resulting ca

109 Finally, we showed that the carboxylase was carboxylated in vivo.

110 ysis and increased dissociation of partially carboxylated, inactive VKD proteins.

111 secreted from the four cell lines was highly carboxylated, indicating fIX-carboxylase engagement duri

112 side chain at position 166 might process the carboxylated intermediate predominantly to pyruvate.

113 how alterations in the environment around N-carboxylated K70 affect the ability of that modified res

114 coating leads to decreased retention of the carboxylated latex nanoparticle.

115 y low activity with the above substrates but carboxylated long chain acyl-CoA.

116 t includes species-specific probes linked to carboxylated Luminex microspheres that hybridize to a Cr

117 55, His 57, His 201, His 230, Asp 301, and a carboxylated Lys 169.

118 beta/alpha)8-barrel domain that contains the carboxylated Lys 173.

119 phosphate substrate by a carbamate oxygen of carboxylated Lys 201 (spinach enzyme).

120 Substitution of the carboxylated lysine (K70), on the other hand, results in

121 -lactamases depends critically on an unusual carboxylated lysine as the general base residue for both

122 ing that it has a critical and unusual Nzeta-carboxylated lysine at position 394.

123 ion, we establish the functional role of the carboxylated lysine in OXA-1 and highlight its specific

124 mases are characterized by the presence of a carboxylated lysine in the active site that participates

125 The two zincs are bridged by a carboxylated lysine residue (Lys 162) and a solvent mole

126 inuta contains two divalent metal ions and a carboxylated lysine residue.

127 The protein was shown to contain the unusual carboxylated lysine that activates the active site serin

128 ctamases by the presence of an active-site N-carboxylated lysine that serves as a general base to act

129 the conventional SPRI format, which utilized carboxylated magnetic beads and a magnetic field.

130 lectin, glycosphingolipids were adsorbed to carboxylated magnetic polystyrene microspheres, which we

131 ) aptamer was first covalently conjugated to carboxylated-magnetic beads (MBs) using the succinimide

132 opposite direction of the as-synthesized or carboxylated membranes.

133 sma levels of uncarboxylated MGP (ucMGP) and carboxylated MGP (cMGP) than controls.

134 the MGP construct, which produced non-gamma-carboxylated MGP and fully gamma-carboxylated MGP.

135 in does not associate with reduced levels of carboxylated MGP, and inhibitory effects of quercetin do

136 d non-gamma-carboxylated MGP and fully gamma-carboxylated MGP.

137 d glass slides, maleimide-activated protein, carboxylated microspheres and NHS-biotin to provide quan

138 ation of nAChR or Ls-AChBP on the surface of carboxylated microspheres and the competition of cyclic

139 Carboxylated microspheres embedded in cytoplasm through

140 Particle tracking of carboxylated microspheres imbedded in the cytoplasm prod

141 found that the motion of negatively charged, carboxylated microspheres in mucus from pregnant patient

142 GF10 in HeLa cells facilitated engulfment of carboxylated microspheres to a similar extent, and there

143 hoxy-poly(ethylene glycol) to the surface of carboxylated microspheres.

144 We previously reported an unusual carboxylated modification on N:-glycans isolated from wh

145 lic acids are negatively charged nine-carbon carboxylated monosaccharides that often cap glycans on g

146 ilization of glutamate oxidase (GluOx) onto, carboxylated multi walled carbon nanotubes (cMWCNT), gol

147 ures composed of gamma-Fe2O3 (maghemite) and carboxylated-multi walled carbon nanotube (cMWCNT) were

148 non-Gla domain substrate indicate that it is carboxylated multiple times in a processive manner.

149 engineer this immunosensor, uniform layer of carboxylated multiwall carbon nanotubes (MWCNT) was depo

150 Secondary antibodies (Ab(2)) attached to carboxylated multiwall carbon nanotubes with 106 HRP lab

151 thylene green as electron transfer mediator, carboxylated-multiwall carbon nanotubes as electron tran

152 chment of antibodies (Abs) on the surface of carboxylated multiwalled carbon nanotube-polystyrene (MW

153 stigated the photochemical transformation of carboxylated multiwalled carbon nanotubes (COOH-MWCNTs),

154 old nanoparticle based strip biosensors, the carboxylated MWCNTs were selected as the labeling substr

155 S100A8/A9 proteins bind to carboxylated N-glycans expressed on the receptor for adv

156 her, these results indicate that these novel carboxylated N:-glycans are constitutively expressed on

157 We recently showed that a class of novel carboxylated N:-glycans was constitutively expressed on

158 he activated "enolase" from G. kaustophilus (carboxylated on Lys 173) liganded with Mg2+ and 2,3-dike

159 Class D beta-lactamases are carboxylated on the epsilon-amino group of an active sit

160 vine lung by their differential affinity for carboxylated or neutralized glycans.

161 bowel manipulation, after which fluorescent carboxylated or paramagnetic microspheres were administe

162 etermined the influence of a suite of simple carboxylated organic acids on Mg content.

163 Under-gamma-carboxylated osteocalcin (ucOC) increases insulin secret

164 In contrast, elevated carboxylated osteocalcin and total osteocalcin were asso

165 the lowest tertiles of total osteocalcin and carboxylated osteocalcin at baseline had higher baseline

166 The concentration of carboxylated osteocalcin at baseline was inversely assoc

167 se in the concentration of serum under-gamma-carboxylated osteocalcin followed by increased immunoche

168 The concentration of serum under-gamma-carboxylated osteocalcin was lower when subjects consume

169 conversion to quaternary C-acetylated and C-carboxylated oxindoles is observed, even for substrates

170 fied glassy carbon (GC) electrode using G2.5-carboxylated PAMAM dendrimer (Den) as linking agent is r

171 Chickens acutely exposed to carboxylated particles (50 nm in diameter) had a lower i

172 ltralow diffusion constant of protons in the carboxylated PCCA as predicted earlier by the Tanaka gro

173 caprolactone) (PCL), and negatively-charged, carboxylated PCL (CPCL).

174 A tetra(carboxylated) PCP pincer ligand has been synthesized as

175 erdiamine additives in the aqueous phase and carboxylated perfluorocarbon surfactants in the oil phas

176 ptothecin (10HCPT) was encapsulated within a carboxylated PGLSA dendrimer ([G4]-PGLSA-COONa).

177 The recombinant Conus carboxylase carboxylated Phe-Leu-Glu-Glu-Leu and the 28-residue pept

178 ce by acting as a receptor for Gas6, a gamma-carboxylated phosphatidylserine-binding protein that bri

179 n of the recombinant proteins as fully gamma-carboxylated, physiologically competent proteins.

180 equilibrate the levels of phenolic acids and carboxylated phytohormones and their glucoconjugates.

181 orm-particle-shaped Nanovesicles-immobilized Carboxylated poly(3,4-ethylenedioxythiophene) (CPEDOT) N

182 ing reminiscent of endocytotic vesicles, the carboxylated polymer revealed a characteristic filamento

183 QDs solubilized with a carboxylated polymeric ligand and pretreated with Ni(2+)

184 s containing various original, sulfated, and carboxylated polysaccharides.

185 100 nm silicon oxide (Si) and 100 nm carboxylated polystyrene (PS-COOH) NPs cloaked by human

186 mercial carboxylated QDs (CdTe and CdSe) and carboxylated polystyrene latex (nPL) as a model nanopart

187 tant of 50 nM and tethered to the surface of carboxylated polystyrene NPs.

188 of hundreds of individual amine-modified and carboxylated polystyrene particles (diameter 100-500 nm)

189 e ((19)F) NMR spectroscopy and 1000 nm-sized carboxylated polystyrene particles loaded with varying c

190 Carboxylated polystyrene particles with a density and su

191 fluorescent phospholipids to the surface of carboxylated polystyrene particles.

192 Mg-rich phases nucleate exclusively on carboxylated polystyrene spheres along with calcite, whe

193 Carboxylated, polystyrene microparticles were covalently

194 ty of PRGP2 is present in the gamma-glutamyl carboxylated, propeptide-cleaved (mature) form.

195 in S is a secreted vitamin K-dependent gamma-carboxylated protein that is mainly made in the liver.

196 nspecific binding properties against that of carboxylated, protein-coated, and poly(ethylene glycol)

197 ssing and block the secretion of under-gamma-carboxylated prothrombin (FII) in the rat but not in the

198 43-355 VKS peptide had a higher affinity for carboxylated prothrombin (K(d) = 5 microm) than uncarbox

199 munochemical detection of plasma under-gamma-carboxylated prothrombin (PIVKA-II), and by a decreased

200 Under-gamma-carboxylated prothrombin is also secreted from warfarin-

201 etermining the metabolic fate of under-gamma-carboxylated prothrombin precursors during processing.

202 on platelets and endothelial cells on fully carboxylated prothrombin reveals new mechanistic insight

203 , and a less sensitive assay for under-gamma-carboxylated prothrombine were not.

204 two different surface charges where chosen, carboxylated (PS-COOH) and amine (PS-NH2) polystyrene, t

205 e concentration of cation-exchanger sites of carboxylated PVC-NPOE was found to be higher (1.62 mmol/

206 tive sites were engineered using pyrrole and carboxylated pyrrole that was one-step electropolymerize

207 Two carboxylated QDs (CdSe and CdTe) with different surface

208 udy assessed the transport of two commercial carboxylated QDs (CdTe and CdSe) and carboxylated polyst

209 A new general synthetic access to carboxylated quaterpyridines (qpy), of interest as ligan

210 ketoarabinitol 1,5-bisphosphate (CKABP), the carboxylated reaction intermediate.

211 improve production of functional fully gamma-carboxylated recombinant human clotting factor IX (r-hFI

212 However, the fraction of total MGP that was carboxylated (relative cMGP concentration = cMGP/[cMGP +

213 Both cell lines secrete carboxylated reporter when fed vitamin K or vitamin K ep

214 h the prothrombin propeptide was fully gamma-carboxylated, representing a substantial improvement ove

215 pumping activity in E. coli cells, although carboxylated residues are at the positions of the Schiff

216 Lys 102, which is carboxylated, serves as a bridging ligand between the tw

217 romanol linked with a 9- or 13-carbon-length carboxylated side chain, inhibits COX-2 with an IC(50) o

218 sfer from biological electron donors through carboxylated single-walled carbon nanotubes (C-SWCNT) to

219 or the preconcentration and determination of carboxylated single-walled carbon nanotubes (c-SWNTs) in

220 Soluble, ultra-short (length < 60 nm), carboxylated, single-walled carbon nanotubes (SWNTs) hav

221 6.9, substantially higher than expected from carboxylated steroid in an aqueous environment.

222 existence of both sulfated and non-sulfated/carboxylated substrates, predominately composed of an al

223 long chain acyl-CoA with a predilection for carboxylated substrates.

224 s uncarboxylated and a second is fully gamma-carboxylated, supporting the notion that the gamma-carbo

225 gments demonstrated a high affinity for this carboxylated surface.

226 18x faster on the hybrid substrates than on carboxylated surfaces, but the free energy barriers to c

227 tudy, we examined the phototransformation of carboxylated SWCNTs and associated amorphous carbon impu

228 The second-order rate constant for carboxylated SWCNTs reacting with (*)OH was estimated to

229 We found that while carboxylated SWCNTs were rather unreactive with respect

230 l characteristics similar to those of parent carboxylated SWCNTs whose amorphous carbon was removed b

231 Further studies using carboxylated SWCNTs with and without base washing indica

232 amining these factors with both pristine and carboxylated SWNTs through a variety of techniques inclu

233 We have reported recently the degradation of carboxylated SWNTs through enzymatic catalysis with hors

234 The interaction between pristine and carboxylated SWNTs with HRP was further studied by compu

235 However, neither cell line carboxylated the reporter when fed KO in the presence of

236 Although all three ENPs used here are carboxylated, they differ in the type of surface coating

237 Subsequently, the dextran chains are carboxylated through treatment with bromoacetic acid.

238 carrier of the C(3) unit that is ultimately carboxylated to acetoacetate, releasing CoM.

239 nt evidence suggests that GAS6 must be gamma-carboxylated to bind and activate any of the cognate tyr

240 emediation is likely due to hydroxylated and carboxylated transformation products of the 3- and 4-rin

241 s were achieved when the channel surface was carboxylated via UV/ozone treatment followed by the immo

242 pisodes because of decreased levels of gamma-carboxylated VKD clotting factors.

243 s of Glu's are converted to Gla's, and fully carboxylated VKD proteins are normally secreted.

244 ers of different end-terminal functionality (carboxylated vs. pyrrolidonated) by two phenotypically d

245 d loop formed by a disulfide bond, was fully carboxylated when expressed in Chinese hamster ovary cel

246 mated that one out of three carbon atoms was carboxylated, while one out of 10 carbon atoms was sulfo

247 FIX-carboxylase complexes were in vitro carboxylated with or without excess VKD substrate or pro