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1 ite) and an amino acid analogue (azetidine-2-carboxylic acid).
2 n of the resulting C1 primary alcohol to the carboxylic acid.
3 and the ethylene precursor aminocyclopropane-carboxylic acid.
4 c C-O bond cleavage to release an alcohol or carboxylic acid.
5 xyl ring and/or the electronic effect of the carboxylic acid.
6 sence of a long-chain amine and a long-chain carboxylic acid.
7 -methoxybenzyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid.
8 id hydrolysis of the ester into the inactive carboxylic acid.
9 electronically different substituents on the carboxylic acid.
10 xylated, beta-fluorinated, and beta-arylated carboxylic acids.
11 riegated building blocks of chemistry: alkyl carboxylic acids.
12 with dicarbonyls, hydroxycarbonyls, and oxo-carboxylic acids.
13 ge in regioselectivity and form unconjugated carboxylic acids.
14 from those observed for sulfones or aromatic carboxylic acids.
15 derivatives are better protective groups for carboxylic acids.
16 vated Ascaris eggs through exposure to these carboxylic acids.
17 d urea units achieves this goal with hydroxy carboxylic acids.
18 l is suitable for many primary and secondary carboxylic acids.
19 y important derivatives such as nitriles and carboxylic acids.
20 thiol-ene modification to introduce pendant carboxylic acids.
21 erification of amides derived from aliphatic carboxylic acids.
22 ickel complex that couples aryl halides with carboxylic acids.
23 O2 (44 Da) and C2H6O2Si (90 Da) for aromatic carboxylic acids.
24 eactions using H2O2 in the presence of added carboxylic acids.
25 s an intermediate to the final conversion to carboxylic acids.
26 rated by synthesizing several derivatives of carboxylic acids.
27 before their fermentation into alcohols and carboxylic acids.
28 decarboxylation of redox-activated aromatic carboxylic acids.
29 t oxidation of aldehydes to their respective carboxylic acids.
30 rs, anti-1-amino-3-(18)F-fluorocyclobutane-1-carboxylic acid ((18)F-FACBC or (18)F-fluciclovine) has
31 (18)F-labeled 1-amino-3-fluorocyclobutane-1-carboxylic acid ((18)F-fluciclovine) is a leucine analog
32 atile fraction mainly contains esters (38%), carboxylic acids (19%), aldehydes (11%), alcohols (14%),
33 by (2S,4R)-4-(2-carboxyphenoxy)pyrrolidine-2-carboxylic acid (1b), for cloned homomeric kainic acid r
34 erivative cis-2-(carboxymethyl)cyclohexane-1-carboxylic acid [(1R,2R)-/(1S,2S)-2-(carboxymethyl)cyclo
35 n-6-amine (LY2784544) and 1H-benzimidazole-4-carboxylic acid, 2-methyl-1-[[2-methyl-3-(trifluoromethy
37 e, 1 [Ga(tpfc)], with either sulfonic (2) or carboxylic acids (3, 4) as macrocyclic ring substituents
38 amides, (2) hydrolysis of N-methoxyamides to carboxylic acids, (3) metal- and oxidant-free benzocouma
39 ion of 3-((furan-2-ylmethyl)amino)pyridine-4-carboxylic acid 34 and 3-(((3-methylthiophen-2-yl)methyl
40 -methylthiophen-2-yl)methyl)amino)pyridine-4-carboxylic acid 39 that are inhibitors of the KDM4 (JMJD
41 )-5-ethyl-1,6-dihydroxycyclohexa-2,4-diene-1-carboxylic acid (4) into compound 3, the latter being a
42 oughout the colony, with 5-methylphenazine-1-carboxylic acid (5-MCA) and pyocyanin (PYO) localized to
44 (hexanal, pentenal, nonanal and nonenal) and carboxylic acids (9-oxononanoic acid, octanoic acid, non
46 tetramers) of cis-2-(aminomethyl)cyclobutane carboxylic acid, a gamma-amino acid featuring a cyclobut
47 4,5-dihydroxy-2,3,4,5-tetrahydropyridazine-3-carboxylic acid, a gamma-halogenated piperazic acid, and
51 of this regulation is 1-aminocyclopropane-1-carboxylic acid (ACC) synthases (ACS), generally the rat
53 enosyl-L-methionine to 1-aminocyclopropane-1-carboxylic acid (ACC)] and PsACO (encode enzymes that co
54 t added acid due to the in situ formation of carboxylic acids, accounting for the long-known catalyti
55 no-2-carboxyethyl]-4,5-dihydro-1H-pyrazole-3-carboxylic acid (ACEPC) competitive GluN2 antagonists, o
57 ) and P(2-MeOPh)3 (2 mol%), sterically tuned carboxylic acid additives, and an environmentally friend
59 produces polyfunctional low molecular weight carboxylic acids after oxidative cleavage of the aromati
61 igid arylated derivatives or flexible linear carboxylic acids, alcohols, olefins and amines in both m
62 rbonyl radiopharmaceuticals based on labeled carboxylic acids, amides, carbamates and ureas now accou
63 ere readily converted into primary alcohols, carboxylic acids, amides, isocyanates, and carbamates, a
64 Cross-metathesis with olefins that contain a carboxylic acid, an aldehyde, an allylic alcohol, an ary
68 r, KAHA, KATs, etc.) that could involve both carboxylic acid and amine surrogates are treated separat
72 catalysis, to extract carbon dioxide from a carboxylic acid and economically replace it with an orga
73 nantiomers of 2-amino-3-hydroxycyclobutane-1-carboxylic acid and of 2-amino-4-hydroxycyclobutanecarbo
74 unctional groups in these molecules, such as carboxylic acid and phenol moieties, become deprotonated
76 tones were the most efficient stimuli, while carboxylic acids and aliphatics/aromatics were comparati
78 ation of sp(3)-sp(3) bonds using only simple carboxylic acids and alkyl halides as the nucleophilic a
79 m of the zirconium-catalyzed condensation of carboxylic acids and amines for direct formation of amid
80 AD(P)(+)-dependent oxidation of aldehydes to carboxylic acids and are important for metabolism and de
83 to amino acids, peptides and carbohydrates, carboxylic acids and compatible solutes may be essential
84 investigated linear peroxy acids but not for carboxylic acids and could therefore serve as a diagnost
85 essible through reactions between ubiquitous carboxylic acids and coupling agents widely used in amid
87 probe to enable rapid quantification of both carboxylic acids and hydroperoxides in hydrocarbon sampl
93 ylates from Se/LiEt3BH and acyl chlorides or carboxylic acids and their reaction with sugar azides.
94 is fast at acidic pH and tolerates alcohols, carboxylic acids, and even secondary amines in the subst
95 mposition routes for furanoids and aliphatic carboxylic acids, and mechanistic pathways for the radio
96 clopentylation" of amines, alcohols, thiols, carboxylic acids, and other heteroatoms is introduced.
97 nated PAMAM dendrimers, we confirm safety of carboxylic acid- and pyrrolidone-terminated PAMAM dendri
99 how that low molecular weight and oligomeric carboxylic acids are kinetically equivalent at accelerat
104 ionalization of the beta-C(sp(3))-H bonds of carboxylic acids are well documented, but only a few rep
105 iscovery of 2-acylaminocycloalkylthiophene-3-carboxylic acid arylamides (AACTs) as inhibitors of TMEM
108 reaction relies upon the activation of alkyl carboxylic acids as their redox-active ester derivatives
109 on of primary, secondary, and tertiary alkyl carboxylic acids as well as a diverse range of natural-p
110 oduced by oxidation of 1-aminocyclopropane-1-carboxylic acid, as catalyzed by 1-aminocyclopropane-1-c
112 of the hydrazone to a mixture of oxidant and carboxylic acid avoids the buildup of the diazo compound
113 ures show that vegetable-sourced azetidine-2-carboxylic acid (Aze), a dual mimic of proline and alani
114 h analogues of varying ring sizes (azetidine carboxylic acid, Aze, and piperidine carboxylic acid, Pi
115 sive polymers classified as polyacids (e.g., carboxylic acid based polymers, sulfonamides, anionic po
116 her and also from sulfonamides and aliphatic carboxylic acids based on reactions with TMMS and one or
117 surfaces by pre-attaching probe molecules to carboxylic acid bearing termonomers of pyrrole phenylene
119 be system based on 4'-substituted biphenyl-2-carboxylic acids (BPAs) for analysis of photooxidants ge
120 -methoxybenzyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid (BQCA) (1), but markedly improved positi
121 restored by treatment with benzyl quinolone carboxylic acid (BQCA) and benzoquinazoline-12 (BQZ-12),
122 for constructing amide bonds join amines and carboxylic acids by dehydrative couplings-processes that
123 hnique for selective fluorination of various carboxylic acids by exposure to gaseous sulfur tetrafluo
124 phoresis, as well as the separation of small carboxylic acids by gradient elution moving boundary ele
127 of judicious catalyst design, the acidity of carboxylic acids can be modulated, for instance by stabi
128 tion approach, is especially useful in rapid carboxylic acid carbon isotope labeling, however develop
129 studies of six Ru polypyridyl compounds with carboxylic acid/carboxylate group(s) revealed that some
130 an, but not 2-aminobicyclo-(2,2,1)-heptane-2-carboxylic acid, competitively inhibited (11)C-sarcosine
131 y of Ascaris eggs as a function of uncharged carboxylic acid concentration for n-butyric acid and n-c
134 y have described highly potent and selective carboxylic acid containing MMP-13 inhibitors; however, n
135 pH/proton concentration and the structure of carboxylic acids contribute to sour GRN activation.
136 sensitivity to functional group addition is carboxylic acid (COOH) approximately hydroxyl (OH) > nit
137 eophilic groups on Wnt proteins to activated carboxylic acid (COOH) or glutaraldehyde (COH) groups fu
139 f the beta2AR bound to a polyethylene glycol-carboxylic acid derivative (Cmpd-15PA) of this modulator
140 ve the decarboxylative coupling of aliphatic carboxylic acid derivatives (specifically, readily avail
141 akin-West reaction of advanced pyrrolidine 2-carboxylic acid derivatives that can be assembled stereo
142 kyl-5-aryl/alkyl/methoxycarbonyl-1H-pyrrol-3-carboxylic acid derivatives typically under mild conditi
143 ivated enamides, known as the least reactive carboxylic acid derivatives, toward alkylation with orga
146 se inhibitor and 4-amino-tetrahydropyranyl-4-carboxylic acid derived dipeptide GSK-2793660, which is
147 two bioactive peptides: 2-aminoadamantane-2-carboxylic acid derived P2X7-evoked glutamate release in
149 rther, we report the first example of a free carboxylic acid-directed Pd(II)-catalyzed C(sp(3))-H bro
150 res a scalable classical resolution of tetra-carboxylic acid enantiomers with recycling of the resolv
151 an optical pH indicator, SNARF-5F, 5-(and-6)-Carboxylic Acid, encapsulated into polyacrylamide nanopa
152 est alkyl chain, -(CH2)2-, and a hydrophilic carboxylic acid end group are found to be the most effec
153 )-1-methyl-4-nitro-3,5-diphenylpyrrolidine-2-carboxylic acid (endo-6) and (2S,3S,4R,5S)-1-methyl-4-ni
154 -methoxybenzyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid, enhanced acetylcholine-mediated phospho
155 the one-pot preparation of alpha-quaternary carboxylic acids, esters, and amides with a high degree
156 )-1-methyl-4-nitro-3,5-diphenylpyrrolidine-2-carboxylic acid (exo-6), combined with 1,8-diazabicyclo[
160 , while in biochar was featured by saturated carboxylic acids from hemi/cellulose and lipids with con
161 ctors was primarily due to 5:3 fluorotelomer carboxylic acid (FTCA - 3.9 nmol/L) and perfluorohexanoi
162 landfill leachate samples, 5:3 fluorotelomer carboxylic acid (FTCA) was dominant and variations in co
164 ), titanium dioxide nanofibers (TiO2NFs) and carboxylic acid functionalized multi-walled carbon nanot
165 sor design involves disposable devices using carboxylic acid-functionalized magnetic microparticles s
167 ins are folded in a hairpin manner near each carboxylic acid group, giving rise to multiple embedded
168 by probing the vibrational signatures of the carboxylic acid group, representing the nondissociated a
170 itive case of a hydrogel containing multiple carboxylic acid groups at each crosslinking point in the
172 sorbent coating featuring halide anions and carboxylic acid groups in the cationic portion exhibited
174 precise linear architecture, namely, pendant carboxylic acid groups precisely every 21st backbone car
175 to the porphyrin and proton transfer from a carboxylic acid hanging group or an external acid to the
177 bly between a phosphoric acid catalyst and a carboxylic acid has recently been established as a new a
178 catalyzed amino lactonization of unsaturated carboxylic acids has been achieved as well as the analog
180 ediated cleavage of ketones into alkanes and carboxylic acids has been reinvestigated and the substra
181 ,2R)-/(1S,2S)-2-(carboxymethyl)cyclohexane-1-carboxylic acid] has previously been identified as metab
182 c(NN) is 2-amino-5-nitronylnitroxide-indan-2-carboxylic acid, have been inserted at positions i and i
184 diazole and alpha,alpha-dimethylation of the carboxylic acid, improving DGAT1 potency and gut permeab
185 ogenous phenazines pyocyanin and phenazine-1-carboxylic acid in both cytosolic and membrane fractions
186 ctional groups on the beta-carbon (e.g., the carboxylic acid in glycine) that facilitate carbon-carbo
188 dicate that in situ biological production of carboxylic acids in HFM provides a promising method of p
189 To fill this gap, we measured gas-phase carboxylic acids in real-time inside and outside of a un
190 les-derived from Fukuyama amines-and peptide carboxylic acids in Ugi and Passerini reactions to affor
192 l-5 -yl)-[1,1'-biphenyl]-4-yl)cyclopropane-1-carboxylic acid) in rhesus monkeys to image LPA1 in the
194 ate-stage C-H functionalization converting a carboxylic acid into a lactone through the oxidation of
195 is a classic, powerful method for converting carboxylic acids into protected amines, but its widespre
198 erminal and substituted alkynes from various carboxylic acids is described using both nickel- and iro
200 (2-(2-carboxyethyl)-4-methyl-5-propylfuran-3-carboxylic acid) is a metabolite that circulates at high
201 e (LND; 1-(2,4-dichlorobenzyl)-1H-indazole-3-carboxylic acid) is known to interfere with energy-yield
203 essment of the physicochemical properties of carboxylic acid isosteres would be desirable to enable m
204 ovel and efficient method for alkyl and aryl carboxylic acid isotopic labeling using a single reagent
205 pH2cH = 2,2'-bipyridine-6-phosphonic acid-6'-carboxylic acid, L = 4-picoline or isoquinoline) catalys
206 otency and pharmacokinetic properties of non-carboxylic acid leads resulting in the identification of
210 is due to the presence of negatively charged carboxylic acid moieties from PAA grafts that electrosta
211 ed SPME sorbent coatings, the PIL containing carboxylic acid moieties in the monomer and halide-based
212 a known azetidine FFA2 antagonist, we used a carboxylic acid moiety known not to be critical for rece
213 icyclic nortropine-substituted benzothiazole carboxylic acid moiety onto a trisubstituted isoxazole s
215 ne-pot synthesis of thioesters directly from carboxylic acids, N,N'-diphenylthiourea, triethylamine,
218 D-amino acid substrate was linked to the carboxylic acid on the magnetic nanoparticles using EDC/
219 etathesis of silylated alkynes with aromatic carboxylic acids on the Ag(111) and Au(111) surfaces to
220 able N-substituted amides or their requisite carboxylic acids or acid chlorides have been used to con
221 nd with the acceptor groups varied as either carboxylic acids or benzoic acids on the pi-bridge.
222 N bond to release the corresponding alcohol, carboxylic acid, or amine when an electron-donating amin
224 essing the activity of 1-aminocyclopropane-1-carboxylic acid oxidase (ACO), the enzyme catalysing the
226 .g., with no pre- or in situ activation of a carboxylic acid partner) approaches for the construction
227 oduction reveals distribution of phenazine-1-carboxylic acid (PCA) throughout the colony, with 5-meth
229 ) and measured contents of FBPs (pyrrolidone carboxylic acid [PCA] and urocanic acid [UCA]) using UPL
230 UnDA, representing long-chain perfluoroalkyl carboxylic acids (PFCAs), showed a more homogeneous spat
231 acids (PFSAs; C4,6,8,10) and perfluoroalkyl carboxylic acids (PFCAs; C6-15) along with six perfluoro
233 and significant generation of perfluoroalkyl carboxylic acid (PFOA) at a yield of 30 mol % by day 180
234 etidine carboxylic acid, Aze, and piperidine carboxylic acid, Pip) to produce different trans/cis rat
236 s by methylation of alcohol, thiol, amine or carboxylic acid precursors using [(11)C]methyl iodide or
238 o]phenyl]-5-(trifluoromethyl)-1H-p yrazole-4-carboxylic acid prevents AIAD in mice, (2) TRPC3 channel
239 adenylation of substrates, amidation of the carboxylic acid proceeds by direct reaction of the acyl
240 peroxide anion 7' to afford the aldehyde-to-carboxylic acid product or as a hydroperoxy derivative 7
243 d donors and chiral phosphoric acids, chiral carboxylic acids provide the opportunity to activate a d
244 (MNPs) coated with poly(pyrrole-co-pyrrole-2-carboxylic acid) (Py/Py-COOH) for high efficient detecti
245 (primary alcohol, phenol, vicinal diol, and carboxylic acid), ranging in complexity from methanol to
246 hat differ in the relative position of their carboxylic acid recognition site: either para (M(p)) or
248 aratus of BT3686 does not comprise a pair of carboxylic acid residues but, uniquely, a single histidi
249 mistry has been developed for aryl and alkyl carboxylic acids respectively with two rationally design
251 posing oleate-capped quantum dots to primary carboxylic acids results in a one-for-one exchange that
252 for decarboxylative fluorination of several carboxylic acids showcases the performance of the comple
254 ,6,6-tetramethyl-piperidine-1-oxyl-4-amino-4-carboxylic acid substituted for a single amino acid.
258 boxylic and amines ( section 2 ); the use of carboxylic acid surrogates ( section 3 ); and the use of
259 uction and expression of aminocyclopropane-1-carboxylic acid synthase gene, the first committed step
260 ell lines depend on glutamine as a major tri-carboxylic acid (TCA) cycle anaplerotic substrate to sup
262 ,6,6-tetramethyl-piperidine-1-oxyl-4-amino-4-carboxylic acid, the probe is rigidly and stereospecific
263 se of electron-rich alkynes or highly acidic carboxylic acids, the reaction rate could be increased.
264 tor has been employed for the methylation of carboxylic acids, the synthesis of alpha-chloro ketones
265 (DA) is used to convert the TAT's amines to carboxylic acid; the resulting DA-TAT is conjugated to p
266 s well as a diverse range of natural-product carboxylic acids, thereby demonstrating its broad utilit
267 divergent resolution of racemic alpha-chiral carboxylic acids, thus providing access to a variety of
268 atic system by coordination of an amine or a carboxylic acid to the boron center enabled N-H activati
269 ) catalyze the reduction of a broad range of carboxylic acids to aldehydes using the cofactors adenos
271 catalyzed coupling of alpha,beta-unsaturated carboxylic acids to aryl alkenes to access chiral alpha-
273 n the regioselective Markovnikov addition of carboxylic acids to terminal alkynes, yielding valuable
274 lexes that specifically respond to amines or carboxylic acids - two classes of semiochemicals that ha
275 N-hydroxyphthalimide ester derivative of the carboxylic acid under visible light at room temperature
276 ect conversion of arylacetic acids into aryl carboxylic acids under metal-free conditions has been de
277 e method is applicable to a large variety of carboxylic acids using diazo compounds that are formed f
278 carbons and the Schmidt reaction of aromatic carboxylic acids using the superacidic trimethylsilyl az
279 ns from a variety of benzoisothiazolones and carboxylic acids using triethylphosphite as the terminal
280 step-economic alpha,beta-dehydrogenation of carboxylic acids via enediolates is reported through the
283 of this direct amination protocol, aromatic carboxylic acids were additionally chosen as substrates.
284 ighest number of carbohydrates, polymers and carboxylic acids were consumed in the SF sourdough.
287 compounds were transformed to perfluorinated carboxylic acids, which underwent further degradation un
288 xidation of aldehydes to their corresponding carboxylic acid while reducing NAD(P)(+) to NAD(P)H via
289 four metal-binding sites in the form of four carboxylic acids, while zirconyl chloride octahydrate is
292 al light-induced decarboxylative coupling of carboxylic acids with (hetero)aromatic nitriles at ambie
294 that enables chemists to couple simple alkyl carboxylic acids with aryl zinc reagents under Ni-cataly
295 ng of primary, secondary, and tertiary alkyl carboxylic acids with both aryl and heteroaryl organomet
296 zed decarboxylative coupling of heterocyclic carboxylic acids with heterocyclic halides to achieve th
297 ecades to make simple C-N (amide) bonds from carboxylic acids with loss of water can be used to make
299 ters (both isolated and derived in situ from carboxylic acids) with organozinc and organomagnesium sp
300 rovided good yields of nitrile products from carboxylic acids, with complete retention of isotopic pu
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