ライフサイエンスコーパス: cardiac contractility

1 ator of beta-adrenoceptor/cAMP signaling and cardiac contractility.

2 utative heart failure therapeutic, increases cardiac contractility.

3 can be selectively blocked without reducing cardiac contractility.

4 isoprenaline- or preload-induced increase in cardiac contractility.

5 , phospholamban, are essential components of cardiac contractility.

6 chemical changes that lead to an increase in cardiac contractility.

7 OS-activated signaling enzymes that regulate cardiac contractility.

8 represent important regulatory mechanisms of cardiac contractility.

9 of the systolic Ca(2+) transient and thence cardiac contractility.

10 ic reticulum Ca(2+)-ATPase (SERCA) regulates cardiac contractility.

11 ticulum Ca(2+) release and thereby modulates cardiac contractility.

12 rotein-C (cMyBP-C) phosphorylation modulates cardiac contractility.

13 iency, duration of transgene expression, and cardiac contractility.

14 sarcomere force production, thereby reducing cardiac contractility.

15 throughout the heart, predicting defects in cardiac contractility.

16 ic cardiac growth and fibrosis, which impair cardiac contractility.

17 oronary flow reserve and perfusion-dependent cardiac contractility.

18 ribute to the negative effect of diabetes on cardiac contractility.

19 TnI and cMyBP-C phosphorylation to increased cardiac contractility.

20 complex and is critical to the regulation of cardiac contractility.

21 cardiac remodeling in an effort to normalize cardiac contractility.

22 functional Casq2 display surprisingly normal cardiac contractility.

23 t as well as the subsequent establishment of cardiac contractility.

24 ted mitochondrial dysfunction, and preserved cardiac contractility.

25 cytoplasm into the myocite lumen, regulating cardiac contractility.

26 heavy chain expression, a key determinant of cardiac contractility.

27 eby optimizing beta-adrenergic modulation of cardiac contractility.

28 -ATPase alpha 1 isoform in the regulation of cardiac contractility.

29 pressure, cardiac output, stroke volume, and cardiac contractility.

30 e, and this is thought to be detrimental for cardiac contractility.

31 In cardiac myocytes, [Ca2+]SR regulates cardiac contractility.

32 activating the RyR2 channel, and increasing cardiac contractility.

33 zyme affinity for Ca2+ and thereby regulates cardiac contractility.

34 ascular physiology that reduces vascular and cardiac contractility.

35 in the regulation of blood pressure, and in cardiac contractility.

36 increasing intracellular Ca(2+) release and cardiac contractility.

37 This effect would be expected to enhance cardiac contractility.

38 chanical activation time were used to assess cardiac contractility.

39 ta(1)ARs and beta(2)ARs), play a key role in cardiac contractility.

40 ated Ca2+ influx may contribute to decreased cardiac contractility.

41 angiotensin II receptor is known to promote cardiac contractility.

42 roperty of the proapoptotic gene caspase3 on cardiac contractility.

43 f the P2X4 receptor, that of stimulating the cardiac contractility.

44 n be used to enhance SR Ca(2+) transport and cardiac contractility.

45 this signaling pathway in the regulation of cardiac contractility.

46 f intracellular pH (pHi) typically depresses cardiac contractility.

47 account for the effects of cytochalasin D on cardiac contractility.

48 mic reticulum Ca(2+) ATPase (SERCA2a) and of cardiac contractility.

49 eveal a novel role of p38 MAPK in regulating cardiac contractility.

50 ms play a major role in the determination of cardiac contractility.

51 mode of MEG's action is related to improved cardiac contractility.

52 ailure is a common, often lethal disorder of cardiac contractility.

53 a isoform and how its overexpression affects cardiac contractility.

54 ERCA pump level is a critical determinant of cardiac contractility.

55 ent of left ventricular function and reduced cardiac contractility.

56 also associated with impaired intraoperative cardiac contractility.

57 2 expression in cardiomyocytes and impaired cardiac contractility.

58 uding humans, increased heart rate increases cardiac contractility.

59 increased cardiac filling leads to enhanced cardiac contractility.

60 these two systems can have a large impact on cardiac contractility.

61 ombined haplodeficiency resulted in impaired cardiac contractility.

62 Caffeine modifies vascular/cardiac contractility.

63 c oxide-dependent signaling, which modulates cardiac contractility.

64 neuronal sodium channels can safely increase cardiac contractility.

65 on of sarcoplasmic reticulum Ca2+ release or cardiac contractility.

66 ctivation of PKA with isoproterenol improved cardiac contractility.

67 ative inotropic effect, resulting in reduced cardiac contractility.

68 handling proteins, which resulted in altered cardiac contractility.

69 Ser23, an important mechanism for regulating cardiac contractility.

70 ological role of MyBP-C in the regulation of cardiac contractility.

71 yocytes and lead to increased heart rate and cardiac contractility.

72 PLB decreases Ca(2+) affinity and depresses cardiac contractility.

73 that have been implicated in the control of cardiac contractility.

74 nt pathway for beta-adrenergic modulation of cardiac contractility.

75 nsport in cardiomyocytes, thereby modulating cardiac contractility.

76 nificant 1.6-fold improvement in recovery of cardiac contractility (69 +/- 5% of base line, p = 0.01

77 lated cardiomyopathy manifested by a loss of cardiac contractility, abnormal mitochondria ultrastruct

78 Acute beta-adrenergic stimulation enhances cardiac contractility, accelerates muscle relaxation, an

79 entricular dilation and a severe decrease in cardiac contractility accompanied by myocyte degeneratio

80 ardiovascular system, resulting in decreased cardiac contractility, adrenergic responsiveness, and va

81 tein, increased NO production, and decreased cardiac contractility after 2 h of incubation.

82 ATPase using Cre-Lox technology and analyzed cardiac contractility after administration of ouabain.

83 is and increases anterior wall thickness and cardiac contractility after infarction.

84 rbidity or mortality but displayed depressed cardiac contractility, altered sarcomeric structure and

85 e F-actin disrupter cytochalasin D depresses cardiac contractility, an effect previously ascribed to

86 Cardiac contractility analysis in isolated hearts and in

87 del of chronic HF, including preservation of cardiac contractility and a reduction in cardiac fibroti

88 myocardium with an associated impairment of cardiac contractility and a unique distortion in morphol

89 Apelin treatment also increased cardiac contractility and ACE2 levels in AT1R-deficient

90 In addition, actc1a mutants show defects in cardiac contractility and altered blood flow within the

91 vity with 6-bromoindirubin-3'-oxime improved cardiac contractility and ameliorated intraventricular c

92 r understand hMSC PS and HC effects on human cardiac contractility and arrhythmogenicity by integrati

93 g (HC) and paracrine signaling (PS) on human cardiac contractility and arrhythmogenicity remain unres

94 vel relative hMSC PS and HC effects on human cardiac contractility and arrhythmogenicity, and provide

95 tify PKC-alpha as a fundamental regulator of cardiac contractility and Ca(2+) handling in myocytes.

96 l, unrestrained p38 MAPK activity diminished cardiac contractility and Ca2+ handling, which was acute

97 normal state causes significant increase in cardiac contractility and cardiac output.

98 lication of isoproterenol severely depressed cardiac contractility and caused 95% mortality in mdx mi

99 NO attenuates cardiac contractility and contributes to contractile dys

100 can induce cardiac arrhythmias and decrease cardiac contractility and coronary flow.

101 irectly into the cardiac vasculature depress cardiac contractility and decrease coronary flow.

102 intraventricular wall hemorrhage, depressed cardiac contractility and early postnatal death.

103 te survival, biomechanical stress responses, cardiac contractility and electrical conduction.

104 n kinase II (CaMKII) plays a central role in cardiac contractility and heart disease.

105 Calpha, PKCbeta, and PKCgamma for effects on cardiac contractility and heart failure susceptibility.

106 ctly from PKCbeta and PKCgamma in regulating cardiac contractility and heart failure, and broad-actin

107 as preceded by a transient, profound drop in cardiac contractility and heart rate and an increase in

108 en suggested that cardiac trabeculae enhance cardiac contractility and intra-ventricular conduction,

109 ns involved in cardiac energy production and cardiac contractility and is distinct from that observed

110 gated the function of p38 MAPK in regulating cardiac contractility and its underlying mechanisms.

111 of Erk5 in mice (Erk5-CKO) leads to dampened cardiac contractility and mitochondrial abnormalities wi

112 causes embryonic lethality due to defects in cardiac contractility and morphology but, in contrast to

113 HES injection did not modify cardiac contractility and nuclear translocation of NF-ka

114 stant total NTP) that significantly enhances cardiac contractility and obtain greater understanding o

115 gene networks were consistent with a better cardiac contractility and performance.

116 epinephrine probably mediated the increased cardiac contractility and possibly contributed to the im

117 ent of the same neuronal population enhances cardiac contractility and prolongs exercise endurance.

118 energic receptor (beta-AR) blockade improves cardiac contractility and prolongs survival in patients

119 an important second messenger that regulates cardiac contractility and protects the heart from hypert

120 tence of a novel regulatory DMPK pathway for cardiac contractility and provide a molecular mechanism

121 The sympathetic nervous system modulates cardiac contractility and rate by activating beta-adrene

122 ifferential roles for H(2)O(2) in control of cardiac contractility and receptor-dependent NOS activat

123 lacking the gene for PKCalpha have enhanced cardiac contractility and reduced susceptibility to hear

124 lacking the gene for PKCalpha show enhanced cardiac contractility and reduced susceptibility to hear

125 PP1-dependent signaling pathways, including cardiac contractility and regulation of learning and mem

126 Compared with wild-type littermates, cardiac contractility and relaxation were enhanced in is

127 rff model, to be effective in improving both cardiac contractility and relaxation when challenged wit

128 rgic stimulation induces positive changes in cardiac contractility and relaxation.

129 evels of SERCA2 in heart and mildly impaired cardiac contractility and relaxation.

130 loss of one copy of the SERCA2 gene impairs cardiac contractility and relaxation.

131 nt pathway for beta-adrenergic modulation of cardiac contractility and relaxation.

132 energic receptors (AR) are key regulators of cardiac contractility and remodeling in response to cate

133 Esmolol infusion increased cardiac contractility and restored mesenteric vasoreacti

134 cle lim protein gene significantly augmented cardiac contractility and restored pump function.

135 betaARKct significantly improved cardiac contractility and reversed left ventricular remo

136 Beta-adrenergic agonists stimulate cardiac contractility and simultaneously blunt this resp

137 -ssARKct transgenic mice have normal in vivo cardiac contractility and ssAR responsiveness indistingu

138 c insight into how oxygen directly modulates cardiac contractility and suggest that cardiac function

139 l activities: cardiovascular (stimulation of cardiac contractility and suppression of blood pressure)

140 necessary compensatory response to maintain cardiac contractility and systemic blood pressure.

141 hibits apoptosis and fibrosis, and increases cardiac contractility and that the antiapoptotic effect

142 We conclude that LPS depresses cardiac contractility and the contractile response to be

143 inase II (CaMKII) plays an important role in cardiac contractility and the development of heart failu

144 ptor subtype in the heart, where it mediates cardiac contractility and the force of contraction.

145 mplete blood count, blood chemistry profile, cardiac contractility and tissue histologies from liver,

146 d that DMPK is critical to the modulation of cardiac contractility and to the maintenance of proper c

147 of anandamide and the associated decrease in cardiac contractility and total peripheral resistance (T

148 nction in rats and mice resulted in impaired cardiac contractility and upregulation of G-protein-coup

149 ent at 18 hours after surgery was focused on cardiac contractility and vascular ex vivo function.

150 Knockdown of genes essential for cardiac contractility and vascular flow to the kidney, s

151 d septic shock management enhances intrinsic cardiac contractility and vascular responsiveness to cat

152 ving extracellular fluid volume homeostasis, cardiac contractility and vascular tone through renal, n

153 have a unique function in the maintenance of cardiac contractility and ventricular chamber morphogene

154 ng demonstrated no significant difference in cardiac contractility and viability between the CSC and

155 NCX and NCKX are important in regulation of cardiac contractility and visual processes, respectively

156 a(2+)-cycling proteins are key regulators of cardiac contractility, and alterations in sarcoplasmic r

157 or example, they maintain ejection fraction, cardiac contractility, and cardiac output in severe hypo

158 monstrate that the alpha 1 isoform regulates cardiac contractility, and that both the alpha 1 and alp

159 acid amidohydrolase reduces blood pressure, cardiac contractility, and vascular resistance to levels

160 Changes in Ca2+ handling and decreased cardiac contractility are apparent 1 week after Galpha q

161 Furthermore, MAPK activation and cardiac contractility are markedly impaired in heart-spe

162 contributions to the enhancement of in vivo cardiac contractility are unknown.

163 of energy, in the form of ATP, required for cardiac contractility, are closely interconnected with t

164 eveloped dilated cardiomyopathy with reduced cardiac contractility, arrhythmias, and susceptibility t

165 SVPs and CSCs alone improved cardiac contractility as assessed by echocardiography at

166 However, the mutant hearts had abnormal cardiac contractility as measured by fractional shorteni

167 However, the increase in cardiac contractility as well as the acceleration of pre

168 exhibit normal growth, cardiac anatomy, and cardiac contractility, as assessed by echocardiography.

169 phospholamban phosphorylation and augmented cardiac contractility at the cellular and intact animal

170 slate into reduced fractional shortening and cardiac contractility at the in vivo level.

171 ac N-terminal extension functions to improve cardiac contractility at the myofilament level and impro

172 ression of phospholamban, a key regulator of cardiac contractility, at both the transcript and protei

173 le to explain the changes in cardiac output, cardiac contractility, blood pressure, vascular resistan

174 mic hemodynamic responses (vascular tone and cardiac contractility), both under basal conditions and

175 m the full venom by chromatography increased cardiac contractility but did neither provoke ventricula

176 on is thought to be important for supporting cardiac contractility, but is hardly detectable in cultu

177 crucial in the regulation of [Ca(2+)](i) and cardiac contractility, but key details of its dynamic fu

178 creasing systolic sodium influx can increase cardiac contractility, but most sodium channel activator

179 ng mutant human TnT (I79N-Tg) have increased cardiac contractility, but no ventricular hypertrophy or

180 itation-contraction coupling that can impair cardiac contractility, but the role of these abnormaliti

181 Nitric oxide (NO) can directly modulate cardiac contractility by accelerating relaxation and red

182 olemmal Na+-Ca2+ exchanger (NCX1) influences cardiac contractility by extruding Ca2+ from myocytes.

183 (+)-Ca(2+) exchanger plays a central role in cardiac contractility by maintaining Ca(2+) homeostasis.

184 alase lowers blood pressure, heart rate, and cardiac contractility by metabolizing circulating catech

185 to evaluate whether p110alpha also controls cardiac contractility by regulating the LTCC.

186 PKC-alpha functions as a nodal integrator of cardiac contractility by sensing intracellular Ca(2+) an

187 ngineering approach to directly tune in vivo cardiac contractility by tailoring the ability of the he

188 will highlight the regulatory mechanisms of cardiac contractility by the multimeric SERCA/PLN-ensemb

189 stress-responsive cardiac genes, and loss of cardiac contractility comparable to wild-type littermate

190 signaling to adenylyl cyclase and decreased cardiac contractility compared with Gly 389 hearts.

191 ic mice also showed a remarkable increase in cardiac contractility compared with wild-type controls a

192 nels that play important roles in regulating cardiac contractility, controlling heart rate, and media

193 Diabetic mice had a cardiac contractility defect, reduced PI 3-kinase signal

194 tension determined in vitro, and indices of cardiac contractility determined in vivo.

195 c cardiomyopathy is characterized by reduced cardiac contractility due to direct changes in heart mus

196 earts, CGRP (20 pmol/kg per minute) enhanced cardiac contractility (eg, +33+/-4.2% in end-systolic el

197 Comparable to apelin, ELA increased cardiac contractility, ejection fraction, and cardiac ou

198 , Hsp20 has been implicated in modulation of cardiac contractility ex vivo.

199 isoform of the Na,K-ATPase, and we analyzed cardiac contractility following selective inhibition of

200 the cadherin protein complex, hypertension, cardiac contractility, glaucoma, microRNA processing, an

201 Calcium is central in the regulation of cardiac contractility, growth and gene expression.

202 These three manipulations of cardiac contractility had distinct effects on disease pr

203 two models revealed that subjects with lower cardiac contractility had greater body mass, higher fast

204 e role of the acidic N' region in modulating cardiac contractility has not been fully defined.

205 nalase infusion in rats caused a decrease in cardiac contractility, heart rate, and blood pressure an

206 -adrenergic receptor-mediated enhancement of cardiac contractility; however, recent identification of

207 Ro-32-0432 also increased cardiac contractility in 2 different models of heart fai

208 inase C (PKC) family of kinases can modulate cardiac contractility in a complex manner, such that con

209 alpha1 also contributes to the deficiency in cardiac contractility in animal models.

210 s a novel therapeutic strategy for enhancing cardiac contractility in certain stages of heart failure

211 d molecular mechanism of albumin infusion on cardiac contractility in experimental cirrhosis with asc

212 ude that endocannabinoids tonically suppress cardiac contractility in hypertension and that enhancing

213 e multipollutant mixtures decreases LVDP and cardiac contractility in isolated non-ischemic murine he

214 Na,K-ATPase isozyme mediates ouabain-induced cardiac contractility in mice.

215 electively in their hearts exhibit increased cardiac contractility in response to beta-adrenergic rec

216 e TG heart also showed a greater increase of cardiac contractility in response to the P2X receptor ag

217 by human PLN was associated with attenuated cardiac contractility in the intact-animal, organ, and c

218 Weakened cardiac contractility in vivo in alcoholic animals is al

219 2-0432 or Ro-31-8220 significantly augmented cardiac contractility in vivo or in an isolated work-per

220 o, but, importantly, show that Akt modulates cardiac contractility in vivo without directly affecting

221 of the affinity of SERCA2a for Ca(2+) and of cardiac contractility in vivo.

222 ed enteric smooth muscle gamma-actin reduces cardiac contractility in wild-type and heterozygous mice

223 ble PKCalpha/beta/gamma inhibitor, increased cardiac contractility in wild-type and PKCbetagamma(-/-)

224 osin light chain 2, an essential protein for cardiac contractility in zebrafish.

225 along with measurements of hemodynamics and cardiac contractility, in assessing the mechanism(s) tha

226 oforms influence other important features of cardiac contractility, including the Ca2+ sensitivity of

227 Respiratory rate and cardiac contractility increased during this phase.

228 c deletion of miR-214 in mice causes loss of cardiac contractility, increased apoptosis, and excessiv

229 Apelin infusion increased cardiac contractility, indicated by a significant increa

230 rine, caused normalization of all indices of cardiac contractility, indicating that the presumed decr

231 Existing drugs increase cardiac contractility indirectly through signaling casca

232 against the hypothesis that abnormalities in cardiac contractility initiate the heart failure syndrom

233 Decreased cardiac contractility is a central feature of systolic h

234 Impaired cardiac contractility is a fundamental component of the

235 Decrease in cardiac contractility is a hallmark of chronic diabetes.

236 It is becoming increasingly clear that cardiac contractility is also regulated through structur

237 Together these data suggest cardiac contractility is enhanced when only 10% of the c

238 gene expression in human heart failure where cardiac contractility is impaired significantly.

239 However, cMyBP-C's ability to modulate cardiac contractility is not well understood.

240 Cardiac contractility is regulated by changes in intrace

241 Importantly, we find that blood flow/cardiac contractility is required for the transition fro

242 ich elevates intracellular cAMP and enhances cardiac contractility, is severely impaired in the faili

243 elin is among the most potent stimulators of cardiac contractility known.

244 cardiomyopathy is characterized by impaired cardiac contractility leading to poor myocardial perform

245 sarcoplasmic reticulum calcium handling and cardiac contractility may be regulated by the differenti

246 xamined the effects of long-term delivery of cardiac contractility modulation (CCM) electric signals

247 chanism of co-operative Ca(2+) regulation of cardiac contractility must therefore be intrinsic to the

248 myriad of functions in the heart, including cardiac contractility, myocardial metabolism,and gene ex

249 not PKCbetagamma(-/-) mice, showed increased cardiac contractility, myocyte cellular contractility, C

250 Current inotropic therapies used to increase cardiac contractility of the failing heart center on inc

251 bition of HIF2alpha reversed the compromised cardiac contractility of vhl(-/-) embryos and partially

252 CRFR2-deficient mice showed no alteration in cardiac contractility or blood pressure in response to U

253 Stem cells may directly increase cardiac contractility or passively limit infarct expansi

254 After albumin injection cardiac contractility (P < 0.01), protein expression of

255 lic nucleotides in diverse processes such as cardiac contractility, platelet aggregation, lipolysis,

256 d on this core paradigm, drugs that increase cardiac contractility (positive inotropes) are theoretic

257 tone and beta-adrenergic agonist-stimulated cardiac contractility, previously ascribed exclusively t

258 In the hemodynamic realm, an elevation of cardiac contractility prompted increased stroke volume,

259 t threonine 75 represents a new mechanism of cardiac contractility regulation, partially through the

260 I phosphorylation sites in the regulation of cardiac contractility remains a topic of intense debate,

261 Genes important for maintaining cardiac contractility, repressing cardiac hypertrophy, p

262 Diminished cardiac contractility resulting from less beta(1)-AR exp

263 During each heartbeat, cardiac contractility results from calcium-activated sli

264 is directly linked to the proper control of cardiac contractility, rhythm, and the expression of Ca(

265 ested that angiotensin II (Ang II) modulates cardiac contractility, rhythm, metabolism, and structure

266 s characterized by substantial reductions in cardiac contractility, severe arrhythmia, and reduced my

267 SR calcium transport function and increased cardiac contractility, suggesting that SERCA2b plays a h

268 Cardiac contractility tended to decline (P=0.096), where

269 in left ventricular anterior wall thickness, cardiac contractility, tetrahydrobiopterin, the dimers o

270 Molecular inotropy refers to cardiac contractility that can be modified to affect ove

271 ndividuals with diabetes experience impaired cardiac contractility that cannot be explained by hypert

272 TnC can specifically and precisely modulate cardiac contractility that when combined with gene thera

273 ell signaling pathways leading to changes in cardiac contractility, the hypertrophic response, and to

274 Catecholamines stimulate cardiac contractility through beta(1)-adrenergic recepto

275 k-filament-associated protein that modulates cardiac contractility through interactions of its N-term

276 inhibition by epicardial lidocaine decreased cardiac contractility to a greater extent in CHF rats th

277 sential for late heart morphogenesis and for cardiac contractility to support postnatal life.

278 ity of cAMP signals is necessary to optimize cardiac contractility upon adrenergic activation.

279 Interleukin (IL)-6 decreases cardiac contractility via a nitric oxide (NO)-dependent

280 nterleukin (IL)-6 has been shown to decrease cardiac contractility via a nitric oxide synthase (NOS)-

281 Finally, FGF23 increases cardiac contractility via FGFR4, while known effects of

282 Phospholamban (PLN) regulates cardiac contractility via its modulation of sarco(endo)p

283 Cardiac contractility was elevated in mice overexpressin

284 Cardiac contractility was recorded ex vivo in rats with

285 After saline intravenous injection, cardiac contractility was significantly reduced in rats

286 eins, which are associated with the enhanced cardiac contractility, we performed a proteomics-based a

287 f increased relative beta-MyHC expression on cardiac contractility, we used acute genetic engineering

288 cts of overexpression of the SR Ca2+ pump on cardiac contractility, we used the isolated perfused wor

289 The systemic vascular resistance and cardiac contractility were decreased in response to the

290 Interestingly, these protective effects on cardiac contractility were not observed in S2814A mice a

291 specific JPH2 knockdown resulted in impaired cardiac contractility, which caused heart failure and in

292 hearts of mice leads to a marked increase in cardiac contractility, which is apparently due to the lo

293 n a decrease in peripheral vascular tone and cardiac contractility, which results in profound hypoten

294 vation of the CSAR evokes little increase in cardiac contractility with an exaggerated peripheral vas

295 th streptozotocin caused severe reduction of cardiac contractility with enhancing urinary and cardiac

296 mouse exhibited significantly elevated basal cardiac contractility with greater rates of contraction

297 lacking Epac1 (Epac1 KO) exhibited decreased cardiac contractility with reduced phospholamban (PLN) p

298 AT1R blocker losartan were unable to enhance cardiac contractility with volume loading, treatment wit

299 Raf1(L613V) enhances Ca(2+) sensitivity and cardiac contractility without causing hypertrophy.

300 New therapeutic approaches to improve cardiac contractility without severe risk would improve