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1 t-related proteins such as chitinase and JHE-carboxylesterase.
2 cated that the isolated enzyme was rat serum carboxylesterase.
3 e IC50 for PPD compared to cells lacking the carboxylesterase.
4 genes, CYP2B1 and secreted human intestinal carboxylesterase.
5 ecently proposed mechanism for hydrolysis by carboxylesterases.
6 active site consensus sequence G-X-S-X-G of carboxylesterases.
7 several known and characterized lipases and carboxylesterases.
8 converted to the active metabolite SN-38 by carboxylesterases.
9 me is highly homologous with other rat liver carboxylesterases.
10 oxaz carbamate prodrug that is hydrolyzed by carboxylesterases.
11 A) was also characterized as an inhibitor of carboxylesterases.
12 sed proteomics approach, we identified liver carboxylesterase 1 (CES1) as a novel SORT1-interacting p
16 xyl ester by human cathepsin A (CatA) and/or carboxylesterase 1 (CES1), is a stereospecific reaction.
17 (KISS1) related to reduced migration and low carboxylesterase 1 (CES1), to impaired survival in patie
23 tal structures of the serine hydrolase human carboxylesterase 1 (hCE1), a broad-spectrum drug metabol
26 sterase 1 (CES1) gene encodes for the enzyme carboxylesterase 1, a serine esterase governing both met
27 approach, we identified a specific esterase, carboxylesterase 1, whose function had a clear impact no
32 ) is a prodrug of Doxaz that is activated by carboxylesterase 2 (CES2), which is expressed by liver,
35 ived from sixteen different environments for carboxylesterase activity and identified 714 positive hi
38 Simulations varying tumor permeability and carboxylesterase activity predicted a concave increase i
39 with a panel of hydrolase assays revealed a carboxylesterase activity with a preference for short ac
40 f this superfamily possess phospholipase and carboxylesterase activity with diverse substrate specifi
41 holly or partly the consequence of intrinsic carboxylesterase activity, as indicated by high-performa
50 l activity, do not require interactions with carboxylesterases, and do not inhibit human acetylcholin
51 nes, est30 and est55, encoding two different carboxylesterases, and genetic rearrangement in the est5
57 terase (BChE) and structurally close to them carboxylesterase (CaE), as well their binding to NMDA-re
58 r substrate specificity from the human liver carboxylesterase called hCE-1, which hydrolyzes the meth
60 luate the concept that transfer of the human carboxylesterase (CE) gene will overcome the drug resist
63 We have isolated a cDNA encoding a rabbit carboxylesterase (CE; EC 3.1.1.1) that converts the camp
69 s an antitumor prodrug that is hydrolyzed by carboxylesterases (CE) to yield SN-38, a potent topoisom
70 onyloxycamptothecin (CPT-11) is activated by carboxylesterases (CE) to yield the potent topoisomerase
71 be completely inhibited with the nonspecific carboxylesterase (CES) inhibitor bis(4-nitrophenyl) phos
79 ecific inhibitor loperamide, indicating that carboxylesterase Ces2a, which was appropriately up-regul
80 eptidic precursors as the substrates of both carboxylesterases (CESs) and alkaline phosphatases (ALPs
83 uentially in both liver and tumor tissues by carboxylesterases, cytidine deaminase, and thymidine pho
84 defense molecules and insecticides, such as carboxylesterases, cytochrome P450, gluthathione S-trans
88 030120 and Sopen05g030130) encoding putative carboxylesterase enzymes of the alpha/beta-hydrolase sup
92 dition to previously characterized rat liver carboxylesterases ES10, ES4, ES3, the protein products f
96 r, the 20(S)-glycinate esters do not require carboxylesterase for conversion to their active forms.
97 characterized Silicibacter sp. protein was a carboxylesterase for short fatty acyl chains, similar to
98 hest sequence identity with the rabbit liver carboxylesterase form 2 (73%) and the hamster liver carb
100 al and functional study of a novel bacterial carboxylesterase (FTT258) from F. tularensis, a homologu
102 uggest that local gene transfer of the human carboxylesterase gene and concomitant local administrati
103 novirus vector (AdCMV.CE) carrying the human carboxylesterase gene driven by the cytomegalovirus (CMV
104 e concept that in vivo transfer of the human carboxylesterase gene will confer sensitivity of a solid
105 n as few as 10% of cells expressed the human carboxylesterase gene, there was bystander growth suppre
106 bers of the three major enzyme families- the carboxylesterases, glutathione transferases, and cytochr
111 atment of the cells with inhibitors of human carboxylesterase I and II, both in terms of total number
112 yl-10-hydroxycamptothecin) by a rabbit liver carboxylesterase in vitro and growth-inhibitory activity
113 study provides insight into the mechanism of carboxylesterase inhibition and raises the possibility t
118 f expression of any one of the six different carboxylesterase isoenzymes will regulate the metabolism
119 ates were observed, suggesting that multiple carboxylesterase isozymes are responsible for the array
120 recessive mutation predicted to inactivate a carboxylesterase known to hydrolyze lysophospholipids an
121 steryl ester hydrolase (hncCEH) and rat lung carboxylesterase (LCE), proteins differing by only 4 res
122 ry mechanism by which Iw1 acts to suppress a carboxylesterase-like protein gene, W1-COE, within the W
127 ers, was shown previously to bind the murine carboxylesterase promoter in chromatin immunoprecipitati
128 del in which E2F1-specific regulation of the carboxylesterase promoter requires both E2F1/DNA interac
129 Rather, E2F1 could no longer bind to the carboxylesterase promoter that contained the consensus E
133 protein is, in fact, a cell wall-associated carboxylesterase rather than a proteinase, as initially
134 the cDNA encoding a secreted form of rabbit carboxylesterase (rCE) to disseminated neuroblastoma tum
135 he presence of high levels of a rabbit liver carboxylesterase (rCE), which can efficiently activate t
136 s of two model polyesters by eight different carboxylesterases revealed increasing hydrolysis with in
138 ly investigated the effects of polyester and carboxylesterase structure on the hydrolysis of nanomete
139 hlights the importance of both polyester and carboxylesterase structure to enzymatic polyester hydrol
140 smic reticulum (ER) via interaction with two carboxylesterases (termed gp60a and gp60b), which themse
141 aptoglobin, serum amyloid protein (SAP), and carboxylesterase that bear oligosaccharides with termina
142 to deliver the cDNA encoding a rabbit liver carboxylesterase that efficiently activates the prodrug
143 lyses of human proteins show that Notum is a carboxylesterase that removes an essential palmitoleate
144 a form suitable for further cleavage by the carboxylesterases that also contribute to tau-fluvalinat
146 that is hydrolyzed by hepatic and intestinal carboxylesterase to form SN-38, which in turn is detoxif
147 the molecular basis for the ability of alpha-carboxylesterases to confer OP resistance to insects is
148 or selective hydrolysis by one or more human carboxylesterases to release doxazolidine (Doxaz), the f
149 plification conferring metabolic resistance (carboxylesterase) to organophosphates and carbamates in
150 ophoretic mobility indicating that the liver carboxylesterase was a glycoprotein of the high mannose
152 general characteristics of the family of rat carboxylesterases, we hypothesized that one member, ES-4
156 e that MT2282 encodes a cell wall-associated carboxylesterase, which is required for full virulence o
157 However, the potential use of bacterial carboxylesterases, which have the advantage of high stab
158 erse enzymes and novel families of microbial carboxylesterases, whose activity could not have been pr
161 this enzyme, and showed that it is a serine carboxylesterase, with a catalytic triad formed by S117,
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